Prof Martin Knight

BEng, MSc, PhD, FHEA

Professor of Mechanobiology
Dean for Research (Faculty of Science and Engineering)

School of Engineering and Materials Science
Queen Mary University of London

m.m.knight@qmul.ac.uk

www.sems.qmul.ac.uk/staff/m.m.knight/

Centre for Bioengineering

Research
Publications
Grants

Research

Organ-on-a-Chip, NAMs, Mechanobiology, Primary Cilia, Musculoskeletal Bioengineering, Cancer

Interests

A key aspect of Prof Knight's work explores the development of organ-on-a-chip models for understanding human biology in health and disease and predicting the response to therapeutics. This technology, which includes New Approach Methodologies (NAMs) for safety testing, is set to replace/reduce the use of animals in science whilst improving the understanding of human biology and speeding up the delivery of new medicines.

Prof Knight is the Co-Director of the Queen Mary Centre for Predictive in vitro Models (https://www.cpm.qmul.ac.uk/) and one of the directors of the associated EPSRC Centre for Doctoral Training in Next Generation Organ-on-a-chip Technology.

As a Professor of 'Mechanobiology', Prof Knight is particularly interested in the incorporation of physiological and pathological biomechanical stimuli to improve the predictive power of these in vitro models. His research group work on a variety of different musculoskeletal, cardiovascular and epithelial tissues including cartilage, synovium, bone, kidney and artery, as well as diseases including osteoarthritis, cancer, atherosclerosis and inflammation.

Prof Knight is also interested in the fundamental mechanisms of how living cells and tissues respond to biomechanical stimuli. This led him to examine the role of the cellular structures known as primary cilia. Knight's research group conducted pioneering research showing the involvement of cilia in mechanosignalling and inflammation and is now investigating whether manipulation of cilia can be used as a therapeutic strategy.

Prof Knight runs a large multidisciplinary research group which currently consists of 4-6 post docs, a technician, and 6 PhD students as primary supervisor and more as second supervisor.

Publications

Publications of specific relevance to the Centre for Bioengineering

2024

Nonlinear Stress‐Induced Transformations in Collagen Fibrillar Organization, Disorder and Strain Mechanisms in the Bone‐Cartilage Unit
Badar W, Inamdar SR, Fratzl P, Snow T, Terrill NJ, Knight MM and Gupta HS
Advanced Science, Wiley, e2407649-e2407649.

DOI 10.1002/advs.202407649

QMRO

11-11-2024

Air Pollution and Osteoporosis
Allen O, Knight MM and Verbruggen SW
Current Osteoporosis Reports, Springer Science and Business Media Llc

DOI 10.1007/s11914-024-00889-9

QMRO

20-09-2024

A Self‐Assembled 3D Model Demonstrates How Stiffness Educates Tumor Cell Phenotypes and Therapy Resistance in Pancreatic Cancer
Liu Y, Okesola BO, de la Peña DO, Li W, Lin M, Trabulo S, Tatari M, Lawlor RT, Scarpa A, Wang W, Knight M, Loessner D, Heeschen C, Mata A and Pearce OMT
Advanced Healthcare Materials, Wiley vol. 13 (17)

DOI 10.1002/adhm.202301941

QMRO

22-03-2024

2023

A Novel Primary Cilium‐Mediated Mechanism Through which Osteocytes Regulate Metastatic Behavior of Both Breast and Prostate Cancer Cells
Verbruggen SW, Nolan J, Duffy MP, Pearce OMT, Jacobs CR and Knight MM
Advanced Science, Wiley vol. 11 (2), 2305842-2305842.

DOI 10.1002/advs.202305842

QMRO

15-11-2023

Human vascularised synovium-on-a-chip: a mechanically stimulated, microfluidic model to investigate synovial inflammation and monocyte recruitment
Thompson CL, Hopkins T, Bevan C, Screen HRC, Wright KT and Knight MM
Biomedical Materials, Iop Publishing vol. 18 (6)

DOI 10.1088/1748-605x/acf976

QMRO

10-10-2023

Organ-on-a-Chip and Microfluidic Platforms for Oncology in the UK
Nolan J, Pearce OMT, Screen HRC, Knight MM and Verbruggen SW
Cancers, Mdpi vol. 15 (3)

DOI 10.3390/cancers15030635

QMRO

19-01-2023

2022

Techniques for Visualization and Quantification of Primary Cilia in Chondrocytes
Meng H, Thompson CL, Coveney CR, Wann AK and Knight MM
In Cartilage Tissue Engineering, Springer Nature 157-176.

DOI 10.1007/978-1-0716-2839-3_12

11-11-2022

YAP activation inhibits inflammatory signalling and cartilage breakdown associated with reduced primary cilia expression
Meng H, Fu S, Ferreira MB, Hou Y, Pearce OM, Gavara N and Knight MM
Osteoarthritis and Cartilage, Elsevier vol. 31 (5), 600-612.

DOI 10.1016/j.joca.2022.11.001

QMRO

08-11-2022

Mechanostimulation of breast myoepithelial cells induces functional changes associated with DCIS progression to invasion
Hayward M-K, Allen MD, Gomm JJ, Goulding I, Thompson CL, Knight MM, Marshall JF and Jones JL
Npj Breast Cancer, Springer Nature vol. 8 (1)

DOI 10.1038/s41523-022-00464-4

QMRO

20-09-2022

Collagen pre-strain discontinuity at the bone—Cartilage interface
Badar W, Ali H, Brooker ON, Newham E, Snow T, Terrill NJ, Tozzi G, Fratzl P, Knight MM and Gupta HS
Plos One, Public Library of Science (Plos) vol. 17 (9)

DOI 10.1371/journal.pone.0273832

QMRO

15-09-2022

Oscillations of the circadian clock protein, BMAL-1, align to daily cycles of mechanical stimuli: a novel means to integrate biological time within predictive in vitro model systems
Heywood HK, Gardner L, Knight MM and Lee DA
In Vitro Models, Springer Nature, 1-8.

DOI 10.1007/s44164-022-00032-x

QMRO

31-08-2022

2021

Reversible changes in the 3D collagen fibril architecture during cyclic loading of healthy and degraded cartilage
Inamdar SR, Prévost S, Terrill NJ, Knight MM and Gupta HS
Acta Biomaterialia, Elsevier vol. 136, 314-326.

DOI 10.1016/j.actbio.2021.09.037

QMRO

24-11-2021

Abstract 2642: Using 3-Dimensional in vitro models to unravel the complexity of the metastatic microenvironment in high-grade serous ovarian cancer
Malacrida B, Delaine-Smith R, Nichols S, Maniati E, Jones RL, Knight MM, Pearce OM and Balkwill FR
Cancer Research. vol. 81 (13_Supplement), 2642-2642.

DOI 10.1158/1538-7445.am2021-2642

01-07-2021

Mechanical Stimulation Modulates Osteocyte Regulation of Cancer Cell Phenotype
Verbruggen SW, Thompson CL, Duffy MP, Lunetto S, Nolan J, Pearce OMT, Jacobs CR and Knight MM
Cancers, Mdpi vol. 13 (12)

DOI 10.3390/cancers13122906

QMRO

10-06-2021

A human multi-cellular model shows how platelets drive production of diseased extracellular matrix and tissue invasion
Malacrida B, Nichols S, Maniati E, Jones R, Delanie-Smith R, Roozitalab R, Tyler EJ, Thomas M, Boot G, Mackerodt J, Lockley M, Knight MM, Balkwill FR and Pearce OMT
Iscience, Elsevier vol. 24 (6)

DOI 10.1016/j.isci.2021.102676

QMRO

29-05-2021

Modelling TGFβR and Hh pathway regulation of prognostic matrisome molecules in ovarian cancer
Delaine-Smith RM, Maniati E, Malacrida B, Nichols S, Roozitalab R, Jones RR, Lecker LSM, Pearce OMT, Knight MM and Balkwill FR
Iscience, Elsevier vol. 24 (6)

DOI 10.1016/j.isci.2021.102674

QMRO

29-05-2021

Polycystin-2 is required for chondrocyte mechanotransduction and traffics to the primary cilium in response to mechanical stimulation
Thompson C, Mcfie M, Chapple J, BEALES P and Knight M
International Journal of Molecular Sciences, Mdpi Ag

DOI 10.3390/ijms22094313

QMRO

21-04-2021

Sub-toxic levels of cobalt ions impair mechanostranduction via HDAC6-depedent primary cilia shortening.
Wu H, Wang Z, Liu S, Meng H, Shelton JC, Thompson CL, Fu S and Knight MM
Biochem Biophys Res Commun

DOI 10.1016/j.bbrc.2021.03.157

QMRO

15-04-2021

Corrigendum: Mechanical Stimulation: A Crucial Element of Organ-on-Chip Models
Thompson CL, Fu S, Heywood HK, Knight MM and Thorpe SD
Frontiers in Bioengineering and Biotechnology, Frontiers vol. 9

DOI 10.3389/fbioe.2021.658873

QMRO

18-02-2021

Modelling TGFβR and Hh pathway regulation of prognostic matrisome molecules in ovarian cancer
Delaine-Smith R, Maniati E, Malacrida B, Nichols S, Roozitalab R, Jones R, Lecker L, Pearce O, Knight M and Balkwill F
Biorxiv.Org Editors: Balkwill F.

DOI 10.1101/2021.02.01.428374

QMRO

02-02-2021

Activation of TRPV4 by mechanical, osmotic or pharmaceutical stimulation is anti-inflammatory blocking IL-1β mediated articular cartilage matrix destruction
Fu S, Meng H, Inamdar S, Das B, Gupta H, Wang W, Thompson C and Knight M
Osteoarthritis and Cartilage, Elsevier Editors: Block JA.

DOI 10.1016/j.joca.2020.08.002

QMRO

01-01-2021

Using 3-Dimensional in vitro models to unravel the complexity of the metastatic microenvironment in high-grade serous ovarian cancer.
Malacrida B, Delaine-Smith R, Nichols S, Maniati E, Jones RL, Knight MM, Pearce OM and Balkwill FR
CANCER RESEARCH. vol. 81 (13)
01-01-2021

2020

Mechanical Stimulation: A Crucial Element of Organ-on-Chip Models
Thompson CL, Fu S, Heywood HK, Knight MM and Thorpe SD
Frontiers in Bioengineering and Biotechnology, Frontiers Media Sa vol. 8

DOI 10.3389/fbioe.2020.602646

QMRO

10-12-2020

Solution-Processed Epitaxial Growth of Arbitrary Surface Nanopatterns on Hybrid Perovskite Monocrystalline Thin Films.
Zhang J, Guo Q, Li X, Li C, Wu K, Abrahams I, Yan H, Knight MM, Humphreys CJ and Su L
Acs Nano, American Chemical Society

DOI 10.1021/acsnano.9b08553

QMRO

27-08-2020

Nanoscale mapping reveals functional differences in ion channels populating the membrane of primary cilia
Torres-Pérez JV, Naeem H, Thompson CL, Knight MM and Novak P
Cellular Physiology and Biochemistry vol. 54 (1), 15-26.

DOI 10.33594/000000202

QMRO

10-01-2020

2019

Sub-toxic levels of Co2+ are anti-inflammatory and protect cartilage from degradation caused by IL-1β
Fu S, Meng H, Freer F, Kwon J, Shelton JC and Knight MM
Clinical Biomechanics, Elsevier vol. 79

DOI 10.1016/j.clinbiomech.2019.12.006

24-12-2019

Ciliary exclusion of Polycystin-2 promotes kidney cystogenesis in an autosomal dominant polycystic kidney disease model
Walker RV, Keynton JL, Grimes DT, Sreekumar V, Williams DJ, Esapa C, Wu D, Knight MM and Norris DP
Nature Communications, Springer Nature vol. 10 (1)

DOI 10.1038/s41467-019-12067-y

QMRO

06-09-2019

Proteoglycan degradation mimics static compression by altering the natural gradients in fibrillar organisation in cartilage
Inamdar SR, Barbieri E, Terrill NJ, Knight MM and Gupta HS
Acta Biomaterialia, Elsevier vol. 97, 437-450.

DOI 10.1016/j.actbio.2019.07.055

QMRO

30-07-2019

Transglutaminase-2 Mediates the Biomechanical Properties of the Colorectal Cancer Tissue Microenvironment that Contribute to Disease Progression
Delaine-Smith R, Wright N, Hanley C, Hanwell R, Bhome R, Bullock M, Drifka C, Eliceiri K, Thomas G, Knight M, Mirnezami A and Peake N
Cancers, Mdpi Ag

DOI 10.3390/cancers11050701

QMRO

21-05-2019

Mechanical loading inhibits cartilage inflammatory signalling via an HDAC6 and IFT-dependent mechanism regulating primary cilia elongation
Fu S, Thompson CL, Ali A, Wang W, Chapple JP, Mitchison HM, Beales PL, Wann AKT and Knight MM
Osteoarthritis and Cartilage, Elsevier vol. 27 (7), 1064-1074.

DOI 10.1016/j.joca.2019.03.003

QMRO

25-03-2019

An in vitro investigation of the inflammatory response to the strain amplitudes which occur during high frequency oscillation ventilation and conventional mechanical ventilation
Harris C, THORPE SD, Rushwan S, Wang W, THOMPSON C, Peacock J, KNIGHT M, Gooptu B and Greenough A
Journal of Biomechanics, Elsevier

DOI 10.1016/j.jbiomech.2019.03.024

QMRO

22-03-2019

Oncometabolite induced primary cilia loss in pheochromocytoma
O’Toole SM, Watson DS, Novoselova TV, Romano LEL, King PJ, Bradshaw TY, Thompson CL, Knight MM, Sharp TV, Barnes MR, Srirangalingam U, Drake WM and Chapple JP
Endocrine-Related Cancer vol. 26 (1), 165-180.

DOI 10.1530/ERC-18-0134

QMRO

01-01-2019

Transglutaminase-2 mediates stromal biomechanics in colorectal cancer
Delaine-Smith R, Wright N, Hanley CJ, Hanwell R, Bhome R, Bullock M, Drifka CR, Eliceiri KW, Thomas G, Knight MM, Mirnezami AH and Peake NJ
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 100 (4), A15-A16.
01-01-2019

2018

Mechanical loading induces primary cilia disassembly in tendon cells via TGFβ and HDAC6
Rowson DT, Shelton JC, Screen HRC and Knight MM
Scientific Reports, Springer Nature vol. 8 (1)

DOI 10.1038/s41598-018-29502-7

QMRO

23-07-2018

Cobalt ions stimulate a fibrotic response through matrix remodelling, fibroblast contraction and release of pro-fibrotic signals from macrophages
Xu J, Nyga A, Li W, Zhang X, Gavara N, Knight MM and Shelton JC
European Cells and Materials vol. 36, 142-155.

DOI 10.22203/eCM.v036a11

QMRO

01-07-2018

Tissue stiffening promotes keratinocyte proliferation through activation of epidermal growth factor signaling
Kenny FN, Drymoussi Z, Delaine-Smith R, Kao AP, Laly AC, Knight MM, Philpott MP and Connelly JT
Journal of Cell Science vol. 131 (10), 215780-215780.

DOI 10.1242/jcs.215780

QMRO

15-05-2018

Cobalt (II) ions and nanoparticles induce macrophage retention by ROS-mediated down-regulation of RhoA expression.
Xu J, Yang J, Nyga A, Ehteramyan M, Moraga A, Wu Y, Zeng L, Knight MM and Shelton JC
Acta Biomater vol. 72, 434-446.

DOI 10.1016/j.actbio.2018.03.054

QMRO

09-04-2018

Investigating drivers of the tumour matrisome, and their role in disease progression
Pearce OMT, Nichols S, Delaine-Smith R, Jones RR, Maniati E, Rootizalab R, Mackerodt J, Knight MM and Balkwill FR
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 99 (6), A49-A49.
01-01-2018

2017

Deconstruction of a metastatic tumor microenvironment reveals a common matrix response in human cancers.
Pearce OMT, Delaine-Smith R, Maniati E, Nichols S, Wang J, Böhm S, Rajeeve V, Ullah D, Chakravarty P, Jones RR, Montfort A, Dowe T, Gribben J, Jones JL, Kocher HM, Serody JS, Vincent BG, Connelly J, Brenton JD, Chelala C, et al.
Cancer Discov

DOI 10.1158/2159-8290.CD-17-0284

QMRO

01-12-2017

Chondrocyte expansion is associated with loss of primary cilia and disrupted hedgehog signalling.
Thompson CL, Plant JC, Wann AK, Bishop CL, Novak P, Mitchison HM, Beales PL, Chapple JP and Knight MM
Eur Cell Mater vol. 34, 128-141.

DOI 10.22203/eCM.v034a09

QMRO

20-09-2017

The Secret Life of Collagen: Temporal Changes in Nanoscale Fibrillar Pre-Strain and Molecular Organization During Physiological Loading of Cartilage.
Inamdar SR, Knight DP, Terrill NJ, Karunaratne A, Cacho-Nerin F, Knight MM and Gupta HS
Acs Nano

DOI 10.1021/acsnano.7b00563

QMRO

11-08-2017

Topography of calcium phosphate ceramics regulates primary cilia length and TGF receptor recruitment associated with osteogenesis.
Zhang J, Dalbay MT, Luo X, Vrij E, Barbieri D, Moroni L, de Bruijn JD, van Blitterswijk CA, Chapple JP, Knight MM and Yuan H
Acta Biomater vol. 57, 487-497.

DOI 10.1016/j.actbio.2017.04.004

QMRO

15-07-2017

Abstract 5558: Deconstruction of a human tumor microenvironment
Balkwill FR, Pearce OM, Delaine-Smith R, Maniati E, Nichols S, Wang J, Bessant C and Knight M
Cancer Research. vol. 77 (13_Supplement), 5558-5558.

DOI 10.1158/1538-7445.am2017-5558

01-07-2017

P07 Interleukin response to cyclical mechanical stretch with models of different neonatal ventilation modes
Harris C, Rushwan S, Wang W, Thorpe S, Thompson C, Peacock J, Knight M, Gooptu B and Greenough A
Plenary. vol. 102 (Suppl 1)

DOI 10.1136/archdischild-2017-313087.7

QMRO

01-05-2017

Smoothened‐antagonists reverse homogentisic acid‐induced alterations of Hedgehog signaling and primary cilium length in alkaptonuria
Gambassi S, Geminiani M, Thorpe SD, Bernardini G, Millucci L, Braconi D, Orlandini M, Thompson CL, Petricci E, Manetti F, Taddei M, Knight MM and Santucci A
Journal of Cellular Physiology, Wiley vol. 232 (11), 3103-3111.

DOI 10.1002/jcp.25761

QMRO

29-03-2017

Reduced Primary Cilia Length and Altered Arl13b Expression Are Associated with Deregulated Chondrocyte Hedgehog Signalling in Alkaptonuria
THORPE SD, Gambassi S, Thompson CL, Chandrakumar C, Santucci A and Knight MM
Journal of Cellular Physiology, John Wiley & Sons Inc.

DOI 10.1002/jcp.25839

QMRO

03-02-2017

Primary cilia mechanobiology
Knight MM
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 98 (1), A3-A4.

QMRO

01-01-2017

A Cd98hc-Dependent Mechanism Mediates Pro-Inflammatory Cytokine Release In Cell And Animal Models Of Lung Injury
Gooptu B, Rushwan S, Wang W, Harris C, Thorpe S, Knight M and Sethi T
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. vol. 195

QMRO

01-01-2017

Polycystins are required for primary cilia-mediated mechanotransduction in chondrocytes
Thompson CL, Chapple JP, Beales PL, Mitchison HM, Ramachandran M and Knight MM
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 98 (1), A14-A14.

QMRO

01-01-2017

Cyclic loading leads to primary cilia disassembly in human tenocytes
Rowson DT, Knight MM and Screen HRC
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 98 (1), A6-A6.

QMRO

01-01-2017

2016

Experimental validation of a flat punch indentation methodology calibrated against unconfined compression tests for determination of soft tissue biomechanics
Delaine-Smith RM, Burney S, Balkwill FR and Knight MM
Journal of The Mechanical Behavior of Biomedical Materials, Elsevier vol. 60, 401-415.

DOI 10.1016/j.jmbbm.2016.02.019

01-07-2016

Chondrocyte dedifferentiation increases cell stiffness by strengthening membrane-actin adhesion
Sliogeryte K, Botto L, Lee DA and Knight MM
Osteoarthritis and Cartilage, Elsevier vol. 24 (5), 912-920.

DOI 10.1016/j.joca.2015.12.007

QMRO

01-05-2016

Chondrocyte dedifferentiation down regulates mechano-responsiveness and hedgehog signalling associated with changes in primary cilia structure
Kelly T-AN, Thompson CL, Tan E, Wann AK, Thorpe SD, Chapple JP, Hung CT and Knight MM
World Congress of the Osteoarthritis-Research-Society-International (OARSI) on Osteoarthritis 31 Mar 2016 - 3 Apr 2016. vol. 24, S342-S343.

DOI 10.1016/j.joca.2016.01.614

01-04-2016

Changes in chondrocyte primary cilia structure and function are associated with altered mechanoregulation in Alkaptonuria
Thorpe SD, Gambassi S, Patel R, Santucci A and Knight MM
Osteoarthritis and Cartilage. vol. 24, s174-s175.

DOI 10.1016/j.joca.2016.01.343

QMRO

01-04-2016

Zonal variation in primary cilia elongation correlates with localized biomechanical degradation in stress deprived tendon.
Rowson D, Knight MM and Screen HRC
J Orthop Res vol. 34 (12), 2146-2153.

DOI 10.1002/jor.23229

QMRO

23-03-2016

IFT88 influences chondrocyte actin organization and biomechanics
KNIGHT MM, wang W, wang Z, wann A, thompson C and hassen A
Osteoarthritis and Cartilage

DOI 10.1016/j.joca.2015.10.003

QMRO

01-03-2016

Lithium chloride modulates chondrocyte primary cilia and inhibits Hedgehog signaling
Thompson CL, Wiles A, Poole CA and Knight MM
Faseb Journal vol. 30 (2), 716-726.

DOI 10.1096/fj.15-274944

QMRO

01-02-2016

Differential effects of LifeAct-GFP and actin-GFP on cell mechanics assessed using micropipette aspiration
Sliogeryte K, Thorpe SD, Wang Z, Thompson CL, Gavara N and Knight MM
Journal of Biomechanics, Elsevier vol. 49 (2), 310-317.

DOI 10.1016/j.jbiomech.2015.12.034

QMRO

25-01-2016

Physiology of urethral flow
Knight M, Buchholz N and Bourdoumis A
In Handbook of Urinary Stents: Basic Science and Clinical Applications, Jaypee Brothers Medical Publishing 219-219.

DOI 10.5005/jp/books/12884_30

01-01-2016

2015

Hedgehog signalling does not stimulate cartilage catabolism and is inhibited by Interleukin-1β
Thompson CL, Patel R, Kelly T-AN, Wann AKT, Hung CT, Chapple JP and Knight MM
Arthritis Research & Therapy vol. 17 (1)

DOI 10.1186/s13075-015-0891-z

QMRO

24-12-2015

Cytokine preconditioning of engineered cartilage provides protection against interleukin-1 insult.
Tan AR, VandenBerg CD, Attur M, Abramson SB, Knight MM, Bulinski JC, Ateshian GA, Cook JL and Hung CT
Arthritis Res Ther vol. 17, 361-361.

DOI 10.1186/s13075-015-0876-y

QMRO

14-12-2015

Lithium chloride modulates chondrocyte primary cilia and inhibits Hedgehog signaling
Thompson CL, Poole CA and Knight MM
The Faseb Journal, Federation of American Society of Experimental Biology vol. 100 (4), A39-A40.

DOI 10.1096/fj.15-274944

QMRO

23-10-2015

Lithium chloride prevents interleukin- 1β induced cartilage degradation and loss of mechanical properties
KNIGHT MM, Thompson CL, Yasmin H, Varone A, Wiles A and Poole CA
Journal of Orthopaedic Research, Wiley: 12 Months

DOI 10.1002/jor.22913

QMRO

01-10-2015

FINITE ELEMENT ANALYSIS OF MECHANICAL DEFORMATION OF CHONDROCYTE TO 2D SUBSTRATE AND 3D SCAFFOLD
CHEN J, BADER DL, LEE DA and KNIGHT MM
Journal of Mechanics in Medicine and Biology, World Scientific Publishing vol. 15 (05)

DOI 10.1142/s0219519415500773

01-10-2015

Adipogenic Differentiation of hMSCs is Mediated by Recruitment of IGF‐1r Onto the Primary Cilium Associated With Cilia Elongation
Dalbay MT, Thorpe SD, Connelly JT, Chapple JP and Knight MM
Stem Cells, Oxford University Press (Oup) vol. 33 (6), 1952-1961.

DOI 10.1002/stem.1975

QMRO

21-05-2015

2014

Stem cell differentiation increases membrane-actin adhesion regulating cell blebability, migration and mechanics
Sliogeryte K, Thorpe SD, Lee DA, Botto L and Knight MM
Scientific Reports, Springer Nature vol. 4 (1)

DOI 10.1038/srep07307

QMRO

04-12-2014

The rate of hypo-osmotic challenge influences regulatory volume decrease (RVD) and mechanical properties of articular chondrocytes
Wang Z, Irianto J, Kazun S, Wang W and Knight MM
Osteoarthritis and Cartilage, Elsevier vol. 23 (2), 289-299.

DOI 10.1016/j.joca.2014.11.003

QMRO

11-11-2014

89 Primary Cilia In Tenocytes From The Inter-fascicular Matrix And The Fascicular Matrix
Rowson D, Knight M and Screen H
British Journal of Sports Medicine, Bmj vol. 48 (Suppl 2), a58-a59.

DOI 10.1136/bjsports-2014-094114.88

01-09-2014

The primary cilium influences interleukin-1β-induced NFκB signalling by regulating IKK activity.
Wann AKT, Chapple JP and Knight MM
Cell Signal vol. 26 (8), 1735-1742.

DOI 10.1016/j.cellsig.2014.04.004

QMRO

01-08-2014

Quantification of chromatin condensation level by image processing.
Irianto J, Lee DA and Knight MM
Med Eng Phys vol. 36 (3), 412-417.

DOI 10.1016/j.medengphy.2013.09.006

01-03-2014

Primary cilia disassembly down-regulates mechanosensitive hedgehog signalling: a feedback mechanism controlling ADAMTS-5 expression in chondrocytes.
Thompson CL, Chapple JP and Knight MM
Osteoarthritis Cartilage vol. 22 (3), 490-498.

DOI 10.1016/j.joca.2013.12.016

QMRO

01-03-2014

Depletion of chondrocyte primary cilia reduces the compressive modulus of articular cartilage.
Irianto J, Ramaswamy G, Serra R and Knight MM
J Biomech vol. 47 (2), 579-582.

DOI 10.1016/j.jbiomech.2013.11.040

QMRO

22-01-2014

In vitro encrustation of a semi-permanent polymer-covered nitinol ureter stent: an artificial urine model
Shaheen T, Edirisinghe T, Gabriel M, Bourdoumis A, Buchholz N and Knight M
Urolithiasis vol. 42 (3), 203-207.

DOI 10.1007/s00240-014-0652-5

01-01-2014

2013

Correction: Super-Resolution Imaging Strategies for Cell Biologists Using a Spinning Disk Microscope
Hosny NA, Song M, Connelly JT, Ameer-Beg S, Knight MM and Wheeler AP
Plos One, Public Library of Science (Plos) vol. 8 (12)

DOI 10.1371/annotation/d96769fb-4e7d-4f47-98cf-443447c1471e

30-12-2013

Surface topography regulates wnt signaling through control of primary cilia structure in mesenchymal stem cells.
McMurray RJ, Wann AKT, Thompson CL, Connelly JT and Knight MM
Sci Rep vol. 3

DOI 10.1038/srep03545

QMRO

18-12-2013

Interleukin-1β sequesters hypoxia inducible factor 2α to the primary cilium.
Wann AK, Thompson CL, Chapple JP and Knight MM
Cilia vol. 2 (1)

DOI 10.1186/2046-2530-2-17

QMRO

13-12-2013

Stent encrustation in feline and human artificial urine: does the low molecular weight composition account for the difference?
Shafat M, Rajakumar K, Syme H, Buchholz N and Knight MM
Urolithiasis vol. 41 (6), 481-486.

DOI 10.1007/s00240-013-0608-1

01-11-2013

Osmotic challenge drives rapid and reversible chromatin condensation in chondrocytes.
Irianto J, Swift J, Martins RP, McPhail GD, Knight MM, Discher DE and Lee DA
Biophys J vol. 104 (4), 759-769.

DOI 10.1016/j.bpj.2013.01.006

19-02-2013

THE ROLE OF PRIMARY CILIA IN CARTILAGE HEALTH AND DISEASE
Knight MM
OSTEOARTHRITIS AND CARTILAGE. vol. 21, S2-S2.

DOI 10.1016/j.joca.2013.02.013

QMRO

01-01-2013

Super-resolution imaging strategies for cell biologists using a spinning disk microscope.
Hosny NA, Song M, Connelly JT, Ameer-Beg S, Knight MM and Wheeler AP
Plos One vol. 8 (10)

DOI 10.1371/journal.pone.0074604

QMRO

01-01-2013

Bardet-Biedl syndrome proteins control the cilia length through regulation of actin polymerization
Hernandez-Hernandez V, Pravincumar P, Diaz-Font A, May-Simera H, Jenkins D, Knight M and Beales PL
Human Molecular Genetics vol. 22 (19), 3858-3868.

DOI 10.1093/hmg/ddt241

QMRO

01-01-2013

Super-resolution imaging strategies for Cell Biologists using a spinning disk microscope
Hosny NA, Song M, Knight MM and Wheeler AP
Molecular Biology of The Cell vol. 24
01-01-2013

2012

Heat shock induces rapid resorption of primary cilia
Prodromou NV, Thompson CL, Osborn DPS, Cogger KF, Ashworth R, Knight MM, Beales PL and Chapple JP
Development, The Company of Biologists vol. 139 (24), e2408-e2408.

DOI 10.1242/dev.091405

15-12-2012

Heat shock induces rapid resorption of primary cilia
Prodromou NV, Thompson CL, Osborn DPS, Cogger KF, Ashworth R, Knight MM, Beales PL and Chapple JP
Journal of Cell Science vol. 125 (18), 4297-4305.

DOI 10.1242/jcs.100545

01-12-2012

Heat-shock induces rapid resorption of primary cilia
Thompson C, Prodromou N, Osborn D, Ashworth R, Knight M, Beales P and Chapple J
Cilia, Springer Nature vol. 1 (Suppl 1)

DOI 10.1186/2046-2530-1-s1-p52

01-11-2012

Mechanical strain disrupts primary cilia structure and modulates hedgehog signalling in adult chondrocytes
Thompson C, Chapple J and Knight M
Cilia, Springer Nature vol. 1 (Suppl 1)

DOI 10.1186/2046-2530-1-s1-p53

01-11-2012

Topographical regulation of primary cilia orientation and length in mesenchymal stem cells
McMurray R and Knight M
Cilia, Springer Nature vol. 1 (Suppl 1)

DOI 10.1186/2046-2530-1-s1-p34

01-11-2012

A role for IFT88/the primary cilium in the inflammatory response to interleukin-1
Wann A and Knight M
Cilia, Springer Nature vol. 1 (Suppl 1)

DOI 10.1186/2046-2530-1-s1-p60

01-11-2012

The primary cilium conducts chondrocyte mechanotransduction
Wann A, Zuo N, Haycraft C, Jensen C, Poole C, McGlashan S and Knight M
Cilia, Springer Nature vol. 1 (Suppl 1)

DOI 10.1186/2046-2530-1-s1-p59

01-11-2012

Bardet-Biedl syndrome proteins control cilia length through regulation of actin polymerisation
Hernandez V, Pravincumar P, Diaz-Font A, May-Simera H, Jenkins D, Knight M and Beales P
Cilia, Springer Nature vol. 1 (Suppl 1)

DOI 10.1186/2046-2530-1-s1-p88

01-11-2012

The Shape of the Urine Stream - From Biophysics to Diagnostics
Wheeler APS, Morad S, Buchholz N and Knight MM
Plos One vol. 7 (10)

DOI 10.1371/journal.pone.0047133

QMRO

16-10-2012

Cell mechanics, structure, and function are regulated by the stiffness of the three-dimensional microenvironment.
Chen J, Irianto J, Inamdar S, Pravincumar P, Lee DA, Bader DL and Knight MM
Biophys J vol. 103 (6), 1188-1197.

DOI 10.1016/j.bpj.2012.07.054

19-09-2012

Viscoelastic Cell Mechanics and Actin Remodelling Are Dependent on the Rate of Applied Pressure
Pravincumar P, Bader DL and Knight MM
Plos One vol. 7 (9)

DOI 10.1371/journal.pone.0043938

QMRO

11-09-2012

Primary cilia elongation in response to interleukin-1 mediates the inflammatory response
Wann AKT and Knight MM
Cellular and Molecular Life Sciences vol. 69 (17), 2967-2977.

DOI 10.1007/s00018-012-0980-y

QMRO

01-09-2012

Dynamic compressive strain influences chondrogenic gene expression in human periosteal cells: a case study.
Bonzani IC, Campbell JJ, Knight MM, Williams A, Lee DA, Bader DL and Stevens MM
J Mech Behav Biomed Mater vol. 11, 72-81.

DOI 10.1016/j.jmbbm.2011.06.015

01-07-2012

PRESSURE RATE SENSITIVE VISCOELASTIC CELL DEFORMATION INVOLVES ACTIN REMODELLING
Pravincumar P, Bader D and Knight M
Journal of Biomechanics, Elsevier vol. 45

DOI 10.1016/s0021-9290(12)70424-4

01-07-2012

Primary cilia mediate mechanotransduction through control of ATP-induced Ca²⁺ signaling in compressed chondrocytes
Wann AKT, Zuo N, Haycraft CJ, Jensen CG, Poole CA, McGlashan SR and Knight MM
Faseb Journal vol. 26 (4), 1663-1671.

DOI 10.1096/fj.11-193649

01-04-2012

Improved outcome after peripheral nerve injury in mice with increased levels of endogenous Omega-3 polyunsaturated fatty acids
Gladman SJ, Huang W, Lim SN, Dyall SC, Boddy S, Kang JX, Knight MM, Priestley JV and Michael-Titus AT
Journal of Neuroscience vol. 32 (2), 563-571.

DOI 10.1523/JNEUROSCI.3371-11.2012

11-01-2012

Single photon counting fluorescence lifetime detection of pericellular oxygen concentrations.
Hosny NA, Lee DA and Knight MM
J Biomed Opt vol. 17 (1)

DOI 10.1117/1.JBO.17.1.016007

01-01-2012

Gap junction permeability between tenocytes within tendon fascicles is suppressed by tensile loading
Maeda E, Ye S, Wang W, Bader DL, Knight MM and Lee DA
Biomechanics and Modeling in Mechanobiology vol. 11 (3-4), 439-447.

DOI 10.1007/s10237-011-0323-1

01-01-2012

The Role of the Primary Cilium in Chondrocyte Response to Mechanical Loading
Wann AKT, Thompson C and Knight MM
In Mechanically Gated Channels and Their Regulation, Springer Nature 405-426.

DOI 10.1007/978-94-007-5073-9_15

01-01-2012

Topographical regulation of primary cilia orientation and length in mesenchymal stem cells
McMurray R and Knight MM
Cilia vol. 1 (Suppl 1), P34-P34.
01-01-2012

Heat-shock induces rapid resorption of primary cilia
Thompson CL, Prodromou NV, Osborn DP, Ashworth R, Knight MM, Beales PL and Chapple JP
Cilia vol. 1 (Suppl 1), P52-P52.
01-01-2012

2011

Omega-3 fatty acids and acute neurological trauma: A perspective on clinical translation
Gladman S, Lim SN, Dyall S, Knight MM, Priestley JV and Michael-Titus AT
Ocl - Oleagineux Corps Gras Lipides vol. 18 (6), 317-323.

DOI 10.1684/ocl.2011.0421

01-11-2011

E84 Can Shockwave lithotripsy remove encrustation from ureteric nitinol stents?
Gabriel CEL, Nedilko T, Paulose PA, Bach C, Buchholz N and Knight MM
European Urology Open Science, Elsevier vol. 10 (7)

DOI 10.1016/s1569-9056(11)61205-0

01-10-2011

E70 The influence of extracorporeal shock wave lithotripsy on tissue viability around metallic ureteral stents
Edirisinghe TY, Knight MM, Buchholz N and Bach C
European Urology Open Science, Elsevier vol. 10 (7)

DOI 10.1016/s1569-9056(11)61191-3

01-10-2011

E189 Does the composition of feline urine prevent calcium oxalate encrustation of urethral stents?
Shafat M, Nedilko T, Syme H, Buchholz N and Knight MM
European Urology Open Science, Elsevier vol. 10 (7), 517-518.

DOI 10.1016/s1569-9056(11)61304-3

01-10-2011

E75 Comparison of encrustation rates between ureteric metal stents and Double J stents
Nedilko T, Paulose PA, Buchholz N and Knight MM
European Urology Open Science, Elsevier vol. 10 (7)

DOI 10.1016/s1569-9056(11)61196-2

01-10-2011

DOI 10.1007/s10237-011-0323-1

01-01-2011

Stem cell mechanobiology.
Lee DA, Knight MM, Campbell JJ and Bader DL
J Cell Biochem vol. 112 (1), 1-9.

DOI 10.1002/jcb.22758

01-01-2011

2010

The effect of mechanical strain or hypoxia on cell death in subpopulations of rat dorsal root ganglion neurons in vitro
Gladman SJ, Ward RE, Michael-Titus AT, Knight MM and Priestley JV
Neuroscience vol. 171 (2), 577-587.

DOI 10.1016/j.neuroscience.2010.07.009

01-12-2010

The potential of pulsed low intensity ultrasound to stimulate chondrocytes matrix synthesis in agarose and monolayer cultures
Vaughan NM, Grainger J, Bader DL and Knight MM
Medical and Biological Engineering and Computing vol. 48 (12), 1215-1222.

DOI 10.1007/s11517-010-0681-3

QMRO

01-12-2010

Eicosapentaenoic acid and docosahexaenoic acid reduce interleukin-1β-mediated cartilage degradation
Wann AKT, Mistry J, Blain EJ, Michael-Titus AT and Knight MM
Arthritis Research and Therapy vol. 12 (6)

DOI 10.1186/ar3183

QMRO

08-11-2010

Both superficial and deep zone articular chondrocyte subpopulations exhibit the crabtree effect but have different basal oxygen consumption rates
Heywood HK, Knight MM and Lee DA
Journal of Cellular Physiology vol. 223 (3), 630-639.

DOI 10.1002/jcp.22061

01-06-2010

Cyclic loading opens hemichannels to release ATP as part of a chondrocyte mechanotransduction pathway
Garcia M and Knight MM
Journal of Orthopaedic Research vol. 28 (4), 510-515.

DOI 10.1002/jor.21025

01-04-2010

A compartment model to evaluate the permeability of gap junctions between tenocytes in tendon fascicles
Ye S, Maeda E, Knight M, Lee D, Bader D and Wang W
Faseb Journal vol. 24

DOI 10.1096/fasebj.24.1_supplement.975.9

01-01-2010

Measuring the biomechanical properties of cartilage cells
Bader DL and Knight MM
, 106-136.

DOI 10.1533/9781845697792.1.106

01-01-2010

Mechanical loading modulates chondrocyte primary cilia incidence and length
McGlashan SR, Knight MM, Chowdhury TT, Joshi P, Jensen CG, Kennedy S and Poole CA
Cell Biology International vol. 34 (5), 441-446.

DOI 10.1042/CBI20090094

01-01-2010

Contributor contact details
Archer C, Ralphs J, Säämänen A-M, Arokoski JPA, Jurvelin JS, Kiviranta I, Hinz B, Hunziker EB, Bader DL, Knight MM, Dell’accio F, Vincent TL, Aigner T, Schmitz N, Söder S, McIlwraith CW, Hangody L, Kish G, Koreny T, Hangody LR, et al.
In Regenerative Medicine and Biomaterials For The Repair of Connective Tissues, Elsevier xiii-xvii.

DOI 10.1016/b978-1-84569-417-3.50022-6

01-01-2010

4 Measuring the biomechanical properties of cartilage cells
Bader DL and Knight MM
In Regenerative Medicine and Biomaterials For The Repair of Connective Tissues, Elsevier 106-136.

DOI 10.1533/9781845697792.1.106

01-01-2010

1P338 1J1450 Mechano-regulation of gap junction communications between tenocytes within isolated fascicles(Bioengineering,Oral Presentations,The 48th Annual Meeting of the Biophysical Society of Japan)
Maeda E, Ye S, Knight M, Wang W, Bader D and Lee D
Seibutsu Butsuri, Biophysical Society of Japan vol. 50 (supplement2)

DOI 10.2142/biophys.50.s79_4

01-01-2010

2009

Articular chondrocytes express connexin 43 hemichannels and P2 receptors - A putative mechanoreceptor complex involving the primary cilium?
Knight MM, Mcglashan SR, Garcia M, Jensen CG and Poole CA
Journal of Anatomy vol. 214 (2), 275-283.

DOI 10.1111/j.1469-7580.2008.01021.x

05-02-2009

2008

Biomechanical analysis of structural deformation in living cells
Bader DL and Knight MM
Medical and Biological Engineering and Computing vol. 46 (10), 951-963.

DOI 10.1007/s11517-008-0381-4

27-08-2008

Mechanosensitive Purinergic Calcium Signalling in Articular Chondrocytes
Pingguan-Murphy B and Knight MM
In Mechanosensitive Ion Channels, Springer Nature 235-251.

DOI 10.1007/978-1-4020-6426-5_10

01-01-2008

2007

Loading alters actin dynamics and up-regulates cofilin gene expression in chondrocytes
Campbell JJ, Blain EJ, Chowdhury TT and Knight MM
Biochemical and Biophysical Research Communications vol. 361 (2), 329-334.

DOI 10.1016/j.bbrc.2007.06.185

21-09-2007

Loading alters actin dynamics and up-regulates cofilin gene expression in chondrocytes
KNIGHT MM, Chowdhury TT, Campbell JJ and Blain EJ
Biochemical and Biophysical Research Communications vol. 361 (21), 329-334.

DOI 10.1016/j.bbrc.2007.06.185

01-09-2007

An improved confocal FRAP technique for the measurement of long-term actin dynamics in individual stress fibers
Campbell JJ and Knight MM
Microscopy Research and Technique vol. 70 (12), 1034-1040.

DOI 10.1002/jemt.20513

01-01-2007

2006

Purinergic pathway suppresses the release of NO and stimulates proteoglycan synthesis in chondrocyte/agarose constructs subjected to dynamic compression
Chowdhury TT and Knight MM
Journal of Cellular Physiology vol. 209 (3), 845-853.

DOI 10.1002/jcp.20768

01-12-2006

Cyclic compression of chondrocytes modulates a purinergic calcium signalling pathway in a strain rate- and frequency-dependent manner
Pingguan-Murphy B, El-Azzeh M, Bader DL and Knight MM
Journal of Cellular Physiology vol. 209 (2), 389-397.

DOI 10.1002/jcp.20747

01-11-2006

Ultrastructure of insect and spider cocoon silks
Hakimi O, Knight DP, Knight MM, Grahn MF and Vadgama P
Biomacromolecules vol. 7 (10), 2901-2908.

DOI 10.1021/bm060528h

01-10-2006

Mitochondrial dynamics in chondrocytes and their connection to the mechanical properties of the cytoplasm
Bomzon Z, Knight MM, Bader DL and Kimmel E
Journal of Biomechanical Engineering vol. 128 (5), 674-679.

DOI 10.1115/1.2246239

01-10-2006

Intracellular mechanics and mechanotransduction associated with chondrocyte deformation during pipette aspiration
Ohashi T, Hagiwara M, Bader DL and Knight MM
Biorheology vol. 43 (3-4), 201-214.

DOI 10.1177/0006355x2006043003004005

18-08-2006

Chondrocyte deformation induces mitochondrial distortion and heterogeneous intracellular strain fields
Knight MM, Bomzon Z, Kimmel E, Sharma AM, Lee DA and Bader DL
Biomech Model Mechan vol. 5 (2-3), 180-191.

DOI 10.1007/s10237-006-0020-7

01-06-2006

Mechanical compression and hydrostatic pressure induce reversible changes in actin cytoskeletal organisation in chondrocytes in agarose.
Knight MM, Toyoda T, Lee DA and Bader DL
J Biomech vol. 39 (8), 1547-1551.

DOI 10.1016/j.jbiomech.2005.04.006

01-01-2006

Chondrocyte Deformation and Mechanotransduction in Cartilage Model Systems(International Workshop 2)
Bader DL, Lee DA and Knight MM
The Proceedings of The Bioengineering Conference Annual Meeting of Bed/Jsme, Japan Society of Mechanical Engineers vol. 2005.18, 2-3.

DOI 10.1299/jsmebio.2005.18.2

01-01-2006

Probing mechanical heterogeneity in chondrocytes using passive microtheology
Bomzon Z, Knight MM, Bader DL and Kimmel E
Journal of Biomechanics, Elsevier vol. 39

DOI 10.1016/s0021-9290(06)83854-6

01-01-2006

2005

Activation of chondrocytes calcium signalling by dynamic compression is independent of number of cycles.
Pingguan-Murphy B, Lee DA, Bader DL and Knight MM
Arch Biochem Biophys vol. 444 (1), 45-51.

DOI 10.1016/j.abb.2005.09.015

01-12-2005

2004

Confocal analysis of local and cellular strains in chondrocyte-agarose constructs subjected to mechanical shear.
Sawae Y, Shelton JC, Bader DL and Knight MM
Ann Biomed Eng vol. 32 (6), 860-870.

DOI 10.1023/b:abme.0000030261.38396.c0

01-06-2004

Mechanical loading of chondrocytes embedded in 3D constructs: in vitro methods for assessment of morphological and metabolic response to compressive strain.
Lee DA and Knight MM
Methods Mol Med vol. 100, 307-324.

DOI 10.1385/1-59259-810-2:307

01-01-2004

Increased presence of cells with multiple elongated processes in osteoarthritic femoral head cartilage.
Holloway I, Kayser M, Lee DA, Bader DL, Bentley G and Knight MM
Osteoarthritis Cartilage vol. 12 (1), 17-24.

DOI 10.1016/j.joca.2003.09.001

01-01-2004

Mechanical Loading of Chondrocytes Embedded in 3D Constructs
Lee DA and Knight MM
In Cartilage and Osteoarthritis, Springer Nature 307-324.

DOI 10.1385/1-59259-810-2:307

01-01-2004

2003

Live cell imaging using confocal microscopy induces intracellular calcium transients and cell death.
Knight MM, Roberts SR, Lee DA and Bader DL
Am J Physiol Cell Physiol vol. 284 (4), C1083-C1089.

DOI 10.1152/ajpcell.00276.2002

01-04-2003

Confocal Analysis of Local and Cellular Strains in Chondrocyte - Agarose Constructs Subjected to Shear.
Bader DL, SHELTON JC, Knight MM and Sawae Y
J Biochemical Engineering Asme

DOI 10.1023/B:ABME.0000030261.38396.c0

01-01-2003

2002

Mechanical strain and hydrostatic pressure induce reversible changes in actin cytoskeletal organisation in chondrocytes in agarose
Knight MM, Toyoda T, Bader DL and Lee DA
Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products.
01-12-2002

Light-induced calcium signalling in chondrocytes
Knight MM, Roberts SR, Lee DA and Bader DL
European Cells and Materials. vol. 4 (SUPPL. 2), 7-8.
01-12-2002

Cell and nucleus deformation in compressed chondrocyte-alginate constructs: temporal changes and calculation of cell modulus.
Knight MM, van de Breevaart Bravenboer J, Lee DA, van Osch GJVM, Weinans H and Bader DL
Biochim Biophys Acta vol. 1570 (1), 1-8.

DOI 10.1016/s0304-4165(02)00144-7

15-02-2002

Light-induced calcium signalling in chondrocytes.
Knight MM, Roberts SR, LEE DA and Bader DL
TCES 2002 Annual meeting of the UK Tissue and Cell Engineering Society University of Glasgow, Scotland 19 Sep 2002 - 20 Sep 2002. vol. 4 (Suppl 2), 7-8.
01-01-2002

Changes in cell morphology and cytoskeletal organisation in osteoarthritic cartilage.
Holloway I, Knight MM, LEE DA, Bader DL and Bentley G
ECM III Cartilage & Joint repair Tutorials, Basic Research & Clinical Methods Davos, Switzerland 1 Jul 2002 - 3 Jul 2002. vol. 4 suppl 1, 52-53.
01-01-2002

Mechanical strain and hydrostatic pressure induce reversible changes in actin cytoskeletal organisation in chondrocytes in agarose.
Knight MM, Toyoda T, LEE DA and Bader DL
48th Annual Meeting of the Orthopaedic Research Society. vol. 27, 35-35.
01-01-2002

Characterisation of cell morphology, cytoskeletal organization and apoptosis in human osteoarthritic cartilage.
Holloway I, Knight MM, LEE DA, Bader DL and Bentley G
48th Annual Meeting of the Orthopaedic Research Society. vol. 27
01-01-2002

Deformation properties of articular chondrocytes: a critique of three separate techniques.
Bader DL, Ohashi T, Knight MM, Lee DA and Sato M
Biorheology Netherlands. vol. 39 (1-2), 69-78.

DOI 10.1177/0006355x2002039001002009

01-01-2002

2001

Chondrocyte deformation within mechanically and enzymatically extracted chondrons compressed in agarose.
Knight MM, Ross JM, Sherwin AF, Lee DA, Bader DL and Poole CA
Biochim Biophys Acta vol. 1526 (2), 141-146.

DOI 10.1016/s0304-4165(01)00118-0

03-05-2001

Temporal changes in cytoskeletal organisation within isolated chondrocytes quantified using a novel image analysis technique.
Knight MM, Idowu BD, Lee DA and Bader DL
Med Biol Eng Comput vol. 39 (3), 397-404.

DOI 10.1007/BF02345297

01-05-2001

Mechanical compression influences intracellular Ca2+ signaling in chondrocytes seeded in agarose constructs.
Roberts SR, Knight MM, Lee DA and Bader DL
J Appl Physiol (1985) vol. 90 (4), 1385-1391.

DOI 10.1152/jappl.2001.90.4.1385

01-04-2001

Compressive deformation and damage of muscle cell subpopulations in a model system.
Bouten CV, Knight MM, Lee DA and Bade DL
Ann Biomed Eng vol. 29 (2), 153-163.

DOI 10.1114/1.1349698

01-02-2001

Temporal changes in cell and nucleus deformation in isolated chondrocytes compressed in alginate scaffolds.
Knight MM, van de Breevaart Brevenboer J, van Osch G, Weinans H, LEE DA and Bader DL
47th Annual Meeting, Orthopaedic Research Society San Francisco, California 25 Feb 2001 - 28 Feb 2001. vol. 26, 611-611.
01-01-2001

Mechanical compression influences cytoskeletal oragnisation within chondrocytes seeded in agarose constructs.
LEE DA, Idowu BD, Knight MM and Bader DL
47th Annual Meeting, Orthopaedic Research Society San Francisco, California 25 Feb 2001 - 28 Feb 2001. vol. 26, 263-263.
01-01-2001

2000

Intracellular - CA2+ signalling in compressed chondrocyte agarose constructs
Roberts SR, Knight MM, Lee DA and Bader DL
Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling.
01-12-2000

Compression induced cell and nucleus deformation in chondrocyte-alginate constructs
Knight MM, Van De Breevaart Bravenboer J, Bader DL and Lee DA
Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling.
01-12-2000

Confocal analysis of cytoskeletal organisation within isolated chondrocyte sub-populations cultured in agarose.
Idowu BD, Knight MM, Bader DL and Lee DA
Histochem J vol. 32 (3), 165-174.

DOI 10.1023/a:1004095207330

01-03-2000

Intracellular calcium signalling in compressed chondrocyte agarose constructs
Roberts SR, Knight MM, Lee DA and Bader DL
J PHYSIOL-LONDON. vol. 523, 12P-12P.
01-02-2000

Beta transition and stress-induced phase separation in the spinning of spider dragline silk
Knight DP, KNIGHT MM and Vollrath F
International Journal of Biological Macromolecules vol. 27 (3), 205-210.

DOI 10.1016/s0141-8130(00)00124-0

01-01-2000

Chondrocyte deformation within compressed agarose constructs at the cellular and sub-cellular levels.
Lee DA, Knight MM, Bolton JF, Idowu BD, Kayser MV and Bader DL
J Biomech vol. 33 (1), 81-95.

DOI 10.1016/s0021-9290(99)00160-8

01-01-2000

1998

Prize-winning peeks at the microscopic world
Hing K and Knight M

01-12-1998

Response of chondrocyte subpopulations cultured within unloaded and loaded agarose.
Lee DA, Noguchi T, Knight MM, O'Donnell L, Bentley G and Bader DL
J Orthop Res vol. 16 (6), 726-733.

DOI 10.1002/jor.1100160615

01-11-1998

The influence of elaborated pericellular matrix on the deformation of isolated articular chondrocytes cultured in agarose.
Knight MM, Lee DA and Bader DL
Biochim Biophys Acta vol. 1405 (1-3), 67-77.

DOI 10.1016/s0167-4889(98)00102-5

21-10-1998

Measurement of the deformation of isolated chondrocytes in agarose subjected to cyclic compression.
Knight MM, Ghori SA, Lee DA and Bader DL
Med Eng Phys vol. 20 (9), 684-688.

DOI 10.1016/s1350-4533(98)00080-0

01-01-1998

Grants

Grants of specific relevance to the Centre for Bioengineering

Organ-chip Facility: A world-class in vitro models facility for the UK community, reducing the barriers to adoption to drive animal replacement
Hazel Screen, Stefaan Verbruggen, Martin Knight, Julia Shelton, Timothy Hopkins and John Connelly
£573,537 NC3Rs National Center for the Replacement, Refinement and Reduction of Animals in Research

Grant Summary

07-10-2024 - 14-03-2025

Micro-manufacturing of tissue patterned organ-chips for accelerated deployment of new medicines
Martin Knight, Hazel Screen, Julien Gautrot, Timothy Hopkins, John Connelly, Liisa Blowes and Xavier Griffin
£1,787,725 EPSRC Engineering and Physical Sciences Research Council

Grant Summary

01-10-2024 - 30-09-2027

EPSRC Centre for Doctoral Training in Next Generation Organ-on-a-Chip Technology (COaCT)
Hazel Screen, Martin Knight, Thomas Iskratsch, Caroline Roney, Yi Sui, David Lee, Julia Shelton, Zion Tse, John Connelly, Adrian Biddle and Lucy Norling
£7,066,811 EPSRC Engineering and Physical Sciences Research Council

Grant Summary

01-07-2024 - 30-09-2032

Development of an Organ-on-a-chip model of polycystic kidney disease using CRISPR modified human kidney cell line
Martin Knight and Cleo Bishop
£39,986 Kidney Research UK

Grant Summary

01-12-2023 - 30-11-2025

Epithelial Exchange Surfaces – From organizing principles to novel culture models of the gatekeepers of the body
Martin Knight, Hazel Screen, Wen Wang, Clare Thompson and Cleo Bishop
£260,676 EPSRC - EU Scheme

Grant Summary

01-12-2023 - 30-11-2027

Precision Musculoskeletal Care
John Whiteley, Costantino Pitzalis, Martin Knight, Greg Slabaugh and Xavier Griffin
£3,343,542 NIHR National Institute for Health Research
01-12-2022 - 30-11-2027

Incorporating physical cues in organ-chip models
Hazel Screen and Martin Knight
£20,000 Emulate Inc.
01-10-2022 - 30-09-2026

Human synovium-cartilage organ-chip for personalised surgical screening
Martin Knight
£311,203 AR-UK Versus Arthritis
01-04-2022 - 30-06-2026

Organ-on-a-chip Centre of Excellence
Martin Knight and Hazel Screen
£420,794 Emulate Inc.
20-08-2019 - 01-10-2029

Production of a Human Growth Plate Organ-Chip Model of Skeletal Development
Martin Knight, Clare Thompson and Hazel Screen
£197,923 BBSRC Biotechnology and Biological Sciences Research Council
01-02-2023 - 31-07-2024

Highthroughput Light Sheet Microscopy: Imaging Across Scales
Viji Draviam Sastry, Caroline Brennan, Vidya Chandran Darbari, Chema Martin Duran, Ivan Kadurin, Isabel M Palacios, Richard Pickersgill, Sarah McClelland, Tyson Sharp and Martin Knight
£386,205 MRC Medical Research Council
01-10-2022 - 31-03-2023

Correlating structural and proteomic techniques on cartilage
Himadri Gupta and Martin Knight
£18,515 MRC Medical Research Council
24-07-2022 - 28-02-2023

Emulate Organs-on-Chips Centre Technician
Martin Knight, Hazel Screen and Clare Thompson
£49,584 Emulate Inc.
01-01-2021 - 31-12-2023

Organ-on-a-chip model of breast cancer bone metastases
Martin Knight and Oliver Pearce
£268,711 CR-UK Cancer Research UK
01-01-2021 - 30-06-2024

MICA: Organ-on-a-chip models for safety testing of regenerative medicine products
Hazel Screen and Martin Knight
£473,325 MRC Medical Research Council
24-08-2020 - 24-05-2024

EPSRC Core Equipment Call
Wen Wang, Martin Knight, Clive Parini and Isaac Abrahams
£125,000 EPSRC Engineering and Physical Sciences Research Council
13-02-2020 - 12-08-2021

Does the biological clock within cartilage align to diurnal patterns in activity?
David Lee, Hannah Heywood and Martin Knight
£9,954 EPSRC Engineering and Physical Sciences Research Council
01-10-2019 - 31-10-2020

Pharmaceutical modulation of cilia expression
Martin Knight
£3,000 Royal College of Surgeons
07-05-2019 - 07-11-2019

Organ-on-a-chip technologies
Hazel Screen and Martin Knight
£479,339 MRC Medical Research Council
01-08-2018 - 30-09-2022

The effect of cobalt ions on primary cilia in bone cells
Martin Knight and Frances Freer
£2,500 Royal College of Surgeons
01-05-2018 - 01-12-2018

META-DORM - Mechanobiology of METAstatic and DORMant cancer cells in bone marrow lesions
Martin Knight
£152,740 EU Commission - Horizon 2020
01-01-2018 - 29-06-2020

Collagen Fibrillar Network in Ageing Cartilage
Himadri Gupta and Martin Knight
£374,874 BBSRC Biotechnology and Biological Sciences Research Council
01-10-2017 - 24-07-2023

Innovation Fund: High-throughput Library Screen
Martin Knight
£9,960 BBSRC Biotechnology and Biological Sciences Research Council
01-09-2016 - 31-08-2018

Osteoarthritis May Be Treated as an Environmental Ciliopathy
Martin Knight
£365,598 MRC Medical Research Council
01-09-2014 - 20-03-2020