Dr Paul J. Hurd
Reader in Genome Regulation and Epigenetics
School of Biological and Behavioural Sciences
Queen Mary University of London
Queen Mary University of London
Research
Honey bee, Functional Genomics, Epigenetics, Chromatin, Phenotypic plasticity
Publications
Publications of specific relevance to the Centre for Brain and Behaviour2024
Annelid methylomes reveal ancestral developmental and aging-associated epigenetic erosion across BilateriaGuynes K, Sarre LA, Carrillo-Baltodano AM, Davies BE, Xu L, Liang Y, Martín-Zamora FM, Hurd PJ, de Mendoza A and Martín-Durán JM
Genome Biology, Springer Nature vol. 25 (1), 204-204.
01-08-2024
2023
The PWWP domain and the evolution of unique DNA methylation toolkits in HymenopteraKucharski R, Ellis N, Jurkowski TP, Hurd PJ and Maleszka R
Iscience, Cell Press vol. 26 (11)
17-11-2023
2022
Chromatin accessibility-based characterisation of brain gene regulatory networks in three distinct honey bee polyphenisms.Lowe R, Wojciechowski M, Ellis N and Hurd PJ
Nucleic Acids Research, Oxford University Press
04-11-2022
2021
Novel structure in the nuclei of honey bee brain neurons revealed by immunostainingHurd PJ, Grübel K, Wojciechowski M, Maleszka R and Rössler W
Scientific Reports, Nature Publishing Group vol. 11 (1)
01-12-2021
Dataset of the next-generation sequencing of variable 16S rRNA from bacteria and ITS2 regions from fungi and plants derived from honeybees kept under anthropogenic landscapesGancarz M, Hurd PJ, Latoch P, Polaszek A, Michalska-Madej J, Grochowalski Ł, Strapagiel D, Gnat S, Załuski D, Rusinek R, Starosta AL, Krutmuang P, Hernández RM, Pascual MH and Ptaszyńska AA
Data in Brief, Elsevier vol. 36
02-04-2021
Amplicon Sequencing of Variable 16S rRNA from Bacteria and ITS2 Regions from Fungi and Plants, Reveals Honeybee Susceptibility to Diseases Results from Their Forage Availability under Anthropogenic LandscapesPtaszyńska AA, Latoch P, Hurd PJ, Polaszek A, Michalska-Madej J, Grochowalski Ł, Strapagiel D, Gnat S, Załuski D, Gancarz M, Rusinek R, Krutmuang P, Hernández RM, Pascual MH and Starosta AL
Pathogens, Mdpi vol. 10 (3)
22-03-2021
2020
Phenotypic responses to temperature in the ciliate Tetrahymena thermophilaWeber de Melo V, Lowe R, Hurd PJ and Petchey OL
Ecology and Evolution, Wiley
01-07-2020
2019
Acute social isolation alters neurogenomic state in songbird forebrain.George JM, Bell ZW, Condliffe D, Dohrer K, Abaurrea T, Spencer K, Leitão A, Gahr M, Hurd PJ and Clayton DF
Proc Natl Acad Sci U S A
22-07-2019
2018
Phenotypically distinct female castes in honey bees are defined by alternative chromatin states during larval developmentWOJCIECHOWSKI M, LOWE R, Maleszka J, CONN D, Maleszka R and HURD PJ
Genome Research, Cold Spring Harbor Laboratory Press
22-08-2018
Changes in the bioelement content of summer and winter western honeybees (Apis mellifera) induced by Nosema ceranae infectionPtaszyńska AA, Gancarz M, Hurd PJ, Borsuk G, Wiącek D, Nawrocka A, Strachecka A, Załuski D and Paleolog J
Plos One, Public Library of Science (Plos) vol. 13 (7)
25-07-2018
2015
Binding loci of RelA-containing nuclear factor-kappaB dimers in promoter regions of PHM1-31 myometrial smooth muscle cells.Cookson VJ, Waite SL, Heath PR, Hurd PJ, Gandhi SV and Chapman NR
Mol Hum Reprod vol. 21 (11), 865-883.
01-11-2015
Arginine methylation and citrullination of splicing factor proline- and glutamine-rich (SFPQ/PSF) regulates its association with mRNA.Snijders AP, Hautbergue GM, Bloom A, Williamson JC, Minshull TC, Phillips HL, Mihaylov SR, Gjerde DT, Hornby DP, Wilson SA, Hurd PJ and Dickman MJ
Rna vol. 21 (3), 347-359.
01-03-2015
2014
S6 kinase 2 is bound to chromatin-nuclear matrix cellular fractions and is able to phosphorylate histone H3 at threonine 45 in vitro and in vivo.Ismail HMS, Hurd PJ, Khalil MIM, Kouzarides T, Bannister A and Gout I
J Cell Biochem vol. 115 (6), 1048-1062.
01-06-2014
2013
Epigenetic mechanisms in development and disease.Murrell A, Hurd PJ and Wood IC
Biochem Soc Trans vol. 41 (3), 697-699.
01-06-2013
Inactive or moderately active human promoters are enriched for inter-individual epialleles.Gemma C, Ramagopalan SV, Down TA, Beyan H, Hawa MI, Holland ML, Hurd PJ, Giovannoni G, Leslie RD, Ebers GC and Rakyan VK
Genome Biol vol. 14 (5)
25-05-2013
Extensive histone post-translational modification in honey bees.Dickman MJ, Kucharski R, Maleszka R and Hurd PJ
Insect Biochem Mol Biol vol. 43 (2), 125-137.
01-02-2013
2012
2010
Systems biology for ecology. From molecules to ecosystemsPurdy KJ, Hurd PJ, Moya-Laraño J, Trimmer M, Oakley BB and Woodward G
30-11-2010
Systems Biology for Ecology: From Molecules to EcosystemsPurdy KJ, Hurd PJ, Moya-Larano J, Trimmer M, Oakley BB and Woodward G
Adv Ecol Res vol. 43, 87-149.
01-01-2010
Chapter 3 Systems Biology for Ecology From Molecules to EcosystemsPurdy KJ, Hurd PJ, Moya-Laraño J, Trimmer M, Oakley BB and Woodward G
In Integrative Ecology: From Molecules to Ecosystems, Elsevier 87-149.
01-01-2010
2009
Phosphorylation of histone H3 Thr-45 is linked to apoptosis.Hurd PJ, Bannister AJ, Halls K, Dawson MA, Vermeulen M, Olsen JV, Ismail H, Somers J, Mann M, Owen-Hughes T, Gout I and Kouzarides T
J Biol Chem vol. 284 (24), 16575-16583.
12-06-2009
Advantages of next-generation sequencing versus the microarray in epigenetic research.Hurd PJ and Nelson CJ
Brief Funct Genomic Proteomic vol. 8 (3), 174-183.
01-05-2009
2008
Heritable gene repression through the action of a directed DNA methyltransferase at a chromosomal locusSmith AE, Hurd PJ, Bannister AJ, Kouzarides T and Ford KG
J Biol Chem vol. 283 (15), 9878-9885.
11-04-2008
DNMT1 interacts with the developmental transcriptional repressor HESX1.Sajedi E, Gaston-Massuet C, Andoniadou CL, Signore M, Hurd PJ, Dattani M and Martinez-Barbera JP
Biochim Biophys Acta vol. 1783 (1), 131-143.
01-01-2008
2007
Directed de novo DNA methylation of a genomic locus leads to heritable transcriptional repressionFord KG, Hurd PJ, Bannister AJ, Kouzarides T and Smith AE
BLOOD. vol. 110 (11), 108A-108A.
16-11-2007
2006
Dynamic distribution of the replacement histone variant H3.3 in the mouse oocyte and preimplantation embryosTorres-Padilla ME, Bannister AJ, Hurd PJ, Kouzarides T and Zernicka-Goetz M
Int J Dev Biol vol. 50 (5), 455-461.
01-01-2006
2003
The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase.Fuks F, Hurd PJ, Deplus R and Kouzarides T
Nucleic Acids Res vol. 31 (9), 2305-2312.
01-05-2003
The Methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylationFuks F, Hurd PJ, Wolf D, Nan XS, Bird AP and Kouzarides T
J Biol Chem vol. 278 (6), 4035-4040.
07-02-2003
2002
Characterisation of site-biased DNA methyltransferases: specificity, affinity and subsite relationshipsMcNamara AR, Hurd PJ, Smith AEF and Ford KG
Nucleic Acids Res vol. 30 (17), 3818-3830.
01-09-2002
Zebularine: a novel DNA methylation inhibitor that forms a covalent complex with DNA methyltransferases.Zhou L, Cheng X, Connolly BA, Dickman MJ, Hurd PJ and Hornby DP
J Mol Biol vol. 321 (4), 591-599.
23-08-2002
1999
Mechanism-based inhibition of C5-cytosine DNA methyltransferases by 2-H pyrimidinone.HURD PJ, Whitmarsh AJ, Baldwin GS, Kelly SM, Waltho JP, Price NC, Connolly BA and Hornby DP
Journal of Molecular Biology vol. 286 (2), 389-401.
01-01-1999
Grants
Grants of specific relevance to the Centre for Brain and BehaviourThe Role of Nutrition as an Epigenetic Modulator of Phenotypic Plasticity during Honeybee DevelopmentPaul J. Hurd
£672,317 BBSRC Biotechnology and Biological Sciences Research Council
01-05-2022 - 30-04-2026
Genomic experiments and data generation for UoMunsterPaul J. Hurd
£10,188 University of Munster
01-02-2021 - 31-10-2023