Dr Matthew Day

TopBP1 utilises a bipartite GINS binding mode to support genome replication
Day M, Tetik B, Parlak M, Almeida-Hernández Y, Räschle M, Kaschani F, Siegert H, Marko A, Sanchez-Garcia E, Kaiser M, Barker IA, Pearl LH, Oliver AW and Boos D
Nature Communications, Springer Nature vol. 15 (1) 
27-02-2024

Structure of the human RAD17–RFC clamp loader and 9–1–1 checkpoint clamp bound to a dsDNA–ssDNA junction
Day M, Oliver AW and Pearl LH
Nucleic Acids Research, Oxford University Press (OUP) vol. 50 (14), 8279-8289.  
12-07-2022

Phosphorylation-dependent assembly of DNA damage response systems and the central roles of TOPBP1
Day M, Oliver AW and Pearl LH
DNA Repair, Elsevier vol. 108 
29-09-2021

CK2 Phosphorylation of Human Papillomavirus 16 E2 on Serine 23 Promotes Interaction with TopBP1 and Is Critical for E2 Interaction with Mitotic Chromatin and the Viral Life Cycle
Prabhakar AT, James CD, Das D, Otoa R, Day M, Burgner J, Fontan CT, Wang X, Glass SH, Wieland A, Donaldson MM, Bristol ML, Li R, Oliver AW, Pearl LH, Smith BO and Morgan IM
Mbio, American Society For Microbiology vol. 12 (5), 10.1128/mbio.01163-10.1128/mbio.01121.  
21-09-2021

Structural basis for recruitment of the CHK1 DNA damage kinase by the CLASPIN scaffold protein
Day M, Parry-Morris S, Houghton-Gisby J, Oliver AW and Pearl LH
Structure, Elsevier vol. 29 (6), 531-539.e3.  
30-03-2021

Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint
Bigot N, Day M, Baldock RA, Watts FZ, Oliver AW and Pearl LH
Elife, Elife vol. 8 
28-05-2019

MDC1 Interacts with TOPBP1 to Maintain Chromosomal Stability during Mitosis
Leimbacher P-A, Jones SE, Shorrocks A-MK, de Marco Zompit M, Day M, Blaauwendraad J, Bundschuh D, Bonham S, Fischer R, Fink D, Kessler BM, Oliver AW, Pearl LH, Blackford AN and Stucki M
Molecular Cell, Elsevier vol. 74 (3), 571-583.e8.  
18-03-2019

BRCT domains of the DNA damage checkpoint proteins TOPBP1/Rad4 display distinct specificities for phosphopeptide ligands
Day M, Rappas M, Ptasinska K, Boos D, Oliver AW and Pearl LH
Elife, Elife vol. 7 
08-10-2018

ATM Localization and Heterochromatin Repair Depend on Direct Interaction of the 53BP1-BRCT2 Domain with γH2AX
Baldock RA, Day M, Wilkinson OJ, Cloney R, Jeggo PA, Oliver AW, Watts FZ and Pearl LH
Cell Reports, Elsevier vol. 13 (10), 2081-2089.  
25-11-2015

Phosphorylation-Dependent Assembly and Coordination of the DNA Damage Checkpoint Apparatus by Rad4TopBP1
Qu M, Rappas M, Wardlaw CP, Garcia V, Ren J-Y, Day M, Carr AM, Oliver AW, Du L-L and Pearl LH
Molecular Cell, Elsevier vol. 51 (6), 723-736.  
01-09-2013