Research
Spatial navigation, Virtual reality, Sensory integration
Interests
The ability to navigate is an essential skill required by both humans and animals. Animals can use sensory cues across modalities, such as visual, auditory, olfactory, integrated with self-motion cues, to find their way home from a food searching journey. Neural activity in the hippocampus and adjacent cortical areas, has been shown to correlate with the physical location of an organism. However, it is not clear how an internal unified representation of space, which supports navigation, is generated by integrating sensory inputs across modalities.
Virtual reality offers a powerful tool for investigating spatial cognition, allowing environmental manipulations that are impossible in the real world. Two-dimensional immersive virtual reality allows a close approximation of spatial representation in the real world. Hence, my laboratory is studying the across-modal navigation in virtual environments, combining virtual reality techniques with in vivo electrophysiological recording (tetrode and Neuropixels probe recordings) and 2-photon imaging.
Publications
Publications of specific relevance to the Centre for Brain and Behaviour
2024
Visual boundary cues suffice to anchor place and grid cells in virtual realityYang X, Cacucci F, Burgess N, Wills TJ and
Chen G Current Biology,
Elsevier vol. 34 (10), 2256-2264.e3.
01-05-20242020
The Tolman-Eichenbaum Machine: Unifying Space and Relational Memory through Generalization in the Hippocampal FormationWhittington JCR, Muller TH, Mark S,
Chen G, Barry C, Burgess N and Behrens TEJ
Cell,
Elsevier (Cell Press) vol. 183 (5), 1249-1263.e23.
25-11-2020 2019
Differential influences of environment and self-motion on place and grid cell firingChen G, Lu Y, King JA, Cacucci F and Burgess N
Nature Communications,
Nature Research (Part of Springer Nature) vol. 10 (1)
07-02-2019 2018
Identifying posture cells in the brain.Chen G Science vol. 362 (6414), 520-521.
02-11-2018 Spatial cell firing during virtual navigation of open arenas by head-restrained miceChen G, King JA, Lu Y, Cacucci F and Burgess N
Elife,
Elife Sciences Publications Ltd vol. 7
18-06-2018 2017
The characterization of hippocampal theta-driving neurons — a time-delayed mutual information approachLi S, Xu J,
Chen G, Lin L, Zhou D and Cai D
Scientific Reports,
Springer Nature vol. 7 (1)
17-07-2017 2016
Absence of Visual Input Results in the Disruption of Grid Cell Firing in the Mouse.Chen G, Manson D, Cacucci F and Wills TJ
Current Biology,
Elsevier (Cell Press) vol. 26 (17), 2335-2342.
12-09-2016 Theta Rhythmic Clock-Like Activity of Single Units in the Mouse HippocampusZhang L, Ma X,
Chen G, Barkai E and Lin L
Journal of Neuroscience,
Society For Neuroscience vol. 36 (16), 4415-4420.
20-04-2016 2013
Mapping and Deciphering Neural Codes of NMDA Receptor-Dependent Fear Memory Engrams in the HippocampusZhang H,
Chen G, Kuang H and Tsien JZ
Plos One,
Public Library of Science (Plos) vol. 8 (11)
26-11-2013 On brain activity mapping: insights and lessons from Brain Decoding Project to map memory patterns in the hippocampusTsien JZ, Li M, Osan R,
Chen G, Lin L, Wang PL, Frey S, Frey J, Zhu D, Liu T, Zhao F and Kuang H
Science China Life Sciences,
Springer Nature vol. 56 (9), 767-779.
30-07-2013 On initial Brain Activity Mapping of episodic and semantic memory code in the hippocampusTsien JZ, Li M, Osan R,
Chen G, Lin L, Wang PL, Frey S, Frey J, Zhu D, Liu T, Zhao F and Kuang H
Neurobiology of Learning and Memory,
Elsevier vol. 105, 200-210.
06-07-2013 2012
How vision and movement combine in the hippocampal place codeChen G, King JA, Burgess N and O'Keefe J
Proceedings of The National Academy of Sciences of The United States of America,
Proceedings of The National Academy of Sciences vol. 110 (1), 378-383.
19-12-2012 Hippocampal theta‐driving cells revealed by Granger causalityZhang L,
Chen G, Niu R, Wei W, Ma X, Xu J, Wang J, Wang Z and Lin L
Hippocampus,
Wiley vol. 22 (8), 1781-1793.
14-03-2012 2011
Differential Consolidation and Pattern Reverberations within Episodic Cell Assemblies in the Mouse HippocampusOşan R,
Chen G, Feng R and Tsien JZ
Plos One,
Public Library of Science (Plos) vol. 6 (2)
15-02-2011 2009
Neural Population-Level Memory Traces in the Mouse HippocampusChen G, Wang LP and Tsien JZ
Plos One,
Public Library of Science (Plos) vol. 4 (12)
16-12-2009 2007
Neural encoding of the concept of nest in the mouse brainLin L,
Chen G, Kuang H, Wang D and Tsien JZ
Proceedings of The National Academy of Sciences of The United States of America,
Proceedings of The National Academy of Sciences vol. 104 (14), 6066-6071.
03-04-2007 2006
Large-scale neural ensemble recording in the brains of freely behaving miceLin L,
Chen G, Xie K, Zaia KA, Zhang S and Tsien JZ
Journal of Neuroscience Methods,
Elsevier vol. 155 (1), 28-38.
22-03-2006 2003
Generation of a bioactive neuropeptide in a cell-free systemJiang C,
Chen G, Zeng X, Ouyang K and Hu Y
Analytical Biochemistry,
Elsevier vol. 316 (1), 34-40.
01-05-2003
