Research
Cognition, Motivation, Neural Circuits, Functional Connectivity, Appetite, Memory
Interests
A good memory system is key to effective foraging. When searching for food animals are best served by remembering the location of different food sources (spatial memory), their nutritional content (appetitive memory) and the motor repertoire for securing and consuming a meal (motor memory) - all the while cautiously on the lookout for potential dangers that may have been previously experienced (fear memory). Foraging therefore is a key behaviour to gain insights into rodent cognition.
My research builds on the premise that cognition has evolved to meet the competitive demand for resources and that by investigating different memory systems one can shed light on the interplay between these systems for understanding decision-making. To do so we use advanced recording and manipulation tools in transgenic rodents to monitor and interrogate distinct neural circuits related to food seeking and memory. Our research takes a bottom-up approach where brain anatomy informs potential pathways for investigating function using advanced recording and neural manipulation techniques in behaving animals.
Publications

Publications of specific relevance to the Centre for Brain and Behaviour
2023
Involvement of A13 dopaminergic neurons in prehensile movements but not reward in the ratGarau C, Hayes J, Chiacchierini G, McCutcheon JE and
Apergis-Schoute J Current Biology,
Elsevier vol. 33 (22), 4786-4797.e4.
09-10-20232022
Restriction of dietary protein in rats increases progressive-ratio motivation for proteinChiacchierini G, Naneix F,
Apergis-Schoute J and McCutcheon JE
Physiology & Behavior,
Elsevier vol. 254
11-06-20222021
Predictive and motivational factors influencing anticipatory contrast: A comparison of contextual and gustatory predictors in food restricted and free-fed ratsHayes J, Garau C, Chiacchierini G, Urcelay GP, McCutcheon JE and
Apergis-Schoute J Physiology & Behavior,
Elsevier vol. 242
23-09-2021
Protein appetite drives macronutrient-related differences in ventral tegmental area neural activityChiacchierini G, Naneix F, Peters KZ,
Apergis-Schoute J, Snoeren EMS and McCutcheon JE
Journal of Neuroscience,
Society For Neuroscience vol. 41 (23)
29-04-20212019
Editorial: Neuronal Co-transmissionApergis-Schoute J, Burnstock G, Nusbaum MP, Parker D, Morales MA, Trudeau L-E and Svensson E
Frontiers in Neural Circuits,
Frontiers vol. 13
26-03-2019
General Principles of Neuronal Co-transmission: Insights From Multiple Model SystemsSvensson E,
Apergis-Schoute J, Burnstock G, Nusbaum MP, Parker D and Schiöth HB
Frontiers in Neural Circuits,
Frontiers vol. 12
21-01-20192018
Basal Forebrain and Brainstem Cholinergic Neurons Differentially Impact Amygdala Circuits and Learning-Related BehaviorAitta-aho T, Hay YA, Phillips BU, Saksida LM, Bussey TJ, Paulsen O and
Apergis-Schoute J Current Biology,
Elsevier vol. 28 (16), 2557-2569.e4.
01-08-20182017
Cell Class-Dependent Intracortical Connectivity and Output Dynamics of Layer 6 Projection Neurons of the Rat Primary Visual CortexCotel F, Fletcher LN, Croft SK-D,
Apergis-Schoute J and Williams SR
Cerebral Cortex,
Oxford University Press (Oup) vol. 28 (7), 2340-2350.
07-06-2017
Accumbal Cholinergic Interneurons Differentially Influence Motivation Related to Satiety SignalingAitta-aho T, Phillips BU, Pappa E, Hay YA, Harnischfeger F, Heath CJ, Saksida LM, Bussey TJ and
Apergis-Schoute J Eneuro,
Society For Neuroscience vol. 4 (2), eneuro.0328-eneu16.2017.
01-03-20172016
Cellular activation of hypothalamic hypocretin/orexin neurons facilitates short-term spatial memory in miceAitta-aho T, Pappa E, Burdakov D and
Apergis-Schoute J Neurobiology of Learning and Memory,
Elsevier vol. 136, 183-188.
13-10-2016
Sex difference in physical activity, energy expenditure and obesity driven by a subpopulation of hypothalamic POMC neuronsBurke LK, Doslikova B, D'Agostino G, Greenwald-Yarnell M, Georgescu T, Chianese R, de Morentin PBM, Ogunnowo-Bada E, Cansell C, Valencia-Torres L, Garfield AS,
Apergis-Schoute J, Lam DD, Speakman JR, Rubinstein M, Low MJ, Rochford JJ, Myers MG, Evans ML and Heisler LK
Molecular Metabolism,
Elsevier vol. 5 (3), 245-252.
22-01-20162015
Nicotinic α4 Receptor-Mediated Cholinergic Influences on Food Intake and Activity Patterns in Hypothalamic CircuitsGarcía AP, Aitta-aho T, Schaaf L, Heeley N, Heuschmid L, Bai Y, Barrantes FJ and
Apergis-Schoute J Plos One,
Public Library of Science (Plos) vol. 10 (8)
06-08-2015
Optogenetic Evidence for Inhibitory Signaling from Orexin to MCH Neurons via Local MicrocircuitsApergis-Schoute J, Iordanidou P, Faure C, Jego S, Schöne C, Aitta-Aho T, Adamantidis A and Burdakov D
Journal of Neuroscience,
Society For Neuroscience vol. 35 (14), 5435-5441.
08-04-20152014
Left–right dissociation of hippocampal memory processes in miceShipton OA, El-Gaby M,
Apergis-Schoute J, Deisseroth K, Bannerman DM, Paulsen O and Kohl MM
Proceedings of The National Academy of Sciences of The United States of America,
Proceedings of The National Academy of Sciences vol. 111 (42), 15238-15243.
22-09-2014
Coreleased Orexin and Glutamate Evoke Nonredundant Spike Outputs and Computations in Histamine NeuronsSchöne C,
Apergis-Schoute J, Sakurai T, Adamantidis A and Burdakov D
Cell Reports,
Elsevier vol. 7 (3), 697-704.
24-04-20142012
Optogenetic Probing of Fast Glutamatergic Transmission from Hypocretin/Orexin to Histamine Neurons In SituSchöne C, Cao ZFH,
Apergis-Schoute J, Adamantidis A, Sakurai T and Burdakov D
Journal of Neuroscience,
Society For Neuroscience vol. 32 (36), 12437-12443.
05-09-20122011
Activation of Central Orexin/Hypocretin Neurons by Dietary Amino AcidsKarnani MM,
Apergis-Schoute J, Adamantidis A, Jensen LT, de Lecea L, Fugger L and Burdakov D
Neuron,
Elsevier vol. 72 (4), 616-629.
01-11-20112010
Methods for predicting cortical UP and DOWN states from the phase of deep layer local field potentialsSaleem AB, Chadderton P,
Apergis-Schoute J, Harris KD and Schultz SR
Journal of Computational Neuroscience,
Springer Nature vol. 29 (1-2), 49-62.
12-03-20102009
Maximum entropy decoding of multivariate neural spike trainsSeiler H, Zhang Y, Saleem AB, Bream P,
Apergis-Schoute J and Schultz SR
Bmc Neuroscience,
Springer Nature vol. 10 (Suppl 1)
13-07-20092008
Amygdala intercalated neurons are required for expression of fear extinctionLikhtik E, Popa D,
Apergis-Schoute J, Fidacaro GA and Paré D
Nature,
Springer Nature vol. 454 (7204), 642-645.
01-07-20082007
Muscarinic Control of Long-Range GABAergic Inhibition within the Rhinal CorticesApergis-Schoute J, Pinto A and Paré D
Journal of Neuroscience,
Society For Neuroscience vol. 27 (15), 4061-4071.
11-04-20072004
Low-Probability Transmission of Neocortical and Entorhinal Impulses Through the Perirhinal CortexPelletier JG,
Apergis J and Paré D
Journal of Neurophysiology,
American Physiological Society vol. 91 (5), 2079-2089.
01-05-2004
Lesions in the bed nucleus of the stria terminalis disrupt corticosterone and freezing responses elicited by a contextual but not by a specific cue-conditioned fear stimulusSullivan GM,
Apergis J, Bush DEA, Johnson LR, Hou M and Ledoux JE
Neuroscience,
Elsevier vol. 128 (1), 7-14.
01-01-20042003
Rodent doxapram model of panic: behavioral effects and c-Fos immunoreactivity in the amygdalaSullivan GM,
Apergis J, Gorman JM and LeDoux JE
Biological Psychiatry,
Elsevier vol. 53 (10), 863-870.
01-05-20032001
Two different lateral amygdala cell populations contribute to the initiation and storage of memoryRepa JC, Muller J,
Apergis J, Desrochers TM, Zhou Y and LeDoux JE
Nature Neuroscience,
Springer Nature vol. 4 (7), 724-731.
01-07-2001