Dr Paul J. Hurd

Paul J. Hurd

Reader in Genome Regulation and Epigenetics
Head of The Centre for Evolutionary and Functional Genomics

School of Biological and Behavioural Sciences
Queen Mary University of London
ORCID

Research

Honey bee, Functional Genomics, Epigenetics, Chromatin, Phenotypic plasticity

Publications

solid heart iconPublications of specific relevance to the Centre for Evolutionary and Functional Genomics

2024

Relevant PublicationGuynes K, Sarre LA, Carrillo-Baltodano AM, Davies BE, Xu L, Liang Y, Martín-Zamora FM, Hurd PJ, de Mendoza A and Martín-Durán JM (2024). Annelid methylomes reveal ancestral developmental and aging-associated epigenetic erosion across Bilateria. Genome Biology, Springer Nature vol. 25 (1), 204-204.  
01-08-2024

2023

Relevant PublicationKucharski R, Ellis N, Jurkowski TP, Hurd PJ and Maleszka R (2023). The PWWP domain and the evolution of unique DNA methylation toolkits in Hymenoptera. iScience, Cell Press vol. 26 (11) 
17-11-2023

2022

Relevant PublicationLowe R, Wojciechowski M, Ellis N and Hurd PJ (2022). Chromatin accessibility-based characterisation of brain gene regulatory networks in three distinct honey bee polyphenisms. Nucleic Acids Research, Oxford University Press 
04-11-2022

2021

Relevant PublicationHurd PJ, Grübel K, Wojciechowski M, Maleszka R and Rössler W (2021). Novel structure in the nuclei of honey bee brain neurons revealed by immunostaining. Scientific Reports, Nature Publishing Group vol. 11 (1) 
01-12-2021
Relevant PublicationGancarz M, Hurd PJ, Latoch P, Polaszek A, Michalska-Madej J, Grochowalski Ł, Strapagiel D, Gnat S, Załuski D, Rusinek R, Starosta AL, Krutmuang P, Hernández RM, Pascual MH and Ptaszyńska AA (2021). Dataset of the next-generation sequencing of variable 16S rRNA from bacteria and ITS2 regions from fungi and plants derived from honeybees kept under anthropogenic landscapes. Data in Brief, Elsevier vol. 36 
02-04-2021
Relevant PublicationPtaszyńska AA, Latoch P, Hurd PJ, Polaszek A, Michalska-Madej J, Grochowalski Ł, Strapagiel D, Gnat S, Załuski D, Gancarz M, Rusinek R, Krutmuang P, Hernández RM, Pascual MH and Starosta AL (2021). Amplicon Sequencing of Variable 16S rRNA from Bacteria and ITS2 Regions from Fungi and Plants, Reveals Honeybee Susceptibility to Diseases Results from Their Forage Availability under Anthropogenic Landscapes. Pathogens, MDPI vol. 10 (3) 
22-03-2021

2020

Relevant PublicationWeber de Melo V, Lowe R, Hurd PJ and Petchey OL (2020). Phenotypic responses to temperature in the ciliate Tetrahymena thermophila. Ecology and Evolution, Wiley 
01-07-2020

2019

Relevant PublicationGeorge JM, Bell ZW, Condliffe D, Dohrer K, Abaurrea T, Spencer K, Leitão A, Gahr M, Hurd PJ and Clayton DF (2019). Acute social isolation alters neurogenomic state in songbird forebrain. Proc Natl Acad Sci U S A 
22-07-2019

2018

Relevant PublicationWOJCIECHOWSKI M, LOWE R, Maleszka J, CONN D, Maleszka R and HURD PJ (2018). Phenotypically distinct female castes in honey bees are defined by alternative chromatin states during larval development. Genome Research, Cold Spring Harbor Laboratory Press 
22-08-2018
Relevant PublicationPtaszyńska AA, Gancarz M, Hurd PJ, Borsuk G, Wiącek D, Nawrocka A, Strachecka A, Załuski D and Paleolog J (2018). Changes in the bioelement content of summer and winter western honeybees (Apis mellifera) induced by Nosema ceranae infection. PLOS ONE, Public Library of Science (PLoS) vol. 13 (7) 
25-07-2018

2015

Relevant PublicationCookson VJ, Waite SL, Heath PR, Hurd PJ, Gandhi SV and Chapman NR (2015). Binding loci of RelA-containing nuclear factor-kappaB dimers in promoter regions of PHM1-31 myometrial smooth muscle cells. Mol Hum Reprod vol. 21 (11), 865-883.  
01-11-2015
Relevant PublicationSnijders AP, Hautbergue GM, Bloom A, Williamson JC, Minshull TC, Phillips HL, Mihaylov SR, Gjerde DT, Hornby DP, Wilson SA, Hurd PJ and Dickman MJ (2015). Arginine methylation and citrullination of splicing factor proline- and glutamine-rich (SFPQ/PSF) regulates its association with mRNA. RNA vol. 21 (3), 347-359.  
01-03-2015

2014

Relevant PublicationIsmail HMS, Hurd PJ, Khalil MIM, Kouzarides T, Bannister A and Gout I (2014). S6 kinase 2 is bound to chromatin-nuclear matrix cellular fractions and is able to phosphorylate histone H3 at threonine 45 in vitro and in vivo. J Cell Biochem vol. 115 (6), 1048-1062.  
01-06-2014

2013

Relevant PublicationMurrell A, Hurd PJ and Wood IC (2013). Epigenetic mechanisms in development and disease. Biochem Soc Trans vol. 41 (3), 697-699.  
01-06-2013
Relevant PublicationGemma C, Ramagopalan SV, Down TA, Beyan H, Hawa MI, Holland ML, Hurd PJ, Giovannoni G, Leslie RD, Ebers GC and Rakyan VK (2013). Inactive or moderately active human promoters are enriched for inter-individual epialleles. Genome Biol vol. 14 (5) 
25-05-2013
Relevant PublicationDickman MJ, Kucharski R, Maleszka R and Hurd PJ (2013). Extensive histone post-translational modification in honey bees. Insect Biochem Mol Biol vol. 43 (2), 125-137.  
01-02-2013

2012

Relevant PublicationMurrell A, Hurd P and Wood I (2012). Meeting preview. The Biochemist, Portland Press vol. 34 (5) 
01-10-2012

2010

Relevant PublicationHurd PJ (2010). The era of epigenetics. Brief Funct Genomics vol. 9 (5-6), 425-428.  
01-12-2010
Relevant PublicationPurdy KJ, Hurd PJ, Moya-Laraño J, Trimmer M, Oakley BB and Woodward G (2010). Systems biology for ecology. From molecules to ecosystems. 
30-11-2010
Relevant PublicationPurdy KJ, Hurd PJ, Moya-Larano J, Trimmer M, Oakley BB and Woodward G (2010). Systems Biology for Ecology: From Molecules to Ecosystems. ADV ECOL RES vol. 43, 87-149.  
01-01-2010
Relevant PublicationPurdy KJ, Hurd PJ, Moya-Laraño J, Trimmer M, Oakley BB and Woodward G (2010). Chapter 3 Systems Biology for Ecology From Molecules to Ecosystems. Integrative Ecology: From Molecules to Ecosystems  87-149.  
01-01-2010

2009

Relevant PublicationHurd PJ, Bannister AJ, Halls K, Dawson MA, Vermeulen M, Olsen JV, Ismail H, Somers J, Mann M, Owen-Hughes T, Gout I and Kouzarides T (2009). Phosphorylation of histone H3 Thr-45 is linked to apoptosis. J Biol Chem vol. 284 (24), 16575-16583.  
12-06-2009
Relevant PublicationHurd PJ and Nelson CJ (2009). Advantages of next-generation sequencing versus the microarray in epigenetic research. Brief Funct Genomic Proteomic vol. 8 (3), 174-183.  
01-05-2009

2008

Relevant PublicationSmith AE, Hurd PJ, Bannister AJ, Kouzarides T and Ford KG (2008). Heritable gene repression through the action of a directed DNA methyltransferase at a chromosomal locus. J BIOL CHEM vol. 283 (15), 9878-9885.  
11-04-2008
Relevant PublicationSajedi E, Gaston-Massuet C, Andoniadou CL, Signore M, Hurd PJ, Dattani M and Martinez-Barbera JP (2008). DNMT1 interacts with the developmental transcriptional repressor HESX1. Biochim Biophys Acta vol. 1783 (1), 131-143.  
01-01-2008

2007

Relevant PublicationFord KG, Hurd PJ, Bannister AJ, Kouzarides T and Smith AE (2007). Directed de novo DNA methylation of a genomic locus leads to heritable transcriptional repression. 
16-11-2007

2006

Relevant PublicationTorres-Padilla ME, Bannister AJ, Hurd PJ, Kouzarides T and Zernicka-Goetz M (2006). Dynamic distribution of the replacement histone variant H3.3 in the mouse oocyte and preimplantation embryos. INT J DEV BIOL vol. 50 (5), 455-461.  
01-01-2006

2003

Relevant PublicationFuks F, Hurd PJ, Deplus R and Kouzarides T (2003). The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase. Nucleic Acids Res vol. 31 (9), 2305-2312.  
01-05-2003
Relevant PublicationFuks F, Hurd PJ, Wolf D, Nan XS, Bird AP and Kouzarides T (2003). The Methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation. J BIOL CHEM vol. 278 (6), 4035-4040.  
07-02-2003

2002

Relevant PublicationMcNamara AR, Hurd PJ, Smith AEF and Ford KG (2002). Characterisation of site-biased DNA methyltransferases: specificity, affinity and subsite relationships. NUCLEIC ACIDS RES vol. 30 (17), 3818-3830.  
01-09-2002
Relevant PublicationZhou L, Cheng X, Connolly BA, Dickman MJ, Hurd PJ and Hornby DP (2002). Zebularine: a novel DNA methylation inhibitor that forms a covalent complex with DNA methyltransferases. J Mol Biol vol. 321 (4), 591-599.  
23-08-2002

1999

Relevant PublicationHURD PJ, Whitmarsh AJ, Baldwin GS, Kelly SM, Waltho JP, Price NC, Connolly BA and Hornby DP (1999). Mechanism-based inhibition of C5-cytosine DNA methyltransferases by 2-H pyrimidinone. Journal of Molecular Biology vol. 286 (2), 389-401.  
01-01-1999

Grants

solid heart iconGrants of specific relevance to the Centre for Evolutionary and Functional Genomics
solid heart iconThe Role of Nutrition as an Epigenetic Modulator of Phenotypic Plasticity during Honeybee Development
Paul J. Hurd
£672,317 BBSRC Biotechnology and Biological Sciences Research Council (01-05-2022 - 30-04-2026)


solid heart iconGenomic experiments and data generation for UoMunster
Paul J. Hurd
£10,188 University of Munster (01-02-2021 - 31-10-2023)