Research
Gene regulation, Single-cell genomics, Cancer biology, Epigenetics
Interests
I am a computational and molecular biologist, interested in understanding how genetic and epigenetic alterations shape cell behaviour during disease development, particularly in cancer.
I have a PhD in Molecular Biology from the Humboldt University of Berlin, which I earned from working in the group Ana Pombo at the Berlin Institute for Medical Systems Biology (part of the Max Delbruck Center for Molecular Medicine). After that, I was a postdoctoral researcher in the labs of Aviv Regev and Brad Bernstein at Broad Institute of MIT and Harvard/ Dana Farber Cancer Institute (Boston, MA, US). I joined QMUL in Feb 2024.
See more information about my research interests at:
https://ettlab.science/
Publications
Publications of specific relevance to the Centre for Molecular Cell Biology
2023
B-cell-specific checkpoint molecules that regulate anti-tumour immunityBod L, Kye Y-C, Shi J,
Torlai Triglia E, Schnell A, Fessler J, Ostrowski SM, Von-Franque MY, Kuchroo JR, Barilla RM, Zaghouani S, Christian E, Delorey TM, Mohib K, Xiao S, Slingerland N, Giuliano CJ, Ashenberg O, Li Z, Rothstein DM,
et al. Nature,
Springer Nature vol. 619 (7969), 348-356.
21-06-20232022
Stepwise-edited, human melanoma models reveal mutations’ effect on tumor and microenvironmentHodis E,
Torlai Triglia E, Kwon JYH, Biancalani T, Zakka LR, Parkar S, Hütter J-C, Buffoni L, Delorey TM, Phillips D, Dionne D, Nguyen LT, Schapiro D, Maliga Z, Jacobson CA, Hendel A, Rozenblatt-Rosen O, Mihm MC, Garraway LA and Regev A
Science,
American Association For The Advancement of Science (Aaas) vol. 376 (6592), eabi8175-eabi8175.
29-04-2022 2021
Cell-type specialization is encoded by specific chromatin topologiesWinick-Ng W, Kukalev A, Harabula I, Zea-Redondo L, Szabó D, Meijer M, Serebreni L, Zhang Y, Bianco S, Chiariello AM, Irastorza-Azcarate I, Thieme CJ, Sparks TM, Carvalho S, Fiorillo L, Musella F, Irani E,
Torlai Triglia E, Kolodziejczyk AA, Abentung A,
et al. Nature,
Springer Nature vol. 599 (7886), 684-691.
17-11-2021 Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographicsMuus C, Luecken MD, Eraslan G, Sikkema L, Waghray A, Heimberg G, Kobayashi Y, Vaishnav ED, Subramanian A, Smillie C, Jagadeesh KA, Duong ET, Fiskin E,
Torlai Triglia E, Ansari M, Cai P, Lin B, Buchanan J, Chen S, Shu J,
et al. Nature Medicine,
Springer Nature vol. 27 (3), 546-559.
02-03-2021 Skin-resident innate lymphoid cells converge on a pathogenic effector stateBielecki P, Riesenfeld SJ, Hütter J-C,
Torlai Triglia E, Kowalczyk MS, Ricardo-Gonzalez RR, Lian M, Amezcua Vesely MC, Kroehling L, Xu H, Slyper M, Muus C, Ludwig LS, Christian E, Tao L, Kedaigle AJ, Steach HR, York AG, Skadow MH, Yaghoubi P,
et al. Nature,
Springer Nature vol. 592 (7852), 128-132.
03-02-2021 2019
R-Loops Enhance Polycomb Repression at a Subset of Developmental Regulator GenesSkourti-Stathaki K,
Torlai Triglia E, Warburton M, Voigt P, Bird A and Pombo A
Molecular Cell,
Elsevier vol. 73 (5), 930-945.e4.
29-01-2019 2017
RNA polymerase II primes Polycomb‐repressed developmental genes throughout terminal neuronal differentiationFerrai C,
Torlai Triglia E, Risner‐Janiczek JR, Rito T, Rackham OJL, Santiago I, Kukalev A, Nicodemi M, Akalin A, Li M, Ungless MA and Pombo A
Molecular Systems Biology,
Springer Nature vol. 13 (10), 946-946.
01-10-2017 Flipping between Polycomb repressed and active transcriptional states introduces noise in gene expression.Kar G, Kim JK, Kolodziejczyk AA, Natarajan KN,
Torlai Triglia E, Mifsud B, Elderkin S, Marioni JC, Pombo A and Teichmann SA
Nat Commun,
Macmillan Publishers Limited, Part of Springer Nature vol. 8 (1), 36-36.
26-06-2017 Keep Them Close: PRC2 Poises Enhancer-Promoter Interactions at Anterior Neuronal GenesCaglio G,
Torlai Triglia E and Pombo A
01-05-2017 Active and poised promoter states drive folding of the extended HoxB locus in mouse embryonic stem cellsBarbieri M, Xie SQ,
Torlai Triglia E, Chiariello AM, Bianco S, de Santiago I, Branco MR, Rueda D, Nicodemi M and Pombo A
Nature Structural & Molecular Biology,
Springer Nature vol. 24 (6), 515-524.
24-04-2017 A Finer Print Than TADs: PRC1-Mediated DomainsTorlai Triglia E, Rito T and Pombo A
01-02-2017 2015
Methylation of RNA polymerase II non-consensus Lysine residues marks early transcription in mammalian cellsDias JD, Rito T,
Torlai Triglia E, Kukalev A, Ferrai C, Chotalia M, Brookes E, Kimura H and Pombo A
Elife,
Elife vol. 4, e11215-e11215.
19-12-2015
