Prof Himadri Gupta

Himadri Gupta

Professor of Bioengineering and Biophysics
Director of Graduate Studies (SEMS)

School of Engineering and Materials Science
Queen Mary University of London
www.sems.qmul.ac.uk/staff/h.gupta/
Centre for Bioengineering
ORCID Google Scholar

Research

Multimodal X-ray imaging, Nano- and micro biomechanics, Extracellular matrix, Collagen structure, Small-angle X-ray scattering and diffraction, Synchrotron technique development

Interests

HG is a bioengineer pioneering the analysis of nanoscale biophysics in the ECM of musculoskeletal tissues, by developing high-brilliance synchrotron X-ray nanomechanical imaging methods. His research has quantified the fundamental hierarchical deformation processes in bone at the Angstrom-micron level, uncovered ultrastructural mechanisms for fragility in osteoporosis models, and developed novel X-ray reconstruction models for complex biological tissues (ORCiD 0000-0003-2201-8933). More recently, his BBSRC (BB/R003610/1) funded research has focused on the mechanics of ageing collagen in cartilage, and he leads an EPSRC consortium (EP/V011235/1) to develop and disseminate TomoSAXS, a novel 3D molecular-to-macro scale biomechanical imaging technology for musculoskeletal tissues.

Publications

solid heart iconPublications of specific relevance to the Centre for Bioengineering

2024

Relevant PublicationNonlinear Stress‐Induced Transformations in Collagen Fibrillar Organization, Disorder and Strain Mechanisms in the Bone‐Cartilage Unit
Badar W, Inamdar SR, Fratzl P, Snow T, Terrill NJ, Knight MM and Gupta HS
Advanced Science, Wiley, e2407649-e2407649.  
11-11-2024
bullet iconImpact of SWCNTs and CMCS on efficacy of anastomosis and optical properties in vivo during laser biological tissue soldering
Chen Y, Wang K, Li X, Huang J, Gupta HS, Rui Y and Forster L
Optics & Laser Technology, Elsevier vol. 176 
01-09-2024
bullet iconA step towards 6D WAXD tensor tomography
Zhao X, Dong Z, Zhang C, Gupta H, Wu Z, Hua W, Zhang J, Huang P, Dong Y and Zhang Y
Iucrj, International Union of Crystallography (Iucr) vol. 11 (Pt 4), 502-509.  
09-05-2024
bullet iconInvestigation of collagen reconstruction mechanism in skin wound through dual-beam laser welding: Insights from multi-spectroscopy, molecular dynamics simulation, and finite element multiphysics simulation
Chen Y, Forster L, Wang K, Gupta HS, Li X, Huang J and Rui Y
Journal of Photochemistry and Photobiology B Biology, Elsevier vol. 255 
26-04-2024
Relevant PublicationAccelerating the remodeling of collagen in cutaneous full‐thickness wound using FIR soldering technology with bio‐targeting nanocomposites hydrogel
Chen Y, Chen M, Wang K, Huang J, Gupta HS, He K and Rui Y
Journal of Biophotonics, Wiley vol. 17 (5) 
08-02-2024

2023

Relevant PublicationIs Stress Relaxation in Sea Cucumber Dermis Chemoelastic?
Barbieri E and Gupta HS
Marine Drugs, Mdpi vol. 21 (12) 
25-11-2023
Relevant PublicationP08 Dissection of the molecular and cellular heterogeneity of dermal fibroblasts in skin fibrosis
Ahmed A, Kirk T, Forster L, O’Toole E, Gupta H and Rognoni E
British Journal of Dermatology, Oxford University Press (Oup) vol. 189 (1), e17-e17.  
07-07-2023
Relevant Publication1458 Dissection of the molecular and cellular heterogeneity of dermal fibroblasts in skin fibrosis
Ahmed A, Kirk T, Forster L, O'Toole E, Gupta H and Rognoni E
Journal of Investigative Dermatology, Elsevier vol. 143 (5) 
01-05-2023
Relevant PublicationFast extraction of three-dimensional nanofiber orientation from WAXD patterns using machine learning
Sun M, Dong Z, Wu L, Yao H, Niu W, Xu D, Chen P, Gupta HS, Zhang Y, Dong Y, Chen C and Zhao L
Iucrj, International Union of Crystallography (Iucr) vol. 10 (Pt 3), 297-308.  
25-03-2023
Relevant PublicationDissection of the molecular and cellular heterogeneity of dermal fibroblasts in skin fibrosis
Ahmed A, Kirk T, Forster L, O'Toole E, Gupta H and Rognoni E
JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 143 (5), S250-S250.  
01-01-2023

2022

Relevant PublicationCollagen pre-strain discontinuity at the bone—Cartilage interface
Badar W, Ali H, Brooker ON, Newham E, Snow T, Terrill NJ, Tozzi G, Fratzl P, Knight MM and Gupta HS
Plos One, Public Library of Science (Plos) vol. 17 (9) 
15-09-2022
Relevant PublicationChemoviscoelasticity of the interfibrillar matrix of the dermis of the black sea cucumber Holuthuria atria
Barbieri E, Mo J and Gupta HS
Mechanics of Materials, Elsevier vol. 168 
01-05-2022
Relevant PublicationIn situ determination of the extreme damage resistance behavior in stomatopod dactyl club
Dong Z, Chen S, Gupta HS, Zhao X, Yang Y, Chang G, Xue J, Zhang Y, Luo S and Dong Y
Journal of Synchrotron Radiation, International Union of Crystallography (Iucr) vol. 29 (3), 775-786.  
14-03-2022
Relevant PublicationInvestigating the Fibrillar Ultrastructure and Mechanics in Keloid Scars Using In Situ Synchrotron X-ray Nanomechanical Imaging.
Zhang Y, Hollis D, Ross R, Snow T, Terrill NJ, Lu Y, Wang W, Connelly J, Tozzi G and Gupta HS
Materials (Basel), Mdpi vol. 15 (5) 
01-03-2022
bullet iconEffect of interphase boundaries on nanoindentation experiments on a Ni-base alloy
Schöberl T and Gupta HS
International Journal of Materials Research (Formerly Zeitschrift Fuer Metallkunde) vol. 94 (7), 813-818.  
25-01-2022

2021

bullet iconPrecipitate Size Distribution in Alloys with and without Lattice Misfit
Weinkamer R, Gupta H, Lebowitz JL and Fratzl P
International Journal of Materials Research vol. 92 (1), 9-13.  
21-12-2021
Relevant PublicationReversible changes in the 3D collagen fibril architecture during cyclic loading of healthy and degraded cartilage
Inamdar SR, Prévost S, Terrill NJ, Knight MM and Gupta HS
Acta Biomaterialia, Elsevier vol. 136, 314-326.  
24-11-2021
Relevant PublicationThe Mutable Collagenous Tissue of Echinoderms: From Biology to Biomedical Applications
Elphick M
Soft Matter For Biomedical Applications, Royal Society of Chemistry 
11-06-2021
Relevant PublicationSeparating effects of bone-quality changes at multiple scales in steroid-induced osteoporosis: Combining multiscale experimental and modelling approaches
Xi L, Barbieri E, Wang P, Wu W and Gupta H
Mechanics of Materials, Elsevier vol. 157 
01-06-2021
Relevant PublicationTomographic X‐ray scattering based on invariant reconstruction: analysis of the 3D nanostructure of bovine bone
De Falco P, Weinkamer R, Wagermaier W, Li C, Snow T, Terrill NJ, Gupta HS, Goyal P, Stoll M, Benner P and Fratzl P
Journal of Applied Crystallography, International Union of Crystallography (Iucr) vol. 54 (2), 486-497.  
03-03-2021
Relevant PublicationActivation of TRPV4 by mechanical, osmotic or pharmaceutical stimulation is anti-inflammatory blocking IL-1β mediated articular cartilage matrix destruction
Fu S, Meng H, Inamdar S, Das B, Gupta H, Wang W, Thompson C and Knight M
Osteoarthritis and Cartilage, Elsevier Editors: Block JA. 
01-01-2021
Relevant PublicationChapter 2 Synchrotron X-ray Imaging Combined with Multiscale Modeling Applied to Biological Soft Tissues
Gupta HS, Barbieri E, Inamdar SR and Mo J
In Soft Matter For Biomedical Applications, Royal Society of Chemistry (Rsc) 34-60.  
01-01-2021

2020

Relevant PublicationMolecular to Macroscale Energy Absorption Mechanisms in Biological Body Armour Illuminated by Scanning X-ray Diffraction with In Situ Compression.
Zhang Y, Garrevoet J, Wang Y, Roeh JT, Terrill NJ, Falkenberg G, Dong Y and Gupta HS
Acs Nano, American Chemical Society 
09-10-2020
Relevant PublicationA multiscale study of structural and compositional changes in a natural nanocomposite: Osteoporotic bone with chronic endogenous steroid excess
Xi L, Zhang Y, Gupta H, Terrill N, Wang P, Zhao T and Fang D
Bone, Elsevier vol. 143 
29-09-2020

2019

Relevant PublicationReduction of fibrillar strain-rate sensitivity in steroid-induced osteoporosis linked to changes in mineralized fibrillar nanostructure
Xi L, De Falco P, Barbieri E, Karunaratne A, Bentley L, Esapa CT, Davis GR, Terrill NJ, Cox RD, Pugno NM, Thakker RV, Weinkamer R, Wu WW, Fang DN and Gupta HS
Bone, Elsevier vol. 131 
11-11-2019
Relevant PublicationMatrix-induced pre-strain and mineralization-dependent interfibrillar shear transfer enable 3D fibrillar deformation in a biogenic armour
Wang Y, Zhang Y, Terrill NJ, Barbieri E, Pugno NM and Gupta HS
Acta Biomaterialia, Elsevier 
26-09-2019
Relevant PublicationProteoglycan degradation mimics static compression by altering the natural gradients in fibrillar organisation in cartilage
Inamdar SR, Barbieri E, Terrill NJ, Knight MM and Gupta HS
Acta Biomaterialia, Elsevier vol. 97, 437-450.  
30-07-2019

2018

Relevant PublicationIn Situ Mechanical Behavior of Regenerating Rat Calvaria Bones Under Tensile Load via Synchrotron Diffraction Characterization

Residual Stresses 2018. vol. 6, 117-122.  
11-09-2018
Relevant PublicationMultilayer stag beetle elytra perform better under external loading via non-symmetric bending properties.
Kundanati L, Signetti S, Gupta HS, Menegon M and Pugno NM
J R Soc Interface vol. 15 (144) 
25-07-2018
Relevant PublicationBone matrix development in steroid-induced osteoporosis is associated with a consistently reduced fibrillar stiffness linked to altered bone mineral quality
Xi L, De Falco P, Barbieri E, Karunaratne A, Bentley L, Esapa CT, Terrill NJ, Brown SDM, Cox RD, Davis GR, Pugno NM, Thakker RV and Gupta HS
Acta Biomaterialia, Elsevier vol. 76, 295-307.  
15-06-2018
Relevant PublicationUnlocking the secrets of mutable collagenous tissue
Gupta HS, Szulgit G, Elphick MR and Mo J
Biochemist vol. 40 (1), 8-11.  
01-02-2018

2017

Relevant PublicationThe Secret Life of Collagen: Temporal Changes in Nanoscale Fibrillar Pre-Strain and Molecular Organization During Physiological Loading of Cartilage.
Inamdar SR, Knight DP, Terrill NJ, Karunaratne A, Cacho-Nerin F, Knight MM and Gupta HS
Acs Nano 
11-08-2017
Relevant PublicationTowards in situ determination of 3D strain and reorientation in the interpenetrating nanofibre networks of cuticle.
Zhang Y, De Falco P, Wang Y, Barbieri E, Paris O, Terrill NJ, Falkenberg G, Pugno NM and Gupta HS
Nanoscale 
19-07-2017
Relevant PublicationBody wall structure in the starfish Asterias rubens
Blowes LM, Egertova M, Liu Y, Davis GR, Terrill NJ, Gupta HS and ELPHICK MR
Journal of Anatomy, Wiley 
16-07-2017
Relevant PublicationStaggered Fibrils and Damageable Interfaces Lead Concurrently and Independently to Hysteretic Energy Absorption and Inhomogeneous Strain Fields in Cyclically Loaded Antler Bone
De Falco P, Barbieri E, Pugno N and Gupta HS
Acs Biomaterials Science & Engineering 
12-01-2017

2016

Relevant PublicationStructural Building Blocks of Soft Tissues: Tendons and Heart Valves
Gupta HS and Screen HRC
In Material Parameter Identification and Inverse Problems in Soft Tissue Biomechanics, Springer Nature 1-35.  
13-10-2016
Relevant PublicationInterfibrillar stiffening of echinoderm mutable collagenous tissue demonstrated at the nanoscale.
Mo J, Prévost SF, Blowes LM, Egertová M, Terrill NJ, Wang W, Elphick MR and Gupta HS
Proc Natl Acad Sci U S A 
05-10-2016
Relevant PublicationUncovering three-dimensional gradients in fibrillar orientation in an impact-resistant biological armour
Zhang Y, Paris O, Terrill NJ and Gupta HS
Scientific Reports, Nature Publishing Group: Open Access Journals - Option C vol. 6, 26249-26249.  
23-05-2016

2015

Relevant PublicationMultiscale alterations in bone matrix quality increased fragility in steroid induced osteoporosis
Karunaratne A, Xi L, Bentley L, Sykes D, Boyde A, Esapa CT, Terrill NJ, Brown SDM, Cox RD, Thakker RV and Gupta HS
Bone, Elsevier vol. 84, 15-24.  
02-12-2015
Relevant PublicationNaturally inspired polyelectrolyte multilayer composite films synthesised through layer-by-layer assembly and chemically infiltrated with CaCO 3
Patel IF, Kiryukhin MV, Yakovlev NL, Gupta HS and Sukhorukov GB
Journal of Materials Chemistry B, Royal Society of Chemistry (Rsc) vol. 3 (24), 4821-4830.  
01-01-2015

2014

Relevant PublicationIntegrative and comparative analysis of coiled-coil based marine snail egg cases - A model for biomimetic elastomers
Guerette PA, Z. Tay G, Hoon S, Loke JJ, Hermawan AF, Schmitt CNZ, Harrington MJ, Masic A, Karunaratne A, Gupta HS, Tan KS, Schwaighofer A, Nowak C and Miserez A
Biomaterials Science vol. 2 (5), 710-722.  
01-01-2014
Relevant PublicationSynchrotron Nano-Mechanical Imaging Techniques to Understand How Altered Bone Quality Increases Fracture Risk in Secondary Osteoporosis
Karunaratne A, Bentley L, Cox R, Boyde A, Esapa CT, Terrill NJ, Davis GR, Brown SDM, Thakker RV and Gupta HS
IFMBE Proceedings. vol. 43, 24-27.  
01-01-2014

2013

Relevant PublicationNanointerfacial strength between non-collagenous protein and collagen fibrils in antler bone
Hang F, Gupta HS and BARBER AH
Journal of The Royal Society Interface, Royal Society Publishing vol. 11 (92) 
18-12-2013
Relevant PublicationIntrafibrillar plasticity through mineral/collagen sliding is the dominant mechanism for the extreme toughness of antler bone
Gupta HS, Krauss S, Kerschnitzki M, Karunaratne A, Dunlop JWC, Barber AH, Boesecke P, Funari SS and Fratzl P
Journal of The Mechanical Behavior of Biomedical Materials vol. 28, 366-382.  
01-12-2013
Relevant PublicationSymmetrically reduced stiffness and increased extensibility in compression and tension at the mineralized fibrillar level in rachitic bone
Karunaratne A, Boyde A, Esapa CT, Hiller J, Terrill NJ, Brown SDM, Cox RD, Thakker RV and Gupta HS
Bone vol. 52 (2), 689-698.  
01-02-2013
Relevant PublicationSynchrotron X-ray nanomechanical imaging of mineralized fiber composites.
Karunaratne A, Terrill NJ and Gupta HS
Methods Enzymol vol. 532, 415-473.  
01-01-2013
Relevant PublicationNaturally inspired mineralized ceramic/polyelectrolyte multilayer films assembled by physicochemical processes
Sukhorukov GB, Patel I, Sali C, Nzeako J, Zhang Y, Kiryukhin M, Terrill N, Barber AH and Gupta HS
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. vol. 245 
01-01-2013

2012

Relevant PublicationPseudoelastic behaviour of a natural material is achieved via reversible changes in protein backbone conformation
Harrington MJ, Wasko SS, Masic A, Fischer FD, Gupta HS and Fratzl P
Journal of The Royal Society Interface vol. 9 (76), 2911-2922.  
07-11-2012
Relevant PublicationHypophosphatemic rickets is associated with disruption of mineral orientation at the nanoscale in the flat scapula bones of rachitic mice with development
Karunaratne A, Davis GR, Hiller J, Esapa CT, Terrill NJ, Brown SDM, Cox RD, Thakker RV and Gupta HS
Bone vol. 51 (3), 553-562.  
01-09-2012
bullet iconRecording IR spectra for individual electrospun fibers using an in situ AFM-synchrotron technique
Stachewicz U, Hang F, Bailey RJ, Gupta HS, Frogley MD, Cinque G and Barber AH
Materials Research Society Symposium Proceedings vol. 1424, 19-23.  
20-08-2012
Relevant PublicationDISRUPTION OF MUSCLE STRESS-MEDIATED MINERAL ORIENTATION AT THE NANOSCALE IN THE SCAPULAR BONES OF RICKETS MICE WITH DEVELOPMENT
Karunaratne A, Davis G, Hiller J, Esapa C, Terrill N, Brown S, Cox R, Thakker R and Gupta H
Journal of Biomechanics, Elsevier vol. 45 
01-07-2012
Relevant PublicationStrain transfer through the aortic valve
Anssari-Benam A, Gupta HS and Screen HRC
Journal of Biomechanical Engineering vol. 134 (6) 
29-06-2012
Relevant PublicationSignificant deterioration in nanomechanical quality occurs through incomplete extrafibrillar mineralization in rachitic bone: Evidence from in-situ synchrotron X-ray scattering and backscattered electron imaging
Karunaratne A, Esapa CR, Hiller J, Boyde A, Head R, Bassett JHD, Terrill NJ, Williams GR, Brown MA, Croucher PI, Brown SDM, Cox RD, Barber AH, Thakker RV and Gupta HS
Journal of Bone and Mineral Research vol. 27 (4), 876-890.  
01-04-2012
Relevant PublicationAccelerated growth plate mineralization and foreshortened proximal limb bones in fetuin-A knockout mice.
Seto J, Busse B, Gupta HS, Schäfer C, Krauss S, Dunlop JWC, Masic A, Kerschnitzki M, Zaslansky P, Boesecke P, Catalá-Lehnen P, Schinke T, Fratzl P and Jahnen-Dechent W
Plos One vol. 7 (10) 
01-01-2012
Relevant PublicationDisruption in fibrillar level fracture mechanisms in rachitic mice bone: Measured using in-situ cantilever bending with microfocus saxd
Karunaratne A, Esapa C, Hiller J, Terril N, Brown S, Cox R, Thakker R and Gupta H
BONE. vol. 50, S123-S123.  
01-01-2012
Relevant PublicationFUNCTIONAL LINK BETWEEN MATERIAL LEVEL STRUCTURAL ALTERATIONS IN STEROID INDUCED OSTEOPOROTIC BONE AND ITS INCREASED FRAGILITY
Karunaratne A, Esapa C, Hiller J, Terrill N, Thakker R and Gupta H
OSTEOPOROSIS INTERNATIONAL. vol. 23, S573-S574.  
01-01-2012

2011

Relevant PublicationExtrafibrillar diffusion and intrafibrillar swelling at the nanoscale are associated with stress relaxation in the soft collagenous matrix tissue of tendons
Screen HRC, Seto J, Krauss S, Boesecke P and Gupta HS
Soft Matter vol. 7 (23), 11243-11251.  
07-11-2011
Relevant PublicationDeformation and fracture mechanisms of bone and nacre
Wang R and Gupta HS
Annual Review of Materials Research vol. 41, 41-73.  
04-08-2011
Relevant PublicationSynchrotron 3D SAXS analysis of bone nanostructure
Seidel R, Gourrier A, Kerschnitzki M, Burghammer M, Fratzl P, Gupta HS and Wagermaier W
Bioinspired, Biomimetic and Nanobiomaterials vol. 1, 123-131.  
01-01-2011

2010

Relevant PublicationNanoscale Deformation Mechanisms in Biological Tissues
Gupta HS
In Nanotechnologies For The Life Sciences, Wiley 
11-08-2010
Relevant PublicationBone Nanostructure and its Relevance for Mechanical Performance, Disease and Treatment
Fratzl P, Gupta HS, Roschger P and Klaushofer K
In Nanotechnology, Wiley 345-360.  
15-07-2010
Relevant PublicationBone material properties in lysyl oxidase knock-out mice
Blouin S, Paschalis E, Gupta H, Fratzl-Zelman N, Pischon N, Trackman PC, Mäki JM, Roschger P and Klaushofer K
Bone, Elsevier vol. 47 
01-06-2010
Relevant PublicationIn situ multi-level analysis of viscoelastic deformation mechanisms in tendon collagen
Gupta HS, Seto J, Krauss S, Boesecke P and Screen HRC
Journal of Structural Biology vol. 169 (2), 183-191.  
01-02-2010
Relevant PublicationMechanisms of Bone Deformation and Fracture
Gupta H, Fratzl P, Kerschnitzki M, Krauss S, Seto J, Wagermaier W, Benecke G, Boesecke P, Funari S, Currey J and Estevez J
BONE. vol. 46, S12-S12.  
01-01-2010

2009

bullet iconPreface
Kisailus D, Estroff L, Gupta HS, Landis WJ and Zavattieri PD
Materials Research Society Symposium Proceedings. vol. 1187 
01-12-2009
Relevant PublicationRational synthesis of a nanocrystalline calcium phosphate cement exhibiting rapid conversion to hydroxyapatite
Neira IS, Kolen'ko YV, Lebedev OI, Van Tendeloo G, Gupta HS, Matsushita N, Yoshimura M and Guitián F
Materials Science and Engineering C vol. 29 (7), 2124-2132.  
31-08-2009
Relevant PublicationCollagen insulated from tensile damage by domains that unfold reversibly: In situ X-ray investigation of mechanical yield and damage repair in the mussel byssus
Harrington MJ, Gupta HS, Fratzl P and Waite JH
Journal of Structural Biology vol. 167 (1), 47-54.  
01-07-2009
Relevant PublicationInhomogeneous fibril stretching in antler starts after macroscopic yielding: Indication for a nanoscale toughening mechanism
Krauss S, Fratzl P, Seto J, Currey JD, Estevez JA, Funari SS and Gupta HS
Bone vol. 44 (6), 1105-1110.  
01-06-2009
Relevant PublicationNanomedicine
Fratzl P, Gupta HS, Roschger P and Klaushofer K
In Nanomedicine, Vch Pub 345-360. Editors: Vogel V, Schmid G, Krug H, Waser R and Fuchs H. 
11-05-2009
Relevant PublicationDigital image correlation shows localized deformation bands in inelastic loading of fibrolamellar bone
Benecke G, Kerschnitzki M, Fratzl P and Gupta HS
Journal of Materials Research vol. 24 (2), 421-429.  
01-02-2009
Relevant PublicationNanoscale deformation mechanisms in bone
Gupta H, Krauss S, Seto J, Wagermaier W, Kerschnitzki M, Benecke G, Zaslansky P, Boesecke P, Funari SS, Kirchner HOK and Fratzl P
Bone vol. 44, S33-S34.  
01-01-2009
Relevant PublicationAn Effective Morphology Control of Hydroxyapatite Crystals via Hydrothermal Synthesis
Neira IS, Kolen'ko YV, Lebedev OI, Van Tendeloo G, Gupta HS, Guitian F and Yoshimura M
Cryst Growth Des vol. 9 (1), 466-474.  
01-01-2009

2008

Relevant PublicationNanoscale deformation mechanisms in collagen
Gupta HS
, 155-173.  
01-12-2008
Relevant PublicationFracture of bone tissue: The 'hows' and the 'whys'
Gupta HS and Zioupos P
Medical Engineering and Physics vol. 30 (10), 1209-1226.  
01-12-2008
Relevant PublicationTough lessons from bone: Extreme mechanical anisotropy at the mesoscale
Seto J, Gupta HS, Zaslansky P, Wagner HD and Fratzl P
Advanced Functional Materials vol. 18 (13), 1905-1911.  
09-07-2008
Relevant PublicationCollagen: Structure and Mechanics
Gupta HS
In Collagen, Springer Verlag 155-173. Editors: Fratzl P. 
30-05-2008
Relevant PublicationNanoscale Mechanisms of Bone Deformation and Fracture
Fratzl P and Gupta HS
vol. 1, 397-414.  
20-03-2008
Relevant PublicationMicrostructure of cortical bone as studied by Raman spectroscopy (composition vs orientation)
Gamsjager S, Kazanci M, Manjubala I, Gupta HS, Roschger P, Paschalis EP, Klaushofer K and Fratzl P
CALCIFIED TISSUE INT. vol. 82, S190-S190.  
01-01-2008

2007

Relevant PublicationHindered crack propagation in materials with periodically varying young's modulus - Lessons from biological materials
Fratzl P, Gupta HS, Fischer FD and Kolednik O
Advanced Materials vol. 19 (18), 2657-2661.  
17-09-2007
Relevant PublicationRaman imaging of two orthogonal planes within cortical bone
Kazanci M, Wagner HD, Manjubala NI, Gupta HS, Paschalis E, Roschger P and Fratzl P
Bone vol. 41 (3), 456-461.  
01-09-2007
Relevant PublicationEvidence for an elementary process in bone plasticity with an activation enthalpy of 1 eV
Gupta HS, Fratzl P, Kerschnitzki M, Benecke G, Wagermaier W and Kirchner HOK
Journal of The Royal Society Interface vol. 4 (13), 277-282.  
22-04-2007
Relevant PublicationScanning X-ray imaging with small-angle scattering contrast
Gourrier A, Wagermaier W, Burghammer M, Lammie D, Gupta HS, Fratzl P, Riekel C, Wess TJ and Paris O
Journal of Applied Crystallography vol. 40 (SUPPL. 1) 
01-04-2007
Relevant PublicationMechanical functionality by hierarchical structuring — Lessons from biological materials
Fratzl P, Gupta H and Burgert I
Comparative Biochemistry and Physiology Part a Molecular & Integrative Physiology, Elsevier vol. 146 (4) 
01-04-2007
Relevant PublicationScanning texture analysis of lamellar bone using microbeam synchrotron X-ray radiation
Wagermaier W, Gupta HS, Gourrier A, Paris O, Roschger P, Burghammer M, Riekel C and Fratzl P
Journal of Applied Crystallography vol. 40 (1), 115-120.  
12-01-2007
Relevant PublicationHandbook of Biomineralization: . Biological aspects and structure formation
Gupta HS and Fratzl P
In Handbook of Biomineralization: . Biological Aspects and Structure Formation, Vch Pub 397-414. Editors: Bäeuerlein E, Behrens P and Epple M. 
01-01-2007

2006

Relevant PublicationCooperative deformation of mineral and collagen in bone at the nanoscale.
Gupta HS, Seto J, Wagermaier W, Zaslansky P, Boesecke P and Fratzl P
Proc Natl Acad Sci U S A vol. 103 (47), 17741-17746.  
21-11-2006
Relevant PublicationMaterials science basis of bone quality
Fratzl P, Roschger P, Gupta HS, Peterlik H, Paschalis EP and Klaushofer K
BONE. vol. 39 (5), S15-S15.  
01-11-2006
Relevant PublicationMechanical modulation at the lamellar level in osteonal bone
Gupta HS, Stachewicz U, Wagermaier W, Roschger P, Wagner HD and Fratzl P
Journal of Materials Research vol. 21 (8), 1913-1921.  
01-08-2006
Relevant PublicationFibrillar level fracture in bone beyond the yield point
Gupta HS, Wagermaier W, Zickler GA, Hartmann J, Funari SS, Roschger P, Wagner DH and Fratzl P
International Journal of Fracture vol. 139 (3-4), 425-436.  
01-06-2006
Relevant PublicationSpiral twisting of fiber orientation inside bone lamellae
Wagermaier W, Gupta HS, Gourrier A, Burghammer M, Roschger P and Fratzl P
Biointerphases vol. 1 (1), 1-5.  
01-03-2006

2005

Relevant PublicationRetrosynthesis of nacre via amorphous precursor particles
Gehrke N, Nassif N, Pinna N, Antonietti M, Gupta HS and Cölfen H
Chemistry of Materials vol. 17 (26), 6514-6516.  
27-12-2005
Relevant PublicationNanoscale deformation mechanisms in bone
Gupta HS, Wagermaier W, Zickler GA, Aroush DRB, Funari SS, Roschger P, Wagner HD and Fratzl P
Nano Letters vol. 5 (10), 2108-2111.  
01-10-2005
Relevant PublicationScanning texture analysis of lamellar bone using microbeam synchrotron radiation
Wagermaier W, Gupta HS, Gourrier A, Roschger P, Burghammer M, Paris O, Riekel C and Fratzl P
Acta Crystallographica Section A: Foundations and advances. vol. 61 (a1), c311-c311.  
23-08-2005
Relevant PublicationMicrobeam diffraction of hierarchical nanocomposites
Paris O, Fratzl P, Gourrier A, Gupta H, Wagermaier W, Loidl D, Peterlik H, Burghammer M and Riekel C
Acta Crystallographica Section A: Foundations and advances. vol. 61 (a1), c63-c64.  
23-08-2005
Relevant PublicationTime- and position-resolved X-ray scattering of bone and cartilage
Fratzl P, Gupta HS, Wagermaier W, Roschger P, Gourrier A and Paris O
Acta Crystallographica Section A: Foundations and advances. vol. 61 (a1), c123-c123.  
23-08-2005
Relevant PublicationDiffracting stacks of cards - Some thoughts about small-angle scattering from bone
Fratzl P, Gupta HS, Paris O, Valenta A, Roschger P and Klaushofer K
Progress in Colloid and Polymer Science vol. 130, 33-39.  
29-07-2005
Relevant PublicationCorrelation of nanomechanical properties and bone organic/inorganic components in osteolathyritic treated rat bones
Manjubala I, Roschger P, Paschalis E, Zoehrer R, Gupta HS, Klaushofer K and Fratzl P
BONE. vol. 36, S240-S241.  
01-06-2005
Relevant PublicationTwo different correlations between nanoindentation modulus and mineral content in the bone-cartilage interface
Gupta HS, Schratter S, Tesch W, Roschger P, Berzlanovich A, Schoeberl T, Klaushofer K and Fratzl P
Journal of Structural Biology vol. 149 (2), 138-148.  
01-02-2005

2004

Relevant PublicationOn the role of interface polymers for the mechanics of natural polymeric composites
Fratzl P, Burgert I and Gupta HS
Physical Chemistry Chemical Physics vol. 6 (24), 5575-5579.  
21-12-2004
Relevant PublicationMechanical properties of spruce wood cell walls by nanoindentation
Gindl W, Gupta HS, Schöberl T, Lichtenegger HC and Fratzl P
Applied Physics a: Materials Science and Processing vol. 79 (8), 2069-2073.  
01-12-2004
Relevant PublicationSynchrotron diffraction study of deformation mechanisms in mineralized tendon
Gupta HS, Messmer P, Roschger P, Bernstorff S, Klaushofer K and Fratzl P
Physical Review Letters vol. 93 (15) 
08-10-2004
Relevant PublicationStructure and mechanical quality of the collagen-mineral nano-composite in bone
Fratzl P, Gupta HS, Paschalis EP and Roschger P
Journal of Materials Chemistry vol. 14 (14), 2115-2123.  
21-07-2004
bullet iconUsing kinetic Monte Carlo simulations to study phase separation in alloys
Weinkamer R, Fratzl P, Gupta HS, Penrose O and Lebowitz JL
Phase Transitions vol. 77 (5-7), 433-456.  
01-05-2004

2003

bullet iconMeasurements of mechanical properties in Ni-base superalloys using nanoindentation and atomic force microscopy
Schöberl T, Gupta HS and Fratzl P
Materials Science and Engineering: A vol. 363 (1-2), 211-220.  
20-12-2003
Relevant PublicationBone quality at material level as defined by concentration, size, shape, and alignment of mineral particles
Roschger P, Gupta HS, Weber M, Valenta A, Misof BM, Schratter S, Jager I, Klaushofer K and Fratzl P
BONE. vol. 33 (5), S22-S22.  
01-11-2003
Relevant PublicationMineralized microstructure of calcified avian tendons: A scanning small angle X-ray scattering study
Gupta HS, Roschger P, Zizak I, Fratzl-Zelman N, Nader A, Klaushofer K and Fratzl P
Calcified Tissue International vol. 72 (5), 567-576.  
01-05-2003
Relevant PublicationConstant mineralization density distribution in cancellous human bone
Roschger P, Gupta HS, Berzlanovich A, Ittner G, Dempster DW, Fratzl P, Cosman F, Parisien M, Lindsay R, Nieves JW and Klaushofer K
Bone vol. 32 (3), 316-323.  
01-03-2003
bullet iconEffect of interphase boundaries on nanoindentation experiments on a Ni-base alloy
Schöberl T and Gupta HS
Zeitschrift Fuer Metallkunde/Materials Research and Advanced Techniques vol. 94 (7), 813-818.  
01-01-2003

2002

Relevant PublicationLignification of spruce tracheid secondary cell walls related to longitudinal hardness and modulus of elasticity using nano-indentation
Gindl W, Gupta HS and Grunwald C
Can J Bot vol. 80 (10), 1029-1033.  
01-10-2002
bullet iconScanning-SAXS: a tool for structural characterization of complex materials at the micrometer and the nanometer scale
Paris O, Gupta H, Tesch W, Roschger P and Fratzl P
Acta Crystallographica Section A: Foundations and advances. vol. 58 (s1), c25-c25.  
06-08-2002
Relevant PublicationCell-wall hardness and Young's modulus of melamine-modified spruce wood by nano-indentation
Gindl W and Gupta HS
Composites Part a: Applied Science and Manufacturing vol. 33 (8), 1141-1145.  
01-08-2002

2001

bullet iconPrecipitate size distribution in alloys with and without lattice misfit
Weinkamer R, Gupta H, Lebowitz JL and Fratzl P
Zeitschrift Fuer Metallkunde/Materials Research and Advanced Techniques vol. 92 (1), 9-13.  
01-01-2001
bullet iconMicroscopic computer simulations of directional coarsening in face-centered cubic alloys
Gupta H, Weinkamer R, Fratzl P and Lebowitz JL
Acta Materialia, Elsevier vol. 49 (1), 53-63.  
01-01-2001

2000

bullet iconDynamics of mesoscopic precipitate lattices in phase-separating alloys under external load
Weinkamer R, Gupta H, Fratzl P and Lebowitz JL
Europhysics Letters vol. 52 (2), 224-230.  
01-01-2000

1996

bullet iconBackbones of traffic jams
Gupta HS and Ramaswamy R
Journal of Physics a: Mathematical and Theoretical, Iop Publishing vol. 29 (21) 
07-11-1996

Grants

solid heart iconGrants of specific relevance to the Centre for Bioengineering
solid heart iconTomo-SAXS: Imaging full-field molecular-to-macroscale biophysics of fibrous tissues
Himadri Gupta
£451,556 EPSRC Engineering and Physical Sciences Research Council
26-04-2021 - 25-10-2025

solid heart iconCorrelating structural and proteomic techniques on cartilage
Himadri Gupta and Martin Knight
£18,515 MRC Medical Research Council
24-07-2022 - 28-02-2023
solid heart iconTTL X-ray imaging
Himadri Gupta
£58,375 MRC Medical Research Council
01-05-2018 - 30-04-2022
solid heart iconCollagen Fibrillar Network in Ageing Cartilage
Himadri Gupta and Martin Knight
£374,874 BBSRC Biotechnology and Biological Sciences Research Council
01-10-2017 - 24-07-2023