Dr Ewan Main

Decoupling a tandem-repeat protein: impact of multiple loop insertions on a modular scaffold
Perez-Riba A, Komives E, Main E and Itzhaki L
Scientific Reports, Nature Publishing Group 
28-10-2019

Scalable Geometrically Designed Protein Cages Assembled via Genetically Encoded Split Inteins.
Wright JN, Wong WL, Harvey JA, Garnett JA, Itzhaki LS and Main ERG
Structure vol. 27 (5), 776-784.e4.  
07-05-2019

Context-dependent energetics of loop extensions in a family of tandem-repeat proteins
Perez-Riba A, Lowe A, MAIN E and Itzhaki L
Biophysical Journal, Biophysical Society 
05-06-2018

Programmed Protein Self-Assembly Driven by Genetically Encoded Intein-Mediated Native Chemical Ligation.
Harvey JA, Itzhaki LS and Main ERG
Acs Synth Biol vol. 7 (4), 1067-1074.  
20-04-2018

PyFolding: Open-Source Graphing, Simulation, and Analysis of the Biophysical Properties of Proteins.
Lowe AR, Perez-Riba A, Itzhaki LS and Main ERG
Biophys J vol. 114 (3), 516-521.  
06-02-2018

Entropically-Challenged Tandem-repeat Proteins: Breakdown of Nearest-Neighbour Cooperativity
Perez-Riba A, Lowe A, Main E, Komives E and Itzhaki L
PROTEIN SCIENCE. vol. 26, 108-108.  
01-01-2017

Ising Model Reprogramming of a Repeat Protein's Equilibrium Unfolding Pathway.
Millership C, Phillips JJ and Main ERG
J Mol Biol vol. 428 (9 Pt A), 1804-1817.  
08-05-2016

The Effect of Loop Insertions on the Folding of Tandem-Repeat Proteins
Perez-Riba A, Main ER and Itzhaki LS
Biophysical Journal. vol. 110 (3) 
01-02-2016

Dissecting and reprogramming the folding and assembly of tandem-repeat proteins.
Rowling PJE, Sivertsson EM, Perez-Riba A, Main ERG and Itzhaki LS
Biochemical Society Transactions, Portland Press vol. 43 (5), 881-888.  
01-10-2015

Repeat protein engineering: creating functional nanostructures/biomaterials from modular building blocks.
Main ERG, Phillips JJ and Millership C
Biochem Soc Trans vol. 41 (5), 1152-1158.  
01-10-2013

LcrH, a class II chaperone from the type three secretion system, has a highly flexible native structure.
Singh SK, Boyle AL and Main ERG
J Biol Chem vol. 288 (6), 4048-4055.  
08-02-2013

Fibrous nanostructures from the self-assembly of designed repeat protein modules.
Phillips JJ, Millership C and Main ERG
Angew Chem Int Ed Engl vol. 51 (52), 13132-13135.  
21-12-2012

Fibrous Nanostructures from the Self‐Assembly of Designed Repeat Protein Modules
Phillips JJ, Millership C and Main ERG
Angewandte Chemie, Wiley vol. 124 (52), 13309-13312.  
10-12-2012

Modulation of the multistate folding of designed TPR proteins through intrinsic and extrinsic factors.
Phillips JJ, Javadi Y, Millership C and Main ERG
Protein Sci vol. 21 (3), 327-338.  
01-03-2012

A high-throughput fluorescence chemical denaturation assay as a general screen for protein-ligand binding.
Mahendrarajah K, Dalby PA, Wilkinson B, Jackson SE and Main ERG
Anal Biochem vol. 411 (1), 155-157.  
01-04-2011

Characterisation of the SUMO-like domains of Schizosaccharomyces pombe Rad60.
Boyd LK, Mercer B, Thompson D, Main E and Watts FZ
Plos One vol. 5 (9) 
27-09-2010

Protein denaturation and protein:drugs interactions from intrinsic protein fluorescence measurements at the nanolitre scale
Gaudet M, Remtulla N, Jackson SE, Main ERG, Bracewell DG, Aeppli G and Dalby PA
Protein Sci vol. 19 (8), 1544-1554.  
01-08-2010

Exploring the folding energy landscape of a series of designed consensus tetratricopeptide repeat proteins
Javadi Y and Main ERG
P Natl Acad Sci Usa vol. 106 (41), 17383-17388.  
13-10-2009

A recurring theme in protein engineering: the design, stability and folding of repeat proteins
Main ERG, Lowe AR, Mochrie SGJ, Jackson SE and Regan L
Curr Opin Struc Biol vol. 15 (4), 464-471.  
01-08-2005

A new folding paradigm for repeat proteins
Kajander T, Cortajarena AL, Main ERG, Mochrie SGJ and Regan L
J Am Chem Soc vol. 127 (29), 10188-10190.  
27-07-2005

Local and long-range stability in tandemly arrayed tetratricopeptide repeats
Main ERG, Stott K, Jackson SE and Regan L
P Natl Acad Sci Usa vol. 102 (16), 5721-5726.  
19-04-2005

Protein folding: Defining a standard set of experimental conditions and a preliminary kinetic data set of two-state proteins
Maxwell KL, Wildes D, Zarrine-Afsar A, de los Rios MA, Brown AG, Friel CT, Hedberg L, Horng JC, Bona D, Miller EJ, Vallee-Belisle A, Main ERG, Bemporad F, Qiu LL, Teilum K, Vu ND, Edwards AM, Ruczinski I, Poulsen FM, Kragelund BB, et al.
Protein Sci vol. 14 (3), 602-616.  
01-03-2005

The folding and design of repeat proteins: reaching a consensus
Main ERG, Jackson SE and Regan L
Curr Opin Struc Biol vol. 13 (4), 482-489.  
01-08-2003

Design of stable alpha-helical arrays from an idealized TPR motif
Main ERG, Xiong Y, Cocco MJ, D'Andrea L and Regan L
Structure vol. 11 (5), 497-508.  
01-05-2003

A comparison of experimental and computational methods for mapping the interactions present in the transition state for folding of FKBP12
Main ERG, Fulton KF, Daggett V and Jackson SE
J Biol Phys vol. 27 (2), 99-117.  
01-01-2001

Does trifluoroethanol affect folding pathways and can it be used as a probe of structure in transition states?
Main ERG and Jackson SE
Nat Struct Biol vol. 6 (9), 831-835.  
01-09-1999

Folding pathway of FKBP12 and characterisation of the transition state
Main ERG, Fulton KF and Jackson SE
J Mol Biol vol. 291 (2), 429-444.  
13-08-1999

Mapping the interactions present in the transition state for unfolding/folding of FKBP12
Fulton KF, Main ERG, Daggett V and Jackson SE
J Mol Biol vol. 291 (2), 445-461.  
13-08-1999

Context-dependent nature of destabilizing mutations on the stability of FKBP12
Main ERG, Fulton KF and Jackson SE
Biochemistry-Us vol. 37 (17), 6145-6153.  
28-04-1998