Prof Caroline Brennan

FRSB, Member of the Royal Society Industry Fellows' College

Professor of Molecular Genetics
Interim Head of The School of Biological and Behavioural Sciences

School of Biological and Behavioural Sciences
Queen Mary University of London

020 7882 8888

c.h.brennan@qmul.ac.uk

www.qmul.ac.uk/sbbs/staff/carolinebrennan.html

Centre for Brain and Behaviour
Centre for Evolutionary and Functional Genomics
Centre for Molecular Cell Biology

Research
Publications
Grants

Research

zebrafish, development, comparative cognition, addiction, neurobiology

Interests

All aspects of the use of zebrafish as a developmental and behavioural model organism including cell biological and behavioural analysis in this species. Current research focuses on cell and developmental processes underlying vulnerability to behavioural and metabolic disease as well as comparative psychology approaches to cognition and psychiatric disorders. We collaborate with human geneticists to explore the cell biology underlying genetic variants associated with human disease phenotypes, and to test hypotheses regarding mechanisms of gene action, and with evolutionary geneticists to explore genetic control of behaviour.

Research web page : https://brennanlab.sbcs.qmul.ac.uk/

Publications

Publications of specific relevance to the Centre for Brain and Behaviour

2024

Housing and Husbandry Factors Affecting Zebrafish (Danio rerio) Novel Tank Test Responses: A Global Multi-Laboratory Study.
Hillman C, Fontana BD, Amstislavskaya TG, Gorbunova MA, Altenhofen S, Barthelson K, Bastos LM, Borba JV, Bonan CD, Brennan CH, Farias-Cea A, Cooper A, Corcoran J, Dondossola ER, Martinez-Duran LM, Gallas-Lopes M, Galstyan DS, Garcia EO, Gerken E, Hindges R, et al.
Res Sq

DOI 10.21203/rs.3.rs-4849877/v1

16-10-2024

Pleiotropic contribution of rbfox1 to psychiatric and neurodevelopmental phenotypes in two zebrafish models
Antón-Galindo E, Adel MR, García-González J, Leggieri A, López-Blanch L, Irimia M, Norton WHJ, Brennan CH, Fernàndez-Castillo N and Cormand B
Translational Psychiatry, Springer Nature vol. 14 (1)

DOI 10.1038/s41398-024-02801-6

QMRO

19-02-2024

2023

Aryl hydrocarbon receptor-interacting protein (aip) loss causes failure-to-thrive and cardiac defects in zebrafish
Wang X, Haworth O, Abdi-Aziz N, Leggieri A, Jhosadara E-FA, Korbonits M and Brennan CH
Endocrine Abstracts, Bioscientifica

DOI 10.1530/endoabs.94.oc3.6

QMRO

31-10-2023

THU079 Danio Rerio (Zebrafish): A New Model Of AIP Loss Of Function
Wang X, Leggieri A, Anagianni S, Brennan CH and Korbonits M
Journal of The Endocrine Society, The Endocrine Society vol. 7 (Supplement_1)

DOI 10.1210/jendso/bvad114.1159

QMRO

05-10-2023

EXPLORING THE GENETICS OF NUMEROSITY, FROM FISH TO MAN
Brennan C, Sheardown E, Pérez JVT, Petrazzini MEM, Messina A, Potrich D, Anagianni S, Perrino M, Luu P, Truong T, Fraser S and Vallortigara G
Ibro Neuroscience Reports, Elsevier vol. 15

DOI 10.1016/j.ibneur.2023.08.212

01-10-2023

LOSS-OF-FUNCTION ZEBRAFISH (DANIO RERIO) FOR GENES ASSOCIATED WITH WILLIAMS SYNDROME SHOW ALTERED QUANTITY DISCRIMINATION
Pérez JVT, Anagianni S, Sheardown E, Petrazzini MEM, Fraser S, Butterworth B, Vallortigara G and Brennan C
Ibro Neuroscience Reports, Elsevier vol. 15

DOI 10.1016/j.ibneur.2023.08.1898

01-10-2023

The Role of Crosslinker Content of Positively Charged NIPAM Nanogels on the In Vivo Toxicity in Zebrafish
Bilardo R, Traldi F, Brennan CH and Resmini M
Pharmaceutics, Mdpi vol. 15 (7)

DOI 10.3390/pharmaceutics15071900

QMRO

07-07-2023

2022

baz1b loss-of-function in zebrafish produces phenotypic alterations consistent with the domestication syndrome
Torres-Pérez JV, Anagianni S, Mech AM, Havelange W, García-González J, Fraser SE, Vallortigara G and Brennan CH
Iscience, Elsevier vol. 26 (1)

DOI 10.1016/j.isci.2022.105704

QMRO

01-12-2022

A zebrafish model of AIP loss of function
Wang X, Leggieri A, Anagianni S, Brennan CH and Korbonits M
Endocrine Abstracts, Bioscientifica

DOI 10.1530/endoabs.86.p239

QMRO

27-10-2022

Quantity as a Fish Views It: Behavior and Neurobiology
Messina A, Potrich D, Perrino M, Sheardown E, Petrazzini MEM, Luu P, Nadtochiy A, Truong TV, Sovrano VA, Fraser SE, Brennan CH and Vallortigara G
Frontiers in Neuroanatomy, Frontiers vol. 16

DOI 10.3389/fnana.2022.943504

QMRO

14-07-2022

Characterizing ontogeny of quantity discrimination in zebrafish
Sheardown E, Torres-Perez JV, Anagianni S, Fraser SE, Vallortigara G, Butterworth B, Miletto-Petrazzini ME and Brennan CH
Proceedings of The Royal Society B: Biological Sciences, The Royal Society vol. 289 (1968)

DOI 10.1098/rspb.2021.2544

QMRO

09-02-2022

Ankk1 Loss of Function Disrupts Dopaminergic Pathways in Zebrafish
Leggieri A, García-González J, Torres-Perez JV, Havelange W, Hosseinian S, Mech AM, Keatinge M, Busch-Nentwich EM and Brennan CH
Frontiers in Neuroscience, Frontiers vol. 16

DOI 10.3389/fnins.2022.794653

QMRO

08-02-2022

Translational relevance of forward genetic screens in animal models for the study of psychiatric disease
Sheardown E, Mech AM, Petrazzini MEM, Leggieri A, Gidziela A, Hosseinian S, Sealy IM, Torres-Perez JV, Busch-Nentwich EM, Malanchini M and Brennan CH
Neuroscience and Biobehavioral Reviews, Elsevier vol. 135

DOI 10.1016/j.neubiorev.2022.104559

QMRO

04-02-2022

Behavioral and Gene Regulatory Responses to Developmental Drug Exposures in Zebrafish
Mech AM, Merteroglu M, Sealy IM, Teh M-T, White RJ, Havelange W, Brennan CH and Busch-Nentwich EM
Frontiers in Psychiatry, Frontiers vol. 12

DOI 10.3389/fpsyt.2021.795175

QMRO

10-01-2022

2021

A systematic review of the mental health risks and resilience among pollution-exposed adolescents
Theron LC, Abreu-Villaça Y, Augusto-Oliveira M, Brennan C, Crespo-Lopez ME, de Paula Arrifano G, Glazer L, Gwata N, Lin L, Mareschal I, Mermelstein S, Sartori L, Stieger L, Trotta A and Hadfield K
Journal of Psychiatric Research, Elsevier vol. 146, 55-66.

DOI 10.1016/j.jpsychires.2021.12.012

QMRO

23-12-2021

Developmental Exposure to Low Concentrations of Methylmercury Causes Increase in Anxiety-Related Behaviour and Locomotor Impairments in Zebrafish
Glazer L and Brennan CH
International Journal of Molecular Sciences, Mdpi vol. 22 (20)

DOI 10.3390/ijms222010961

QMRO

11-10-2021

Neurons in the Dorso-Central Division of Zebrafish Pallium Respond to Change in Visual Numerosity
Messina A, Potrich D, Schiona I, Sovrano VA, Fraser SE, Brennan CH and Vallortigara G
Cerebral Cortex, Oxford University Press (Oup) vol. 32 (2), 418-428.

DOI 10.1093/cercor/bhab218

QMRO

28-07-2021

Conservation of mechanisms regulating emotional-like responses on spontaneous nicotine withdrawal in zebrafish and mammals
Ponzoni L, Melzi G, Marabini L, Martini A, Petrillo G, Teh M-T, Torres-Perez JV, Morara S, Gotti C, Braida D, Brennan CH and Sala M
Progress in Neuro-Psychopharmacology and Biological Psychiatry, Elsevier vol. 111

DOI 10.1016/j.pnpbp.2021.110334

QMRO

24-04-2021

Effects of pollution on adolescent mental health: a systematic review protocol
Theron LC, Abreu-Villaça Y, Augusto-Oliveira M, Brennan CH, Crespo-Lopez ME, de Paula Arrifano G, Glazer L, Lin L, Mareschal I, Sartori L, Stieger L, Trotta A and Hadfield K
Systematic Reviews, Springer Nature vol. 10 (1)

DOI 10.1186/s13643-021-01639-z

QMRO

27-03-2021

Behavioral Effects of Developmental Exposure to JWH-018 in Wild-Type and Disrupted in Schizophrenia 1 (disc1) Mutant Zebrafish
García-González J, de Quadros B, Havelange W, Brock AJ and Brennan CH
Biomolecules, Mdpi vol. 11 (2)

DOI 10.3390/biom11020319

QMRO

19-02-2021

Stress reactivity elicits a tissue-specific reduction in telomere length in aging zebrafish (Danio rerio)
Evans JR, Torres-Pérez JV, Miletto Petrazzini ME, Riley R and Brennan CH
Scientific Reports, Nature Publishing Group vol. 11 (1)

DOI 10.1038/s41598-020-79615-1

QMRO

01-01-2021

Restoring Wnt/β-catenin pathway as potential therapeutics for Williams syndrome-associated anxiety disorders
Torres-Perez JV and Brennan CH
BRITISH JOURNAL OF PHARMACOLOGY. vol. 178 (2), 447-448.
01-01-2021

2020

Are cerebral and behavioural lateralization related to anxiety-like traits in the animal model zebrafish (Danio rerio)?
Petrazzini MEM, Gambaretto L, Dadda M, Brennan C and Agrillo C
Laterality Asymmetries of Body Brain and Cognition, Taylor & Francis vol. 26 (1-2), 144-162.

DOI 10.1080/1357650x.2020.1854280

17-12-2020

Increased Response to 3,4-Methylenedioxymethamphetamine (MDMA) Reward and Altered Gene Expression in Zebrafish During Short- and Long-Term Nicotine Withdrawal
Ponzoni L, Teh MT, Torres-Perez JV, Brennan CH, Braida D and Sala M
Molecular Neurobiology, Springer (Part of Springer Nature)

DOI 10.1007/s12035-020-02225-5

QMRO

24-11-2020

Application of an abstract concept across magnitude dimensions by fish
Miletto Petrazzini ME and Brennan CH
Scientific Reports, Springer Nature vol. 10 (1)

DOI 10.1038/s41598-020-74037-5

QMRO

09-10-2020

The effects of polygenic risk for psychiatric disorders and smoking behaviour on psychotic experiences in UK Biobank
García-González J, Ramírez J, Howard DM, Brennan CH, Munroe PB and Keers R
Translational Psychiatry, Nature Publishing Group vol. 10 (1)

DOI 10.1038/s41398-020-01009-8

QMRO

28-09-2020

Moderate early life stress improves adult zebrafish (Danio rerio) working memory but does not affect social and anxiety-like responses
Fontana BD, Gibbon AJ, Cleal M, Sudwarts A, Pritchett D, Miletto Petrazzini ME, Brennan CH and Parker MO
Developmental Psychobiology, Wiley

DOI 10.1002/dev.21986

QMRO

04-06-2020

Response to change in the number of visual stimuli in zebrafish:A behavioural and molecular study
Messina A, Potrich D, Schiona I, Sovrano VA, Fraser SE, Brennan CH and Vallortigara G
Scientific Reports, Nature Publishing Group vol. 10 (1)

DOI 10.1038/s41598-020-62608-5

QMRO

01-04-2020

Identification of Slit3 as a locus affecting nicotine preference in zebrafish and human smoking behaviour
Garcia Gonzalez J, Brock A, Parker M, Riley R, Joliffe D, SUDWARTS A, Teh M-T, Busch-Nentwich E, Stemple D, Martineau A, Kaprio J, Kuan V, Walton R and Brennan C
Elife, Elife Sciences Publications Ltd

DOI 10.7554/eLife.51295

QMRO

25-03-2020

Chapter 7 Classical and operant conditioning in larval zebrafish
Pritchett D and Brennan CH
In Behavioral and Neural Genetics of Zebrafish, Elsevier 107-122.

DOI 10.1016/b978-0-12-817528-6.00007-3

01-01-2020

2019

DOI 10.1101/2019.12.19.19015339

QMRO

21-12-2019

BEHAVIOURAL EFFECTS OF DEVELOPMENTAL EXPOSURE TO THE SYNTHETIC CANNABINOID JWH-018 IN WILD TYPE AND DISRUPTED IN SCHIZOPHRENIA 1 (DISC1) MUTANT ZEBRAFISH
Garcia-Gonzalez J, De Quadros B, Akkari M and Brennan C
The XXVIth World Congress of Psychiatric Genetics (WCPG), 11 - 15 October 2018. vol. 29, 1274-1274.

DOI 10.1016/j.euroneuro.2018.08.376

QMRO

26-07-2019

2018

Food or friends? What motivates zebrafish (Danio rerio) performing a visual discrimination
BRENNAN CH, Brown VJ and Daggett J
Behavioural Brain Research vol. 359

DOI 10.1016/j.bbr.2018.11.002

QMRO

06-11-2018

2017

Assessing the Value of the Zebrafish Conditioned Place Preference Model for Predicting Human Abuse Potential.
Brock AJ, Goody SMG, Mead AN, Sudwarts A, Parker MO and Brennan CH
J Pharmacol Exp Ther vol. 363 (1), 66-79.

DOI 10.1124/jpet.117.242628

QMRO

15-09-2017

Zebrafish Behavioral Models of Ageing
Brock AJ, Sudwarts A, Parker MO and Brennan CH
In The Rights and Wrongs of Zebrafish: Behavioral Phenotyping of Zebrafish, Springer Nature 241-258.

DOI 10.1007/978-3-319-33774-6_11

01-01-2017

2016

Translational Pharmacology of a Putative Measure of Motor Impulsivity in Larval Zebrafish
Parker M and Brennan C
Current Psychopharmacologye, Bentham Science Publishers vol. 5 (2), 73-84.

DOI 10.2174/2211556005666160526111902

28-07-2016

Corrigendum: Beta 1-integrin-c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes.
Barrow-McGee R, Kishi N, Joffre C, Ménard L, Hervieu A, Bakhouche BA, Noval AJ, Mai A, Guzmán C, Robbez-Masson L, Iturrioz X, Hulit J, Brennan CH, Hart IR, Parker PJ, Ivaska J and Kermorgant S
Nat Commun vol. 7, 12392-12392.

DOI 10.1038/ncomms12392

22-07-2016

Beta 1-integrin–c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes
Barrow-McGee R, Kishi N, Joffre C, Ménard L, Hervieu A, Bakhouche BA, Noval AJ, Mai A, Guzmán C, Robert-Masson L, Iturrioz X, Hulit J, Brennan CH, Hart IR, Parker PJ, Ivaska J and Kermorgant S
Nature Communications, Nature Publishing Group: Nature Communications vol. 7, 11942-11942.

DOI 10.1038/ncomms11942

QMRO

23-06-2016

A Small Molecule Inhibitor of PDK1/PLCγ1 Interaction Blocks Breast and Melanoma Cancer Cell Invasion
Raimondi C, Calleja V, Ferro R, Fantin A, Riley AM, Potter BVL, Brennan CH, Maffucci T, Larijani B and Falasca M
Scientific Reports, Nature Publishing Group: Open Access Journals - Option C vol. 6, 26142-26142.

DOI 10.1038/srep26142

QMRO

20-05-2016

Sustained Effects of Developmental Exposure to Ethanol on Zebrafish Anxiety-Like Behaviour
Baiamonte M, Parker MO, Vinson GP and Brennan CH
Plos One, Public Library of Science (Plos) vol. 11 (2)

DOI 10.1371/journal.pone.0148425

QMRO

10-02-2016

2015

Suppression of TGFβ and Angiogenesis by Type VII Collagen in Cutaneous SCC.
Martins VL, Caley MP, Moore K, Szentpetery Z, Marsh ST, Murrell DF, Kim MH, Avari M, McGrath JA, Cerio R, Kivisaari A, Kähäri VM, Hodivala-Dilke K, Brennan CH, Chen M, Marshall JF and O'Toole EA
J Natl Cancer Inst vol. 108 (1)

DOI 10.1093/jnci/djv293

QMRO

16-10-2015

Developmental role of acetylcholinesterase in impulse control in zebrafish
Parker MO, Brock AJ, Sudwarts A, Teh M-T, Combe FJ and Brennan CH
Frontiers in Behavioral Neuroscience, Frontiers vol. 9

DOI 10.3389/fnbeh.2015.00271

QMRO

16-10-2015

Correction: Sustained Action of Developmental Ethanol Exposure on the Cortisol Response to Stress in Zebrafish Larvae and Adults
Baiamonte M, Brennan CH and Vinson GP
Plos One, Public Library of Science (Plos) vol. 10 (5)

DOI 10.1371/journal.pone.0128050

08-05-2015

Speed–accuracy trade-offs and individually consistent decision making by individuals and dyads of zebrafish in a colour discrimination task
Wang M-Y, Brennan CH, Lachlan RF and Chittka L
Animal Behaviour, Elsevier vol. 103, 277-283.

DOI 10.1016/j.anbehav.2015.01.022

QMRO

01-05-2015

Sustained Action of Developmental Ethanol Exposure on the Cortisol Response to Stress in Zebrafish Larvae and Adults
Baiamonte M, Brennan CH and Vinson GP
Plos One, Public Library of Science (Plos) vol. 10 (4)

DOI 10.1371/journal.pone.0124488

QMRO

13-04-2015

Molecular psychiatry of zebrafish.
Stewart AM, Ullmann JFP, Norton WHJ, Parker MO, Brennan CH, Gerlai R and Kalueff AV
Mol Psychiatry vol. 20 (1), 2-17.

DOI 10.1038/mp.2014.128

QMRO

01-02-2015

2014

The utility of zebrafish to study the mechanisms by which ethanol affects social behavior and anxiety during early brain development
Parker MO, Annan LV, Kanellopoulos AH, Brock AJ, Combe FJ, Baiamonte M, Teh MT and Brennan CH
Progress in Neuro-Psychopharmacology and Biological Psychiatry vol. 55, 94-100.

DOI 10.1016/j.pnpbp.2014.03.011

QMRO

03-12-2014

Moderate alcohol exposure during early brain development increases stimulus-response habits in adulthood
Parker MO, Evans AMD, Brock AJ, Combe FJ, Teh MT and Brennan CH
Addiction Biology

DOI 10.1111/adb.12176

QMRO

21-08-2014

The receptor tyrosine kinase Axl regulates cell-cell adhesion and stemness in cutaneous squamous cell carcinoma.
Cichoń MA, Szentpetery Z, Caley MP, Papadakis ES, Mackenzie IC, Brennan CH and O'Toole EA
Oncogene vol. 33 (32), 4185-4192.

DOI 10.1038/onc.2013.388

07-08-2014

Atomoxetine reduces anticipatory responding in a 5-choice serial reaction time task for adult zebrafish.
Parker MO, Brock AJ, Sudwarts A and Brennan CH
Psychopharmacology (Berl) vol. 231 (13), 2671-2679.

DOI 10.1007/s00213-014-3439-z

QMRO

01-07-2014

The utility of zebrafish to study the mechanisms by which ethanol affects social behavior and anxiety during early brain development
Parker MO, Annan LV, Kanellopoulos AH, Brock AJ, Combe FJ, Baiamonte M, Teh M-T and Brennan CH
Progress in Neuro-Psychopharmacology and Biological Psychiatry

DOI 10.1016/j.pnpbp.2014.03.011

QMRO

01-01-2014

Parallel mechanisms for visual search in zebrafish.
Proulx MJ, Parker MO, Tahir Y and Brennan CH
Plos One vol. 9 (10)

DOI 10.1371/journal.pone.0111540

QMRO

01-01-2014

2013

Behavioural phenotyping of casper mutant and 1-pheny-2-thiourea treated adult zebrafish.
Parker MO, Brock AJ, Millington ME and Brennan CH
Zebrafish vol. 10 (4), 466-471.

DOI 10.1089/zeb.2013.0878

01-12-2013

Addiction and the adrenal cortex.
Vinson GP and Brennan CH
Endocr Connect vol. 2 (3), R1-R14.

DOI 10.1530/EC-13-0028

QMRO

01-09-2013

The role of zebrafish (Danio rerio) in dissecting the genetics and neural circuits of executive function
Parker MO, Brock AJ, Walton RT and Brennan CH
Frontiers in Neural Circuits (MAR)

DOI 10.3389/fncir.2013.00063

QMRO

19-03-2013

S100P is a metastasis-associated gene that facilitates transendothelial migration of pancreatic cancer cells.
Barry S, Chelala C, Lines K, Sunamura M, Wang A, Marelli-Berg FM, Brennan C, Lemoine NR and Crnogorac-Jurcevic T
Clin Exp Metastasis vol. 30 (3), 251-264.

DOI 10.1007/s10585-012-9532-y

01-03-2013

Development and automation of a test of impulse control in zebrafish.
Parker MO, Ife D, Ma J, Pancholi M, Smeraldi F, Straw C and Brennan CH
Front Syst Neurosci vol. 7

DOI 10.3389/fnsys.2013.00065

QMRO

01-01-2013

2012

Zebrafish (Danio rerio) models of substance abuse: Harnessing the capabilities
Parker MO and Brennan CH
Behaviour vol. 149 (10-12), 1037-1062.

DOI 10.1163/1568539X-00003010

05-12-2012

Low and moderate alcohol consumption during pregnancy: effects on social behaviour and propensity to develop substance abuse in later life.
Parker MO and Brennan CH
Bjog vol. 119 (13), 1671-1672.

DOI 10.1111/1471-0528.12006

01-12-2012

Low and Moderate alcohol consumption during pregnancy: effects on social behaviour and propensity to develop substance abuse in later life
PARKER M and BRENNAN CH
Bjog: An International Journal of Obstetrics and Gynaecology (13), 1671-1672.

DOI 10.1111/1471-0528.12006

01-12-2012

The role of primary cilia in mouse adrenal and zebrafish interrenal development
Cogger K, Guasti L, Ashworth R, Brennan C, Beales P, Marion V and King P
Cilia, Springer Nature vol. 1 (Suppl 1)

DOI 10.1186/2046-2530-1-s1-p64

01-11-2012

Discrimination reversal and attentional sets in zebrafish (Danio rerio).
Parker MO, Gaviria J, Haigh A, Millington ME, Brown VJ, Combe FJ and Brennan CH
Behav Brain Res vol. 232 (1), 264-268.

DOI 10.1016/j.bbr.2012.04.035

15-06-2012

Development and implementation of a three-choice serial reaction time task for zebrafish (Danio rerio).
Parker MO, Millington ME, Combe FJ and Brennan CH
Behav Brain Res vol. 227 (1), 73-80.

DOI 10.1016/j.bbr.2011.10.037

01-02-2012

Housing conditions differentially affect physiological and behavioural stress responses of zebrafish, as well as the response to anxiolytics.
Parker MO, Millington ME, Combe FJ and Brennan CH
Plos One vol. 7 (4)

DOI 10.1371/journal.pone.0034992

QMRO

01-01-2012

2011

Ryanodine receptors, a family of intracellular calcium ion channels, are expressed throughout early vertebrate development.
Wu HH, Brennan C and Ashworth R
Bmc Res Notes vol. 4

DOI 10.1186/1756-0500-4-541

QMRO

14-12-2011

AGR2 is a novel surface antigen that promotes the dissemination of pancreatic cancer cells through regulation of cathepsins B and D.
Dumartin L, Whiteman HJ, Weeks ME, Hariharan D, Dmitrovic B, Iacobuzio-Donahue CA, Brentnall TA, Bronner MP, Feakins RM, Timms JF, Brennan C, Lemoine NR and Crnogorac-Jurcevic T
Cancer Res vol. 71 (22), 7091-7102.

DOI 10.1158/0008-5472.CAN-11-1367

15-11-2011

Erratum

Personalized Medicine, Taylor & Francis vol. 8 (6), 692-692.

DOI 10.2217/pme.11.82

01-11-2011

ChemInform Abstract: Modular “Click” Sensors for Zinc and Their Application in vivo.
Jobe K, Brennan CH, Motevalli M, Goldup SM and Watkinson M
Cheminform, Wiley vol. 42 (40), no-no.

DOI 10.1002/chin.201140167

08-09-2011

Treatment for tobacco dependence: a potential application for stratified medicine?
Brock AJ, Takeda A, Brennan C and Walton RT
Pers Med vol. 8 (5), 571-579.

DOI 10.2217/PME.11.60

01-09-2011

USING ZEBRAFISH TO EXAMINE THE GENETICS OF DRUG SEEKING AND IMPULSIVITY
Brennan CH, Parker MO and Millington ME
JOURNAL OF PSYCHOPHARMACOLOGY. vol. 25 (8), A6-A6.
01-08-2011

Modular 'click' sensors for zinc and their application in vivo.
Jobe K, Brennan CH, Motevalli M, Goldup SM and Watkinson M
Chem Commun (Camb) vol. 47 (21), 6036-6038.

DOI 10.1039/c1cc11213a

07-06-2011

Zebrafish behavioural assays of translational relevance for the study of psychiatric disease
Brennan CH
Rev Neuroscience vol. 22 (1), 37-48.

DOI 10.1515/RNS.2011.006

01-01-2011

2010

AGR2 Regulates the Invasion of Pancreatic Cancer Cells Through Cathepsins B and D
Dumartin L, Whiteman HJ, Weeks ME, Timms JF, Brentnall TA, Bronner MP, Brennan C, Lemoine NR and Crnogorac-Jurcevic T
Pancreas vol. 39 (8), 1318-1319.
01-11-2010

Zebrafish Conditioned Place Preference Models of Drug Reinforcement and Relapse to Drug Seeking
Parmar A, Parmar M and Brennan CH
Neuromethods, Springer Nature vol. 51, 75-84.

DOI 10.1007/978-1-60761-953-6_6

11-10-2010

Conditioned Place Preference Models of Drug Dependence and Relapse to Drug Seeking: Studies with Nicotine and Ethanol
Brennan CH, Parmar A, Kily LKM, Ananthathevan A, Doshi A and Patel S
Neuromethods, Springer Nature vol. 52, 163-179.

DOI 10.1007/978-1-60761-922-2_7

15-09-2010

Report of the European Zebrafish Principal Investigator Meeting in Padua, Italy, March 18–22, 2010.
Brennan C, Dosch R, Haramis A-P, Luckenbach T, Martinez-Morales J-R, Moro E, Polok B, Ramesh TM, Russell C, Argenton F and Strähle U
Zebrafish vol. 7 (3), 305-310.

DOI 10.1089/zeb.2010.0668

01-09-2010

2009

A Novel Role for Ryanodine Receptors during Embryonic Development: Studies in Zebrafish.
Wu HHT, Brennan C and Ashworth R
JOURNAL OF GENERAL PHYSIOLOGY. vol. 134 (1), 17A-17A.
01-07-2009

2008

Eph receptors and zonation in the rat adrenal cortex.
Brennan CH, Chittka A, Barker S and Vinson GP
J Endocrinol vol. 198 (1), 185-191.

DOI 10.1677/JOE-08-0084

01-07-2008

Gene expression changes in a zebrafish model of drug dependency suggest conservation of neuro-adaptation pathways.
Kily LJM, Cowe YCM, Hussain O, Patel S, McElwaine S, Cotter FE and Brennan CH
J Exp Biol vol. 211 (Pt 10), 1623-1634.

DOI 10.1242/jeb.014399

01-05-2008

2007

Regeneration-enhancing effects of EphA4 blocking peptide following corticospinal tract injury in adult rat spinal cord.
Fabes J, Anderson P, Brennan C and Bolsover S
Eur J Neurosci vol. 26 (9), 2496-2505.

DOI 10.1111/j.1460-9568.2007.05859.x

01-11-2007

2006

Accumulation of the inhibitory receptor EphA4 may prevent regeneration of corticospinal tract axons following lesion
Fabes J, Anderson P, Yanez-Munoz RJ, Thrasher A, Brennan C and Bolsover S
Eur J Neurosci vol. 23 (7), 1721-1730.

DOI 10.1111/j.1460-9568.2006.04704.x

01-04-2006

2005

Acetylcholine and calcium signalling regulates muscle fibre formation in the zebrafish embryo.
Brennan C, Mangoli M, Dyer CEF and Ashworth R
J Cell Sci vol. 118 (Pt 22), 5181-5190.

DOI 10.1242/jcs.02625

15-11-2005

Use of transgenic zebrafish reporter lines to study calcium signalling in development.
Ashworth R and Brennan C
Brief Funct Genomic Proteomic vol. 4 (2), 186-193.

DOI 10.1093/bfgp/4.2.186

01-07-2005

Zebrafish in vivo modelling of the 11Q23 region of deletion in chronic lymphatic leukaemia
Auer R, Costagli A, Newland A, Fegan C, Brennan C and Cotter F
ANNALS OF ONCOLOGY. vol. 16, 87-87.
01-06-2005

Definition and zebrafish modelling of the 11 q23 critical region of deletion in CLL
Auer RL, Costagli A, Newland AC, Fegan CD, Brennan C and Cotter FE
BRITISH JOURNAL OF HAEMATOLOGY. vol. 129, 25-26.
01-04-2005

2004

EphA/ephrin-A interactions during optic nerve regeneration: restoration of topography and regulation of ephrin-A2 expression
Rodger J, Vitale PN, Tee LBG, King CE, Bartlett CA, Fall A, Brennan C, O'Shea JE, Dunlop SA and Beazley LD
Mol Cell Neurosci vol. 25 (1), 56-68.

DOI 10.1016/j.mcn.2003.09.010

01-01-2004

2003

Eph/Ephrin signaling regulates the mesenchymal-to-epithelial transition of the paraxial mesoderm during somite morphogenesis
Barrios A, Poole RJ, Durbin L, Brennan C, Holder N and Wilson SW
Curr Biol vol. 13 (18), 1571-1582.

DOI 10.1016/j.cub.2003.08.030

16-09-2003

Alkaline phosphatase fusion proteins as affinity probes for protein localization studies.
Brennan C and Fabes J
Sci Stke vol. 2003 (168)

DOI 10.1126/stke.2003.168.pl2

04-02-2003

2002

Somitogenesis.
Brennan C, Amacher SL and Currie PD
Results Probl Cell Differ vol. 40, 271-297.

DOI 10.1007/978-3-540-46041-1_14

01-01-2002

2001

Morphogenesis of prechordal plate and notochord requires intact Eph/ephrin B signaling
Chan J, Mably JD, Serluca FC, Chen JN, Goldstein NB, Thomas MC, Cleary JA, Brennan C, Fishman MC and Roberts TM
Dev Biol vol. 234 (2), 470-482.

DOI 10.1006/dbio.2001.0281

15-06-2001

Eph signalling functions downstream of Val to regulate cell sorting and boundary formation in the caudal hindbrain.
Cooke J, Moens C, Roth L, Durbin L, Shiomi K, Brennan C, Kimmel C, Wilson S and Holder N
Development vol. 128 (4), 571-580.

DOI 10.1242/dev.128.4.571

01-02-2001

Eph Receptor Signalling and Formation of the Somites in Zebrafish
BRENNAN CH
In The Origin and Fate of Somites, Ios Press. 220-235. Editors: Sanders EJ, Lash JW and Ordahl CP.
01-01-2001

2000

Anteroposterior patterning is required within segments for somite boundary formation in developing zebrafish
Durbin L, Sordino P, Barrios A, Gering M, Thisse C, Thisse B, Brennan C, Green A, Wilson S and Holder N
Development, The Company of Biologists vol. 127 (8), 1703-1713.

DOI 10.1242/dev.127.8.1703

15-04-2000

Ephrin-B Regulates the Ipsilateral Routing of Retinal Axons at the Optic Chiasm
Nakagawa S, Brennan C, Johnson KG, Shewan D, Harris WA and Holt CE
Neuron, Elsevier vol. 25 (3), 599-610.

DOI 10.1016/s0896-6273(00)81063-6

01-03-2000

1999

Requirement for the zebrafish mid-hindbrain boundary in midbrain polarisation, mapping and confinement of the retinotectal projection*
Picker A, Brennan C, Reifers F, Clarke JDW, Holder N and Brand M
Development, The Company of Biologists vol. 126 (13), 2967-2978.

DOI 10.1242/dev.126.13.2967

01-07-1999

Zebrafish aussicht mutant embryos exhibit widespread overexpression of ace (fgf8) and coincident defects in CNS development
Heisenberg C-P, Brennan C and Wilson SW
Development, The Company of Biologists vol. 126 (10), 2129-2140.

DOI 10.1242/dev.126.10.2129

15-05-1999

An early developmental role for Eph-ephrin interaction during vertebrate gastrulation
Oates AC, Lackmann M, Power M-A, Brennan C, Down LM, Do C, Evans B, Holder N and Boyd AW
Cells and Development, Elsevier vol. 83 (1-2), 77-94.

DOI 10.1016/s0925-4773(99)00036-2

01-05-1999

1998

Eph signaling is required for segmentation and differentiation of the somites
Durbin L, Brennan C, Shiomi K, Cooke J, Barrios A, Shanmugalingam S, Guthrie B, Lindberg R and Holder N
Genes & Development, Cold Spring Harbor Laboratory vol. 12 (19), 3096-3109.

DOI 10.1101/gad.12.19.3096

01-10-1998

MINI‐REVIEW The Eph receptor tyrosine kinases and the ephrins – roles in nervous system development
Holder N, Cooke J and Brennan C
European Journal of Neuroscience, Wiley vol. 10 (2), 405-408.

DOI 10.1046/j.1460-9568.1998.00032.x

01-02-1998

1997

Analysis of axon tract formation in the zebrafish brain: the role of territories of gene expression and their boundaries
Wilson SW, Brennan C, Macdonald R, Brand M and Holder N
Cell and Tissue Research, Springer Nature vol. 290 (2), 189-196.

DOI 10.1007/s004410050922

01-10-1997

The Pax protein Noi is required for commissural axon pathway formation in the rostral forebrain
Macdonald R, Scholes J, Strähle U, Brennan C, Holder N, Brand M and Wilson SW
Development, The Company of Biologists vol. 124 (12), 2397-2408.

DOI 10.1242/dev.124.12.2397

15-06-1997

Two Eph receptor tyrosine kinase ligands control axon growth and may be involved in the creation of the retinotectal map in the zebrafish
Brennan C, Monschau B, Lindberg R, Guthrie B, Drescher U, Bonhoeffer F and Holder N
Development, The Company of Biologists vol. 124 (3), 655-664.

DOI 10.1242/dev.124.3.655

01-02-1997

1996

34 The role of signalling through eph receptors in patterning the zebrafish neural plate
Holder N, Brennan C, Cooke J, Durbin L and Xu Q
International Journal of Developmental Neuroscience, Wiley vol. 14 (S1), 59-59.

DOI 10.1016/0736-5748(96)80229-2

01-07-1996

Effects of n-3 fatty acids on the NMR profile of plasma lipoproteins.
Bell JD, Barnard ML, Parkes HG, Thomas EL, Brennan CH, Cunnane SC and Dagnelie PC
Journal of Lipid Research, Elsevier vol. 37 (8), 1664-1674.

DOI 10.1016/s0022-2275(20)39109-4

01-01-1996

1995

The AMP‐activated Protein Kinase Gene is Highly Expressed in Rat Skeletal Muscle
Verhoeven AJM, Woods A, Brennan CH, Hawley SA, Hardie DG, Scott J, Beri RK and Carling D
The Febs Journal, Wiley vol. 228 (2), 236-243.

DOI 10.1111/j.1432-1033.1995.0236n.x

01-03-1995

1994

Mammalian AMP-activated protein kinase is homologous to yeast and plant protein kinases involved in the regulation of carbon metabolism
Carling D, Aguan K, Woods A, Verhoeven AJ, Beri RK, Brennan CH, Sidebottom C, Davison MD and Scott J
Journal of Biological Chemistry, Elsevier vol. 269 (15), 11442-11448.

DOI 10.1016/s0021-9258(19)78143-5

01-04-1994

1993

Adaptive changes in numbers of calcium channels in drug dependence.
Littleton J and Brennan C
Biochemical Society Symposia vol. 59, 193-203.
01-01-1993

1991

The Role of Calcium Flux in the Central Nervous System Actions of Ethanol
LITTLETON JM, BRENNAN C and BOUCHENAFA O
Annals of The New York Academy of Sciences, Wiley vol. 625 (1), 388-394.

DOI 10.1111/j.1749-6632.1991.tb33866.x

01-06-1991

Chronic exposure to anxiolytic drugs, working by different mechanisms causes up-regulation of dihydropyridine binding sites on cultured bovine adrenal chromaffin cells
Brennan CH and Littleton JM
Neuropharmacology, Elsevier vol. 30 (2), 199-205.

DOI 10.1016/0028-3908(91)90204-o

01-02-1991

1990

Second messengers involved in genetic regulation of the number of calcium channels in bovine adrenal chromaffin cells in culture
Brennan CH and Littleton JM
Neuropharmacology, Elsevier vol. 29 (7), 689-693.

DOI 10.1016/0028-3908(90)90031-l

01-07-1990

Genetic regulation of dihydropyridine-sensitive calcium channels in brain may determine susceptibility to physical dependence on alcohol
Brennan CH, Crabbe J and Littleton JM
Neuropharmacology, Elsevier vol. 29 (5), 429-432.

DOI 10.1016/0028-3908(90)90163-l

01-05-1990

1989

Genetic up-regulation of calcium channels in a cellular model of ethanol dependence
Harper JC, Brennan CH and Littleton JM
Neuropharmacology, Elsevier vol. 28 (12), 1299-1302.

DOI 10.1016/0028-3908(89)90002-6

01-12-1989

Membrane receptors, involved in up-regulation of calcium channels in bovine adrenal chromaffin cells, chronically exposed to ethanol
Brennan CH, Lewis A and Littleton JM
Neuropharmacology, Elsevier vol. 28 (12), 1303-1307.

DOI 10.1016/0028-3908(89)90003-8

01-12-1989

Chronic Exposure to Ethanol Increases Dihydropyridine‐Sensitive Calcium Channels in Excitable Cells
BRENNAN CH, GUPPY LJ and LITTLETON JM
Annals of The New York Academy of Sciences, Wiley vol. 560 (1), 467-469.

DOI 10.1111/j.1749-6632.1989.tb24140.x

01-06-1989

1988

Adaptation in Membrane Ca2+ Channels as a Basis for Alcohol‐Related Pathology
Littleton JM, Harper JC, Brennan CH and Guppy LJ
Drug and Alcohol Review, Wiley vol. 7 (1), 35-38.

DOI 10.1080/09595238880000091

01-01-1988

1987

Dihydropyridine‐Sensitive Ca2+ Channels and Inositol Phospholipid Metabolism in Ethanol Physical Dependencea
HUDSPITH MJ, BRENNAN CH, CHARLES S and LITTLETON JM
Annals of The New York Academy of Sciences, Wiley vol. 492 (1), 156-170.

DOI 10.1111/j.1749-6632.1987.tb48665.x

01-04-1987

Grants

Grants of specific relevance to the Centre for Brain and Behaviour

NIH: Zebrafish addiction screen
Caroline Brennan
£466,209 NIH National Institutes of Health - USA
01-08-2018 - 31-05-2025

Terpene enhancement of anxiolytic properties of cannabinoids
Caroline Brennan and Mohamed Elbadawi
£35,000 Innovate UK
25-03-2024 - 24-07-2024

Highthroughput Light Sheet Microscopy: Imaging Across Scales
Viji Draviam Sastry, Caroline Brennan, Vidya Chandran Darbari, Chema Martin Duran, Ivan Kadurin, Isabel M Palacios, Richard Pickersgill, Sarah McClelland, Tyson Sharp and Martin Knight
£386,205 MRC Medical Research Council
01-10-2022 - 31-03-2023

A confocal microscope for multidisciplinary dynamic studies of complex biological systems
Conrad Mullineaux, Caroline Brennan, Alexandre De Mendoza Soler, Viji Draviam Sastry, Maurice Elphick, Christoph Engl, Isabel M Palacios, Matteo Palma, Marina Resmini, Alexander Ruban, Peter Thorpe, Angelika Stollewerk, Chema Martin Duran, Paulo Baptista Ribeiro, Susana Alves Godinho, Richard Grose, Stephanie Kermorgant, Peter McCormick and Tyson Sharp
£390,834 BBSRC Biotechnology and Biological Sciences Research Council
01-08-2022 - 31-07-2023

NUMELAT - Numbers in the brain: the impact of brain lateralization on numerical abilities
Caroline Brennan
£156,364 EU Commission - Horizon 2020
01-06-2018 - 31-05-2020

Programme grant: Imaging the neurobiology transformations
Caroline Brennan
£282,872 Human Frontier Science Program (HFSP)
01-12-2017 - 30-06-2022

GSTHgNDD - Role of GST gene variation in susceptibility to mercury (Hg)-induced neurodevelopmental disorders (NDD) in zebrafish
Caroline Brennan
£146,763 EU Commission - Horizon 2020
20-06-2017 - 04-06-2020

The Genetics of Numeracy & the Evolutionary Basis of Number
Caroline Brennan
£312,614 Leverhulme Trust
12-06-2017 - 01-12-2021