Prof Hazel Screen

Professor of Bioengineering
Head of The School of Engineering and Materials Science

School of Engineering and Materials Science
Queen Mary University of London

h.r.c.screen@qmul.ac.uk

www.sems.qmul.ac.uk/staff/h.r.c.screen/

Centre for Bioengineering

Research
Publications
Grants

Research

organ-chips, musculoskeletal, tendon, tissue mechanics, mechanobiology

Interests

Hazel Screen is a Professor of Biomedical Engineering working with organ-chip technology to explore the aetiology of health and disease, with a particular focus on mechanically functional tissues such as those in the musculoskeletal or cardiovascular systems. She focuses on healthy and pathological tissue structure-function relationships and their impact on cell metabolism, developing new models within which to explore fundamental tissue mechanics and biology questions as well as routes to new treatments and drug development. She co-directs the UK Organ-on-a-Chip Technologies Network as well as the Centre for Predictive in vitro Models and Queen Mary & Emulate Organs-on-Chips Centre at QMUL. She plays an active role in helping to shape the field and associated policy and regulation, as well as driving her own research group, funded from a range of UKRI and charity sources.

Publications

Publications of specific relevance to the Centre for Bioengineering

2024

TENDON HEALTH AND DISEASE: EXPLORING THE INTERFASCICULAR NICHE
Screen HRC
Orthopaedic Proceedings, British Editorial Society of Bone & Joint Surgery vol. 106-B (SUPP_2), 105-105.

DOI 10.1302/1358-992x.2024.2.105

QMRO

02-01-2024

2023

Human vascularised synovium-on-a-chip: a mechanically stimulated, microfluidic model to investigate synovial inflammation and monocyte recruitment
Thompson CL, Hopkins T, Bevan C, Screen HRC, Wright KT and Knight MM
Biomedical Materials, Iop Publishing vol. 18 (6)

DOI 10.1088/1748-605x/acf976

QMRO

10-10-2023

Guidelines for ex vivo mechanical testing of tendon
Lake SP, Snedeker JG, Wang VM, Awad H, Screen HRC and Thomopoulos S
Journal of Orthopaedic Research®, Wiley vol. 41 (10), 2105-2113.

DOI 10.1002/jor.25647

QMRO

26-06-2023

The Interfascicular Matrix of Energy Storing Tendons Houses Heterogenous Cell Populations Disproportionately Affected by Aging.
Zamboulis DE, Marr N, Lenzi L, Birch HL, Screen HRC, Clegg PD and Thorpe CT
Aging and Disease, Buck Institute For Age Research

DOI 10.14336/AD.2023.0425-1

QMRO

22-05-2023

Ultrasound Measurement of Local Deformation in the Human Free Achilles Tendon Produced by Dynamic Muscle-Induced Loading: A Systematic Review.
Shivapatham G, Richards S, Bamber J, Screen H and Morrissey D
Ultrasound in Medicine and Biology, Elsevier

DOI 10.1016/j.ultrasmedbio.2023.03.014

QMRO

04-05-2023

Mild hypercholesterolemia impacts achilles sub-tendon mechanical properties in young rats
Waugh CM, Mousavizadeh R, Lee J, Screen HRC and Scott A
Bmc Musculoskeletal Disorders, Biomed Central vol. 24 (1)

DOI 10.1186/s12891-023-06375-0

QMRO

12-04-2023

Development and application of a novel in vivo overload model of the Achilles tendon in rat
Gains CC, Giannapoulos A, Zamboulis DE, Lopez-Tremoleda J and Screen HRC
Journal of Biomechanics, Elsevier vol. 151

DOI 10.1016/j.jbiomech.2023.111546

QMRO

15-03-2023

Self-reported bio-psycho-social factors partially distinguish patellar tendinopathy from other knee problems and explain patellar tendinopathy severity in jumping athletes: A case-control study
Tayfur A, Şendil A, Sezik AÇ, Jean-François K, Sancho I, Le Sant G, Dönmez G, Duman M, Tayfur B, Pawson J, Uzlaşır S, Miller SC, Screen H and Morrissey D
Physical Therapy in Sport, Elsevier vol. 61, 57-65.

DOI 10.1016/j.ptsp.2023.02.009

QMRO

04-03-2023

The impact of mild hypercholesterolemia on injury repair in the rat patellar tendon.
Waugh CM, Mousavizadeh R, Lee J, Screen HRC and Scott A
Journal of Orthopaedic Research, Wiley

DOI 10.1002/jor.25546

QMRO

03-03-2023

Organ-on-a-Chip and Microfluidic Platforms for Oncology in the UK
Nolan J, Pearce OMT, Screen HRC, Knight MM and Verbruggen SW
Cancers, Mdpi vol. 15 (3)

DOI 10.3390/cancers15030635

QMRO

19-01-2023

2022

Organ-on-a-chip: current gaps and future directions
Candarlioglu PL, Dal Negro G, Hughes D, Balkwill F, Harris K, Screen H, Morgan H, David R, Beken S, Guenat O, Rowan W and Amour A
Biochemical Society Transactions, Portland Press vol. 50 (2), 665-673.

DOI 10.1042/BST20200661

QMRO

19-04-2022

Self-reported bio-psycho-social factors partially distinguish patellar tendinopathy from other knee problems and explain severity in jumping athletes: A case–control study
Tayfur A, Sendil A, Sezik AC, Jean-François K, Sancho I, Le Sant G, Donmez G, Duman M, Tayfur B, Pawson J, Uzlasir S, Miller SC, Screen H and Morrissey D
Physiotherapy, Elsevier vol. 114, e105-e106.

DOI 10.1016/j.physio.2021.12.052

QMRO

01-02-2022

Outcome predictors for recovery of patellar tendinopathy in jumping athletes: an international prospective cohort study
Tayfur A, Zenner D, Miller SC, Screen H and Morrissey D
Bmj Open, Bmj Journals

DOI 10.1136/bmjsem-2022-sportskongres.9

QMRO

20-01-2022

TENDON STRUCTURE FUNCTION RELATIONSHIPS: INJURY AND THE INTERFASCICULAR MATRIX
Screen H
TISSUE ENGINEERING PART A. vol. 28, S4-S5.

QMRO

01-01-2022

2021

Are Landing Patterns in Jumping Athletes Associated with Patellar Tendinopathy? A Systematic Review with Evidence Gap Map and Meta-analysis
Tayfur A, Haque A, Salles JI, Malliaras P, Screen H and Morrissey D
Sports Medicine, Springer Nature vol. 52 (1), 123-137.

DOI 10.1007/s40279-021-01550-6

QMRO

23-09-2021

The effects of cholesterol accumulation on Achilles tendon biomechanics: A cross-sectional study
Squier K, Scott A, Hunt MA, Brunham LR, Wilson DR, Screen H and Waugh CM
Plos One, Public Library of Science (Plos) vol. 16 (9)

DOI 10.1371/journal.pone.0257269

QMRO

16-09-2021

Can Achilles tendon xanthoma be distinguished from Achilles tendinopathy using Dixon method MRI? A cross-sectional exploratory study
Zahradnik TM, Cresswell M, Squier K, Waugh C, Brunham L, Screen H and Scott A
Bmc Musculoskeletal Disorders, Springer Nature vol. 22 (1)

DOI 10.1186/s12891-021-04494-0

QMRO

16-07-2021

Structure-function specialisation of the interfascicular matrix in the human achilles tendon
Patel D, Zamboulis DE, Spiesz EM, Birch HL, Clegg PD, Thorpe CT and Screen HRC
Acta Biomaterialia, Elsevier vol. 131, 381-390.

DOI 10.1016/j.actbio.2021.07.019

QMRO

13-07-2021

The Impact of Hypercholesterolemia on Tendon Injury Repair
Waugh C, Mousavizadeh R, Screen H and Scott A
The Faseb Journal, Wiley vol. 35 (S1)

DOI 10.1096/fasebj.2021.35.s1.02060

01-05-2021

Elastase treatment of tendon specifically impacts the mechanical properties of the interfascicular matrix
Godinho MSC, Thorpe CT, Greenwald SE and Screen H
Acta Biomaterialia, Elsevier

DOI 10.1016/j.actbio.2021.01.030

QMRO

26-01-2021

8 Computational modelling of muscle, tendon, and ligaments biomechanics
Siebert T, Screen HRC and Rode C
In Computational Modelling of Biomechanics and Biotribology in The Musculoskeletal System, Elsevier 155-186.

DOI 10.1016/b978-0-12-819531-4.00008-0

01-01-2021

2020

Postnatal mechanical loading drives adaptation of tissues primarily through modulation of the non-collagenous matrix
Zamboulis D, Thorpe CT, Ashraf Kharaz Y, Birch HL, Clegg PD and Screen H
Elife, Elife Sciences Publications Ltd

DOI 10.7554/eLife.58075

QMRO

16-10-2020

Force Transmission Between the Gastrocnemius and Soleus Sub-Tendons of the Achilles Tendon in Rat
Gains C, Correia J, Baan G, Noort W, Screen H and Maas H
Frontiers in Bioengineering and Biotechnology, Frontiers Media vol. 8, 700-700.

DOI 10.3389/fbioe.2020.00700

QMRO

17-07-2020

Patellar tendinopathy outcome predictors in jumping athletes: feasibility of measures for a cohort study
Tayfur A, Salles JI, Miller SC, Screen H and Morrissey D
Physical Therapy in Sport, Elsevier vol. 44, 75-84.

DOI 10.1016/j.ptsp.2020.05.004

QMRO

16-05-2020

A Recruitment Model of Tendon Viscoelasticity That Incorporates Fibril Creep and Explains Strain-Dependent Relaxation.
Shearer T, Parnell WJ, Lynch B, Screen HRC and David Abrahams I
Journal of Biomechanical Engineering, Asme International vol. 142 (7)

DOI 10.1115/1.4045662

24-02-2020

2019

An in vitro investigation into the effects of 10Hz cyclic loading on tenocyte metabolism
Chineye U, Jones E, Riley G, Morrissey D and Screen H
Scandinavian Journal of Medicine and Science in Sports, Wiley

DOI 10.1111/sms.13465

QMRO

18-05-2019

Insights into the micromechanics of stress-relaxation and creep behaviours in the aortic valve.
Anssari-Benam A, Screen HRC and Bucchi A
J Mech Behav Biomed Mater vol. 93, 230-245.

DOI 10.1016/j.jmbbm.2019.02.011

QMRO

12-02-2019

Novel glycopolymer-based biomaterials for tissue engineering
Liu R, Screen HRC and Becer R
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. vol. 257
01-01-2019

2018

Guided Cell Attachment via Aligned Electrospinning of Glycopolymers
Liu R, Becer CR and Screen HRC
Macromolecular Bioscience vol. 18 (12)

DOI 10.1002/mabi.201800293

QMRO

01-12-2018

Magnetic resonance elastography in nonlinear viscoelastic materials under load
Capilnasiu A, Hadjicharalambous M, Fovargue D, Patel D, Holub O, Bilston L, Screen H, Sinkus R and Nordsletten D
Biomechanics and Modeling in Mechanobiology, Springer Nature vol. 18 (1), 111-135.

DOI 10.1007/s10237-018-1072-1

QMRO

27-08-2018

Mechanical loading induces primary cilia disassembly in tendon cells via TGFβ and HDAC6
Rowson DT, Shelton JC, Screen HRC and Knight MM
Scientific Reports, Springer Nature vol. 8 (1)

DOI 10.1038/s41598-018-29502-7

QMRO

23-07-2018

Tendon pathology: Have we missed the first step in the development of pathology?
Cook JL and Screen HR
J Appl Physiol (1985)

DOI 10.1152/japplphysiol.00002.2018

01-07-2018

Postnatal Development of the Functional Specialization of the Equine Superficial Digital Flexor Tendon
Clegg P, Zamboulis D and Screen H
Veterinary and Comparative Orthopaedics and Traumatology, Thieme vol. 31 (S 02), a1-a25.

DOI 10.1055/s-0038-1668213

01-07-2018

Effects of cell adhesion motif, fiber stiffness, and cyclic strain on tenocyte gene expression in a tendon mimetic fiber composite hydrogel
PATEL D, Sharma S, SCREEN HRC and BRYANT S
Biochemical and Biophysical Research Communications, Elsevier

DOI 10.1016/j.bbrc.2018.03.203

QMRO

02-04-2018

Structure and collagen crimp patterns of functionally distinct equine tendons, revealed by quantitative polarised light microscopy (qPLM)
Spiesz EM, Thorpe CT, Thurner PJ and Screen HRC
Acta Biomaterialia vol. 70, 281-292.

DOI 10.1016/j.actbio.2018.01.034

QMRO

01-04-2018

Pre- and post-natal development of the tendon inter-fascicular matrix and fascicles in the equine superficial digital flexor tendon and common digital extensor tendon
Zamboulis DE, Thorpe CT, Birch HL, Screen HR and Clegg PD
Osteoarthritis and Cartilage. vol. 26, s403-s404.

DOI 10.1016/j.joca.2018.02.783

01-04-2018

2017

Elastin is Localised to the Interfascicular Matrix of Energy Storing Tendons and Becomes Increasingly Disorganised With Ageing
Godinho MSC, Thorpe CT, Greenwald SE and Screen HRC
Scientific Reports vol. 7 (1)

DOI 10.1038/s41598-017-09995-4

QMRO

01-12-2017

The relative compliance of energy-storing tendons may be due to the helical fibril arrangement of their fascicles
Shearer T, Thorpe CT, Spiesz E and SCREEN HRC
Journal of The Royal Society Interface, Royal Society, The

DOI 10.1098/rsif.2017.0261

QMRO

09-08-2017

Fascicles and the interfascicular matrix show decreased fatigue life with ageing in energy storing tendons
Thorpe CT, Riley GP, Birch HL, Clegg PD and Screen HRC
Acta Biomaterialia vol. 56, 58-64.

DOI 10.1016/j.actbio.2017.03.024

QMRO

01-07-2017

A2B-Miktoarm Glycopolymer Fibers and Their Interactions with Tenocytes
BECER CR, Screen HRC, Patel D and Liu R
Bioconjugate Chemistry, American Chemical Society

DOI 10.1021/acs.bioconjchem.7b00279

QMRO

21-06-2017

Novel models of late onset, progressive osteoarthritis caused by point mutations in the two alpha chains of collagen type I
Blease AM, Wisby L, Haynes AR, Nicol TL, Falcone S, Lad H, Esapa CT, Horwood N, Thorpe CT, Thakker RV, Screen HR, Vincent TL, Brown SD and Potter PK
Osteoarthritis and Cartilage. vol. 25

DOI 10.1016/j.joca.2017.02.101

QMRO

01-04-2017

Recapitulating the Micromechanical Behavior of Tension and Shear in a Biomimetic Hydrogel for Controlling Tenocyte Response
Patel D, Sharma S, Bryant SJ and Screen HRC
Advanced Healthcare Materials vol. 6 (4)

DOI 10.1002/adhm.201601095

QMRO

22-02-2017

Development of a two-stage gene selection method that incorporates a novel hybrid approach using the cuckoo optimization algorithm and harmony search for cancer classification
Elyasigomari V, Lee DA, Screen HRC and SHAHEED MH
Journal of Biomedical Informatics vol. 67 (2017), 11-20.

DOI 10.1016/j.jbi.2017.01.016

QMRO

03-02-2017

A transverse isotropic viscoelastic constitutive model for aortic valve tissue
Anssari-Benam A, Bucchi A, SCREEN HRC and Evans SL
Royal Society Open Science, Royal Society, The: Open Access

DOI 10.1098/rsos.160585

QMRO

11-01-2017

Cyclic loading leads to primary cilia disassembly in human tenocytes
Rowson DT, Knight MM and Screen HRC
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 98 (1), A6-A6.

QMRO

01-01-2017

Do the sub-bundles within the Achilles tendon originating from distinct muscle bellies differ in structural and mechanical properties?
Corben DC, Notou M, Screen HRC and Birch HL
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 98 (6), A7-A7.

QMRO

01-01-2017

2016

Structural Building Blocks of Soft Tissues: Tendons and Heart Valves
Gupta HS and Screen HRC
In Material Parameter Identification and Inverse Problems in Soft Tissue Biomechanics, Springer Nature 1-35.

DOI 10.1007/978-3-319-45071-1_1

13-10-2016

Fascicles and the interfascicular matrix show adaptation for fatigue resistance in energy storing tendons
Thorpe CT, Riley GP, Birch HL, Clegg PD and Screen HRC
Acta Biomaterialia vol. 42, 308-315.

DOI 10.1016/j.actbio.2016.06.012

QMRO

15-09-2016

Nomenclature of the tendon hierarchy: An overview of inconsistent terminology and a proposed size-based naming scheme with terminology for multi-muscle tendons
Handsfield GG, Slane LC and Screen HRC
Journal of Biomechanics vol. 49 (13), 3122-3124.

DOI 10.1016/j.jbiomech.2016.06.028

QMRO

06-09-2016

The effect of gradations in mineral content, matrix alignment, and applied strain on human mesenchymal stem cell morphology within collagen biomaterials
Mozdzen L, Thorpe S, SCREEN HRC and Harley B
Advanced Healthcare Materials, Wiley: 12 Months

DOI 10.1002/adhm.201600181

QMRO

01-06-2016

Distribution of proteins within different compartments of tendon varies according to tendon type
Thorpe CT, Karunaseelan KJ, Ng Chieng Hin J, Riley GP, Birch HL, Clegg PD and Screen HRC
Journal of Anatomy vol. 229 (3), 450-458.

DOI 10.1111/joa.12485

QMRO

25-04-2016

Zonal variation in primary cilia elongation correlates with localized biomechanical degradation in stress deprived tendon.
Rowson D, Knight MM and Screen HRC
J Orthop Res vol. 34 (12), 2146-2153.

DOI 10.1002/jor.23229

QMRO

23-03-2016

The use of medical infrared thermography in the detection of tendinopathy: a systematic review
Chaudhry S, Fernando R, Screen H, Waugh C, Tucker A and Morrissey D
Physical Therapy Reviews, Taylor & Francis vol. 21 (2), 75-82.

DOI 10.1080/10833196.2016.1223575

03-03-2016

Anatomical heterogeneity of tendon: Fascicular and interfascicular tendon compartments have distinct proteomic composition
Thorpe CT, Peffers MJ, Simpson D, Halliwell E, Screen HRC and Clegg PD
Scientific Reports, Springer Nature vol. 6 (1)

DOI 10.1038/srep20455

QMRO

04-02-2016

Tendon Structure and Composition
Thorpe CT and Screen HRC
Advances in Experimental Medicine and Biology, Springer Nature vol. 920, 3-10.

DOI 10.1007/978-3-319-33943-6_1

01-01-2016

Energy storing and positional human tendons: mechanics and changes with ageing
Patel D, Spiesz EM, Thorpe CT, Birch HL, Riley GP, Clegg PD and Screen HRC
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 97 (6), A3-A3.
01-01-2016

Elastin is more abundant in energy storing tendons and is localised to the tendon interfascicular matrix
Godinho MSC, Screen HRC, Greenwald SE and Thorpe CT

01-01-2016

2015

Cancer classification using a novel gene selection approach by means of shuffling based on data clustering with optimization
Elyasigomari V, Mirjafari MS, Screen HRC and Shaheed MH
Applied Soft Computing Journal vol. 35, 43-51.

DOI 10.1016/j.asoc.2015.06.015

QMRO

06-07-2015

In vivo biological response to extracorporeal shockwave therapy in human tendinopathy
Waugh CM, Morrissey D, Jones E, Riley GP, Langberg H and Screen HRC
Ecells & Materials, European Cells and Materials vol. 29, 268-280.

DOI 10.22203/ecm.v029a20

QMRO

15-05-2015

Tendon extracellular matrix damage, degradation and inflammation in response to in vitro overload exercise
Spiesz EM, Thorpe CT, Chaudhry S, Riley GP, Birch HL, Clegg PD and Screen HRC
Journal of Orthopaedic Research®, Wiley vol. 33 (6), 889-897.

DOI 10.1002/jor.22879

QMRO

29-04-2015

Tendon Functional Extracellular Matrix
Screen HRC, Berk DE, Kadler KE, Ramirez F and Young MF
Journal of Orthopaedic Research®, Wiley vol. 33 (6), 793-799.

DOI 10.1002/jor.22818

QMRO

29-04-2015

The interfascicular matrix enables fascicle sliding and recovery in tendon, and behaves more elastically in energy storing tendons
Thorpe CT, Godinho MSC, Riley GP, Birch HL, Clegg PD and Screen HRC
Journal of The Mechanical Behavior of Biomedical Materials, Elsevier vol. 52, 85-94.

DOI 10.1016/j.jmbbm.2015.04.009

QMRO

16-04-2015

Eccentric and Concentric Exercise of the Triceps Surae: An in Vivo Study of Dynamic Muscle and Tendon Biomechanical Parameters
Chaudhry S, Morrissey D, Woledge RC, Bader DL and Screen HRC
Journal of Applied Biomechanics, Human Kinetics vol. 31 (2), 69-78.

DOI 10.1123/jab.2013-0284

01-04-2015

Eccentric and concentric exercise of the triceps surae: an in vivo study of dynamic muscle and tendon biomechanical parameters.
Chaudhry S, Morrissey D, Woledge RC, Bader DL and Screen HR
J Appl Biomech vol. 31 (2), 69-78.

DOI 10.1123/JAB.2013-0284

01-04-2015

Eccentric and Concentric Exercise of the Triceps Surae: An in Vivo Study of Dynamic Muscle and Tendon Biomechanical Parameters.
Chaudhry S, Morrissey D, Woledge RC, Bader DL and Screen HRC
J Appl Biomech vol. 31 (2), 69-78.

DOI 10.1123/JAB.2013-0284

01-04-2015

The effectiveness of extracorporeal shock wave therapy in lower limb tendinopathy: a systematic review.
Mani-Babu S, Morrissey D, Waugh C, Screen H and Barton C
Am J Sports Med vol. 43 (3), 752-761.

DOI 10.1177/0363546514531911

01-03-2015

Science in brief: Recent advances into understanding tendon function and injury risk
Thorpe CT, Spiesz EM, Chaudhry S, Screen HRC and Clegg PD
Equine Veterinary Journal, Wiley vol. 47 (2), 137-140.

DOI 10.1111/evj.12346

QMRO

03-02-2015

Tendon Physiology and Mechanical Behavior: Structure-Function Relationships
Thorpe CT, Birch HL, Clegg PD and Screen HRC
In Tendon Regeneration: Understanding Tissue Physiology and Development to Engineer Functional Substitutes 3-39.

DOI 10.1016/B978-0-12-801590-2.00001-6

01-01-2015

Chapter 1 Tendon Physiology and Mechanical Behavior Structure–Function Relationships
Thorpe CT, Birch HL, Clegg PD and Screen HRC
In Tendon Regeneration, Elsevier 3-39.

DOI 10.1016/b978-0-12-801590-2.00001-6

01-01-2015

2014

Tendon overload results in alterations in cell shape and increased markers of inflammation and matrix degradation
Thorpe CT, Chaudhry S, Lei II, Varone A, Riley GP, Birch HL, Clegg PD and Screen HRC
Scandinavian Journal of Medicine and Science in Sports, Wiley vol. 25 (4), e381-e391.

DOI 10.1111/sms.12333

QMRO

30-12-2014

Early stage fatigue damage occurs in bovine tendon fascicles in the absence of changes in mechanics at either the gross or micro-structural level.
Shepherd JH, Riley GP and Screen HRC
J Mech Behav Biomed Mater vol. 38, 163-172.

DOI 10.1016/j.jmbbm.2014.06.005

QMRO

01-10-2014

Proteomic analysis reveals age-related changes in tendon matrix composition, with age- and injury-specific matrix fragmentation.
Peffers MJ, Thorpe CT, Collins JA, Eong R, Wei TKJ, Screen HRC and Clegg PD
J Biol Chem vol. 289 (37), 25867-25878.

DOI 10.1074/jbc.M114.566554

QMRO

12-09-2014

78 Human Tenocyte Metabolism Under Pathological And Physiological Loading Conditions
Patel D, Bryant S, Riley G, Jones E and Screen H
British Journal of Sports Medicine, Bmj vol. 48 (Suppl 2), a51-a51.

DOI 10.1136/bjsports-2014-094114.77

01-09-2014

98 Early Inflammatory Response Of Tenocytes To Overload
Spiesz EM, Thorpe CT, Chaudhry S, Riley GP, Birch HL, Clegg PD and Screen HR
British Journal of Sports Medicine, Bmj vol. 48 (Suppl 2), a63-a64.

DOI 10.1136/bjsports-2014-094114.97

01-09-2014

104 Characterisation Of The Proteome Of The Tendon Interfascicular Matrix
Thorpe C, Peffers M, Simpson D, Halliwell E, Screen H and Clegg P
British Journal of Sports Medicine, Bmj vol. 48 (Suppl 2), a68-a68.

DOI 10.1136/bjsports-2014-094114.103

01-09-2014

89 Primary Cilia In Tenocytes From The Inter-fascicular Matrix And The Fascicular Matrix
Rowson D, Knight M and Screen H
British Journal of Sports Medicine, Bmj vol. 48 (Suppl 2), a58-a59.

DOI 10.1136/bjsports-2014-094114.88

01-09-2014

Achillessehnentendinopathie
Morrissey D, Morton S, Anuj CA and Screen H
Sportphysio, Thieme vol. 02 (03), 105-111.

DOI 10.1055/s-0034-1387914

20-08-2014

Effect of fatigue loading on structure and functional behaviour of fascicles from energy-storing tendons.
Thorpe CT, Riley GP, Birch HL, Clegg PD and Screen HRC
Acta Biomater vol. 10 (7), 3217-3224.

DOI 10.1016/j.actbio.2014.04.008

01-07-2014

The effects of extracorporeal shockwave therapy on matrix metalloprotease activity in tendinopathy (1046.8)
Waugh C, Jones E, Riley G, Langberg H, Morrissey D and Screen H
The Faseb Journal, Wiley vol. 28 (S1)

DOI 10.1096/fasebj.28.1_supplement.1046.8

01-04-2014

Fascicles from energy-storing tendons show an age-specific response to cyclic fatigue loading
Thorpe CT, Riley GP, Birch HL, Clegg PD and Screen HRC
Journal of The Royal Society Interface vol. 11 (92)

DOI 10.1098/rsif.2013.1058

06-03-2014

Functionally distinct tendon fascicles exhibit different creep and stress relaxation behaviour.
Shepherd JH, Legerlotz K, Demirci T, Klemt C, Riley GP and Screen HRC
Proc Inst Mech Eng H vol. 228 (1), 49-59.

DOI 10.1177/0954411913509977

QMRO

01-01-2014

Advances in the understanding of tendinopathies: A report on the Second Havemeyer Workshop on equine tendon disease
Smith R, McIlwraith W, Schweitzer R, Kadler K, Cook J, Caterson B, Dakin S, Heinegard D, Screen H, Stover S, Crevier-Denoix N, Clegg P, Collins M, Little C, Frisbie D, Kjaer M, van Weeren R, Werpy N, Denoix J-M, Carr A, et al.
Equine Veterinary Journal vol. 46 (1), 4-9.

DOI 10.1111/evj.12128

01-01-2014

Fatigue loading causes a reduction in the ability of tendon fascicles to recoil
Thorpe CT, Udeze CP, Birch HL, Clegg PD and Screen HR
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 95 (3), A32-A33.
01-01-2014

Matrix damage as a result of cyclic creep loading occurs in the absence of changes in tendon mechanics at either the gross or micro-structural level
Shepherd JH, Riley GP and Screen HRC
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 95 (3), A29-A30.
01-01-2014

2013

Helical sub-structures in energy-storing tendons provide a possible mechanism for efficient energy storage and return.
Thorpe CT, Klemt C, Riley GP, Birch HL, Clegg PD and Screen HRC
Acta Biomater vol. 9 (8), 7948-7956.

DOI 10.1016/j.actbio.2013.05.004

01-08-2013

The role of the non-collagenous matrix in tendon function.
Thorpe CT, Birch HL, Clegg PD and Screen HRC
Int J Exp Pathol vol. 94 (4), 248-259.

DOI 10.1111/iep.12027

01-08-2013

Fatigue loading of tendon.
Shepherd JH and Screen HRC
Int J Exp Pathol vol. 94 (4), 260-270.

DOI 10.1111/iep.12037

01-08-2013

Effect of Fatigue Loading on Tendon Fascicle Extension Mechanisms
Thorpe CT, Birch HL, Clegg PD and Screen HRC
Volume 1B: Extremity; Fluid Mechanics; Gait; Growth, Remodeling, and Repair; Heart Valves; Injury Biomechanics; Mechanotransduction and Sub-Cellular Biophysics; MultiScale Biotransport; Muscle, Tendon and Ligament; Musculoskeletal Devices; Multiscale Mechanics; Thermal Medicine; Ocular Biomechanics; Pediatric Hemodynamics; Pericellular Phenomena; Tissue Mechanics; Biotransport Design and Devices; Spine; Stent Device Hemodynamics; Vascular Solid Mechanics; Student Paper and Design Competitions., v01bt37a001-v01bt37a001.

DOI 10.1115/sbc2013-14009

26-06-2013

Energy Storing and Positional Tendon Fascicles Exhibit Different Fatigue Behaviour
Shepherd JH, Legerlotz K, Demirci T, Klemt C, Riley GP and Screen HRC
Volume 1B: Extremity; Fluid Mechanics; Gait; Growth, Remodeling, and Repair; Heart Valves; Injury Biomechanics; Mechanotransduction and Sub-Cellular Biophysics; MultiScale Biotransport; Muscle, Tendon and Ligament; Musculoskeletal Devices; Multiscale Mechanics; Thermal Medicine; Ocular Biomechanics; Pediatric Hemodynamics; Pericellular Phenomena; Tissue Mechanics; Biotransport Design and Devices; Spine; Stent Device Hemodynamics; Vascular Solid Mechanics; Student Paper and Design Competitions., v01bt55a001-v01bt55a001.

DOI 10.1115/sbc2013-14018

26-06-2013

GAG depletion increases the stress-relaxation response of tendon fascicles, but does not influence recovery.
Legerlotz K, Riley GP and Screen HRC
Acta Biomater vol. 9 (6), 6860-6866.

DOI 10.1016/j.actbio.2013.02.028

01-06-2013

Response to letter to the editor: End effects in mechanical testing of biomaterials
Anssari-Benam A, Legerlotz K, Bader DL and Screen HRC
Journal of Biomechanics vol. 46 (5)

DOI 10.1016/j.jbiomech.2012.12.020

15-03-2013

Cyclic loading of tendon fascicles using a novel fatigue loading system increases interleukin-6 expression by tenocytes
Legerlotz K, Jones GC, Screen HRC and Riley GP
Scandinavian Journal of Medicine and Science in Sports vol. 23 (1), 31-37.

DOI 10.1111/j.1600-0838.2011.01410.x

QMRO

01-02-2013

Capacity for sliding between tendon fascicles decreases with ageing in injury prone equine tendons: a possible mechanism for age-related tendinopathy?
Thorpe CT, Udeze CP, Birch HL, Clegg PD and Screen HR
Eur Cell Mater vol. 25, 48-60.

DOI 10.22203/ecm.v025a04

08-01-2013

Microstructural stress relaxation mechanics in functionally different tendons.
Screen HRC, Toorani S and Shelton JC
Med Eng Phys vol. 35 (1), 96-102.

DOI 10.1016/j.medengphy.2012.04.004

01-01-2013

Microstructural stress relaxation mechanics in functionally different tendons
Screen HRC, Toorani S and Shelton JC
Medical Engineering and Physics vol. 35 (1), 96-102.

DOI 10.1016/j.medengphy.2012.04.004

01-01-2013

Response to letter to the editor: End effects in mechanical testing of biomaterials
Anssari-Benam A, Legerlotz K, Bader DL and Screen HRC
Journal of Biomechanics

DOI 10.1016/j.jbiomech.2012.12.020

01-01-2013

The effects of extracorporeal shock wave therapy (ESWT) on type I collagen synthesis in the Achilles tendon: an intervention study on healthy participants
Mani-Babu S, Waugh CM, Screen HR, Maffulli N and Morrissey D
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 94 (4), A11-A12.
01-01-2013

Helical fascicles in energy storing tendons: a mechanism for efficient recoil?
Thorpe CT, Birch HL, Clegg PD and Screen HRC
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 94 (4), A3-A4.
01-01-2013

The fatigue behaviour of functionally distinct bovine tendons
Shepherd JH, Legerlotz K, Demirci T, Riley GP and Screen HRC
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 94 (4), A10-A10.
01-01-2013

The role of Interleukin-6 in the response of human hamstrings tendon to unloading, loading and overloading
Legerlotz K, Jones ER, Screen HR and Riley GP
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 94 (4), A2-A2.
01-01-2013

Helical sub-structures in energy-storing tendons provide a possible mechanism for efficient energy storage and return
Thorpe CT, Klemt C, Riley GP, Birch HL, Clegg PD and Screen HRC
Acta Biomaterialia vol. 9 (8), 7948-7956.

DOI 10.1016/j.actbio.2013.05.004

01-01-2013

2012

Specialization of tendon mechanical properties results from interfascicular differences
Thorpe CT, Udeze CP, Birch HL, Clegg PD and Screen HRC
Journal of The Royal Society Interface vol. 9 (76), 3108-3117.

DOI 10.1098/rsif.2012.0362

QMRO

07-11-2012

On the specimen length dependency of tensile mechanical properties in soft tissues: gripping effects and the characteristic decay length.
Anssari-Benam A, Legerlotz K, Bader DL and Screen HRC
J Biomech vol. 45 (14), 2481-2482.

DOI 10.1016/j.jbiomech.2012.07.016

21-09-2012

Structure and Biomechanics of Biological Composites
Screen HRC and Tanner KE
In Wiley Encyclopedia of Composites, Wiley 1-12.

DOI 10.1002/9781118097298.weoc015

20-07-2012

Strain transfer through the aortic valve
Anssari-Benam A, Gupta HS and Screen HRC
Journal of Biomechanical Engineering vol. 134 (6)

DOI 10.1115/1.4006812

29-06-2012

Coronal plane hip muscle activation in football code athletes with chronic adductor groin strain injury during standing hip flexion
Morrissey D, Graham J, Screen H, Sinha A, Small C, Twycross-Lewis R and Woledge R
Manual Therapy vol. 17 (2), 145-149.

DOI 10.1016/j.math.2011.12.003

01-04-2012

THE MICRO-STRUCTURAL RESPONSE OF TENDON FASCICLES TO APPLIED MAIN IS ALTERED WITH AGEING
Thorpe CT, Birch HL, Clegg PD and Screen HR
OSTEOARTHRITIS AND CARTILAGE. vol. 20, S246-S247.

DOI 10.1016/j.joca.2012.02.409

01-01-2012

Increased expression of IL-6 family members in tendon pathology
Legerlotz K, Jones ER, Screen HRC and Riley GP
Rheumatology vol. 51 (7), 1161-1165.

DOI 10.1093/rheumatology/kes002

QMRO

01-01-2012

2011

Extrafibrillar diffusion and intrafibrillar swelling at the nanoscale are associated with stress relaxation in the soft collagenous matrix tissue of tendons
Screen HRC, Seto J, Krauss S, Boesecke P and Gupta HS
Soft Matter vol. 7 (23), 11243-11251.

DOI 10.1039/c1sm05656e

07-11-2011

Nonlinearities in soft tissue strain.
Simms C, Screen H and Evans S
J Mech Behav Biomed Mater vol. 4 (8)

DOI 10.1016/j.jmbbm.2011.10.004

01-11-2011

Anisotropic time-dependant behaviour of the aortic valve
Anssari-Benam A, Bader DL and Screen HRC
Journal of The Mechanical Behavior of Biomedical Materials vol. 4 (8), 1603-1610.

DOI 10.1016/j.jmbbm.2011.02.010

01-11-2011

Anisotropic strain transfer through the aortic valve and its relevance to the cellular mechanical environment.
Lewinsohn AD, Anssari-Benham A, Lee DA, Taylor PM, Chester AH, Yacoub MH and Screen HRC
Proc Inst Mech Eng H vol. 225 (8), 821-830.

DOI 10.1177/0954411911406340

01-08-2011

Cyclic loading of tendon fascicles using a novel fatigue loading system increases interleukin-6 expression
Legerlotz K, Jones GC, Riley GP and Screen HRC
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 92 (3), A10-A10.
01-06-2011

The effect of eccentric and concentric calf muscle training on Achilles tendon stiffness
Morrissey D, Roskilly A, Twycross-Lewis R, Isinkaye T, Screen H, Woledge R and Bader D
Clinical Rehabilitation vol. 25 (3), 238-247.

DOI 10.1177/0269215510382600

01-03-2011

A combined experimental and modelling approach to aortic valve viscoelasticity in tensile deformation
Anssari-Benam A, Bader DL and Screen HRC
J Mater Sci-Mater M vol. 22 (2), 253-262.

DOI 10.1007/s10856-010-4210-6

01-02-2011

The effect of loading speed on the force frequency spectrum during eccentric & concentric calf exercise
Chaudhry S, Screen HRC, Woledge RC, Bader D and Morrissey D
British Journal of Sports Medicine, Bmj vol. 45 (2)

DOI 10.1136/bjsm.2010.081554.30

20-01-2011

The effect of eccentric and concentric loading speed on the normal achilles tendon: an in vivo biomechanical study
Sweeney E, Chaudhury S, Screen H, Woledge R, Bader D, Maffulli N and Morrissey D
British Journal of Sports Medicine, Bmj vol. 45 (2)

DOI 10.1136/bjsm.2010.081554.25

20-01-2011

Anisotropic strain transfer through the aortic valve and its relevance to the cellular mechanical environment
Lewinsohn AD, Anssari-Benham A, Lee DA, Taylor PM, Chester AH, Yacoub MH and Screen HRC
P I Mech Eng H vol. 225 (H8), 821-830.

DOI 10.1177/0954411911406340

01-01-2011

Tendon material properties cannot be predicted by the material properties of the tendon fascicles
Thorpe CT, Udeze CP, Birch HL, Clegg PD and Screen HRC
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 92 (6), A10-A10.
01-01-2011

Fiber composite scaffolds uniquely regulate fibroblast response to cyclic tensile strain
Screen HRC, Demirci T, Lynn A, Blackney A, Patel D and Bryant SJ
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 92 (6), A11-A12.
01-01-2011

2010

Specimen dimensions influence the measurement of material properties in tendon fascicles
Legerlotz K, Riley GP and Screen HRC
Journal of Biomechanics vol. 43 (12), 2274-2280.

DOI 10.1016/j.jbiomech.2010.04.040

01-08-2010

Characterization of a novel fiber composite material for mechanotransduction research of fibrous connective tissues
Screen HRC, Byers S, Lynn AD, Nguyen V, Patel D and Bryant SJ
Advanced Functional Materials vol. 20 (5), 738-747.

DOI 10.1002/adfm.200901711

09-03-2010

In situ multi-level analysis of viscoelastic deformation mechanisms in tendon collagen
Gupta HS, Seto J, Krauss S, Boesecke P and Screen HRC
Journal of Structural Biology vol. 169 (2), 183-191.

DOI 10.1016/j.jsb.2009.10.002

01-02-2010

Dynamic Tracking of Tendon Elongation In Ultrasound Imaging
Karimpoor M, Screen H and Morrissey D
MEDICAL IMAGING 2010: VISUALIZATION, IMAGE-GUIDED PROCEDURES, AND MODELING. vol. 7625 Editors: Wong KH and Miga MI.

DOI 10.1117/12.844623

01-01-2010

2009

Measuring strain distributions in the tendon using confocal microscopy and finite elements
Screen HRC and Evans SL
J Strain Anal Eng vol. 44 (5), 327-335.

DOI 10.1243/03093247JSA491

01-07-2009

Hierarchical approaches to understanding tendon mechanics
SCREEN H
Journal of Biomechanical Science and Engineering, Japan Society of Mechanical Engineers vol. 4 (4), 481-499.

DOI 10.1299/jbse.4.481

01-01-2009

2008

Characterizing structure-function relationships in tendon
Toorani S, Shelton JC and Screen HRC
8th World Biomaterials Congress 2008 vol. 2
01-12-2008

Investigating load relaxation mechanics in tendon
Screen HRC
Journal of The Mechanical Behavior of Biomedical Materials vol. 1 (1), 51-58.

DOI 10.1016/j.jmbbm.2007.03.002

01-01-2008

2007

The micro-structural strain response of tendon
Cheng VWT and Screen HRC
J Mater Sci vol. 42 (21), 8957-8965.

DOI 10.1007/s10853-007-1653-3

01-11-2007

The relationship between tendon composition, structure, and mechanical characteristics
Toorani S, Shelton JC and Screen HRC
TISSUE ENGINEERING. vol. 13 (7), 1765-1765.
01-07-2007

Strain mechanisms in tendon fascicles
SCREEN HRC and Cheng VWT
J.Mat.Sci. vol. 21, 8957-8965.

DOI 10.1007/s10853-007-1653-3

01-01-2007

2006

The influence of swelling and matrix degradation on the microstructural integrity of tendon.
Screen HRC, Chhaya VH, Greenwald SE, Bader DL, Lee DA and Shelton JC
Acta Biomater vol. 2 (5), 505-513.

DOI 10.1016/j.actbio.2006.05.008

01-09-2006

2005

Cyclic mechanical conditioning of isolated tendon fascicles results in an upregulation of collagen production
Screen HRC, Bader DL, Shelton JC and Lee DA
Proceedings of The 2005 Summer Bioengineering Conference vol. 2005, 193-194.
01-12-2005

Cyclic tensile strain upregulates collagen synthesis in isolated tendon fascicles.
Screen HRC, Shelton JC, Bader DL and Lee DA
Biochem Biophys Res Commun vol. 336 (2), 424-429.

DOI 10.1016/j.bbrc.2005.08.102

21-10-2005

The influence of noncollagenous matrix components on the micromechanical environment of tendon fascicles.
Screen HRC, Shelton JC, Chhaya VH, Kayser MV, Bader DL and Lee DA
Ann Biomed Eng vol. 33 (8), 1090-1099.

DOI 10.1007/s10439-005-5777-9

01-08-2005

The effect of substrate and medium composition on the response of human dermal fibroblasts to cyclic tensile strain in vitro
Baria KE, Bader DL, Screen HRC and Lee DA
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 86 (3), A32-A33.
01-06-2005

British Society for Matrix Biology Autumn Meeting Joint with the UK Tissue & Cell Engineering Society, University of Bristol, UK

International Journal of Experimental Pathology, Wiley vol. 86 (3), a1-a56.

DOI 10.1111/j.0959-9673.2005.00426.x

24-05-2005

2004

Local Strain Measurement within Tendon
Bader DL, Shelton JC, Lee DA and SCREEN HRC
Strain vol. 40 (4), 157-163.

DOI 10.1111/j.1475-1305.2004.00164.x

01-11-2004

An investigation into the effects of the hierarchical structure of tendon fascicles on micromechanical properties.
Screen HRC, Lee DA, Bader DL and Shelton JC
Proc Inst Mech Eng H vol. 218 (2), 109-119.

DOI 10.1243/095441104322984004

01-01-2004

2003

Development of a technique to determine strains in tendons using the cell nuclei.
Screen HRC, Lee DA, Bader DL and Shelton JC
Biorheology vol. 40 (1-3), 361-368.
01-01-2003

The effects on non-collagenous matrix components on tendon fascicle micromechanics.
SCREEN HRC, Shelton JC, Bader DL and Lee DA
49th Annual Meeting of the Orthopaedic Research Society. vol. 28, 806-806.
01-01-2003

2002

The strain behaviour of tendon under tensile load, using cell nuclei as strain markers.
SCREEN HRC, Lee DA, Bader DL and Shelton JC
48th Annual Meeting of the Orthopaedic Research Society. vol. 27, 604-604.
01-01-2002

Development of a technique to determine strains in tendons using the cell nuclei.
BADER DL, Shelton JC, Lee DA and Screen HRC
Biorheology vol. 40, 361-368.

DOI 10.1177/0006355x2003040001003050

01-01-2002

Non-collagenous matrix components influence the micromechanical environment of tenocytes within tendon fascicles subjected to tensile strain.
Bader DL, Shelton JC, Lee DA and SCREEN HRC
Eur. Cells Mat. vol. 4:S1, 41-42.
01-01-2002

Non-collagenous matrix components influence the micro-mechanical environment of tenocytes within tendon fasciles subjected to tensile strain.
Bader DL, Shelton JC, LEE DA and Screen HRC
Eur. Cells Materials vol. 4 suppl 1, 41-42.
01-01-2002

Grants

Grants of specific relevance to the Centre for Bioengineering

Organ-chip Facility: A world-class in vitro models facility for the UK community, reducing the barriers to adoption to drive animal replacement
Hazel Screen, Stefaan Verbruggen, Martin Knight, Julia Shelton, Timothy Hopkins and John Connelly
£573,537 NC3Rs National Center for the Replacement, Refinement and Reduction of Animals in Research

Grant Summary

07-10-2024 - 14-03-2025

Micro-manufacturing of tissue patterned organ-chips for accelerated deployment of new medicines
Martin Knight, Hazel Screen, Julien Gautrot, Timothy Hopkins, John Connelly, Liisa Blowes and Xavier Griffin
£1,787,725 EPSRC Engineering and Physical Sciences Research Council

Grant Summary

01-10-2024 - 30-09-2027

EPSRC Centre for Doctoral Training in Next Generation Organ-on-a-Chip Technology (COaCT)
Hazel Screen, Martin Knight, Thomas Iskratsch, Caroline Roney, Yi Sui, David Lee, Julia Shelton, Zion Tse, John Connelly, Adrian Biddle and Lucy Norling
£7,066,811 EPSRC Engineering and Physical Sciences Research Council

Grant Summary

01-07-2024 - 30-09-2032

Epithelial Exchange Surfaces – From organizing principles to novel culture models of the gatekeepers of the body
Martin Knight, Hazel Screen, Wen Wang, Clare Thompson and Cleo Bishop
£260,676 EPSRC - EU Scheme

Grant Summary

01-12-2023 - 30-11-2027

Incorporating physical cues in organ-chip models
Hazel Screen and Martin Knight
£20,000 Emulate Inc.
01-10-2022 - 30-09-2026

Organ-on-a-chip Centre of Excellence
Martin Knight and Hazel Screen
£420,794 Emulate Inc.
20-08-2019 - 01-10-2029

Production of a Human Growth Plate Organ-Chip Model of Skeletal Development
Martin Knight, Clare Thompson and Hazel Screen
£197,923 BBSRC Biotechnology and Biological Sciences Research Council
01-02-2023 - 31-07-2024

Consultancy Hazel Screen, Frontier Space Technology Ltd Space Chips.
Hazel Screen
£9,000 Generic Commercial
01-01-2023 - 31-12-2023

Emulate Organs-on-Chips Centre Technician
Martin Knight, Hazel Screen and Clare Thompson
£49,584 Emulate Inc.
01-01-2021 - 31-12-2023

MICA: Organ-on-a-chip models for safety testing of regenerative medicine products
Hazel Screen and Martin Knight
£473,325 MRC Medical Research Council
24-08-2020 - 24-05-2024

Development of a synovium-chondrocyte organ-on-a-chip model with integrated biomechanical
Hazel Screen and Clare Thompson
£9,068 EPSRC Engineering and Physical Sciences Research Council
01-07-2019 - 31-12-2019

Identifying the causes of age-related tendon injury
Hazel Screen
£213,898 DMT Dunhill Medical Trust, The
01-10-2018 - 30-12-2022

Organ-on-a-chip technologies
Hazel Screen and Martin Knight
£479,339 MRC Medical Research Council
01-08-2018 - 30-09-2022

Investigating Tendon mechanics and models of tendon pathology
Hazel Screen
£63,200 TRB CHEMEDICA Ltd
01-10-2017 - 30-09-2021

THaCH - The effects of hypercholesterolemia on tendon health (Tendon Health and CHolesterol)
Hazel Screen
£73,382 EU European Commission - Other
01-09-2016 - 05-11-2021

Effective Injury Management & Prevention
Hazel Screen
£167,426 Horserace Betting Levy Board, T
01-07-2016 - 31-03-2019