Research
Organ-on-a-Chip, In-vitro Modelling, Osteoarthritis, Cartilage, Synovium
Interests
My research focuses on understanding the factors that contribute to the development of osteoarthritis (OA) in the human knee, and on improving treatments that seek to halt disease progression. Currently, I am developing a human synovial joint-on-a-chip model to investigate the interaction between cartilage and synovium which we believe plays a role in the progression of OA and influences individual patient responses to treatment.
Publications
Publications of specific relevance to the Centre for Bioengineering
2024
Intra-Articular Injection of Human Umbilical Cord-Derived Mesenchymal Stromal Cells Reduces Radiographic Osteoarthritis in an Ovine Model.Perry J, Mennan C, Cool P, McCarthy HS, Newell K,
Hopkins T, Hulme C, Wright KT, Henson FMD and Roberts S
Cartilage,
Sage Publications (Immediate Access)
03-11-2024 2023
Human vascularised synovium-on-a-chip: a mechanically stimulated, microfluidic model to investigate synovial inflammation and monocyte recruitmentThompson CL,
Hopkins T, Bevan C,
Screen HRC, Wright KT and
Knight MM Biomedical Materials,
Iop Publishing vol. 18 (6)
10-10-2023 Relationship Between Activity Level and Knee Function Is Influenced by Negative Affect in Patients Undergoing Cell Therapy for Articular Cartilage Defects in the KneeHopkins T, Roberts S, Richardson JB, Gallacher P, Bailey A and Kuiper JH
Orthopaedic Journal of Sports Medicine,
Sage Publications vol. 11 (2)
01-02-2023 2022
Chondrocyte Isolation and ExpansionHarrison P,
Hopkins T, Hulme C, McCarthy H and Wright K
In
Cartilage Tissue Engineering,
Springer Nature Editors: Stoddart MJ, Della Bella E and Armiento AR.
11-11-2022 2021
Identifying Consensus and Open Questions around Assessing or Predicting the Quality and Success of Cartilage Repair: A Delphi StudyHopkins T, Richardson J and Kuiper JH
Surgeries,
Mdpi vol. 2 (3), 286-302.
06-08-2021 An In Vitro System to Study the Effect of Subchondral Bone Health on Articular Cartilage Repair in HumansHopkins T, Wright KT, Kuiper NJ, Roberts S, Jermin P, Gallacher P and Kuiper JH
Cells,
Mdpi vol. 10 (8)
27-07-2021 Short-Term Evaluation of Cellular Fate in an Ovine Bone Formation ModelMarkides H, Foster NC, McLaren JS,
Hopkins T, Black C, Oreffo ROC, Scammell BE, Echevarria I, White LJ and Haj AJE
Cells,
Mdpi vol. 10 (7)
14-07-2021 2020
The use of technology in the subcategorisation of osteoarthritis: a Delphi study approachMennan C,
Hopkins T, Channon A, Elliott M, Johnstone B, Kadir T, Loughlin J, Peffers M, Pitsillides A, Sofat N, Stewart C, Watt FE, Zeggini E, Holt C, Roberts S and Consortium TON
Osteoarthritis and Cartilage Open,
Elsevier vol. 2 (3)
09-06-2020 2019
Combined Autologous Chondrocyte and Bone Marrow Mesenchymal Stromal Cell Implantation in the Knee: An 8-year Follow Up of Two First-In-Man CasesWang J, Wright KT, Perry J, Tins B,
Hopkins T, Hulme C, McCarthy HS, Brown A and Richardson JB
Cell Transplantation,
Sage Publications vol. 28 (7), 924-931.
08-05-2019
