Dr Paul J. Hurd
Reader in Genome Regulation and Epigenetics
Head of The Centre for Evolutionary and Functional Genomics
School of Biological and Behavioural Sciences
Queen Mary University of London
Queen Mary University of London
Research
Honey bee, Functional Genomics, Epigenetics, Chromatin, Phenotypic plasticity
Publications
Publications of specific relevance to the Centre for Evolutionary and Functional Genomics
2024
Guynes K, Sarre LA, Carrillo-Baltodano AM, Davies BE, Xu L, Liang Y, Martín-Zamora FM, Hurd PJ, de Mendoza A and Martín-Durán JM (2024). Annelid methylomes reveal ancestral developmental and aging-associated epigenetic erosion across Bilateria. Genome Biology, Springer Nature vol. 25 (1), 204-204.
01-08-2024
01-08-2024
2023
Kucharski R, Ellis N, Jurkowski TP, Hurd PJ and Maleszka R (2023). The PWWP domain and the evolution of unique DNA methylation toolkits in Hymenoptera. iScience, Cell Press vol. 26 (11)
17-11-2023
17-11-2023
2022
Lowe R, Wojciechowski M, Ellis N and Hurd PJ (2022). Chromatin accessibility-based characterisation of brain gene regulatory networks in three distinct honey bee polyphenisms. Nucleic Acids Research, Oxford University Press
04-11-2022
04-11-2022
2021
Hurd PJ, Grübel K, Wojciechowski M, Maleszka R and Rössler W (2021). Novel structure in the nuclei of honey bee brain neurons revealed by immunostaining. Scientific Reports, Nature Publishing Group vol. 11 (1)
01-12-2021
01-12-2021
Gancarz M, Hurd PJ, Latoch P, Polaszek A, Michalska-Madej J, Grochowalski Ł, Strapagiel D, Gnat S, Załuski D, Rusinek R, Starosta AL, Krutmuang P, Hernández RM, Pascual MH and Ptaszyńska AA (2021). Dataset of the next-generation sequencing of variable 16S rRNA from bacteria and ITS2 regions from fungi and plants derived from honeybees kept under anthropogenic landscapes. Data in Brief, Elsevier vol. 36
02-04-2021
02-04-2021
Ptaszyńska AA, Latoch P, Hurd PJ, Polaszek A, Michalska-Madej J, Grochowalski Ł, Strapagiel D, Gnat S, Załuski D, Gancarz M, Rusinek R, Krutmuang P, Hernández RM, Pascual MH and Starosta AL (2021). Amplicon Sequencing of Variable 16S rRNA from Bacteria and ITS2 Regions from Fungi and Plants, Reveals Honeybee Susceptibility to Diseases Results from Their Forage Availability under Anthropogenic Landscapes. Pathogens, MDPI vol. 10 (3)
22-03-2021
22-03-2021
2020
Weber de Melo V, Lowe R, Hurd PJ and Petchey OL (2020). Phenotypic responses to temperature in the ciliate Tetrahymena thermophila. Ecology and Evolution, Wiley
01-07-2020
01-07-2020
2019
George JM, Bell ZW, Condliffe D, Dohrer K, Abaurrea T, Spencer K, Leitão A, Gahr M, Hurd PJ and Clayton DF (2019). Acute social isolation alters neurogenomic state in songbird forebrain. Proc Natl Acad Sci U S A
22-07-2019
22-07-2019
2018
WOJCIECHOWSKI M, LOWE R, Maleszka J, CONN D, Maleszka R and HURD PJ (2018). Phenotypically distinct female castes in honey bees are defined by alternative chromatin states during larval development. Genome Research, Cold Spring Harbor Laboratory Press
22-08-2018
22-08-2018
Ptaszyńska AA, Gancarz M, Hurd PJ, Borsuk G, Wiącek D, Nawrocka A, Strachecka A, Załuski D and Paleolog J (2018). Changes in the bioelement content of summer and winter western honeybees (Apis mellifera) induced by Nosema ceranae infection. PLOS ONE, Public Library of Science (PLoS) vol. 13 (7)
25-07-2018
25-07-2018
2015
Cookson VJ, Waite SL, Heath PR, Hurd PJ, Gandhi SV and Chapman NR (2015). Binding loci of RelA-containing nuclear factor-kappaB dimers in promoter regions of PHM1-31 myometrial smooth muscle cells. Mol Hum Reprod vol. 21 (11), 865-883.
01-11-2015
01-11-2015
Snijders AP, Hautbergue GM, Bloom A, Williamson JC, Minshull TC, Phillips HL, Mihaylov SR, Gjerde DT, Hornby DP, Wilson SA, Hurd PJ and Dickman MJ (2015). Arginine methylation and citrullination of splicing factor proline- and glutamine-rich (SFPQ/PSF) regulates its association with mRNA. RNA vol. 21 (3), 347-359.
01-03-2015
01-03-2015
2014
Ismail HMS, Hurd PJ, Khalil MIM, Kouzarides T, Bannister A and Gout I (2014). S6 kinase 2 is bound to chromatin-nuclear matrix cellular fractions and is able to phosphorylate histone H3 at threonine 45 in vitro and in vivo. J Cell Biochem vol. 115 (6), 1048-1062.
01-06-2014
01-06-2014
2013
Murrell A, Hurd PJ and Wood IC (2013). Epigenetic mechanisms in development and disease. Biochem Soc Trans vol. 41 (3), 697-699.
01-06-2013
01-06-2013
Gemma C, Ramagopalan SV, Down TA, Beyan H, Hawa MI, Holland ML, Hurd PJ, Giovannoni G, Leslie RD, Ebers GC and Rakyan VK (2013). Inactive or moderately active human promoters are enriched for inter-individual epialleles. Genome Biol vol. 14 (5)
25-05-2013
25-05-2013
Dickman MJ, Kucharski R, Maleszka R and Hurd PJ (2013). Extensive histone post-translational modification in honey bees. Insect Biochem Mol Biol vol. 43 (2), 125-137.
01-02-2013
01-02-2013
2012
Murrell A, Hurd P and Wood I (2012). Meeting preview. The Biochemist, Portland Press vol. 34 (5)
01-10-2012
01-10-2012
2010
Purdy KJ, Hurd PJ, Moya-Laraño J, Trimmer M, Oakley BB and Woodward G (2010). Systems biology for ecology. From molecules to ecosystems.
30-11-2010
30-11-2010
Purdy KJ, Hurd PJ, Moya-Larano J, Trimmer M, Oakley BB and Woodward G (2010). Systems Biology for Ecology: From Molecules to Ecosystems. ADV ECOL RES vol. 43, 87-149.
01-01-2010
01-01-2010
Purdy KJ, Hurd PJ, Moya-Laraño J, Trimmer M, Oakley BB and Woodward G (2010). Chapter 3 Systems Biology for Ecology From Molecules to Ecosystems. Integrative Ecology: From Molecules to Ecosystems 87-149.
01-01-2010
01-01-2010
2009
Hurd PJ, Bannister AJ, Halls K, Dawson MA, Vermeulen M, Olsen JV, Ismail H, Somers J, Mann M, Owen-Hughes T, Gout I and Kouzarides T (2009). Phosphorylation of histone H3 Thr-45 is linked to apoptosis. J Biol Chem vol. 284 (24), 16575-16583.
12-06-2009
12-06-2009
Hurd PJ and Nelson CJ (2009). Advantages of next-generation sequencing versus the microarray in epigenetic research. Brief Funct Genomic Proteomic vol. 8 (3), 174-183.
01-05-2009
01-05-2009
2008
Smith AE, Hurd PJ, Bannister AJ, Kouzarides T and Ford KG (2008). Heritable gene repression through the action of a directed DNA methyltransferase at a chromosomal locus. J BIOL CHEM vol. 283 (15), 9878-9885.
11-04-2008
11-04-2008
Sajedi E, Gaston-Massuet C, Andoniadou CL, Signore M, Hurd PJ, Dattani M and Martinez-Barbera JP (2008). DNMT1 interacts with the developmental transcriptional repressor HESX1. Biochim Biophys Acta vol. 1783 (1), 131-143.
01-01-2008
01-01-2008
2007
Ford KG, Hurd PJ, Bannister AJ, Kouzarides T and Smith AE (2007). Directed de novo DNA methylation of a genomic locus leads to heritable transcriptional repression.
16-11-2007
16-11-2007
2006
Torres-Padilla ME, Bannister AJ, Hurd PJ, Kouzarides T and Zernicka-Goetz M (2006). Dynamic distribution of the replacement histone variant H3.3 in the mouse oocyte and preimplantation embryos. INT J DEV BIOL vol. 50 (5), 455-461.
01-01-2006
01-01-2006
2003
Fuks F, Hurd PJ, Deplus R and Kouzarides T (2003). The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase. Nucleic Acids Res vol. 31 (9), 2305-2312.
01-05-2003
01-05-2003
Fuks F, Hurd PJ, Wolf D, Nan XS, Bird AP and Kouzarides T (2003). The Methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation. J BIOL CHEM vol. 278 (6), 4035-4040.
07-02-2003
07-02-2003
2002
McNamara AR, Hurd PJ, Smith AEF and Ford KG (2002). Characterisation of site-biased DNA methyltransferases: specificity, affinity and subsite relationships. NUCLEIC ACIDS RES vol. 30 (17), 3818-3830.
01-09-2002
01-09-2002
Zhou L, Cheng X, Connolly BA, Dickman MJ, Hurd PJ and Hornby DP (2002). Zebularine: a novel DNA methylation inhibitor that forms a covalent complex with DNA methyltransferases. J Mol Biol vol. 321 (4), 591-599.
23-08-2002
23-08-2002
1999
HURD PJ, Whitmarsh AJ, Baldwin GS, Kelly SM, Waltho JP, Price NC, Connolly BA and Hornby DP (1999). Mechanism-based inhibition of C5-cytosine DNA methyltransferases by 2-H pyrimidinone. Journal of Molecular Biology vol. 286 (2), 389-401.
01-01-1999
01-01-1999
Grants
Grants of specific relevance to the Centre for Evolutionary and Functional Genomics
The Role of Nutrition as an Epigenetic Modulator of Phenotypic Plasticity during Honeybee Development
Paul J. Hurd
£672,317 BBSRC Biotechnology and Biological Sciences Research Council (01-05-2022 - 30-04-2026)
Paul J. Hurd
£672,317 BBSRC Biotechnology and Biological Sciences Research Council (01-05-2022 - 30-04-2026)
Genomic experiments and data generation for UoMunster
Paul J. Hurd
£10,188 University of Munster (01-02-2021 - 31-10-2023)
Paul J. Hurd
£10,188 University of Munster (01-02-2021 - 31-10-2023)