Dr Weini Huang
Reader in Mathematical Biology
Centre Lead for Research Innovation and External Stakeholders Engagement
School of Mathematical Sciences
Queen Mary University of London
Queen Mary University of London
Research
Mathematical Biology, Evolutionary Theory, Math Oncology, Species Coevolution, Stochastic Process, Mutation Accumulation
Interests
Weini Huang currently works on modelling cancer evolution and species interactions in biological systems. Before being a lecturer in mathematical biology in 2018, she worked as a postdoctoral researcher in the Barts Cancer Institute, QMUL for modelling cancer spatial heterogeneity and the evolution of tumour resistance. She obtained her PhD in 2012 in Evolutionary Theory in the Max Planck Institute of Evolutionary Biology, Germany.Currently, Weini supervises 3 PhD students and 2 postdoctoral researchers in the topics of evolutionary theory with application in species coevolution and cancer dynamics . Weini is interested in understanding how diversity and population patterns are formed and maintained in nature/human cell populations through theoretical approaches as well as their connections with experimental/clinical observations. She collaborates with experimental evolution groups and cancer biologists/clinicians on e.g. the evolution of trade-offs in a predator-prey system and drug resistance in ovarian cancer, extrachromosal DNA, mtDNA dynamcis in healthy liver and population stuctures of prostate cancer.
If you are looking for an opportunity of PhD study in math biology, please get in touch!
Publications
Publications of specific relevance to the Centre for Complex Systems2024
Hung KL, Jones MG, Wong IT-L, Curtis EJ, Lange JT, He BJ, Luebeck J, Schmargon R, Scanu E, Brückner L, Yan X, Li R, Gnanasekar A, Chamorro González R, Belk JA, Liu Z, Melillo B, Bafna V, Dörr JR, Werner B, et al. (2024). Coordinated inheritance of extrachromosomal DNAs in cancer cells. Nature, Springer Nature vol. 635 (8037), 201-209. 06-11-2024
Noorani I, Haughey M, Luebeck J, Rowan A, Grönroos E, Terenzi F, Wong IT-L, Kittel J, Bailey C, Weeden C, Bell D, Joo E, Barbe V, Jones MG, Nye E, Green M, Meader L, Norton EJ, Fabian M, Kanu N, et al. (2024). Extrachromosomal DNA driven oncogene spatial heterogeneity and evolution in glioblastoma. 25-10-2024
Moeller M, Werner B and Huang W (2024). Accumulating waves of random mutations before fixation. Physical Review E, American Physical Society (APS) vol. 110 (4) 01-10-2024
Islas ACH, Milne A, Eizaguirre C and Huang W (2024). Parasite-mediated predation determines infection in a complex predator–prey–parasite system. Proceedings of the Royal Society B, The Royal Society vol. 291 (2021), 20232468-20232468. 24-04-2024
Moeller ME, Mon Père NV, Werner B and Huang W (2024). Measures of genetic diversification in somatic tissues at bulk and single-cell resolution. eLife, eLife vol. 12 24-01-2024
2023
Li H, Yang Z, Tu F, Deng L, Han Y, Fu X, Wang L, Gu D, Werner B and Huang W (2023). Mutation divergence over space in tumour expansion. Journal of The Royal Society Interface, The Royal Society vol. 20 (208) 01-11-2023
Passman AM, Haughey MJ, Carlotti E, Williams MJ, Cereser B, Lin M-L, Devkumar S, Gabriel JP, Gringeri E, Cillo U, Russo FP, Hoare M, ChinAleong J, Jansen M, Wright NA, Kocher HM, Huang W, Alison MR and McDonald SAC (2023). Hepatocytes undergo punctuated expansion dynamics from a periportal stem cell niche in normal human liver. Journal of Hepatology, Elsevier vol. 79 (2), 417-432. 21-04-2023
2022
Li H, Wang F and Huang W (2022). A Novel, Simple, and Low-Cost Approach for Machine Learning Screening of Kidney Cancer: An Eight-Indicator Blood Test Panel with Predictive Value for Early Diagnosis. Current Oncology, MDPI vol. 29 (12), 9135-9149. 24-11-2022
Lange JT, Rose JC, Chen CY, Pichugin Y, Xie L, Tang J, Hung KL, Yost KE, Shi Q, Erb ML, Rajkumar U, Wu S, Taschner-Mandl S, Bernkopf M, Swanton C, Liu Z, Huang W, Chang HY, Bafna V, Henssen AG, et al. (2022). The evolutionary dynamics of extrachromosomal DNA in human cancers. Nature Genetics, Springer Nature vol. 54 (10), 1527-1533. 19-09-2022
Hoare JI, Hockings H, Saxena J, Silva VL, Haughey MJ, Wood GE, Nicolini F, Mirza H, McNeish IA, Huang W, Maniati E, Graham TA and Lockley M (2022). A novel cell line panel reveals non-genetic mediators of platinum resistance and phenotypic diversity in high grade serous ovarian cancer. Gynecologic Oncology, Elsevier vol. 167 (1), 96-106. 30-07-2022
Hockings H, Lockley M, Graham T, Lakatos E and Huang W (2022). Abstract PR015: Developing adaptive therapy to suppress the evolution of treatment resistance in high-grade serous ovarian cancer. Cancer Research, American Association for Cancer Research (AACR) vol. 82 (10_Supplement), pr015-pr015. 15-05-2022
Haughey MJ, Bassolas A, Sousa S, Baker A-M, Graham TA, Nicosia V and Huang W (2022). First passage time analysis of spatial mutation patterns reveals evolutionary dynamics of pre-existing resistance in colorectal cancer. 24-02-2022
Hosseinian S and Butenko S (2022). An improved approximation for Maximum k -dependent Set on bipartite graphs. Discrete Applied Mathematics, Elsevier vol. 307, 95-101. 01-01-2022
2021
Evans JA, Carlotti E, Lin M-L, Hackett RJ, Haughey MJ, Passman AM, Dunn L, Elia G, Porter RJ, McLean MH, Hughes F, ChinAleong J, Woodland P, Preston SL, Griffin SM, Lovat L, Rodriguez-Justo M, Huang W, Wright NA, Jansen M, et al. (2021). Clonal Transitions and Phenotypic Evolution in Barrett’s Esophagus. Gastroenterology, Elsevier vol. 162 (4), 1197-1209.e13. 29-12-2021
Lakatos E, Hockings H, Mossner M, Huang W, Lockley M and Graham TA (2021). LiquidCNA: Tracking subclonal evolution from longitudinal liquid biopsies using somatic copy number alterations. iScience, Elsevier vol. 24 (8) 21-07-2021
Lakatos E, Hockings H, Mossner M, Huang W, Lockley M and Graham TA (2021). LiquidCNA: tracking subclonal evolution from longitudinal liquid biopsies using somatic copy number alterations. 06-01-2021
2020
Hoare JI, Hockings H, Saxena J, Silva VL, Maniati E, Mirza HB, Huang W, Wood GE, Nicolini F, Graham TA, McNeish IA and Lockley M (2020). Platinum resistance induces diverse evolutionary trajectories in high grade serous ovarian cancer. 24-07-2020
Passman AM, Haughey MJ, Carlotti E, Williams M, Cereser B, Russo FP, Hoare M, Kocher H, Chin-Aleong J, Graham TA, Wright NA, Huang W, Alison M and McDonald SA (2020). CLONAL DYNAMICS AND CELL-OF-ORIGIN OF NORMAL HEPATOCYTE EXPANSIONS IN HOMEOSTATIC HUMAN LIVERS AND THEIR ASSOCIATION WITH THE BILIARY EPITHELIUM. AACR. 01-05-2020
Passman AM, Haughey MJ, Carlotti E, Williams M, Cereser B, Russo FP, Hoare M, Kocher H, Chin-Aleong J, Graham TA, Wright NA, Huang W, Alison M and McDonald SA (2020). 450 CLONAL DYNAMICS AND CELL-OF-ORIGIN OF NORMAL HEPATOCYTE EXPANSIONS IN HOMEOSTATIC HUMAN LIVERS AND THEIR ASSOCIATION WITH THE BILIARY EPITHELIUM. Gastroenterology, Elsevier vol. 158 (6), s-1276. 01-05-2020
Werner B, Case J, Williams MJ, Chkhaidze K, Temko D, Fernández-Mateos J, Cresswell GD, Nichol D, Cross W, Spiteri I, Huang W, Tomlinson IPM, Barnes CP, Graham TA and Sottoriva A (2020). Measuring single cell divisions in human tissues from multi-region sequencing data. Nature Communications, Springer Nature vol. 11 (1) 25-02-2020
2019
Retel C, Kowallik V, Huang W, Werner B, Becks L, Feulner P and Huang W (2019). The feedback between selection and demography shapes genomic diversity during coevolution. Science Advances 02-10-2019
Chkhaidze K, Heide T, Werner B, Williams MJ, Huang W, Caravagna G, Baker A-M, Graham TA and Sottoriva A (2019). Abstract 4232: Spatially constrained tumor growth affects the patterns of clonal selection and neutral drift in cancer genomic data. Bioinformatics, Convergence Science, and Systems Biology. 01-07-2019
Werner B, Case J, Williams MJ, Chkhaidze K, Temko D, Fernandez-Mateos J, Cresswell GD, Nichol D, Cross W, Spiteri I, Huang W, Tomlinson I, Barnes CP, Graham TA and Sottoriva A (2019). Measuring single cell divisions in human cancers from multi-region sequencing data. 25-02-2019
Chkhaidze K, Heide T, Werner B, Williams MJ, Huang W, Caravagna G, Graham TA and Sottoriva A (2019). Spatially constrained tumour growth affects the patterns of clonal selection and neutral drift in cancer genomic data. 08-02-2019
Park HJ, Pichugin Y, Huang W and Traulsen A (2019). Population size changes and extinction risk of populations driven by mutant interactors. Phys Rev E vol. 99 (2-1), 022305-022305. 06-02-2019
2018
Boddy AM, Huang W and Aktipis A (2018). Life History Trade-Offs in Tumors. Curr Pathobiol Rep vol. 6 (4), 201-207. 10-11-2018
Baker A-M, Huang W, Wang X-MM, Jansen M, Ma X-J, Domingo E, Wright NA, Rodriguez-Justo M, Park E, Tomlinson I and Graham TA (2018). In Situ Mutation Detection Maps the Clonal Architecture of Colorectal Cancer and Adenomas. 01-01-2018
2017
Huang W, Traulsen A, Werner B, Hiltunen T and Becks L (2017). Dynamical trade-offs arise from antagonistic coevolution and decrease intraspecific diversity. Nat Commun, Macmillan Publishers Limited, part of Springer Nature vol. 8 (1), 2059-2059. 12-12-2017
Baker A-M, Huang W, Wang X-MM, Jansen M, Ma X-J, Kim J, Anderson CM, Wu X, Pan L, Su N, Luo Y, Domingo E, Heide T, Sottoriva A, Lewis A, Beggs AD, Wright NA, Rodriguez-Justo M, Park E, Tomlinson I, et al. (2017). Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution. Nat Commun, Macmillan Publishers Limited, part of Springer Nature vol. 8 (1), 1998-1998. 08-12-2017
Baker A-M, Wang M, Ma X-J, Anderson C, Huang W, Domingo E, Lewis A, Bridgewater J, Jansen M, Wright NA, Rodriguez-Justo M, Park E, Tomlinson I and Graham TA (2017). Abstract 3953: Visualization of treatment resistant subclones in colorectal cancer by mutation specific RNA in situ hybridization. 01-07-2017
2016
Amado A, Fernández L, Huang W, Ferreira FF and Campos PRA (2016). Competing metabolic strategies in a multilevel selection model. Royal Society Open Science vol. 3 (11), 160544-160544. 16-11-2016
Huang W, de Araujo Campos PR, Moraes de Oliveira V and Fagundes Ferrreira F (2016). A resource-based game theoretical approach for the paradox of the plankton. PeerJ vol. 4, e2329-e2329. 18-08-2016
2015
Huang W, Hauert C and Traulsen A (2015). Stochastic game dynamics under demographic fluctuations. Proceedings of the National Academy of Sciences of the United States of America, Proceedings of the National Academy of Sciences vol. 112 (29), 9064-9069. 06-07-2015
Amado A, Huang W, Campos PRA and Ferreira FF (2015). Learning process in public goods games. Physica A Statistical Mechanics and its Applications, Elsevier vol. 430, 21-31. 01-07-2015
2012
Huang W, Werner B and Traulsen A (2012). The impact of random frequency-dependent mutations on the average population fitness. BMC Ecology and Evolution, Springer Nature vol. 12 (1) 30-08-2012
Grants
Grants of specific relevance to the Centre for Complex SystemsCancer Grand Challenges Weini Huang & Benjamin WernerWeini Huang and Benjamin Werner
£1,434,952 CR-UK Cancer Research UK (01-06-2022 - 31-05-2027)
EvoGamesPlus - ITN 2020 Weini Huang/Benjamin WernerWeini Huang and Benjamin Werner
£432,596 EU Commission - Horizon 2020 (01-03-2021 - 28-02-2025)
ATI Data Science for Science Programme: Molecular Biology - WHuangWeini Huang and Benjamin Werner
£49,056 Alan Turing Institute, The (01-12-2020 - 31-07-2021)