Prof Julien Gautrot
Professor of Biomaterials and Biointerfaces
School of Engineering and Materials Science
Queen Mary University of London
Queen Mary University of London
Research
Hydrogels, Polymer brush, Stem cells, Cell therapy, Gene delivery
Interests
The reconstruction of artificial micro-environment for tissue engineering and regenerative medicine requires the design of novel biomaterials with controlled chemistry, biochemisty, mechanical properties and geometry, at different length scales. In addition, these platforms should be dynamic in order to allow remodelling events that are necessary to processes such as wound healing, angiogenesis and tissue regeneration.Cell behaviours such as spreading, motility, proliferation, death and differentiation are tightly regulated by the cell micro-environment. Biochemical properties but also its geometric and mechanical properties of this micro-environment control cell phenotype. For regenerative medicine applications, novel biomaterials and patterning tools are required, with controlled chemistry and biochemistry, as well as mechanical and geometric properties at different length scales.
Publications
Publications of specific relevance to the Centre for Bioengineering2024
Biofabrication and biomanufacturing in Ireland and the UKMurphy JF, Lavelle M, Asciak L, Burdis R, Levis HJ, Ligorio C, McGuire J, Polleres M, Smith PO, Tullie L, Uribe-Gomez J, Chen B, Dawson JI, Gautrot JE, Hooper NM, Kelly DJ, Li VSW, Mata A, Pandit A, Phillips JB, et al.
Bio-Design and Manufacturing, Springer Nature vol. 7 (6), 825-856.
23-10-2024
Bioinspired Hyaluronic Acid‐Based Hydrogel Fuels Bi‐Directional Lung Organoid Maturation via PIEZO1 and ITGB1 Mediated MechanosensationZhang J, Marciano D, Wang L, Wang W, Gossen M, Yang M, Peng T, Gautrot J, Xu X and Ma N
Advanced Materials Interfaces, Wiley
03-09-2024
Human 3D Ovarian Cancer Models Reveal Malignant Cell-Intrinsic and -Extrinsic Factors That Influence CAR T-cell Activity.Joy JD, Malacrida B, Laforêts F, Kotantaki P, Maniati E, Manchanda R, Annibaldi A, Hopkins S, Garrobo-Calleja I, Gautrot J and Balkwill FR
Cancer Res vol. 84 (15), 2432-2449.
01-08-2024
BMP-Binding Polysulfonate Brushes to Control Growth Factor Presentation and Regulate Matrix RemodellingMarchena MH, Lambert E, Bogdanović B, Quadir F, Neri-Cruz CE, Luo J, Nadal C, Migliorini E and Gautrot JE
Acs Applied Materials & Interfaces, American Chemical Society (Acs) vol. 16 (31), 40455-40468.
29-07-2024
Strong Elastic Protein Nanosheets Enable the Culture and Differentiation of Induced Pluripotent Stem Cells on MicrodropletsMojares E, Nadal C, Hayler D, Kanso H, Chrysanthou A, Cruz CEN and Gautrot JE
Advanced Materials, Wiley vol. 36 (38)
22-07-2024
Interfacial mechanics of β-casein and albumin mixed protein assemblies at liquid-liquid interfacesChrysanthou A, Bosch-Fortea M, Nadal C, Zarbakhsh A and Gautrot JE
Journal of Colloid and Interface Science, Elsevier vol. 674, 379-391.
15-06-2024
Abstract B079: Human 3D ovarian cancer models reveal malignant cell intrinsic and extrinsic factors that influence CAR-T cell activityJoy JD, Malacrida B, Laforets F, Kotantaki P, Maniati E, Manchanda R, Hopkins S, Garrobo-Calleja I, Annibaldi A, Gautrot J and Balkwill FR
Cancer Research, American Association For Cancer Research (Aacr) vol. 84 (5_Supplement_2), b079-b079.
04-03-2024
Vascularised cardiac spheroids-on-a-chip for testing the toxicity of therapeuticsDi Cio S, Marhuenda E, Haddrick M and Gautrot JE
Scientific Reports, Springer Nature vol. 14 (1)
09-02-2024
Development of an in vitro microfluidic model to study the role of microenvironmental cells in oral cancer metastasisScemama A, Lunetto S, Tailor A, Di Cio S, Dibble M, Gautrot J and Biddle A
F1000research, F1000research vol. 12
15-01-2024
2023
P16 How does skin ageing-related basement membrane collagen loss affect the nucleus?Summan SK, Mayes A, Gunn D, Gautrot J, Caley M and O’Toole E
British Journal of Dermatology, Oxford University Press (Oup) vol. 189 (1), e20-e20.
07-07-2023
A guide to functionalisation and bioconjugation strategies to surface-initiated polymer brushesNeri-Cruz CE, Teixeira FME and Gautrot JE
Chemical Communications, Royal Society of Chemistry vol. 59 (49), 7534-7558.
09-05-2023
741 The effect of skin ageing-related basement membrane collagen loss on the nucleusSumman SK, Mayes A, Gunn DA, Gautrot J, Caley M and O'Toole E
Journal of Investigative Dermatology, Elsevier vol. 143 (5), s127-s127.
01-05-2023
Development of an in vitro microfluidic model to study the role of microenvironmental cells in oral cancer metastasisScemama A, Tailor A, Di Cio S, Dibble M, Gautrot J and Biddle A
F1000research, Taylor and Francis vol. 12, 439-439.
25-04-2023
Programmed Self-Assembly of DNA Nanosheets with Discrete Single-Molecule Thickness and Interfacial Mechanics: Design, Simulation, and Characterization.Cervantes-Salguero K, Gutiérrez Fosado YA, Megone W, Gautrot JE and Palma M
Molecules, Mdpi vol. 28 (9)
24-04-2023
The impact of pericytes on the stability of microvascular networks in response to nanoparticlesDibble M, Di Cio’ S, Luo P, Balkwill F and Gautrot JE
Scientific Reports, Springer Nature vol. 13 (1)
07-04-2023
Abstract 4576: 3D in vitro models uncover malignant cell intrinsic and extrinsic mechanisms of CAR-T cell resistance in high grade serous ovarian cancerJoy JD, Malacrida B, Laforêts F, Kotantaki P, Maniati E, Hopkins S, Garrobo-Calleja I, Gautrot J and Balkwill F
Cancer Research, American Association For Cancer Research (Aacr) vol. 83 (7_Supplement), 4576-4576.
04-04-2023
Growth of mesenchymal stem cells at the surface of silicone, mineral and plant-based oilsPeng L, Nadal C and Gautrot JE
Biomedical Materials, Iop Publishing vol. 18 (3)
17-03-2023
Mesenchymal Stem Cells Sense the Toughness of Nanomaterials and InterfacesPeng L, Matellan C, Bosch‐Fortea M, Gonzalez‐Molina J, Frigerio M, Salentinig S, del Rio Hernandez A and Gautrot JE
Advanced Healthcare Materials, Wiley vol. 12 (13)
21-02-2023
Mechanical Evaluation of Hydrogel–Elastomer Interfaces Generated through Thiol–Ene CouplingNguyen KDQ, Dejean S, Nottelet B and Gautrot JE
Acs Applied Polymer Materials, American Chemical Society (Acs) vol. 5 (2), 1364-1373.
30-01-2023
Co-Surfactant-Free Bioactive Protein Nanosheets for the Stabilization of Bioemulsions Enabling Adherent Cell ExpansionChrysanthou A, Bosch-Fortea M and Gautrot JE
Biomacromolecules, American Chemical Society (Acs) vol. 24 (10), 4465-4477.
23-01-2023
Supercharged Protein Nanosheets for Cell Expansion on BioemulsionsChrysanthou A, Kanso H, Zhong W, Shang L and Gautrot JE
Acs Applied Materials & Interfaces, American Chemical Society (Acs) vol. 15 (2), 2760-2770.
04-01-2023
Thiyl radical induced cis / trans isomerism in double bond containing elastomersKaur A, Gautrot JE, Akutagawa K, Watson D, Bickley A and Busfield JJC
Rsc Advances, Royal Society of Chemistry (Rsc) vol. 13 (34), 23967-23975.
01-01-2023
2022
Kinetic analysis of thiol-ene based cross-linking reaction of polychloroprene rubberKaur A, Gautrot JE, Cavalli G, Watson D, Bickley A, Akutagawa K and Busfield JJC
In Constitutive Models For Rubber Xii, Taylor & Francis 223-229.
28-11-2022
The Architecture of Oligonucleotide-Polycationic Brush Complexes – A Neutron Reflectometry StudyGautrot JE, Chang L, Alexis C, Gutfreund P and Zarbakhsh A
Advanced Materials Interfaces, Wiley
13-10-2022
Design of an Integrated Microvascularized Human Skin-on-a-Chip Tissue Equivalent ModelJones CFE, Di Cio S, Connelly JT and Gautrot JE
Frontiers in Bioengineering and Biotechnology, Frontiers Media vol. 10
19-07-2022
Multi-Scale Analysis of the Composition, Structure, and Function of Decellularized Extracellular Matrix for Human Skin and Wound Healing ModelsSarmin AM, Moussaid NE, Suntornnond R, Tyler EJ, Kim Y-H, Di Cio S, Megone WV, Pearce O, Gautrot JE, Dawson J and Connelly JT
Biomolecules, Mdpi vol. 12 (6)
16-06-2022
Protein Ligand Nanopattern Size Selects for Cellular Adhesion via Hemidesmosomes over Focal AdhesionsGhorbani S, Shahrokhtash A, Gautrot JE and Sutherland DS
Small Methods, Wiley vol. 6 (6)
22-04-2022
Impact of the multiscale viscoelasticity of quasi-2D self-assembled protein networks on stem cell expansion at liquid interfacesKong D, Peng L, Bosch-Fortea M, Chrysanthou A, Alexis CVJM, Matellan C, Zarbakhsh A, Mastroianni G, del Rio Hernandez A and Gautrot JE
Biomaterials, Elsevier vol. 284
06-04-2022
Highly Stretchable Conductive Covalent Coacervate Gels for Electronic SkinNguyen NT, Jennings J, Milani AH, Martino CDS, Nguyen LTB, Wu S, Mokhtar MZ, Saunders JM, Gautrot JE, Armes SP and Saunders BR
Biomacromolecules, American Chemical Society (Acs) vol. 23 (3), 1423-1432.
21-02-2022
2021
Long term expansion profile of mesenchymal stromal cells at protein nanosheet-stabilised bioemulsions for next generation cell culture microcarriersPeng L and Gautrot JE
Materials Today Bio, Elsevier vol. 12, 100159-100159.
16-11-2021
Competitive binding and molecular crowding regulate the cytoplasmic interactome of non-viral polymeric gene delivery vectorsRaynold AAM, Li D, Chang L and Gautrot JE
Nature Communications, Springer Nature vol. 12 (1)
08-11-2021
Ultrafast Photo-Crosslinking of Thiol–Norbornene Opaque Silicone Elastomer Nanocomposites in AirNguyen KDQ, Crespo-Ribadeneyra M, Picot O, Colak B and Gautrot JE
Acs Applied Polymer Materials, American Chemical Society
19-10-2021
Novel Crosslinking System for Poly-Chloroprene Rubber to Enable Recyclability and Introduce Self-HealingKaur A, Gautrot JE, Cavalli G, Watson D, Bickley A, Akutagawa K and Busfield JJC
Polymers, Mdpi vol. 13 (19)
29-09-2021
Impact of the molecular structure of cationic binders on the rheological and adhesive properties of carboxymethyl cellulose-based coacervate hydrogelsMegone W, Tang P, Roohpour N and Gautrot JE
Arkivoc, Arkat Usa vol. 2021 (6), 101-119.
21-07-2021
Cationic Polymer Brush-Coated Bioglass Nanoparticles for the Design of Bioresorbable RNA Delivery VectorsChang L, Yan H, Chang J and Gautrot JE
European Polymer Journal, Elsevier, 110593-110593.
13-06-2021
Hyaluronan (HA) Immobilized on Surfaces via Self-Assembled Monolayers of HA-Binding Peptide Modulates Endothelial Cell Spreading and Migration through Focal Adhesion.Pang X, Li W, Chang L, Gautrot JE, Wang W and Azevedo HS
Acs Applied Materials and Interfaces, American Chemical Society vol. 13 (22), 25792-25804.
26-05-2021
Extreme reversal in mechanical anisotropy in liquid-liquid interfaces reinforced with self-assembled protein nanosheetsMegone W, Kong D, Peng L and Gautrot JE
Journal of Colloid and Interface Science, Elsevier vol. 594, 650-657.
17-03-2021
Precise positioning of enzymes within hierarchical polymer nanostructures for switchable bioelectrocatalysis.Qu F, Ma X and Gautrot JE
Biosensors and Bioelectronics, Elsevier vol. 179, 113045-113045.
18-02-2021
Comparative Adhesion of Chemically and Physically Crosslinked Poly(Acrylic Acid)-Based Hydrogels to Soft TissuesCozens EJ, Roohpour N and Gautrot JE
European Polymer Journal, Elsevier, 110250-110250.
18-01-2021
Chapter 11 Recent Advances in the Design of Surface-initiated Polymer Brushes for Biomedical ApplicationsQu F, Raynold AM and Gautrot JE
In Soft Matter For Biomedical Applications, Royal Society of Chemistry (Rsc) 264-300.
01-01-2021
2020
Nanoengineered electrospun fibers and their biomedical applications: a reviewZhang X, Shi X, Gautrot JE and Peijs T
Nanocomposites, Taylor & Francis vol. 7 (1), 1-34.
29-12-2020
Engineered Cell-Degradable Poly(2-alkyl-2-oxazoline) Hydrogels Improve Epicardial Placement of Mesenchymal Stromal Cells by Stimulating Paracrine Signaling for Cardiac RepairSuzuki K and Gautrot J
Biomaterials, Elsevier
19-09-2020
Engineered cell-degradable poly(2-alkyl-2-oxazoline) hydrogel for epicardial placement of mesenchymal stem cells for myocardial repairYou Y, Kobayashi K, Colak B, Luo P, Cozen E, Fields L, Suzuki K and Gautrot J
Biomaterials, Elsevier, 120356-120356.
19-09-2020
Responsive Polymer Brush Design and Emerging Applications for NanotheranosticsLi D, Xu L, Wang J and Gautrot JE
Advanced Healthcare Materials, Wiley
06-09-2020
Photoconfigurable, Cell-Remodelable Disulfide Cross-linked Hyaluronic Acid Hydrogels.Wu L, Di Cio S, Azevedo HS and Gautrot JE
Biomacromolecules, American Chemical Society
24-08-2020
Modulation of Thiol-Ene Coupling by the Molecular Environment of Polymer Backbones for Hydrogel Formation and Cell EncapsulationColak B, Wu L, Cozens EJ and Gautrot JE
Acs Applied Bio Materials, American Chemical Society
24-08-2020
Functionalization of electrospun PLA fibers using amphiphilic block copolymers for use in carboxy-methyl-cellulose hydrogel compositesZhang X, Megone W, Peijs T and Gautrot JE
Nanocomposites, Taylor & Francis Group
26-06-2020
2019
Contractile myosin rings and cofilin-mediated actin disassembly orchestrate ECM nanotopography sensingDi Cio S, Iskratsch T, Connelly JT and Gautrot JE
Biomaterials, Elsevier vol. 232
16-12-2019
The physico-chemistry of adhesions of protein resistant and weak polyelectrolyte brushes to cells and tissues.Cozens EJ, Kong D, Roohpour N and Gautrot JE
Soft Matter, Royal Society of Chemistry vol. 16 (2), 505-522.
05-12-2019
Core-independent approach for polymer brush-functionalised nanomaterials with a fluorescent tag for RNA delivery.Li D, Wu L, Qu F, Ribadeneyra MC, Tu G and Gautrot J
Chemical Communications, Royal Society of Chemistry vol. 55 (94), 14166-14169.
21-10-2019
Peptide Cross-Linked Poly(2-oxazoline) as a Sensor Material for the Detection of Proteases with a Quartz Crystal Microbalance.Ahmad N, Colak B, Gibbs MJ, Zhang D-W, Gautrot JE, Watkinson M, Becer CR and Krause S
Biomacromolecules vol. 20 (7), 2506-2514.
07-06-2019
Photo‐Responsive Graphene: A Photoaddressable Liquid Crystalline Phase Transition in Graphene Oxide Nanocomposites (Adv. Funct. Mater. 24/2019)Crespo M, Santagiuliana G, Picot O, Portale G, Bilotti E and Gautrot JE
Advanced Functional Materials, Wiley vol. 29 (24)
01-06-2019
A Kinetic Model of Oligonucleotide–Brush Interactions for the Rational Design of Gene Delivery VectorsQu F, Li D, Ma X, Chen F and Gautrot JE
Biomacromolecules, American Chemical Society (Acs) vol. 20 (6), 2218-2229.
24-04-2019
A Photoaddressable Liquid Crystalline Phase Transition in Graphene Oxide NanocompositesCrespo M, Santagiuliana G, Picot O, Portale G, Bilotti E and Gautrot JE
Advanced Functional Materials, Wiley vol. 29 (24)
14-04-2019
Peptide Cross-Linked Poly (Ethylene Glycol) Hydrogel Films as Biosensor Coatings for the Detection of CollagenaseAhmad N, Colak B, Zhang D-W, Gibbs MJ, Watkinson M, Becer CR, Gautrot JE and Krause S
Sensors, Mdpi vol. 19 (7)
08-04-2019
Conformational Dynamics and Responsiveness of Weak and Strong Polyelectrolyte Brushes: Atomistic Simulations of PDMAEMA and PMETACGAUTROT JEE
Langmuir, American Chemical Society
14-03-2019
Modes of adsorption of polyelectrolytes to model substrates of hydroxyapatiteGAUTROT JEE
Journal of Colloid and Interface Science, Elsevier vol. 543, 237-237.
20-02-2019
2018
Collagenase Biosensor Based on the Degradation of Peptide Cross-Linked Poly(Ethylene Glycol) Hydrogel FilmsAhmad N, Colak B, Gibbs MJ, Zhang D-W, Becer CR, Watkinson M, Gautrot JE and Krause S
, Mdpi vol. 2 (13)
30-11-2018
Stem Cell Expansion and Fate Decision on Liquid Substrates Are Regulated by Self-Assembled NanosheetsKong D, Peng L, Di Cio S, Novak P and Gautrot JE
Acs Nano vol. 12 (9), 9206-9213.
25-09-2018
A drug eluting poly(trimethylene carbonate)/poly(lactic acid)-reinforced nanocomposite for the functional delivery of osteogenic moleculesZhang X, Geven MA, Wang X, Qin L, Grijpma DW, Peijs T, Eglin D, Guillaume O and Gautrot JE
International Journal of Nanomedicine, Taylor & Francis vol. 13, 5701-5718.
01-09-2018
Surface-Initiated Poly(oligo(2-alkyl-2-oxazoline)methacrylate) Brushes.Tang P, di Cio S, Wang W and E Gautrot J
Langmuir vol. 34 (34), 10019-10027.
28-08-2018
Hydration dependent mechanical performance of denture adhesive hydrogelsZhang F, An Y, Roohpour N, Barber AH and Gautrot JE
Dental Materials, Elsevier vol. 34 (10), 1440-1448.
28-06-2018
Cardiomyocytes Sense Matrix Rigidity through a Combination of Muscle and Non-muscle Myosin ContractionsPandey P, Hawkes W, Hu J, Megone WV, Gautrot J, Anilkumar N, Zhang M, Hirvonen L, Cox S, Ehler E, Hone J, Sheetz M and Iskratsch T
Developmental Cell, Elsevier vol. 45 (5)
01-06-2018
Impact of surface adhesion and sample heterogeneity on the multiscale mechanical characterisation of soft biomaterials.Megone W, Roohpour N and Gautrot JE
Sci Rep vol. 8 (1), 6780-6780.
30-04-2018
Bioengineering Complexity and Tuneability in HydrogelsMata A, Azevedo HS, Connelly J and Gautrot J
In Hydrogels, Taylor & Francis 301-323.
28-02-2018
Protein Nanosheet Mechanics Controls Cell Adhesion and Expansion on Low-Viscosity Liquids.Kong D, Megone W, Nguyen KDQ, Di Cio S, Ramstedt M and Gautrot JE
Nano Lett
07-02-2018
Cardiomyocytes Sense Matrix Rigidity through a Combination of Muscle and Non-muscle Myosin Contractions.Pandey P, Hawkes W, Hu J, Megone WV, Gautrot J, Anilkumar N, Zhang M, Hirvonen L, Cox S, Ehler E, Hone J, Sheetz M and Iskratsch T
Dev Cell vol. 44 (3), 326-336.e3.
05-02-2018
Highly Stable RNA Capture by Dense Cationic Polymer Brushes for the Design of Cytocompatible, Serum-Stable SiRNA Delivery Vectors.Li D, Sharili AS, Connelly J and Gautrot JE
Biomacromolecules
31-01-2018
Hydrophobic and hydrophilic effects on water structuring and adhesion in denture adhesives.Gill SK, Roohpour N, An Y, Gautrot JE, Topham PD and Tighe BJ
Journal of Biomedical Materials Research Part A, Wiley vol. 106 (5), 1355-1362.
13-01-2018
Biofunctionalised Patterned Polymer Brushes via Thiol-Ene Coupling for the Control of Cell Adhesion and the Formation of Cell Arrays.Colak B, Di Cio S and Gautrot JE
Biomacromolecules
02-01-2018
2017
Design of Polymer Brushes for Cell Culture and Cellular DeliveryLi D and Gautrot JE
In Polymer and Biopolymer Brushes, Wiley 557-603.
04-12-2017
The Solution Conformation of Polymer Brushes Determines their Interactions with DNA and Transfection Efficiency.Krishnamoorthy M, Li D, Sharili AS, Gulin-Sarfraz T, Rosenholm JM and Gautrot JE
Biomacromolecules
11-10-2017
Physico-chemical characterization of Antheraea mylitta silk mats for wound healing applicationsDarshan GH, Kong D, Gautrot J and Vootla S
Scientific Reports, Springer Nature vol. 7 (1)
04-09-2017
Tunable and processable shape memory composites based on degradable polymersZhang X, Geven MA, Grijpma D, Peijs T and Gautrot JE
Polymer
27-06-2017
The culture of HaCaT cells on liquid substrates is mediated by a mechanically strong liquid–liquid interfaceKong D, Nguyen KDQ, Megone W, Peng L and Gautrot JE
Faraday Discuss. vol. 204, 367-381.
06-04-2017
Differential integrin expression regulates cell sensing of the matrix nanoscale geometryDi Cio S, Bøggild TML, Connelly J, Sutherland DS and Gautrot JE
Acta Biomaterialia vol. 50, 280-292.
01-03-2017
Fabrication and Characterization of Conductive Conjugated Polymer-Coated Antheraea mylitta Silk Fibroin Fibers for Biomedical Applications.Gh D, Kong D, Gautrot J and Vootla SK
Macromol Biosci vol. 17 (7)
27-02-2017
Preparing macromolecular systems on surfaces: general discussionAmabilino D, Bâldea I, Barykina O, Batteas J, Besenius P, Beton P, Bilbao N, Buck M, Chi L, Clarke S, Costantini G, Davidson J, Davies P, De Feyter S, Diaz Fernandez Y, Dwivedi D, Ernst K-H, Flood A, Gautrot J, Jabbarzadeh A, et al.
Faraday Discussions, Royal Society of Chemistry (Rsc) vol. 204, 395-418.
01-01-2017
2016
Cell Sensing of the Physical Properties of the Microenvironment at Multiple ScalesGautrot JE
In Mechanobiology, Wiley 297-329.
23-12-2016
Adhesive ligand tether length affects the size and length of focal adhesions and influences cell spreading and attachment.Attwood SJ, Cortes E, Haining AW, Robinson B, Li D, Gautrot J and Del Río Hernández A
Sci Rep vol. 6, 34334-34334.
30-09-2016
Impact of the Molecular Environment on Thiol-Ene Coupling For Biofunctionalization and Conjugation.Colak B, Da Silva JCS, Soares TA and Gautrot JE
Bioconjugate Chemistry, American Chemical Society vol. 27 (9), 2111-2123.
21-09-2016
Ultrafast diffusion-controlled thiol-ene based crosslinking of silicone elastomers with tailored mechanical properties for biomedical applicationsNguyen KDQ, Megone WV, Kong D and Gautrot JE
Polymer Chemistry vol. 7 (33), 5281-5293.
02-08-2016
“Polymer-polymer composites for the design of strong and tough degradable biomaterials”Zhang X, Geven MA, Grijpma DW, Gautrot JE and Peijs T
Materials Today Communications vol. 8, 53-63.
02-06-2016
Failure mechanisms in denture adhesivesAn Y, Li D, Roohpour N, Gautrot JE and Barber AH
Dental Materials, Elsevier vol. 32 (5), 615-623.
01-05-2016
Cell sensing of physical properties at the nanoscale: Mechanisms and control of cell adhesion and phenotypeDi Cio S and Gautrot JE
Acta Biomaterialia vol. 30, 26-48.
15-01-2016
Study of thiol–ene chemistry on polymer brushes and application to surface patterning and protein adsorptionTan KY, Ramstedt M, Colak B, Huck WTS and Gautrot JE
Polymer Chemistry, Royal Society of Chemistry (Rsc) vol. 7 (4), 979-990.
01-01-2016
Biomedical applications of polymers made from natural compoundsJia Y, Wang K, Le Devedec F, Strandman S, Gauthier MA, Gautrot JE and Zhu J
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. vol. 251
01-01-2016
2015
Cell sensing of physical properties at the nanoscale: Mechanisms and control of cell adhesion and phenotypeDi Cio S and Gautrot JE
Acta Biomaterialia, Elsevier vol. 30, 26-48.
17-11-2015
The RAPIDOS project-European and Chinese collaborative research on biomaterials.Eglin D, Alini M, de Bruijn J, Gautrot J, Grijpma DW, Kamer L, Lai Y, Lu S, Peijs T, Peng J, Tang TT, Wang X, Richards RG and Qin L
J Orthop Translat vol. 3 (2), 78-84.
20-03-2015
Conductive surfaces with dynamic switching in response to temperature and saltHackett AJ, Malmström J, Molino PJ, Gautrot JE, Zhang H, Higgins MJ, Wallace GG, Williams DE and Travas-Sejdic J
Journal of Materials Chemistry B, Royal Society of Chemistry (Rsc) vol. 3 (48), 9285-9294.
01-01-2015
2014
High-sensitivity light-addressable potentiometric sensors using silicon on sapphire functionalized with self-assembled organic monolayersWang J, Zhou Y, Watkinson M, Gautrot J and Krause S
Sensors and Actuators B: Chemical, Elsevier vol. 209, 230-236.
26-11-2014
Surface initiated polymer brushes in the biomedical field: Applications in membrane science, biosensing, cell culture, regenerative medicine and antibacterial coatingsKrishnamoorthy M, Hakobyan S, Ramstedt M and GAUTROT JEE
Chemical Reviews, American Chemical Society vol. 114 (21), 10976-11026.
29-10-2014
Biofunctionalization of PEGylated microcapsules for exclusive binding to protein substrates.Deo DI, Gautrot JE, Sukhorukov GB and Wang W
Biomacromolecules vol. 15 (7), 2555-2562.
14-07-2014
The nanoscale geometrical maturation of focal adhesions controls stem cell differentiation and mechanotransductionGautrot JE, Malmström J, Sundh M, Margadant C, Sonnenberg A and Sutherland DS
Nano Letters vol. 14 (7), 3945-3952.
09-07-2014
Directing cell migration using micropatterned and dynamically adhesive polymer brushes.Costa P, Gautrot JE and Connelly JT
Acta Biomater vol. 10 (6), 2415-2422.
01-06-2014
2013
Decoupling geometrical and chemical cues directing epidermal stem cell fate on polymer brush-based cell micro-patterns.Tan KY, Lin H, Ramstedt M, Watt FM, Huck WTS and Gautrot JE
Integr Biol (Camb) vol. 5 (6), 899-910.
01-06-2013
The surface charge of anti-bacterial coatings alters motility and biofilm architectureGAUTROT JEE, Rzhepishevska O, Hakobyan S, Ruhal R, Barbero D and Ramstedt M
Journal of Biomaterials Science: Polymer Edition vol. 1 (6), 589-602.
01-01-2013
2012
Mimicking normal tissue architecture and perturbation in cancer with engineered micro-epidermisGautrot JE, Wang C, Liu X, Goldie SJ, Trappmann B, Huck WTS and Watt FM
Biomaterials vol. 33 (21), 5221-5229.
01-07-2012
Extracellular-matrix tethering regulates stem-cell fateTrappmann B, Gautrot JE, Connelly JT, Strange DGT, Li Y, Oyen ML, Cohen Stuart MA, Boehm H, Li B, Vogel V, Spatz JP, Watt FM and Huck WTS
Nature Materials
01-01-2012
2011
Polymer brushes showing non-fouling in blood plasma challenge the currently accepted design of protein resistant surfaces.Rodriguez-Emmenegger C, Brynda E, Riedel T, Houska M, Šubr V, Alles AB, Hasan E, Gautrot JE and Huck WTS
Macromol Rapid Commun vol. 32 (13), 952-957.
01-07-2011
Formation of pickering emulsions using ion-specific responsive colloids.Tan KY, Gautrot JE and Huck WTS
Langmuir vol. 27 (4), 1251-1259.
15-02-2011
Shape-induced terminal differentiation of human epidermal stem cells requires p38 and is regulated by histone acetylation.Connelly JT, Mishra A, Gautrot JE and Watt FM
Plos One vol. 6 (11)
01-01-2011
Island brushes to control adhesion of water in oil droplets on planar surfacesTan KY, Gautrot JE and Huck WTS
Soft Matter vol. 7 (15), 7013-7020.
01-01-2011
Recent advances in entropy-driven ring-opening polymerizationsStrandman S, Gautrot JE and Zhu XX
Polymer Chemistry vol. 2 (4), 791-799.
01-01-2011
2010
Actin and serum response factor transduce physical cues from the microenvironment to regulate epidermal stem cell fate decisionsConnelly JT, Gautrot JE, Trappmann B, Tan DWM, Donati G, Huck WTS and Watt FM
Nature Cell Biology vol. 12 (7), 711-718.
01-07-2010
Exploiting the superior protein resistance of polymer brushes to control single cell adhesion and polarisation at the micron scaleGautrot JE, Trappmann B, Oceguera-Yanez F, Connelly J, He X, Watt FM and Huck WTS
Biomaterials vol. 31 (18), 5030-5041.
01-06-2010
Protein-resistant NTA-functionalized polymer brushes for selective and stable immobilization of histidine-tagged proteins.Gautrot JE, Huck WTS, Welch M and Ramstedt M
Acs Appl Mater Interfaces vol. 2 (1), 193-202.
01-01-2010
Shape memory properties of main chain bile acids polymersTherien-Aubin H, Gautrot JE, Shao Y, Zhang J and Zhu XX
Polymer vol. 51 (1), 22-25.
01-01-2010
2009
Shape memory polymers based on naturally-occurring bile acidsGautrot JE and Zhu XX
Macromolecules vol. 42 (19), 7324-7331.
13-10-2009
Biofunctionalized protein resistant oligo(ethylene glycol)-derived polymer brushes as selective immobilization and sensing platformsTrmcic-Cvitas J, Hasan E, Ramstedt M, Li X, Cooper MA, Abell C, Huck WTS and Gautrot JE
Biomacromolecules vol. 10 (10), 2885-2894.
12-10-2009
Macrocyclic bile acids: from molecular recognition to degradable biomaterial building blocksGautrot JE and Zhu XX
Journal of Materials Chemistry vol. 19 (32), 5705-5716.
01-01-2009
The effects of surface chemistry on epidermal stem cell differentiationHuck WTS, Gautrot J and Watt F
Abstracts of Papers of The American Chemical Society vol. 237
01-01-2009
Polymers containing in-chain quinone moieties: synthesis and propertiesHodge P and Gautrot JE
Polymer International vol. 58 (3), 261-266.
01-01-2009
New degradable polymers made from natural compounds bile acids by ROMPGautrot JE, Zhang J, Shao Y and Zhu XX
Abstracts of Papers of The American Chemical Society vol. 237
01-01-2009
Synthesis of electron-accepting polymers containing phenanthra-9,10-quinone unitsGautrot JE, Hodge P, Helliwell M, Raftery J and Cupertino D
Journal of Materials Chemistry vol. 19 (24), 4148-4156.
01-01-2009
2008
High molecular weight bile acid and ricinoleic acid-based copolyesters via entropy-driven ring-opening metathesis polymerisation.Gautrot JE and Zhu XX
Chem Commun (Camb) (14), 1674-1676.
14-04-2008
2007
Silver nanoparticles stabilized by nitrocellulose as low conversion temperature precursors for inkjet-printed electronic circuitsNguyen BT, Gautrot JE, Nguyen MT and Zhu XX
2007 Nsti Nanotechnology Conference and Trade Show - Nsti Nanotech 2007, Technical Proceedings vol. 2, 68-71.
23-08-2007
Chondroitin-4-sulfate: a bioactive macromolecule to foster vascular healing around stent-grafts after endovascular aneurysm repair.Charbonneau C, Gautrot JE, Hébert M-J, Zhu XX and Lerouge S
Macromol Biosci vol. 7 (5), 746-752.
10-05-2007
Synthesis and characterization of core-shell microspheres with double thermosensitivity.Chen Y, Gautrot JE and Zhu XX
Langmuir vol. 23 (3), 1047-1051.
30-01-2007
Molar mass of main-chain bile acid-based oligo-esters measured by SEC, MALDI-TOF spectrometry and NMR spectroscopy: a comparative study.Gautrot JE and Zhu XX
Anal Chim Acta vol. 581 (2), 281-286.
09-01-2007
2,6-Diaryl-9,10-anthraquinones as models for electron-accepting polymersGautrot JE, Hodge P, Cupertino D and Helliwell M
New Journal of Chemistry vol. 31 (9), 1585-1593.
01-01-2007
Synthesis and characterization of core-shell microspheres with double thermosensitivityChen Y, Gautrot JE and Zhu XX
Langmuir vol. 23 (3), 1047-1051.
01-01-2007
Preparation and thermo-responsive light diffraction behaviors of soft polymerized crystalline colloidal arraysChen Y, Gautrot JE, Li Z and Zhu XX
Soft Matter vol. 3 (5), 571-579.
01-01-2007
Nitrocellulose-stabilized silver nanoparticles as low conversion temperature precursors useful for inkjet printed electronicsNguyen BT, Gautrot JE, Nguyen MT and Zhu XX
Journal of Materials Chemistry vol. 17 (17), 1725-1730.
01-01-2007
Poly(dibenzo[a,c]phenazine-2,7-diyl)s -: Synthesis and characterisation of a new family of electron-accepting conjugated polymersGautrot JE and Hodge P
Polymer vol. 48 (24), 7065-7077.
01-01-2007
2006
Main-chain bile acid based degradable elastomers synthesized by entropy-driven ring-opening metathesis polymerization.Gautrot JE and Zhu XX
Angew Chem Int Ed Engl vol. 45 (41), 6872-6874.
20-10-2006
Main‐Chain Bile Acid Based Degradable Elastomers Synthesized by Entropy‐Driven Ring‐Opening Metathesis PolymerizationGautrot JE and Zhu XX
Angewandte Chemie, Wiley vol. 118 (41), 7026-7028.
17-10-2006
Enhancing the photoluminescence intensity of conjugated polycationic polymers by using quantum dots as antiaggregation reagents.Nguyen BT, Gautrot JE, Ji C, Brunner P-L, Nguyen MT and Zhu XX
Langmuir vol. 22 (10), 4799-4803.
09-05-2006
Biodegradable polymers based on bile acids and potential biomedical applicationsGautrot JE and Zhu XX
Journal of Biomaterials Science-Polymer Edition vol. 17 (10), 1123-1139.
01-01-2006
Experimental evidence for carbonyl-π electron cloud interactionsGautrot JE, Hodge P, Cupertino D and Helliwell M
New Journal of Chemistry vol. 30 (12), 1801-1807.
01-01-2006
2005
Electrode specific electropolymerization of ethylenedioxythiophene: Injection enhancement in organic transistorsSchroeder R, Majewski LA, Grell M, Maunoury J, Gautrot J, Hodge P and Turner M
Applied Physics Letters vol. 87 (11)
01-01-2005
Grants
Grants of specific relevance to the Centre for BioengineeringMicro-manufacturing of tissue patterned organ-chips for accelerated deployment of new medicinesMartin Knight, Hazel Screen, Julien Gautrot, Timothy Hopkins, John Connelly, Liisa Blowes and Xavier Griffin
£1,787,725 EPSRC Engineering and Physical Sciences Research Council
Grant Summary
01-10-2024 - 30-09-2027
Unravelling mechanisms of drug-induced myocarditis using immune-responsive human cardiovascular chipYung-Yao Lin and Julien Gautrot
£121,420 MRC Medical Research Council
01-10-2024 - 30-09-2028
ProNaGen: Engineering of Recombinant Protein Nanosheet-Based Bioemulsions for Next Generation Bioprocessing and BiomanufacturingJulien Gautrot
£127,041 EPSRC - EU Scheme
01-11-2023 - 30-04-2025
Targeting epigenetic gene regulation in epidermolysis bullosa simplexJohn Connelly, Julien Gautrot and David Kelsell
£199,751 Action Medical Research
01-06-2023 - 31-05-2026
On-Demand Targeted RNA Delivery Nanotheranostics for Glioblastoma TreatmentSilvia Marino and Julien Gautrot
£184,106 Barts and the London Charity
01-03-2023 - 01-04-2026
Engineered Recombinant Strategies to Organogel Design for Food Product FormulationsJulien Gautrot
£31,688 Motif Food Works Inc
01-09-2022 - 31-08-2026
How does ageing related loss of basement membrane collagen regulate epidermal barrier homeostasisEdel O'Toole, Julien Gautrot and Matthew Caley
£64,000 Unilever UK Ltd
01-10-2021 - 30-11-2025
How does ageing related loss of basement membrane collagen regulate epidermal barrier homeostasisEdel O'Toole, Julien Gautrot and Matthew Caley
£116,803 BBSRC Biotechnology and Biological Sciences Research Council
27-09-2021 - 20-12-2025
Costing of MoBioC mini-CDT studentship for bit.bio, 3M, Sphere Fluidics, RB, Unilever, Photocentric and Manchester BiogelJulien Gautrot
£70,000 Bit.Bio Ltd
01-09-2021 - 01-09-2025
Protein Nanosheet-Stabilised Emulsions for Next Generation Biomanufacturing - ERC PoC 2020 Julien GautrotJulien Gautrot
£120,000 EU Commission - Horizon 2020
01-03-2021 - 31-08-2022
Engineering a human microphysiological platform for modelling soft tissue injury and regenerationYung-Yao Lin, Julien Gautrot and John Connelly
£100,000 NC3Rs National Center for the Replacement, Refinement and Reduction of Animals in Research
06-01-2021 - 16-06-2021
3D printing of hydroxyapatiteJulien Gautrot
£57,106 GSK GlaxoSmithKline UK Ltd
03-02-2020 - 31-08-2020
A 3Rs approach to tumour metastasis: investigating the role of cancer stem cells in metastasis using an in vitro microfluidic modelAdrian Biddle and Julien Gautrot
£90,000 NC3Rs National Center for the Replacement, Refinement and Reduction of Animals in Research
01-10-2019 - 30-12-2022
A Biophysical Model of Gum Reintegration on enamelJulien Gautrot
£32,000 GSK GlaxoSmithKline UK Ltd
01-10-2019 - 30-09-2023
Translating Vasculature-on-a-Chips with a Nephrotoxicity ModelJulien Gautrot
£54,373 NC3Rs National Center for the Replacement, Refinement and Reduction of Animals in Research
01-07-2019 - 01-01-2022
Engineered Protein Nanosheets at Liquid-Liquid Interfaces for Stem Cell Expansion, Sorting and Tissue Engineering (PROLICELL)Julien Gautrot
£1,499,542 EU Commission - Horizon 2020
01-09-2018 - 31-08-2024
Impact of Physiogel on tribological properties and structural integrity of the skinJulien Gautrot
£144,385 GSK GlaxoSmithKline UK Ltd
01-09-2018 - 30-11-2019
Imaging Failure of Novel Denture AdhesivesJulien Gautrot
£41,082 GSK GlaxoSmithKline UK Ltd
15-05-2018 - 31-10-2018
2D composites with controlled nano-mechanismsJulien Gautrot
£245,677 Leverhulme Trust
01-03-2018 - 28-02-2021
A Biomimetic Gum Model for Biomechanical TestingJulien Gautrot
£129,822 GSK GlaxoSmithKline UK Ltd
01-12-2017 - 01-03-2020
KTP Project - Novel Crosslinking ChemistriesJulien Gautrot
£225,205 Innovate UK
31-07-2017 - 30-07-2020
Film forming polymer actives in oral health productsJulien Gautrot
£123,153 GSK GlaxoSmithKline UK Ltd
01-07-2017 - 14-09-2018
An Ovarian Cancer Model on a ChipJulien Gautrot
£90,000 MRC Medical Research Council
01-09-2015 - 31-08-2018
EPSRC Industrial CASE Award 2014Julien Gautrot
£69,525 EPSRC Engineering and Physical Sciences Research Council
01-10-2014 - 30-09-2018
EPSRC Industrial CASE Award 2013Julien Gautrot
£68,648 EPSRC Engineering and Physical Sciences Research Council
01-10-2013 - 30-09-2018