Prof David Lee
Professor of Cell and Tissue Engineering
Deputy Vice Principal - Impact (Enterprise and Commercial Innovation)
School of Engineering and Materials Science
Queen Mary University of London
Queen Mary University of London
Research
Mechanobiology, Tissue engineering, Cell engineering, Regenerative medicine, Mesenchymal stem cell, Circadian biology
Interests
My main research interests lie in mechanobiology, a research field that lies at the interface between cell biology and bioengineering, involving studying the mechanisms by which cells and tissues resond to the application of mechanical loading. The response of our tissues to mechanical stimuli is critical to maintain healthy physiology and has been implicated in a range of pathologies, ranging from cancer to osteoarthritis. I have published over 100 refereed papers in chondrocyte and stem cell mechanobiology and my work investigating the effect of dynamic compression on inflammatory mediators was recognised by the prestigious Negma Lerads International Prize for Mechanobiology of Cartilage and Chondrocytes. I have been awarded over £5 million in grant funding as principal investigator in the past 10 years, including from the MRC, BBSRC, ESPRC, Wellcome Trust and an international multi-centre Human Frontier Science Program grant investigating mechanoregulation of nuclear organisation and genome function.My research has largely focussed on musculoskeletal tissues, particularly cartilage and tendon. I have looked at the process by which mechanical forces become transduced into biochemical pathways, for example those linked to MAP kinases and calcium fluxes across the cell membrane. Recent work has looked at stem cells and whether they can be induced to differentiate through mechanical stimuli. My work on mesenchymal stem cells has shown that the application of mechanical force can induce more rapid and robust differentiation than traditional biochemical differentiation cues such as growth factors. Loading seems to have a particularly profound effect on the cell nucleus, inducing alterations in the packing of DNA within chromatin and stiffening the nuclear membrane through changes in the nucleoskeleton.
Recently research has investigated the interplay between mechanobiology and the circadian clock which generates 24-hour cycles of biological activity. These studies are aimed at developing more physiologically relevant in vitro models, for example organ-on-a-chip systems, that may be used in drug discovery and other applications.
Publications
Publications of specific relevance to the Centre for Bioengineering2022
Modulation of sirtuins during monolayer chondrocyte culture influences cartilage regeneration upon transfer to a 3D culture environmentHeywood HK, Thorpe SD, Jeropoulos RM, Caton PW and Lee DA
Frontiers in Bioengineering and Biotechnology, Frontiers Media vol. 10
06-12-2022
Oscillations of the circadian clock protein, BMAL-1, align to daily cycles of mechanical stimuli: a novel means to integrate biological time within predictive in vitro model systemsHeywood HK, Gardner L, Knight MM and Lee DA
In Vitro Models, Springer Nature, 1-8.
31-08-2022
Covariation of Pluripotency Markers and Biomechanical Properties in Mouse Embryonic Stem CellsBrookes O, Thorpe SD, Evans OR, Keeling MC and Lee DA
Frontiers in Cell and Developmental Biology, Frontiers vol. 10
16-05-2022
2021
G Protein-Coupled Estrogen Receptor Regulates Actin Cytoskeleton Dynamics to Impair Cell PolarizationLachowski D, Cortes E, Matellan C, Rice A, Lee DA, Thorpe SD and del Río Hernández AE
Frontiers in Cell and Developmental Biology, Frontiers Media vol. 8, 592628-592628.
22-01-2021
2020
GPER activation inhibits cancer cell mechanotransduction and basement membrane invasion via RhoARice A, Cortes E, Lachowski D, Oertle P, Matellan C, Thorpe SD, Ghose R, Wang H, Lee DA, Plodinec M and Del Río Hernández AE
Cancers, Mdpi Ag vol. 12 (2)
25-01-2020
Syndecan-4 tunes cell mechanics by activating
the kindlin-integrin-RhoA pathwayThorpe S, Chronopoulos A, Cortes E, Lachowski D, Rice A, Mykuliak V, Róg T, Lee D, Hytonen V and del Río Hernández A
Nature Materials, Nature Research
06-01-2020
2018
Tamoxifen mechanically deactivates hepatic stellate cells via the G protein-coupled estrogen receptorCortes E, Lachowski D, Rice A, THORPE SD, Robinson B, Yeldag G, LEE DA, Ghemtio L, Rombouts K and del Río Hernández AE
Oncogene, Springer Nature [Academic Journals On Nature.Com]
21-12-2018
Tamoxifen mechanically reprograms the tumor microenvironment via HIF‐1A and reduces cancer cell survivalCortes E, Lachowski D, Robinson B, Sarper M, Teppo JS, Thorpe SD, Lieberthal TJ, Iwamoto K, Lee DA, Okada‐Hatakeyama M, Varjosalo MT and del Río Hernández AE
Embo Reports, Springer Nature vol. 20 (1)
12-12-2018
GPER is a mechanoregulator of pancreatic stellate cells and the tumor microenvironmentCortes E, Sarper M, Robinson B, Lachowski D, Chronopoulos A, Thorpe SD, Lee DA and del Río Hernández AE
Embo Reports, Springer Nature vol. 20 (1)
11-12-2018
RAR‐β is downregulated in HCC & cirrhosis and its expression inhibits myosin‐driven activation and durotaxis in hepatic stellate cellsCortes E, Lachowski D, Rice A, Chronopoulos A, Robinson B, THORPE SD, LEE DA, Possamai LA, Wang H, Pinato DJ and del Rio Hernández AE
Hepatology, Wiley
28-07-2018
2017
Development of a two-stage gene selection method that incorporates a novel hybrid approach using the cuckoo optimization algorithm and harmony search for cancer classificationElyasigomari V, Lee DA, Screen HRC and SHAHEED MH
Journal of Biomedical Informatics vol. 67 (2017), 11-20.
03-02-2017
Dynamic regulation of nuclear architecture and mechanics—a rheostatic role for the nucleus in tailoring cellular mechanosensitivityTHORPE SD and Lee DA
Nucleus, Taylor & Francis vol. 8 (3), 287-300.
02-02-2017
Stem cell differentiation state modulates Lamin AC localization and phosphorylation in response to cyclic tensile strainThorpe SD, Oti A, Mauck RL and Lee DA
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 98 (1), A13-A14.
01-01-2017
Does lamin A/C play a role in neuronal differentiation?Eraifej J, Thorpe SD, Martins RP and Lee DA
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 98 (1), A12-A12.
01-01-2017
Small molecule activators of SIRT1 augment the regenerative potential of chondrocytes for cell-based cartilage repair techniquesHeywood HK, Thorpe SD, Jeropoulos RM and Lee DA
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 98 (6), A14-A14.
01-01-2017
Uniaxial tensile strain modulates mesenchymal stem cell nuclear structure and histone methylation in a differentiation dependent mannerPanesar KS, Thorpe SD and Lee DA
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 98 (6), A11-A12.
01-01-2017
2016
Differentiation alters stem cell nuclear architecture, mechanics, and mechano-sensitivity.Heo S-J, Driscoll TP, Thorpe SD, Nerurkar NL, Baker BM, Yang MT, Chen CS, Lee DA and Mauck RL
Elife, Elife Sciences Publications Ltd vol. 5
30-11-2016
Oxygen tension modulates the effects of TNFα in compressed chondrocytes.Tilwani RK, Vessillier S, Pingguan-Murphy B, Lee DA, Bader DL and Chowdhury TT
Inflamm Res
22-09-2016
Mechanically Induced Chromatin Condensation Requires Cellular Contractility in Mesenchymal Stem CellsHeo SJ, Han WM, Szczesny SE, Cosgrove BD, Elliott DM, Lee DA, Duncan RL and Mauck RL
Biophysical Journal vol. 111 (4), 864-874.
23-08-2016
Bioenergetic reprogramming of articular chondrocytes by exposure to exogenous and endogenous reactive oxygen species and its role in the anabolic response to low oxygenHeywood HK and Lee DA
Journal of Tissue Engineering and Regenerative Medicine vol. 11 (8), 2286-2294.
22-06-2016
Chondrocyte dedifferentiation increases cell stiffness by strengthening membrane-actin adhesionSliogeryte K, Botto L, Lee DA and Knight MM
Osteoarthritis and Cartilage, Elsevier vol. 24 (5), 912-920.
01-05-2016
States rights and Australia’s adoption of the statute of Westminster, 1931–1942Lee D
History Australia, Taylor & Francis vol. 13 (2), 258-274.
02-04-2016
Type VI Collagen Regulates Dermal Matrix Assembly and Fibroblast MotilityTheocharidis G, Drymoussi Z, Kao AP, Barber AH, Lee DA, Braun KM and Connelly JT
Journal of Investigative Dermatology, Elsevier vol. 136 (1), 74-83.
01-01-2016
Type VI Collagen Regulates Dermal Matrix Assembly and Fibroblast Motility.Theocharidis G, Drymoussi Z, Kao AP, Barber AH, Lee DA, Braun KM and Connelly JT
J Invest Dermatol vol. 136 (1), 74-83.
01-01-2016
SIRT1, an enzyme vital to cartilage homeostasis, is regulated by osmolarity and glucose levelsHeywood HK, Caton PW and Lee DA
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 97 (6), A2-A2.
01-01-2016
2015
Biophysical Regulation of Chromatin Architecture Instills a Mechanical Memory in Mesenchymal Stem CellsHeo S-J, Thorpe SD, Driscoll TP, Duncan RL, Lee DA and Mauck RL
Scientific Reports, Springer Nature vol. 5 (1)
23-11-2015
FINITE ELEMENT ANALYSIS OF MECHANICAL DEFORMATION OF CHONDROCYTE TO 2D SUBSTRATE AND 3D SCAFFOLDCHEN J, BADER DL, LEE DA and KNIGHT MM
Journal of Mechanics in Medicine and Biology, World Scientific Publishing vol. 15 (05)
01-10-2015
2014
Stem cell differentiation increases membrane-actin adhesion regulating cell blebability, migration and mechanicsSliogeryte K, Thorpe SD, Lee DA, Botto L and Knight MM
Scientific Reports, Springer Nature vol. 4 (1)
04-12-2014
Quantification of chromatin condensation level by image processing.Irianto J, Lee DA and Knight MM
Med Eng Phys vol. 36 (3), 412-417.
01-03-2014
Culture expansion in low-glucose conditions preserves chondrocyte differentiation and enhances their subsequent capacity to form cartilage tissue in three-dimensional culture.Heywood HK, Nalesso G, Lee DA and Dell'accio F
Biores Open Access vol. 3 (1), 9-18.
01-02-2014
Mesenchymal stem cell nuclear architecture is differentially regulated by lineage commitment and mechanical stimulationThorpe SD and Lee DA
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 95 (3), A33-A33.
01-01-2014
Reactive oxygen species drive the transformation to an oxidative energy metabolism in cultured articular chondrocytesHeywood HK and Lee DA
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 95 (3), A15-A16.
01-01-2014
Hypoxia amplified catabolic effects induced by TNFα in chondrocytes - response reduced with biomechanical signalsTilwani RK, Lee DA, Pingguan-Murphy B, Abas WABW and Chowdhury TT
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 95 (3), A33-A34.
01-01-2014
2013
Osmotic challenge drives rapid and reversible chromatin condensation in chondrocytes.Irianto J, Swift J, Martins RP, McPhail GD, Knight MM, Discher DE and Lee DA
Biophys J vol. 104 (4), 759-769.
19-02-2013
Continuous and Uninterrupted Oxygen Tension Influences the Colony Formation and Oxidative Metabolism of Human Mesenchymal Stem CellsPattappa G, Thorpe SD, Jegard NC, Heywood HK, de Bruijn JD and Lee DA
Tissue Engineering Part C-Methods vol. 19 (1)
01-01-2013
2012
New functional families (FunFams) in CATH to improve the mapping of conserved functional sites to 3D structuresSillitoe I, Cuff AL, Dessailly BH, Dawson NL, Furnham N, Lee D, Lees JG, Lewis TE, Studer RA, Rentzsch R, Yeats C, Thornton JM and Orengo CA
Nucleic Acids Research, Oxford University Press (Oup) vol. 41 (D1), d490-d498.
29-11-2012
Cell mechanics, structure, and function are regulated by the stiffness of the three-dimensional microenvironment.Chen J, Irianto J, Inamdar S, Pravincumar P, Lee DA, Bader DL and Knight MM
Biophys J vol. 103 (6), 1188-1197.
19-09-2012
Dynamic compressive strain influences chondrogenic gene expression in human periosteal cells: a case study.Bonzani IC, Campbell JJ, Knight MM, Williams A, Lee DA, Bader DL and Stevens MM
J Mech Behav Biomed Mater vol. 11, 72-81.
01-07-2012
The mechanics of flexor tendon adhesionsBranford OA, Lee DA, Bader DL and Grobbelaar AO
Journal of Hand Surgery: European Volume vol. 37 (6), 555-563.
01-07-2012
The attachment of intrinsic and extrinsic, mobilized and immobilized adhesion cells to collagen and fibronectinBranford OA, Lee DA, Rolfe KJ and Grobbelaar AO
Journal of Hand Surgery: European Volume vol. 37 (6), 564-572.
01-07-2012
Improving metabolic flux predictions using absolute gene expression dataLee D, Smallbone K, Dunn WB, Murabito E, Winder CL, Kell DB, Mendes P and Swainston N
Bmc Systems Biology, Springer Nature vol. 6 (1)
19-06-2012
Through pellicle management of haze formation in a wafer fabrication environmentFigliolini A, Archuletta M, LeClaire J, Brinkley D, Doerr D, White R, Bozak R and Lee DA
28th European Mask and Lithography Conference. vol. 8352
16-04-2012
Stanley Melbourne Bruce in London, 1938–41Lee D
The Journal of Imperial & Commonwealth History, Taylor & Francis vol. 40 (1), 45-65.
01-03-2012
Scaling and mesostructure of Carbopol dispersionsGutowski IA, Lee D, de Bruyn JR and Frisken BJ
Rheologica Acta, Springer Nature vol. 51 (5), 441-450.
18-01-2012
Single photon counting fluorescence lifetime detection of pericellular oxygen concentrations.Hosny NA, Lee DA and Knight MM
J Biomed Opt vol. 17 (1)
01-01-2012
Gap junction permeability between tenocytes within tendon fascicles is suppressed by tensile loadingMaeda E, Ye S, Wang W, Bader DL, Knight MM and Lee DA
Biomechanics and Modeling in Mechanobiology vol. 11 (3-4), 439-447.
01-01-2012
Mechanical regulation of nuclear structure and function.Martins RP, Finan JD, Guilak F and Lee DA
Annu Rev Biomed Eng vol. 14, 431-455.
01-01-2012
2011
White Globules in Melanocytic Neoplasms: In Vivo and Ex Vivo CharacteristicsJaimes N, Scope A, Welzel J, Wang KX, Lee DA, Siegel DM and Marghoob AA
Dermatologic Surgery, Wolters Kluwer vol. 38 (1), 128-132.
31-10-2011
Clean and repair of EUV photomasksRobinson T, Yi D, Brinkley D, Roessler K, White R, Bozak R, Archuletta M and Lee D
Photomask Technology 2011. vol. 8166
06-10-2011
The metabolism of human mesenchymal stem cells during proliferation and differentiation.Pattappa G, Heywood HK, de Bruijn JD and Lee DA
J Cell Physiol vol. 226 (10), 2562-2570.
01-10-2011
Anisotropic strain transfer through the aortic valve and its relevance to the cellular mechanical environment.Lewinsohn AD, Anssari-Benham A, Lee DA, Taylor PM, Chester AH, Yacoub MH and Screen HRC
Proc Inst Mech Eng H vol. 225 (8), 821-830.
01-08-2011
Extensive oral herpes simplex virus type 1 infection in a haematopoietic stem cell transplant recipient not responding to aciclovirMoses SE, Osborne W, Valappil M, Collin M, Lee D, Waugh S, Jackson G, Parry CM and Crowley B
Journal of Clinical Virology, Elsevier vol. 52 (2), 67-69.
14-06-2011
Investigating the microstructure of a yield-stress fluid by light scatteringLee D, Gutowski IA, Bailey AE, Rubatat L, de Bruyn JR and Frisken BJ
Physical Review E, American Physical Society (Aps) vol. 83 (3)
01-03-2011
Gap junction permeability between tenocytes within tendon fascicles is suppressed by tensile loadingMaeda E, Ye S, Wang W, Bader DL, Knight MM and Lee DA
Biomechanics and Modeling in Mechanobiology, 1-9.
01-01-2011
Anisotropic strain transfer through the aortic valve and its relevance to the cellular mechanical environmentLewinsohn AD, Anssari-Benham A, Lee DA, Taylor PM, Chester AH, Yacoub MH and Screen HRC
P I Mech Eng H vol. 225 (H8), 821-830.
01-01-2011
Finite Element Modeling of Cell Deformation When Chondrocyte Seeded Agarose Is Subjected to CompressionChen J, Bader DL, Lee DA and Knight MM
8TH INTERNATIONAL CONFERENCE ON CELL & STEM CELL ENGINEERING (ICCE). vol. 30, 17-20.
01-01-2011
Electrospray deposited fibronectin retains the ability to promote cell adhesionMartyn SV, Heywood HK, Rockett P, Paine MD, Wang MJ, Dobson PJ, Sheard SJ, Lee DA and Stark JPW
Journal of Biomedical Materials Research - Part B Applied Biomaterials vol. 96 B (1), 110-118.
01-01-2011
Stem cell mechanobiology.Lee DA, Knight MM, Campbell JJ and Bader DL
J Cell Biochem vol. 112 (1), 1-9.
01-01-2011
1,000 structures and more from the MCSGLee D, de Beer TA, Laskowski RA, Thornton JM and Orengo CA
Bmc Molecular and Cell Biology, Springer Nature vol. 11 (1)
01-01-2011
Novel devices for diagnosis and treatment.Lee DA and Siegel DM
Journal of Drugs in Dermatology vol. 10 (1), 21-22.
01-01-2011
Quantification of mRNA using real-time PCR and Western blot analysis of MAPK events in chondrocyte/agarose constructs.Lee DA, Brand J, Salter D, Akanji O-O and Chowdhury TT
Methods Mol Biol vol. 695, 77-97.
01-01-2011
2010
The metabolism of human mesenchymal stem cells during proliferation and differentiation.Pattappa G, Heywood HK, de Bruijn JD and Lee DA
J Cell Physiol
28-12-2010
Functional analysis of tenocytes gene expression in tendon fascicles subjected to cyclic tensile strainMaeda E, Fleischmann C, Mein CA, Shelton JC, Bader DL and Lee DA
Connective Tissue Research vol. 51 (6), 434-444.
01-12-2010
Both superficial and deep zone articular chondrocyte subpopulations exhibit the crabtree effect but have different basal oxygen consumption ratesHeywood HK, Knight MM and Lee DA
Journal of Cellular Physiology vol. 223 (3), 630-639.
01-06-2010
Through-pellicle defect repair for advanced photomasksRobinson T, White R, Bozak R, LeClaire J, Archuletta M and Lee D
Photomask and Next-Generation Lithography Mask Technology XVII. vol. 7748
29-04-2010
Nanomachining of non-orthogonal mask patternsRobinson T, Yi D, White R, Bozak R, Archuletta M and Lee D
Photomask and Next-Generation Lithography Mask Technology XVII. vol. 7748
29-04-2010
Preliminary results for photomask haze mitigation in a fab environmentKu T, LeClaire J, Tan SK, Chua GS, Bozak R, White R, Robinson T, Archuletta M and Lee D
Metrology, Inspection, and Process Control for Microlithography XXIV. vol. 7638
11-03-2010
A compartment model to evaluate the permeability of gap junctions between tenocytes in tendon fasciclesYe S, Maeda E, Knight M, Lee D, Bader D and Wang W
Faseb Journal vol. 24
01-01-2010
Low oxygen reduces the modulation to an oxidative phenotype in monolayer-expanded chondrocytes.Heywood HK and Lee DA
J Cell Physiol vol. 222 (1), 248-253.
01-01-2010
Extracellular oxygen concentration mapping with confocal multiphoton laser scanning microscope and TCSPC cardHosny NA, Lee DA and Knight MM
MULTIPHOTON MICROSCOPY IN THE BIOMEDICAL SCIENCES X. vol. 7569 Editors: Periasamy A, So PTC and Konig K.
01-01-2010
2009
Effect of intermittent cyclic tensile strain on collagen synthesis by tenocytes in isolated fasciclesMaeda E, Shelton JC, Bader DL and Lee DA
Journal of Biomechanical Science and Engineering vol. 4 (4), 510-517.
01-12-2009
GeMMA: functional subfamily classification within superfamilies of predicted protein structural domainsLee DA, Rentzsch R and Orengo C
Nucleic Acids Research, Oxford University Press (Oup) vol. 38 (3), 720-737.
18-11-2009
New tools to enable photomask repair to the 32nm nodeRobinson T, White R, Bozak R, Roessler K, Arruza B, Hogle D, Archuletta M and Lee D
Photomask Technology 2009. vol. 7488
23-09-2009
The effect of oxygen tension on the proliferation and differentiation of human mesenchymal stem cellsPattappa G, Jegard NC, Lee DA and de Bruijn JD
European Cells and Materials vol. 18 (SUPPL. 1)
01-08-2009
Osteogenic differentiation of human mesenchymal stem cells within a perfused bioreactor systemCampbell JJ, Maeda E, Ye SJ, Wang W and Lee DA
European Cells and Materials vol. 18 (SUPPL. 2)
01-07-2009
The influence of oxygen tension on the colony formation and proliferation of human mesenchymal stem cellsPattappa G, Jegard NC, de Bruijn JD and Lee DA
European Cells and Materials vol. 18 (SUPPL. 2)
01-07-2009
Graded hydrogel constructs for cartilage tissue engineeringMcleod R, Pattappa G, Irianto J, Awan M, Knight MM and Lee DA
European Cells and Materials. vol. 18 (SUPPL. 2)
01-07-2009
Selective removal of persistent particles with no photomask damageRobinson T, Bozak R, White R, Archuletta M and Lee D
Photomask and Next-Generation Lithography Mask Technology XVI. vol. 7379
24-04-2009
Differential regulation of gene expression in isolated tendon fascicles exposed to cyclic tensile strain in vitroMaeda E, Shelton JC, Bader DL and Lee DA
Journal of Applied Physiology vol. 106 (2), 506-512.
01-02-2009
The development of a bioreactor to perfuse radially-confined hydrogel constructs: design and characterization of mass transport properties.Eniwumide JO, Lee DA and Bader DL
Biorheology vol. 46 (5), 417-437.
01-01-2009
Cell-generated forces influence the viability, metabolism and mechanical properties of fibroblast-seeded collagen gel constructs.Berry CC, Shelton JC and Lee DA
J Tissue Eng Regen Med vol. 3 (1), 43-53.
01-01-2009
2008
Metabolic characteristics of human mesenchymal stem cells expanded under normoxic conditionsPattappa G, A. Lee D and De Bruijn JD
8th World Biomaterials Congress 2008 vol. 1
01-12-2008
Analysis of process margin in EUV mask repair with nano-machiningLee S-Y, Kim G-B, Sim H-S, Lee S-H, Kim H-S, Lee J-H, Seo H-S, Han H-S, Kim S-S, Moon S-Y, Woo S-G, Bozak R, Dinsdale A, Robinson T, Lee D and Cho H
Photomask Technology 2008. vol. 7122
17-10-2008
Phenotypic analysis of Arabidopsis mutants: heavy metal stress.Lee D and Schroeder J
Cold Spring Harbor Protocols, Cold Spring Harbor Laboratory vol. 2008 (9)
01-09-2008
Monolayer expansion induces an oxidative metabolism and ROS in chondrocytes.Heywood HK and Lee DA
Biochem Biophys Res Commun vol. 373 (2), 224-229.
22-08-2008
Collagen synthesis by tenocytes in fascicles subjected to intermittent cyclic strainMaeda E, Shelton JC, Bader DL and Lee DA
European Cells and Materials vol. 16 (SUPPL. 3)
01-07-2008
The effect of oxygen supply on chondrocyte metabolic phenotype during monolayer cultureHeywood HK and Lee DA
European Cells and Materials vol. 16 (SUPPL. 3)
01-07-2008
Signal transduction pathways involving p38 MAPK, JNK, NF kappa B and AP-1 influences the response of chondrocytes cultured in agarose constructs to IL-1 beta and dynamic compressionChowdhury TT, Salter DM, Bader DL and Lee DA
Inflamm Res vol. 57 (7), 306-313.
01-07-2008
Advantages, Disadvantages, and Uses of Generalized Activity Networks for Schedule EstimationHughes D, Whitaker Y, Lee D and Eckhause J
Military Operations Research, Military Operations Research Society vol. 13 (3), 27-40.
01-06-2008
Mechanical loading modulates intracellular calcium signaling in human mesenchymal stem cellsCampbell JJ, Bader DL and Lee DA
J Appl Biomater Biom vol. 6 (1), 9-15.
01-01-2008
Dynamic compression counteracts IL-1beta induced inducible nitric oxide synthase and cyclo-oxygenase-2 expression in chondrocyte/agarose constructs.Chowdhury TT, Arghandawi S, Brand J, Akanji OO, Bader DL, Salter DM and Lee DA
Arthritis Res Ther vol. 10 (2)
01-01-2008
Dynamic compression influences interleukin-1 beta-induced nitric oxide and prostaglandin E-2 release by articular chondrocytes via alterations in iNOS and COX-2 expressionChowdhury TT, Akanji OO, Salter DM, Bader DL and Lee DA
Biorheology vol. 45 (3-4), 257-274.
01-01-2008
The effects of direct current stimulation on isolated chondrocytes seeded in 3D agarose constructsAkanji OO, Lee DA and Bader DA
BIORHEOLOGY. vol. 45 (3-4), 229-243.
01-01-2008
Surgeons carry out first implant of pulmonary human heart valveLee DA
Biomedical Materials (MAY)
01-01-2008
2007
52 REAL-TIME PCR USING MOLECULAR BEACONS TO DETECT INOS AND COX-2 EXPRESSION IN CHONDROCYTE/AGAROSE CONSTRUCTS SUBJECTED TO IL-1β AND DYNAMIC COMPRESSIONChowdhury TT, Akanji OO, Arghandawi S, Salter DM, Bader DL and Lee DA
Osteoarthritis and Cartilage, Elsevier vol. 15, c42-c43.
01-12-2007
Predicting protein function from sequence and structureLee D, Redfern O and Orengo C
Nature Reviews Molecular Cell Biology, Springer Nature vol. 8 (12), 995-1005.
01-12-2007
Root contact during insertion of miniscrews for orthodontic anchorage increases the failure rate: an animal studyChen Y-H, Chang H-H, Chen Y-J, Lee D, Chiang H-H and Jane Yao C-C
Clinical Oral Implants Research, Wiley, 071025001541005-???.
23-10-2007
Time dependence of cyclic tensile strain on collagen production in tendon fascicles.Maeda E, Shelton JC, Bader DL and Lee DA
Biochem Biophys Res Commun vol. 362 (2), 399-404.
19-10-2007
Repairing 45 nm node defects through nano-machiningWhite R, Dinsdale A, Robinson T, Brinkley D, Csuy J and Lee D
Photomask Technology 2007. vol. 6730
02-10-2007
Development of an immunoassay for determination of adsorbed fibronectin levels on bio-functionalised substratesHeywood HK and Lee DA
TISSUE ENGINEERING. vol. 13 (7), 1669-1670.
01-07-2007
Mechanical loading modulates calcium signalling within mesenchymal stem cellsCampbell JJ, Bader DL and Lee DA
TISSUE ENGINEERING. vol. 13 (7), 1722-1723.
01-07-2007
Mesenchymal stem cells maintain a glycolytic metabolism under normoxic conditionsPattappa G, De Bruijn JD and Lee DA
TISSUE ENGINEERING. vol. 13 (7), 1725-1725.
01-07-2007
Gene expressions in tendon fascicles subjected to cyclic tensile strainMaeda E, Shelton JC, Bader DL and Lee DA
TISSUE ENGINEERING. vol. 13 (7), 1701-1701.
01-07-2007
The development and characterisation of chondrocyte-seeded gradient hydrogel constructs for cartilage tissue engineeringMcleod R, Pattappa G, Irianto J, Knight MM and Lee DA
TISSUE ENGINEERING. vol. 13 (7), 1763-1763.
01-07-2007
Dynamic compression counteracts IL-1 beta b induced iNOS and COX-2 expression in chondrocytes cultured in agarose constructsChowdhury TT, Akanji OO, Arghandawi , Salter DM, Bader DL and Lee DA
TISSUE ENGINEERING. vol. 13 (7), 1677-1677.
01-07-2007
A model for studying the influence of mechanical loading on human periosteal stem cellsBonzani IC, Knight MM, Lee DA, Bader DL, Williams A and Stevens MM
TISSUE ENGINEERING. vol. 13 (7), 1636-1636.
01-07-2007
Products: CryoLife wins US patent for foam wound sealantLee DA
Biomedical Materials (JULY)
01-01-2007
Products: CryoLife wins rights to distribute replacement pericardiumLee DA and Hall J
Biomedical Materials (MAR.)
01-01-2007
Industry news: CryoLife signs Irish distribution deal with Proxy BiomedicalLee DA
Biomedical Materials (NOV.), 6-7.
01-01-2007
2006
Glucose concentration and medium volume influence cell viability and glycosaminoglycan synthesis in chondrocyte-seeded alginate constructs.Heywood HK, Bader DL and Lee DA
Tissue Eng United States. vol. 12 (12), 3487-3496.
01-12-2006
New aluminum hydroxide and magnesium hydroxide grades with enhanced flame retardancyLee DA and Herbiet R
Society of Petroleum Engineers International Conference on Polyolefins 2006: From Reserves to Retailers - The Changes Confronting the Polyolefins Business Worldwide. vol. 2, 842-878.
23-11-2006
Glucose Concentration and Medium Volume Influences Cell Viability and Glycosaminoglycan Synthesis in Chondrocyte-Seeded Alginate ConstructsHeywood HK, Bader DL and Lee DA
Tissue Engineering, Mary Ann Liebert
20-11-2006
Self-Assembly of Latex Particles into Proton-Conductive MembranesGao J, Yang Y, Lee D, Holdcroft S and Frisken BJ
Macromolecules, American Chemical Society (Acs) vol. 39 (23), 8060-8066.
17-10-2006
Precise and high-throughput femtopulse laser mask repair of large defectsWhite R, LeClaire J, Robinson T, Dinsdale A, Bozak R and Lee DA
Photomask Technology 2006. vol. 6349
06-10-2006
Impact of AFM scan artifacts on photolithographic simulationRobinson T, Lewellen J, Lee DA and Brooker P
Photomask Technology 2006. vol. 6349
06-10-2006
The influence of swelling and matrix degradation on the microstructural integrity of tendon.Screen HRC, Chhaya VH, Greenwald SE, Bader DL, Lee DA and Shelton JC
Acta Biomater vol. 2 (5), 505-513.
01-09-2006
Direct current influences Ca 2+ signalling in chondrocytesAkanji OO, Bader DL and Lee DA
European Cells and Materials vol. 11 (SUPPL.2)
01-06-2006
Chondrocyte deformation induces mitochondrial distortion and heterogeneous intracellular strain fieldsKnight MM, Bomzon Z, Kimmel E, Sharma AM, Lee DA and Bader DL
Biomech Model Mechan vol. 5 (2-3), 180-191.
01-06-2006
Integrin-mediated mechanotransduction in IL-1 beta stimulated chondrocytes.Chowdhury TT, Appleby RN, Salter DM, Bader DA and Lee DA
Biomech Model Mechanobiol vol. 5 (2-3), 192-201.
01-06-2006
1.3 The quantitative assessment of flexor tendon adhesion – a novel use of confocal microscopy to evaluate local strain, orientation and organisationBRANFORD O, LEE D, BADER D and GROBBELAAR A
Journal of Hand Surgery (European Volume), Sage Publications vol. 31, 3-3.
01-06-2006
Femtopulse laser-based mask repair in the DUV wavelength regimeGhadiali F, Tolani V, Nagpal R, Robinson T, LeClaire J, Bozak R, Lee DA and White R
Photomask and Next-Generation Lithography Mask Technology XIII. vol. 6283
03-05-2006
Application of photolithographic simulation and a mask repair system in a production environmentRobinson T, Lewellen J, Bozak R, Lee DA and Brooker P
Photomask and Next-Generation Lithography Mask Technology XIII. vol. 6283
03-05-2006
Comprehensive genome analysis of 203 genomes provides structural genomics with new insights into protein family spaceMarsden RL, Lee D, Maibaum M, Yeats C and Orengo CA
Nucleic Acids Research, Oxford University Press (Oup) vol. 34 (3), 1066-1080.
06-02-2006
Rate of oxygen consumption by isolated articular chondrocytes is sensitive to medium glucose concentrationHeywood HK, Bader DL and Lee DA
Journal of Cellular Physiology vol. 206 (2), 402-410.
01-02-2006
Exploiting protein structure data to explore the evolution of protein function and biological complexityMarsden RL, Ranea JAG, Sillero A, Redfern O, Yeats C, Maibaum M, Lee D, Addou S, Reeves GA, Dallman TJ and Orengo CA
Philosophical Transactions of The Royal Society B Biological Sciences, The Royal Society vol. 361 (1467), 425-440.
01-02-2006
Anti-inflammatory effects of IL-4 and dynamic compression in IL-1beta stimulated chondrocytes.Chowdhury TT, Bader DL and Lee DA
Biochem Biophys Res Commun vol. 339 (1), 241-247.
06-01-2006
Mechanical compression and hydrostatic pressure induce reversible changes in actin cytoskeletal organisation in chondrocytes in agarose.Knight MM, Toyoda T, Lee DA and Bader DL
J Biomech vol. 39 (8), 1547-1551.
01-01-2006
Dynamic compression counteracts IL-1beta induced iNOS and COX-2 activity by human chondrocytes cultured in agarose constructs.Chowdhury TT, Bader DL and Lee DA
Biorheology vol. 43 (3,4), 413-429.
01-01-2006
Dynamic compressive strain influences chondrogenic gene expression in human mesenchymal stem cellsCampbell JJ, Lee DA and Bader DL
BIORHEOLOGY. vol. 43 (3-4), 455-470.
01-01-2006
Chondrocyte Deformation and Mechanotransduction in Cartilage Model Systems(International Workshop 2)Bader DL, Lee DA and Knight MM
The Proceedings of The Bioengineering Conference Annual Meeting of Bed/Jsme, Japan Society of Mechanical Engineers vol. 2005.18, 2-3.
01-01-2006
P140 DYNAMIC COMPRESSION COUNTERACTS FIBRONECTIN FRAGMENT INDUCED UPREGULATION OF NITRIC OXIDEChowdhury TT, Raveenthiran SP, Bader DL and Lee DA
Osteoarthritis and Cartilage, Elsevier vol. 14
01-01-2006
Gene3D: modelling protein structure, function and evolutionYeats C, Maibaum M, Marsden R, Dibley M, Lee D, Addou S and Orengo CA
Nucleic Acids Research, Oxford University Press (Oup) vol. 34 (suppl_1), d281-d284.
01-01-2006
Industry news: CryoLife, BioForm sign glue dealLee DA and Gridley A
Biomedical Materials (DEC.), 7-8.
01-01-2006
Spinal implants: CryoLife's spinal disc repair study completes enrolmentLee DA
Biomedical Materials (SEP.), 9-10.
01-01-2006
Government: US law ensures funding for protein hydrogel developmentLee DA
Biomedical Materials (DEC.)
01-01-2006
Concentration and M/G ratio influence the physiochemical and mechanical properties of alginate constructs for tissue engineering.Enobakhare B, Bader DL and Lee DA
J Appl Biomater Biomech vol. 4 (2), 87-96.
01-01-2006
2005
Cyclic mechanical conditioning of isolated tendon fascicles results in an upregulation of collagen productionScreen HRC, Bader DL, Shelton JC and Lee DA
Proceedings of The 2005 Summer Bioengineering Conference vol. 2005, 193-194.
01-12-2005
Dynamic compression counteracts IL-1-induced iNOS and COX-2 activity by human chondrocytes cultured in agarose constructsChowdhury TT, Bader DL and Lee DA
Proceedings of The 2005 Summer Bioengineering Conference vol. 2005, 251-252.
01-12-2005
Integrin mediated mechanotransduction in IL-1 stimulated bovine chondrocytes cultured in agarose constructsChowdhury TT, Appleby RN, Salter DA, Bader DL and Lee DA
Proceedings of The 2005 Summer Bioengineering Conference vol. 2005, 545-546.
01-12-2005
Dynamic compression activates chondrocyte calcium signaling in a cycle dependent manner involving the release of ATPPingguan B, Lee DA, Bader DL and Knight MM
Proceedings of the 2005 Summer Bioengineering Conference. vol. 2005, 223-224.
01-12-2005
Identification and characterization of deposited fibronectin on biocompatible materials: Comparison of electrospray and wetting methodsWang MJ, Heywood HK, Bader DL, Paine MD, Stark JPW and Lee DA
Proceedings of The 2005 Summer Bioengineering Conference vol. 2005, 439-440.
01-12-2005
Mechanical conditioning of cell-seeded constructs for soft tissue repair - Are optimisation strategies possible?Bader DL and Lee DA
, 165-192.
01-12-2005
Activation of chondrocytes calcium signalling by dynamic compression is independent of number of cycles.Pingguan-Murphy B, Lee DA, Bader DL and Knight MM
Arch Biochem Biophys vol. 444 (1), 45-51.
01-12-2005
Cyclic tensile strain upregulates collagen synthesis in isolated tendon fascicles.Screen HRC, Shelton JC, Bader DL and Lee DA
Biochem Biophys Res Commun vol. 336 (2), 424-429.
21-10-2005
Integration of photolithographic simulation and a mask repair system into a single concurrent work cellRobinson T, Brooker P, Bozak R and Lee DA
25th Annual BACUS Symposium on Photomask Technology. vol. 5992
21-10-2005
Mask repair for the 65-nm technology nodeRobinson T, Dinsdale A, Bozak R, White R, Lee DA and Roessler K
25th Annual BACUS Symposium on Photomask Technology. vol. 5992
21-10-2005
Nutrient utilization by bovine articular chondrocytes: a combined experimental and theoretical approach.Sengers BG, Heywood HK, Lee DA, Oomens CWJ and Bader DL
J Biomech Eng vol. 127 (5), 758-766.
01-10-2005
The influence of noncollagenous matrix components on the micromechanical environment of tendon fascicles.Screen HRC, Shelton JC, Chhaya VH, Kayser MV, Bader DL and Lee DA
Ann Biomed Eng vol. 33 (8), 1090-1099.
01-08-2005
Dynamic compression counteracts IL-1β induced INOS and COX-2 activity by human chondrocytes cultured in agarose constructsChowdhury TT, Bader DL and Lee DA
European Cells and Materials vol. 10 (SUPPL.2)
01-07-2005
Dynamic compression influences the biochemical response of human mesenchymal stem cells cultured in agarose constructsCatuogno C, Chowdhury TT, Bader DL and Lee DA
European Cells and Materials vol. 10 (SUPPL.2)
01-07-2005
Mechanical compression activates chondrocyte Calcium signalling in a cycle dependent Manner Involving the release of ATPPingguna B, Lee DA, Bader DL and Knight MM
European Cells and Materials. vol. 10 (SUPPL.2)
01-07-2005
Perfusion-Enhancement of molecular transport within 3D scaffoldsEniwumide JO, Lee DA and Bader DL
European Cells and Materials vol. 10 (SUPPL.2)
01-07-2005
Superficial and deep chondrocyte subpopulations both express the crabtree effect but exhibit differences in oxygen consumption rateHeywood HK, Bader DL and Lee DA
European Cells and Materials vol. 10 (SUPPL.2)
01-07-2005
Mechanical conditioning Influences Mesenchymal stem cell chondrogenesisCampbell JJ, Lee DA and Bader DL
European Cells and Materials vol. 10 (SUPPL.2)
01-07-2005
Improved cycle time of mask repair by optimizing nanomachining with photolithographic imaging simulationBrooker P, Robinson T, Lewellen J, Naber B, Bozak R and Lee DA
Photomask and Next-Generation Lithography Mask Technology XII. vol. 5853, 1009-1020.
28-06-2005
Self-Assembly of Surface-Charged Latex Nanoparticles: A New Route to the Creation of Continuous Channels for Ion ConductionGao J, Lee D, Yang Y, Holdcroft S and Frisken BJ
Macromolecules, American Chemical Society (Acs) vol. 38 (14), 5854-5856.
15-06-2005
Cyclic tensile strain upregulates collagen production in isolated tendon fasciclesScreen HRC, Shelton JC, Bader DL and Lee DA
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 86 (3), A8-A9.
01-06-2005
Glucose metabolism of chondrocytes in tissue-engineered alginate constructsHeywood HK, Bader DL and Lee DA
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 86 (3), A13-A14.
01-06-2005
The effect of substrate and medium composition on the response of human dermal fibroblasts to cyclic tensile strain in vitroBaria KE, Bader DL, Screen HRC and Lee DA
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 86 (3), A32-A33.
01-06-2005
Compression-induced reorganization of cytoplasmic networks in bovine chondrocytes using mitochondria as markersSharma A, Bomzon Z, Lee DA, Kimmel E, Bader DL and Knight MM
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 86 (3), A34-A34.
01-06-2005
Integrin-mediated mechanotransduction in IL-1 beta-stimulated chondrocytesAppleby RN, Chowdhury TT, Salter DM, Bader DL and Lee DA
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. vol. 86 (3), A38-A39.
01-06-2005
British Society for Matrix Biology Autumn Meeting Joint with the UK Tissue & Cell Engineering Society, University of Bristol, UKInternational Journal of Experimental Pathology, Wiley vol. 86 (3), a1-a56.
24-05-2005
Trimethylamine N-oxide reduces the effects of osmotic stress in EBS keratinocytesRugg EL, Al-Rawi H, Lee D and McNeill AM
JOURNAL OF INVESTIGATIVE DERMATOLOGY. vol. 124 (4), A76-A76.
01-04-2005
Identification and distribution of protein families in 120 completed genomes using Gene3DLee D, Grant A, Marsden RL and Orengo C
Proteins Structure Function and Bioinformatics, Wiley vol. 59 (3), 603-615.
14-03-2005
Compression-induced damage in a muscle cell model in vitro.Wang Y-N, Bouten CVC, Lee DA and Bader DL
Proc Inst Mech Eng H vol. 219 (1), 1-12.
01-01-2005
Autologous chondrocyte implantation. Culture in a TGF-beta-containing medium enhances the re-expression of a chondrocytic phenotype in passaged human chondrocytes in pellet culture.Goldberg AJ, Lee DA, Bader DL and Bentley G
J Bone Joint Surg Br vol. 87 (1), 128-134.
01-01-2005
2004
The CATH Domain Structure Database and related resources Gene3D and DHS provide comprehensive domain family information for genome analysisPearl F, Todd A, Sillitoe I, Dibley M, Redfern O, Lewis T, Bennett C, Marsden R, Grant A, Lee D, Akpor A, Maibaum M, Harrison A, Dallman T, Reeves G, Diboun I, Addou S, Lise S, Johnston C, Sillero A, et al.
Nucleic Acids Research, Oxford University Press (Oup) vol. 33 (suppl_1), d247-d251.
17-12-2004
Inspection and repair issues for Step-and-Flash Imprint Lithography templatesNordquist KJ, Dauksher WJ, Mancini DP, Resnick DJ, Hess HF, Pettibone DW, Adler D, Bertsche K, White R, Csuy JE and Lee D
24th Annual BACUS Symposium on Photomask Technology. vol. 5567
06-12-2004
Delusional discourse: An investigation comparing the spontaneous causal attributions of paranoid and non‐paranoid individualsLee DA, Randall F, Beattie G and Bentall RP
Psychology and Psychotherapy Theory Research and Practice, Wiley vol. 77 (4), 525-540.
01-12-2004
Local Strain Measurement within TendonBader DL, Shelton JC, Lee DA and SCREEN HRC
Strain vol. 40 (4), 157-163.
01-11-2004
Repair of step and flash imprint lithography templatesDauksher WJ, Nordquist KJ, Le NV, Gehoski KA, Mancini DP, Resnick DJ, Casoose L, Bozak R, White R, Csuy J and Lee D
Journal of Vacuum Science & Technology B Nanotechnology and Microelectronics Materials Processing Measurement and Phenomena. vol. 22 (6), 3306-3311.
01-11-2004
Crosslinking density influences the morphology of chondrocytes photoencapsulated in PEG hydrogels during the application of compressive strain.Bryant SJ, Anseth KS, Lee DA and Bader DL
J Orthop Res vol. 22 (5), 1143-1149.
01-09-2004
Integrin-mediated mechanotransduction processes in TGFbeta-stimulated monolayer-expanded chondrocytes.Chowdhury TT, Salter DM, Bader DL and Lee DA
Biochem Biophys Res Commun vol. 318 (4), 873-881.
11-06-2004
Activin Receptor-like Kinase-7 Induces Apoptosis through Activation of MAPKs in a Smad3-dependent Mechanism in Hepatoma Cells*Kim B-C, van Gelder H, Kim TA, Lee H-J, Baik KG, Chun HH, Lee DA, Choi KS and Kim S-J
Journal of Biological Chemistry, Elsevier vol. 279 (27), 28458-28465.
23-04-2004
Crosslinking density influences chondrocyte metabolism in dynamically loaded photocrosslinked poly(ethylene glycol) hydrogels.Bryant SJ, Chowdhury TT, Lee DA, Bader DL and Anseth KS
Ann Biomed Eng vol. 32 (3), 407-417.
01-03-2004
Cyclic preconditioning mediates chondrocytes calcium signaling in unstrained and compressed agarose constructs.Knight MM, Hibbs K, Roberts SR, LEE DA and Bader DL
50th Annual Meeting of the Orthopaedic Research Society. vol. 29, 829-829.
01-01-2004
Non-invasive monitoring of molecular diffusion in neo-cartilage using FRAP technique.Heywood HK, DeRosa E, LEE DA, Bader DL and Netti P
50th Annual Meeting of the Orthopaedic Research Society. vol. 29, 531-531.
01-01-2004
Extracellular matrix influences the response of chondrocytes to dynamic compressionLEE DA, van Osch G, Verhaar JAN, Mandl EW, van der Linden JC, van der Breevaart Bravenboer J and Weinans H
Trans. Orthop.Rev. Soc vol. 29, 839-839.
01-01-2004
Dynamic compression counteracts IL-1 beta-induced iNOS and COX-2 activity in human chondrocytes cultured in agarose constructsChowdhury TT, Bader DL and Lee DA
OSTEOARTHRITIS AND CARTILAGE. vol. 12, S19-S19.
01-01-2004
Heterogeneity of deformation of cytoplasmic networks in compressed chondrocytes.Knight MM, Bonzom Z, Sharma AM, LEE DA, Kimmel E and Bader DL
50th Annual Meeting of the Orthopaedic Research Society. vol. 29, 544-544.
01-01-2004
Mechanical loading of chondrocytes embedded in 3D constructs: in vitro methods for assessment of morphological and metabolic response to compressive strain.Lee DA and Knight MM
Methods Mol Med vol. 100, 307-324.
01-01-2004
Glucose depletion induces an upregulation of oxygen utilisation by chondrocytes.Heywood HK, Bader DL, Bongers M and LEE DA
50th Annual Meeting of the Orthopaedic Research Society. vol. 29, 261-261.
01-01-2004
Integrin-mediated mechanotransduction in IL-1β stimulated chondrocytesChowdhury TT, Appleby RN, Salter DM, Bader DL and Lee DA
OSTEOARTHRITIS AND CARTILAGE. vol. 12, S102-S102.
01-01-2004
An investigation into the effects of the hierarchical structure of tendon fascicles on micromechanical properties.Screen HRC, Lee DA, Bader DL and Shelton JC
Proc Inst Mech Eng H vol. 218 (2), 109-119.
01-01-2004
alpha 5 beta 1 integrin mediates mechanotransduction processes in TGF-beta stimulated human chondrocytes seeded in agarose constructs and subjected to dynamic compression.Chowdhry TT, Salter DM, Bader DL and LEE DA
50th Annual Meeting of the Orthopaedic Research Society. vol. 29, 338-338.
01-01-2004
Increased presence of cells with multiple elongated processes in osteoarthritic femoral head cartilageBader DL, KNIGHT MM, Bentley G, Kayser M and Holloway I
Osteoarthritis Cartilage vol. 12 (1), 17-24.
01-01-2004
Bioreactor Culture Techniques for Cartilage-Tissue EngineeringLee DA and Martin I
In Biopolymer Methods in Tissue Engineering, Springer Nature 159-170.
01-01-2004
Passage in monolayer influences the response of chondrocytes to dynamic compression.Wiseman M, Bader DL, Reisler T and Lee DA
Biorheology vol. 41 (3-4), 283-298.
01-01-2004
Increased presence of cells with multiple elongated processes in osteoarthritic femoral head cartilage.Holloway I, Kayser M, Lee DA, Bader DL, Bentley G and Knight MM
Osteoarthritis Cartilage vol. 12 (1), 17-24.
01-01-2004
Mechanical Loading of Chondrocytes Embedded in 3D ConstructsLee DA and Knight MM
In Cartilage and Osteoarthritis, Springer Nature 307-324.
01-01-2004
Cellular utilization determines viability and matrix distribution profiles in chondrocyte-seeded alginate constructs.Heywood HK, Sembi PK, Lee DA and Bader DL
Tissue Eng vol. 10 (9-10), 1467-1479.
01-01-2004
Combined anti-inflammatory effects of IL-4 and dynamic compression in IL-1beta stimulated bovine chondrocytes cultured in agarose constructs.Chowdhury TT, Bader DL and LEE DA
50th Annual Meeting of the Orthopaedic Research Society. vol. 29, 144-144.
01-01-2004
A structural perspective on genome evolutionLee D, Grant A, Sillitoe I, Dibley M, Ranea JG and Orengo C
Proceedings of the eighth annual international conference on Computational molecular biology - RECOMB '04., 336-336.
01-01-2004
Progress towards mapping the universe of protein foldsGrant A, Lee D and Orengo C
Genome Biology, Springer Nature vol. 5 (5)
01-01-2004
EyeSite: a semi‐automated database of protein families in the eyeLee DA, Fefeu S, Edo-Ukeh AA, Orengo CA and Slingsby C
Nucleic Acids Research, Oxford University Press (Oup) vol. 32 (suppl_1), d148-d152.
01-01-2004
2003
Temporal regulation of chondrocyte metabolism in agarose constructs subjected to dynamic compression.Chowdhury TT, Bader DL, Shelton JC and Lee DA
Arch Biochem Biophys vol. 417 (1), 105-111.
01-09-2003
Dynamic compression counteracts IL-1 beta-induced release of nitric oxide and PGE2 by superficial zone chondrocytes cultured in agarose constructs.Chowdhury TT, Bader DL and Lee DA
Osteoarthritis Cartilage vol. 11 (9), 688-696.
01-09-2003
Influence of external uniaxial cyclic strain on oriented fibroblast-seeded collagen gels.Berry CC, Shelton JC, Bader DL and Lee DA
Tissue Eng vol. 9 (4), 613-624.
01-08-2003
Dynamic compressive strain inhibits nitric oxide synthesis by equine chondrocytes isolated from different areas of the cartilage surface.Wiseman M, Henson F, Lee DA and Bader DL
Equine Vet J vol. 35 (5), 451-456.
01-07-2003
A structural perspective on genome evolutionLee D, Grant A, Buchan D and Orengo C
Current Opinion in Structural Biology, Elsevier vol. 13 (3), 359-369.
01-06-2003
Live cell imaging using confocal microscopy induces intracellular calcium transients and cell death.Knight MM, Roberts SR, Lee DA and Bader DL
Am J Physiol Cell Physiol vol. 284 (4), C1083-C1089.
01-04-2003
Live cell imaging using confocal microscopy induces intracellular calcium transients and cell deathKnight MM, Roberts SR, Lee DA and Bader DL
American Journal of Physiology - Cell Physiology. vol. 284 (4 53-4)
01-04-2003
Expansion of chondrocytes for tissue engineering in alginate beads enhances chondrocytic phenotype compared to conventional monolayer techniques.Lee DA, Reisler T and Bader DL
Acta Orthop Scand vol. 74 (1), 6-15.
01-02-2003
Mechanical conditioning influences the metabolic response of cell-seeded constructs.Shelton JC, Bader DL and Lee DA
Cells Tissues Organs vol. 175 (3), 140-150.
01-01-2003
Trimethylaminuria and a human FMO3 mutation databaseHernandez D, Addou S, Lee D, Orengo C, Shephard EA and Phillips IR
Hum Mutat vol. 22 (3), 209-213.
01-01-2003
alpha5beta1 integrin mediates mechanotransduction processes in TGFbeta3-stimulated human chondrocytes seeded in agarose constructs and subjected to dynamic compression.Chowdhury TT, LEE DA, Salter DM, Shelton JC and Bader DL
ETES. vol. 9 (4), 792-792.
01-01-2003
Dermal fibroblasts respond to mechanical conditioning in a strain profile dependent manner.Berry CC, Cacou C, Lee DA, Bader DL and Shelton JC
Biorheology vol. 40 (1-3), 337-345.
01-01-2003
Development of a technique to determine strains in tendons using the cell nuclei.Screen HRC, Lee DA, Bader DL and Shelton JC
Biorheology vol. 40 (1-3), 361-368.
01-01-2003
alpha5beta1 integrin mediates mechanotransduction processes in TGFbeta-stimulated human chondrocyte / agarose constructs and subjected to dynamic compression.Chowdhury TT, LEE DA, Salter DM, Shelton JC and Bader DL
Osteoarthritis Cartilage vol. 11 (Suppl 1), S2-S3.
01-01-2003
Control of mechanotrasduction processes in dynamically stimulated human and bovine chondrocytes cultured in agarose constructs.Chowdhury TT, Shelton JC, Bader DL and LEE DA
Internat. J. Artificial Organs vol. 26 (9), 858-858.
01-01-2003
The effects on non-collagenous matrix components on tendon fascicle micromechanics.SCREEN HRC, Shelton JC, Bader DL and Lee DA
49th Annual Meeting of the Orthopaedic Research Society. vol. 28, 806-806.
01-01-2003
Experimental and theoretical analysis of glucose dependent oxygen utilization by bovine articular chondrocytesLEE DA, Heywood HK, Baaijens FPT, Oomens CWJ and Sengers BG
Internat. J. Artificial Organs vol. 26, 875-875.
01-01-2003
2002
The influence of uniaxial cyclic strain on orientated fibroblast seeded collagen gelsBerry CC, Shelton JC, Bader DL and Lee DA
Third Smith and Nephew International Symposium - Translating Tissue Engineering Into Products
01-12-2002
Mechanical strain and hydrostatic pressure induce reversible changes in actin cytoskeletal organisation in chondrocytes in agaroseKnight MM, Toyoda T, Bader DL and Lee DA
Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products.
01-12-2002
Light-induced calcium signalling in chondrocytesKnight MM, Roberts SR, Lee DA and Bader DL
European Cells and Materials. vol. 4 (SUPPL. 2), 7-8.
01-12-2002
The design of bioreactor systems for cartilage tissue engineeringLee DA
Third Smith and Nephew International Symposium - Translating Tissue Engineering Into Products
01-12-2002
An in vitro investigation of cartilage mechanotransductionLee DA, Chowdhury TT, Roberts SR, Knight MM and Bader DL
INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS. vol. 25 (7), 617-618.
01-07-2002
The origin of [Fe ii] emission in NGC 4151Turner JEH, Allington-Smith J, Chapman S, Content R, Done C, Haynes R, Lee D and Morris S
Monthly Notices of The Royal Astronomical Society, Oxford University Press (Oup) vol. 331 (2), 284-292.
01-03-2002
Cell and nucleus deformation in compressed chondrocyte-alginate constructs: temporal changes and calculation of cell modulus.Knight MM, van de Breevaart Bravenboer J, Lee DA, van Osch GJVM, Weinans H and Bader DL
Biochim Biophys Acta vol. 1570 (1), 1-8.
15-02-2002
The CATH extended protein‐family database: Providing structural annotations for genome sequencesPearl FMG, Lee D, Bray JE, Buchan DWA, Shepherd AJ and Orengo CA
Protein Science, Wiley vol. 11 (2), 233-244.
01-02-2002
The strain behaviour of tendon under tensile load, using cell nuclei as strain markers.SCREEN HRC, Lee DA, Bader DL and Shelton JC
48th Annual Meeting of the Orthopaedic Research Society. vol. 27, 604-604.
01-01-2002
Light-induced calcium signalling in chondrocytes.Knight MM, Roberts SR, LEE DA and Bader DL
TCES 2002 Annual meeting of the UK Tissue and Cell Engineering Society University of Glasgow, Scotland 19 Sep 2002 - 20 Sep 2002. vol. 4 (Suppl 2), 7-8.
01-01-2002
Development of a technique to determine strains in tendons using the cell nuclei.BADER DL, Shelton JC, Lee DA and Screen HRC
Biorheology vol. 40, 361-368.
01-01-2002
Changes in cell morphology and cytoskeletal organisation in osteoarthritic cartilage.Holloway I, Knight MM, LEE DA, Bader DL and Bentley G
ECM III Cartilage & Joint repair Tutorials, Basic Research & Clinical Methods Davos, Switzerland 1 Jul 2002 - 3 Jul 2002. vol. 4 suppl 1, 52-53.
01-01-2002
Mechanical strain and hydrostatic pressure induce reversible changes in actin cytoskeletal organisation in chondrocytes in agarose.Knight MM, Toyoda T, LEE DA and Bader DL
48th Annual Meeting of the Orthopaedic Research Society. vol. 27, 35-35.
01-01-2002
Non-collagenous matrix components influence the micromechanical environment of tenocytes within tendon fascicles subjected to tensile strain.Bader DL, Shelton JC, Lee DA and SCREEN HRC
Eur. Cells Mat. vol. 4:S1, 41-42.
01-01-2002
Characterisation of cell morphology, cytoskeletal organization and apoptosis in human osteoarthritic cartilage.Holloway I, Knight MM, LEE DA, Bader DL and Bentley G
48th Annual Meeting of the Orthopaedic Research Society. vol. 27
01-01-2002
Deformation properties of articular chondrocytes: a critique of three separate techniques.Bader DL, Ohashi T, Knight MM, Lee DA and Sato M
Biorheology Netherlands. vol. 39 (1-2), 69-78.
01-01-2002
Monitoring neo-cartilage formation in cell seeded alginate constructs of clinically relevant dimensions.Heywood HK, LEE DA and Bader DL
TCES 2002 Annual meeting of the UK Tissue and Cell Engineering Society Glasgow, Scotland 19 Sep 2002 - 20 Sep 2002. vol. 4 suppl 2, 1-2.
01-01-2002
The CATH protein family database: A resource for structural and functional annotation of genomesOrengo CA, Bray JE, Buchan DWA, Harrison A, Lee D, Pearl FMG, Sillitoe I, Todd AE and Thornton JM
Proteomics. vol. 2 (1), 11-21.
01-01-2002
2001
Characterization of Lenslet Arrays for Astronomical SpectroscopyLee D, Haynes R, Ren D and Allington‐Smith J
Publications of The Astronomical Society of The Pacific, Iop Publishing vol. 113 (789), 1406-1419.
08-10-2001
Gene Therapy and Tissue Engineering in Orthopaedic and Sports Medicine (2000) Edited by Johnny Huard and Freddie H. Fu, ISBN 0-8176-4071-1, Birkhauser: Boston pages 1–286Bader D and Lee D
Medical Engineering & Physics, Elsevier vol. 23 (8)
01-10-2001
Properties of optical fibres at cryogenic temperaturesLee D, Haynes R and Skeen DJ
Monthly Notices of The Royal Astronomical Society, Oxford University Press (Oup) vol. 326 (2), 774-780.
01-09-2001
The early-type galaxy population in Abell 2218Ziegler BL, Bower RG, Smail I, Davies RL and Lee D
Monthly Notices of The Royal Astronomical Society, Oxford University Press (Oup) vol. 325 (4), 1571-1590.
21-08-2001
Dynamic compression inhibits the synthesis of nitric oxide and PGE(2) by IL-1beta-stimulated chondrocytes cultured in agarose constructs.Chowdhury TT, Bader DL and Lee DA
Biochem Biophys Res Commun vol. 285 (5), 1168-1174.
03-08-2001
Effects of Tissue Transglutaminase on Retinoic Acid-induced Cellular Differentiation and Protection against Apoptosis*Antonyak MA, Singh US, Lee DA, Boehm JE, Combs C, Zgola MM, Page RL and Cerione RA
Journal of Biological Chemistry, Elsevier vol. 276 (36), 33582-33587.
03-07-2001
Chondrocyte deformation within mechanically and enzymatically extracted chondrons compressed in agarose.Knight MM, Ross JM, Sherwin AF, Lee DA, Bader DL and Poole CA
Biochim Biophys Acta vol. 1526 (2), 141-146.
03-05-2001
Temporal changes in cytoskeletal organisation within isolated chondrocytes quantified using a novel image analysis technique.Knight MM, Idowu BD, Lee DA and Bader DL
Med Biol Eng Comput vol. 39 (3), 397-404.
01-05-2001
Mechanical compression influences intracellular Ca2+ signaling in chondrocytes seeded in agarose constructs.Roberts SR, Knight MM, Lee DA and Bader DL
J Appl Physiol (1985) vol. 90 (4), 1385-1391.
01-04-2001
Compressive deformation and damage of muscle cell subpopulations in a model system.Bouten CV, Knight MM, Lee DA and Bade DL
Ann Biomed Eng vol. 29 (2), 153-163.
01-02-2001
Temporal changes in cell and nucleus deformation in isolated chondrocytes compressed in alginate scaffolds.Knight MM, van de Breevaart Brevenboer J, van Osch G, Weinans H, LEE DA and Bader DL
47th Annual Meeting, Orthopaedic Research Society San Francisco, California 25 Feb 2001 - 28 Feb 2001. vol. 26, 611-611.
01-01-2001
Dynamic compression influences the synthesis of nitric oxide by IL-1beta stimulated chondrocyte sub-populations cultured in agarose constructs.Chowdhury T, Bader DL and LEE DA
47th Annual Meeting, Orthopaedic Research Society San Francisco, California 25 Feb 2001 - 28 Feb 2001. vol. 26, 604-604.
01-01-2001
Compressive deformation and damage of muscle cell subpopulaltions in a model systemBader DL, KNIGHT MM, Lee DA and Bouten CV
Ann. Biomed. Eng. vol. 29 (2), 153-163.
01-01-2001
Mechanical compression influences cytoskeletal oragnisation within chondrocytes seeded in agarose constructs.LEE DA, Idowu BD, Knight MM and Bader DL
47th Annual Meeting, Orthopaedic Research Society San Francisco, California 25 Feb 2001 - 28 Feb 2001. vol. 26, 263-263.
01-01-2001
Physiochemical, biochemical and mechanical characterisation of chondrocyte-alginate constructs.Enobakhare B, Bader DL and LEE DA
47th Annual Meeting, Orthopaedic Research Society San Francisco, California 25 Feb 2001 - 28 Feb 2001. vol. 26, 638-638.
01-01-2001
Embryonic stem cells: scientific possibilities, ethical considerations, and regulation in the UKLee DA
Interdiscipl Sci Rev vol. 26 (2), 112-124.
01-01-2001
VIDA: a virus database system for the organization of animal virus genome open reading framesAlbà MM, Lee D, Pearl FMG, Shepherd AJ, Martin N, Orengo CA and Kellam P
Nucleic Acids Research, Oxford University Press (Oup) vol. 29 (1), 133-136.
01-01-2001
A rapid classification protocol for the CATH Domain Database to support structural genomicsPearl FM, Martin N, Bray JE, Buchan DW, Harrison AP, Lee D, Reeves GA, Shepherd AJ, Sillitoe I, Todd AE, Thornton JM and Orengo CA
Nucleic Acids Research, Oxford University Press (Oup) vol. 29 (1), 223-227.
01-01-2001
2000
Fibre developments at the Anglo-Australian Observatory for SPIRAL and AUSTRALISLee D and Taylor K
Proceedings of SPIE - The International Society for Optical Engineering. vol. 4008
03-12-2000
Characterisation of cooled infrared fibres for the Gemini IRMOSHaynes R, Baldry IK, Taylor K and Lee D
Proceedings of SPIE - The International Society for Optical Engineering. vol. 4008
03-12-2000
Biological response of cyclic strain on developed cell seeded collagen gel modelBerry CC, Cacou C, Shelton JC, Bader DL and Lee DA
Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling
01-12-2000
Intracellular - CA2+ signalling in compressed chondrocyte agarose constructsRoberts SR, Knight MM, Lee DA and Bader DL
Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling.
01-12-2000
Compression induced cell and nucleus deformation in chondrocyte-alginate constructsKnight MM, Van De Breevaart Bravenboer J, Bader DL and Lee DA
Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling.
01-12-2000
Physiochemical, biochemical and mechanical characterisation of chondrocyte-alginate constructsEnobakhare BO, Bader DL and Lee DA
Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling
01-12-2000
Dynamic compression inhibits the synthesis of nitric oxide by IL-1β stimulated chondrocytes cultured in agarose constructsChowdhury TT, Bader DL and Lee DA
Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling
01-12-2000
A system for monitoring the response of uniaxial strain on cell seeded collagen gelsCacou C, Palmer D, Lee DA, Bader DL and Shelton JC
Med Eng Phys vol. 22 (5), 327-333.
01-06-2000
Confocal analysis of cytoskeletal organisation within isolated chondrocyte sub-populations cultured in agarose.Idowu BD, Knight MM, Bader DL and Lee DA
Histochem J vol. 32 (3), 165-174.
01-03-2000
An experimental investigation of immersed gratingsLee D and Allington-Smith JR
Monthly Notices of The Royal Astronomical Society, Oxford University Press (Oup) vol. 312 (1), 57-69.
11-02-2000
Intracellular calcium signalling in compressed chondrocyte agarose constructsRoberts SR, Knight MM, Lee DA and Bader DL
J PHYSIOL-LONDON. vol. 523, 12P-12P.
01-02-2000
Chondrocyte deformation within compressed agarose constructs at the cellular and sub-cellular levels.Lee DA, Knight MM, Bolton JF, Idowu BD, Kayser MV and Bader DL
J Biomech vol. 33 (1), 81-95.
01-01-2000
The influence of mechanical loading on isolated chondrocytes seeded in agarose constructs.Lee DA, Noguchi T, Frean SP, Lees P and Bader DL
Biorheology vol. 37 (1-2), 149-161.
01-01-2000
Assigning genomic sequences to CATHPearl FM, Lee D, Bray JE, Sillitoe I, Todd AE, Harrison AP, Thornton JM and Orengo CA
Nucleic Acids Research, Oxford University Press (Oup) vol. 28 (1), 277-282.
01-01-2000
Chapter 4 Structure – Properties of Soft Tissues Articular CartilageBader D and Lee D
In Structural Biological Materials - Design and Structure-Property Relationships, Elsevier 75-103.
01-01-2000
1999
Transcriptional repression of the transforming growth factor-β type I receptor gene by DNA methylation results in the development of TGF-β resistance in human gastric cancerKang SH, Bang Y-J, Im Y-H, Yang H-K, Lee DA, Lee HY, Lee HS, Kim NK and Kim S-J
Oncogene, Springer Nature vol. 18 (51), 7280-7286.
02-12-1999
Models of government regulation of privatized transit systems in five Latin American citiesLee DA
Transportation Quarterly vol. 53 (1), 21-39.
01-12-1999
Multiple‐Object and Integral Field Near‐Infrared Spectroscopy Using FibersHaynes R, Lee D, Allington‐Smith J, Content R, Dodsworth G, Lewis I, Sharples R, Turner J, Webster J, Done C, Peletier R, Parry I and Chapman S
Publications of The Astronomical Society of The Pacific, Iop Publishing vol. 111 (765), 1451-1468.
01-11-1999
A COMPARATIVE STUDY OF VARIOUS ASSAYS FOR IN VITRO BIOCOMPATIBILITY ASSESSMENT OF EXPERIMENTAL ZIRCONIAHuang J, Hing KA, Best SM, Lee DA, Silvio LD and Bonfield W
Bioceramics., 199-202.
01-10-1999
The effects of storage temperature on the composition, metabolism acid biomechanical properties of human articular cartilageWhite AET, Bentley G, Stephens MD, Bader DL, Giddins GEB and Lee DA
Knee vol. 6 (3), 197-205.
01-08-1999
Introducing Fare Simplification and New Convenience Fares at Connecticut TransitLee DA
Transportation Research Record Journal of The Transportation Research Board, Sage Publications vol. 1669 (1), 109-112.
01-01-1999
1998
A Tour through throughLee D
Journal of English Linguistics, Sage Publications vol. 26 (4), 333-351.
01-12-1998
TEIFU: A thousand element integral field unit for the WHT fed by the ELECTRA AO systemHaynes R, Doei AP, Content R, Allington-Smith J and Lee D
Proceedings of SPIE - The International Society for Optical Engineering. vol. 3355, 786-797.
01-12-1998
Response of chondrocyte subpopulations cultured within unloaded and loaded agarose.Lee DA, Noguchi T, Knight MM, O'Donnell L, Bentley G and Bader DL
J Orthop Res vol. 16 (6), 726-733.
01-11-1998
The influence of elaborated pericellular matrix on the deformation of isolated articular chondrocytes cultured in agarose.Knight MM, Lee DA and Bader DL
Biochim Biophys Acta vol. 1405 (1-3), 67-77.
21-10-1998
Dynamic mechanical compression influences nitric oxide production by articular chondrocytes seeded in agaroseLee DA, Frean SP, Lees P and Bader DL
Biochem Bioph Res Co vol. 251 (2), 580-585.
20-10-1998
SMIRFS-II: multiobject and integral-field near-IR spectroscopy at UKIRTHaynes R, Content R, Turner JE, Allington-Smith JR and Lee D
Infrared Astronomical Instrumentation. vol. 3354, 419-430.
21-08-1998
Characterization of microlens arrays for integral field spectroscopyLee D, Allington-Smith JR, Content R and Haynes R
Optical Astronomical Instrumentation. vol. 3355, 810-820.
09-07-1998
Gemini multiobject spectrographsMurowinski RG, Bond T, Crampton D, Davidge TJ, Fletcher JM, Leckie B, Morbey CL, Roberts SC, Saddlemyer LK, Sebesta J, Stilburn JR, Szeto K, Allington-Smith JR, Content R, Davies RL, Dodsworth GN, Haynes R, Robinson DJ, Robertson DJ, Webster J, et al.
Optical Astronomical Instrumentation. vol. 3355, 188-195.
09-07-1998
The pH-Induced Release of Iron from Transferrin Investigated with a Continuum Electrostatic ModelLee DA and Goodfellow JM
Biophysical Journal, Elsevier vol. 74 (6), 2747-2759.
01-06-1998
Measurement of the deformation of isolated chondrocytes in agarose subjected to cyclic compression.Knight MM, Ghori SA, Lee DA and Bader DL
Med Eng Phys vol. 20 (9), 684-688.
01-01-1998
A specific quantitative assay for collagen synthesis by cells seeded in collagen-based biomaterials using sirius red F3B precipitationLee DA, Assoku E and Doyle V
J Mater Sci-Mater M vol. 9 (1), 47-51.
01-01-1998
Erratum: Use of polymerase chain reaction to provide prognostic information on human cytomegalovirus disease after liver transplantation. (Journal of Medical Virology 51 (152-158))Lao WC, Lee D, Burroughs AK, Lanzani G, Rolles K, Emery VC and Griffiths PD
Journal of Medical Virology vol. 54 (1)
01-01-1998
1997
GMOS: the GEMINI Multiple Object SpectrographsDavies RL, Allington-Smith JR, Bettess P, Chadwick E, Content R, Dodsworth GN, Haynes R, Lee D, Lewis IJ, Webster J, Atad E, Beard SM, Ellis M, Hastings PR and Williams PR
Proceedings of SPIE - The International Society for Optical Engineering. vol. 2871, 1099-1106.
01-12-1997
Effect of Normal Synovial Fluid on the Metabolism of Articular Chondrocytes In VitroLee DA, Salih V, Stockton EF, Stanton JS and Bentley G
Clinical Orthopaedics and Related Research®, Wolters Kluwer vol. 342 (&NA;), 228-238.
01-09-1997
Quantitative Evaluation of the Exploration Strategies of a Mobile RobotLee D and Recce M
The International Journal of Robotics Research, Sage Publications vol. 16 (4), 413-447.
01-08-1997
Compressive strains at physiological frequencies influence the metabolism of chondrocytes seeded in agaroseLee DA and Bader DL
J Orthop Res vol. 15 (2), 181-188.
01-03-1997
Prevalence of anti‐Vif antibodies in HIV‐1 infected individuals assessed using recombinant baculovirus expressed Vif proteinO'Neil C, Lee D, Clewley G, Johnson MA and Emery VC
Journal of Medical Virology, Wiley vol. 51 (3), 139-144.
01-03-1997
Frame conflicts and competing construals in family argumentLee DA
Journal of Pragmatics, Elsevier vol. 27 (3), 339-360.
01-03-1997
Use of polymerase chain reaction to provide prognostic information on human cytomegalovirus disease after liver transplantationLao WC, Lee D, Burroughs AK, Lanzini G, Rolles K, Emery VC and Griffiths PD
Journal of Medical Virology, Wiley vol. 51 (3), 152-158.
01-03-1997
1996
Preliminary Results From the Cancer Research Campaign Trial Evaluating Tamoxifen Duration in Women Aged Fifty Years or Older With Breast CancerGroup CTWPOTCRCBCT
Journal of The National Cancer Institute, Oxford University Press (Oup) vol. 88 (24), 1834-1839.
18-12-1996
Quantification of sulfated glycosaminoglycans in chondrocyte/alginate cultures, by use of 1,9-dimethylmethylene blueEnobakhare BO, Bader DL and Lee DA
Anal Biochem vol. 243 (1), 189-191.
01-12-1996
Specific quantitative assay to determine the rate of collagen synthesis in a collagen gel systemDoyle V, Pearson RG and Lee DA
Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium. vol. 2
01-12-1996
Reduction of weather-related terminal area delays in the free-flight eraJohnson SC, Rovinsky RB, Chin DK, Kostiuk PF, Lee DA, Hemm RV and Wingrove ER
AIAA/IEEE Digital Avionics Systems Conference - Proceedings., 185-190.
01-12-1996
Novel system for the production of chondrocyte seeded alginate constructsEnobakhare B, Bader D and Lee DA
Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium. vol. 1
01-12-1996
Mechanical strain influences the metabolism of chondrocytes cultured in an artificial matrixLee DA and Bader DL
Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium. vol. 1
01-12-1996
Cellular responses to poly-L-lactic acid degradation productsPearson RG, Lee DA, Doyle V and Bader DL
Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium. vol. 1
01-12-1996
J. Virol. Methods Erratum to “Detection of human cytomegalovirus polymerase chain reaction products using oligonucleotide probes directly conjugated to alkaline phosphatase” [61 (1996) 145]Gor D, Lee D and Emery VC
Journal of Virological Methods, Elsevier vol. 62 (2)
01-12-1996
Detection of human cytomegalovirus polymerase chain reaction products using oligonucleotide probes directly conjugated to alkaline phosphataseGor D, Lee D and Emery VC
Journal of Virological Methods, Elsevier vol. 61 (1-2), 145-150.
01-09-1996
An investigation of the growth of human dermal fibroblasts on poly-L-lactic acid in vitroDoyle V, Pearson R, Lee D, Wolowacz S and Mc Taggart S
Journal of Materials Science: Materials in Medicine, Springer Nature vol. 7 (6), 381-385.
01-06-1996
Conformational analysis of pentapeptide sequences matching a proposed recognition motif for lysosomal degradationGorinsky B, Laskowski RA, Lee DA and Bomford A
Biochimica Et Biophysica Acta, Elsevier vol. 1293 (2), 243-253.
01-04-1996
Implementing a Visioning and Strategic Planning Process at CTTransitLee D and Sanders M
Transportation Research Record Journal of The Transportation Research Board, Sage Publications vol. 1521, 58-61.
01-01-1996
1995
The development and characterization of an in vitro system to study strain-induced cell deformation in isolated chondrocytesLee DA and Bader DL
In Vitro Cell Dev-An vol. 31 (11), 828-835.
01-12-1995
1994
Quantitative evaluation of the exploration strategies of a mobile robotLee D and Recce M
Proceedings of the National Conference on Artificial Intelligence. vol. 2
01-12-1994
Quantitative evaluation of the exploration strategies of an intelligent vehicleLee D and Recce M
Intelligent Vehicles Symposium, Proceedings., 538-543.
01-12-1994
Proteoglycan depletion alone is not sufficient to stimulate proteoglycan synthesis in cultured bovine cartilage explantsLee DA, Bentley G and Archer CW
Osteoarthritis and Cartilage, Elsevier vol. 2 (3), 175-185.
01-09-1994
Characterization of the repair tissue in articular cartilage defects using silver-enhanced colloidal gold immunostainingReissis N, Downes S, Kayser M, Lee D and Bentley G
Journal of Materials Science: Materials in Medicine, Springer Nature vol. 5 (6-7), 402-406.
01-06-1994
1993
The control of cell division in articular chondrocytesLee DA, Bentley G and Archer CW
Osteoarthritis and Cartilage, Elsevier vol. 1 (2), 137-145.
01-04-1993
1991
1990
Effects of ascorbate on myogenesis in micromass cultureArcher CW, Cottrill CP and Lee D
In Vitro Cellular & Developmental Biology, Springer Nature vol. 26 (3), 259-264.
01-03-1990
Digitization of the AT&T worldwide intelligent networkLee DA
At&Amp;T Technology vol. 5 (1), 14-19.
01-01-1990
1989
VLSI package reliability risk due to accelerated environmental testingHaupert D, Chen FG and Lee D
01-12-1989
Relation between the rate of cell movement under agarose and the positioning of cells in heterotypic aggregatesJones BM, Evans PM and Lee DA
Experimental Cell Research, Elsevier vol. 180 (1), 287-296.
01-01-1989
1988
INTEGRATED SERVICES DIGITAL NETWORK.Lee D
British Telecommunications Engineering vol. 7 (pt 2), 2-12.
01-07-1988
Moth Density and Oviposition Patterns of the European Corn Borer, Ostrinia nubilalis (Lepidoptera: Pyralidae), in AlbertaLee DA
Environmental Entomology, Oxford University Press (Oup) vol. 17 (2), 220-224.
01-04-1988
1987
Reproductive patterns of the European corn borer (Ostrinia nubilalis) in AlbertaLee DA and Spence JR
Canadian Journal of Zoology, Canadian Science Publishing vol. 65 (7), 1733-1740.
01-07-1987
1985
MECHANICAL CONVEYING SELECTION CONSIDERATIONS.Lee DA
Proceedings of the Technical Program - Powder & Bulk Solids Conference/Exhibition., 435-441.
01-01-1985
1984
GUIDELINES FOR SELECTING PNEUMATIC CONVEYING SYSTEMS.Lee DA
Proceedings of the Technical Program - International Powder and Bulk Solids Handling and Processin., 95-106.
01-12-1984
1983
Prevalence and spectrum of asthma in childhood.Lee DA, Winslow NR, Speight AN and Hey EN
The Bmj, Bmj vol. 286 (6373)
16-04-1983
Underdiagnosis and undertreatment of asthma in childhood.Speight AN, Lee DA and Hey EN
The Bmj, Bmj vol. 286 (6373)
16-04-1983
1981
Sol-Gel Technology Applied to Crystalline Ceramic Nuclear Waste FormsAngelini P, Bond WD, Caputo AJ, Mack JE, Lackey WJ, Lee DA and Stinton DP
01-01-1981
Grants
Grants of specific relevance to the Centre for BioengineeringClock-Chips - Incorporating the Circadian Clock into Organ-on-a-Chip TechnologyDavid Lee and Lei Su
£387,326 BBSRC Biotechnology and Biological Sciences Research Council
01-10-2024 - 31-03-2026
EPSRC Centre for Doctoral Training in Next Generation Organ-on-a-Chip Technology (COaCT)Hazel Screen, Martin Knight, Thomas Iskratsch, Caroline Roney, Yi Sui, David Lee, Julia Shelton, Zion Tse, John Connelly, Adrian Biddle and Lucy Norling
£7,066,811 EPSRC Engineering and Physical Sciences Research Council
Grant Summary
01-07-2024 - 30-09-2032
Harmonised IAA grant - Improve and accelerate the impact of QMUL research BBSRCDavid Lee and Viji Draviam Sastry
£495,000 BBSRC Biotechnology and Biological Sciences Research Council
01-04-2022 - 31-03-2026
Harmonised IAA grant - Improve and accelerate the impact of QMUL research EPSRCDavid Lee and Yang Hao
£882,583 EPSRC Engineering and Physical Sciences Research Council
01-04-2022 - 31-03-2026
Harmonised IAA grant - Improve and accelerate the impact of QMUL research MRCMauro Perretti, Tatjana Crnogorac-Jurcevic and David Lee
£457,000 MRC Medical Research Council
01-04-2022 - 31-03-2026
Engineering Circadian Biology into Human Induced Pluripotent Stem Cell Organ-on-a-Chip modelsDavid Lee and Yung-Yao Lin
£201,874 BBSRC Biotechnology and Biological Sciences Research Council
01-02-2022 - 31-01-2025
Super-Resolution Microscopy of live cells in 3DViji Draviam Sastry, Conrad Mullineaux, Vidya Chandran Darbari, Lakxmi Subramanian, Fabrice Caudron, Richard Pickersgill, Guy Hanke, Alexander Ruban, Peter Thorpe, Christopher Duffy, Chema Martin Duran, John Connelly, Peter McCormick, James Chapple, Vardhman Rakyan, Tyson Sharp, Susana Alves Godinho and David Lee
£369,201 BBSRC Biotechnology and Biological Sciences Research Council
01-12-2020 - 31-03-2022
Does the biological clock within cartilage align to diurnal patterns in activity?David Lee, Hannah Heywood and Martin Knight
£9,954 EPSRC Engineering and Physical Sciences Research Council
01-10-2019 - 31-10-2020
Mecho-Regulation of Genome FunctionDavid Lee
£436,194 BBSRC Biotechnology and Biological Sciences Research Council
01-01-2017 - 31-12-2019