Dr Ewan Main

Frankling CL, Downes MF, Kang AS and Main ERG (2023). Exploring the ‘N-terminal arm’ &‘Convex surface’ Binding Interfaces of the T3SS Chaperone-Translocator Complexes from P. Aeruginosa. Journal of Molecular Biology, Elsevier vol. 435 (15) 
17-05-2023

Frankling CL, Kang AS and Main ERG (2023). Exploring the “N-Terminal Anchor” Binding Interface of the T3SS Chaperone–Translocator Complexes from P. aeruginosa. Biochemistry, American Chemical Society (ACS) vol. 62 (8), 1420-1427.  
30-03-2023

Perez-Riba A, Komives E, Main E and Itzhaki L (2019). Decoupling a tandem-repeat protein: impact of multiple loop insertions on a modular scaffold. Scientific Reports, Nature Publishing Group 
28-10-2019

Wright JN, Wong WL, Harvey JA, Garnett JA, Itzhaki LS and Main ERG (2019). Scalable Geometrically Designed Protein Cages Assembled via Genetically Encoded Split Inteins. Structure vol. 27 (5), 776-784.e4.  
07-05-2019

Perez-Riba A, Lowe A, MAIN E and Itzhaki L (2018). Context-dependent energetics of loop extensions in a family of tandem-repeat proteins. Biophysical Journal, Biophysical Society 
05-06-2018

Harvey JA, Itzhaki LS and Main ERG (2018). Programmed Protein Self-Assembly Driven by Genetically Encoded Intein-Mediated Native Chemical Ligation. ACS Synth Biol vol. 7 (4), 1067-1074.  
20-04-2018

Lowe AR, Perez-Riba A, Itzhaki LS and Main ERG (2018). PyFolding: Open-Source Graphing, Simulation, and Analysis of the Biophysical Properties of Proteins. Biophys J vol. 114 (3), 516-521.  
06-02-2018

Perez-Riba A, Lowe A, Main E, Komives E and Itzhaki L (2017). Entropically-Challenged Tandem-repeat Proteins: Breakdown of Nearest-Neighbour Cooperativity. 
01-01-2017

Millership C, Phillips JJ and Main ERG (2016). Ising Model Reprogramming of a Repeat Protein's Equilibrium Unfolding Pathway. J Mol Biol vol. 428 (9 Pt A), 1804-1817.  
08-05-2016

Perez-Riba A, Main ER and Itzhaki LS (2016). The Effect of Loop Insertions on the Folding of Tandem-Repeat Proteins. 
01-02-2016

Rowling PJE, Sivertsson EM, Perez-Riba A, Main ERG and Itzhaki LS (2015). Dissecting and reprogramming the folding and assembly of tandem-repeat proteins. Biochemical Society Transactions, Portland Press vol. 43 (5), 881-888.  
01-10-2015

Main ERG, Phillips JJ and Millership C (2013). Repeat protein engineering: creating functional nanostructures/biomaterials from modular building blocks. Biochem Soc Trans vol. 41 (5), 1152-1158.  
01-10-2013

Singh SK, Boyle AL and Main ERG (2013). LcrH, a class II chaperone from the type three secretion system, has a highly flexible native structure. J Biol Chem vol. 288 (6), 4048-4055.  
08-02-2013

Phillips JJ, Millership C and Main ERG (2012). Fibrous nanostructures from the self-assembly of designed repeat protein modules. Angew Chem Int Ed Engl vol. 51 (52), 13132-13135.  
21-12-2012

Phillips JJ, Millership C and Main ERG (2012). Fibrous Nanostructures from the Self‐Assembly of Designed Repeat Protein Modules. Angewandte Chemie, Wiley vol. 124 (52), 13309-13312.  
10-12-2012

Phillips JJ, Javadi Y, Millership C and Main ERG (2012). Modulation of the multistate folding of designed TPR proteins through intrinsic and extrinsic factors. Protein Sci vol. 21 (3), 327-338.  
01-03-2012

Mahendrarajah K, Dalby PA, Wilkinson B, Jackson SE and Main ERG (2011). A high-throughput fluorescence chemical denaturation assay as a general screen for protein-ligand binding. Anal Biochem vol. 411 (1), 155-157.  
01-04-2011

Boyd LK, Mercer B, Thompson D, Main E and Watts FZ (2010). Characterisation of the SUMO-like domains of Schizosaccharomyces pombe Rad60. PLoS One vol. 5 (9) 
27-09-2010

Gaudet M, Remtulla N, Jackson SE, Main ERG, Bracewell DG, Aeppli G and Dalby PA (2010). Protein denaturation and protein:drugs interactions from intrinsic protein fluorescence measurements at the nanolitre scale. PROTEIN SCI vol. 19 (8), 1544-1554.  
01-08-2010

Javadi Y and Main ERG (2009). Exploring the folding energy landscape of a series of designed consensus tetratricopeptide repeat proteins. P NATL ACAD SCI USA vol. 106 (41), 17383-17388.  
13-10-2009

Main ERG, Lowe AR, Mochrie SGJ, Jackson SE and Regan L (2005). A recurring theme in protein engineering: the design, stability and folding of repeat proteins. CURR OPIN STRUC BIOL vol. 15 (4), 464-471.  
01-08-2005

Kajander T, Cortajarena AL, Main ERG, Mochrie SGJ and Regan L (2005). A new folding paradigm for repeat proteins. J AM CHEM SOC vol. 127 (29), 10188-10190.  
27-07-2005

Main ERG, Stott K, Jackson SE and Regan L (2005). Local and long-range stability in tandemly arrayed tetratricopeptide repeats. P NATL ACAD SCI USA vol. 102 (16), 5721-5726.  
19-04-2005

Maxwell KL, Wildes D, Zarrine-Afsar A, de los Rios MA, Brown AG, Friel CT, Hedberg L, Horng JC, Bona D, Miller EJ, Vallee-Belisle A, Main ERG, Bemporad F, Qiu LL, Teilum K, Vu ND, Edwards AM, Ruczinski I, Poulsen FM, Kragelund BB, et al. (2005). Protein folding: Defining a standard set of experimental conditions and a preliminary kinetic data set of two-state proteins. PROTEIN SCI vol. 14 (3), 602-616.  
01-03-2005

Main ERG, Jackson SE and Regan L (2003). The folding and design of repeat proteins: reaching a consensus. CURR OPIN STRUC BIOL vol. 13 (4), 482-489.  
01-08-2003

Main ERG, Xiong Y, Cocco MJ, D'Andrea L and Regan L (2003). Design of stable alpha-helical arrays from an idealized TPR motif. STRUCTURE vol. 11 (5), 497-508.  
01-05-2003

Main ERG, Fulton KF, Daggett V and Jackson SE (2001). A comparison of experimental and computational methods for mapping the interactions present in the transition state for folding of FKBP12. J BIOL PHYS vol. 27 (2), 99-117.  
01-01-2001

Main ERG and Jackson SE (1999). Does trifluoroethanol affect folding pathways and can it be used as a probe of structure in transition states? NAT STRUCT BIOL vol. 6 (9), 831-835.  
01-09-1999

Main ERG, Fulton KF and Jackson SE (1999). Folding pathway of FKBP12 and characterisation of the transition state. J MOL BIOL vol. 291 (2), 429-444.  
13-08-1999

Fulton KF, Main ERG, Daggett V and Jackson SE (1999). Mapping the interactions present in the transition state for unfolding/folding of FKBP12. J MOL BIOL vol. 291 (2), 445-461.  
13-08-1999

Main ERG, Fulton KF and Jackson SE (1998). Context-dependent nature of destabilizing mutations on the stability of FKBP12. BIOCHEMISTRY-US vol. 37 (17), 6145-6153.  
28-04-1998