Dr Weini Huang
Reader in Mathematical Biology
Centre Lead for Research Innovation and External Stakeholders Engagement
School of Mathematical Sciences
Queen Mary University of London
Queen Mary University of London
Research
Mathematical Biology, Evolutionary Theory, Math Oncology, Species Coevolution, Stochastic Process, Mutation Accumulation
Interests
Weini Huang currently works on modelling cancer evolution and species interactions in biological systems. Before being a lecturer in mathematical biology in 2018, she worked as a postdoctoral researcher in the Barts Cancer Institute, QMUL for modelling cancer spatial heterogeneity and the evolution of tumour resistance. She obtained her PhD in 2012 in Evolutionary Theory in the Max Planck Institute of Evolutionary Biology, Germany.Currently, Weini supervises 3 PhD students and 2 postdoctoral researchers in the topics of evolutionary theory with application in species coevolution and cancer dynamics . Weini is interested in understanding how diversity and population patterns are formed and maintained in nature/human cell populations through theoretical approaches as well as their connections with experimental/clinical observations. She collaborates with experimental evolution groups and cancer biologists/clinicians on e.g. the evolution of trade-offs in a predator-prey system and drug resistance in ovarian cancer, extrachromosal DNA, mtDNA dynamcis in healthy liver and population stuctures of prostate cancer.
If you are looking for an opportunity of PhD study in math biology, please get in touch!
Publications
Publications of specific relevance to the Centre for Complex Systems2024
Coordinated inheritance of extrachromosomal DNAs in cancer cellsHung KL, Jones MG, Wong IT-L, Curtis EJ, Lange JT, He BJ, Luebeck J, Schmargon R, Scanu E, Brückner L, Yan X, Li R, Gnanasekar A, Chamorro González R, Belk JA, Liu Z, Melillo B, Bafna V, Dörr JR, Werner B, et al.
Nature, Springer Nature vol. 635 (8037), 201-209.
06-11-2024
Extrachromosomal DNA driven oncogene spatial heterogeneity and evolution in glioblastomaNoorani I, Haughey M, Luebeck J, Rowan A, Grönroos E, Terenzi F, Wong IT-L, Kittel J, Bailey C, Weeden C, Bell D, Joo E, Barbe V, Jones MG, Nye E, Green M, Meader L, Norton EJ, Fabian M, Kanu N, et al.
, Cold Spring Harbor Laboratory vol. 5 (10-31)
25-10-2024
Accumulating waves of random mutations before fixationMoeller M, Werner B and Huang W
Physical Review E, American Physical Society (Aps) vol. 110 (4)
01-10-2024
Parasite-mediated predation determines infection in a complex predator–prey–parasite systemIslas ACH, Milne A, Eizaguirre C and Huang W
Proceedings of The Royal Society B, The Royal Society vol. 291 (2021), 20232468-20232468.
24-04-2024
Measures of genetic diversification in somatic tissues at bulk and single-cell resolutionMoeller ME, Mon Père NV, Werner B and Huang W
Elife, Elife vol. 12
24-01-2024
2023
Mutation divergence over space in tumour expansionLi H, Yang Z, Tu F, Deng L, Han Y, Fu X, Wang L, Gu D, Werner B and Huang W
Journal of The Royal Society Interface, The Royal Society vol. 20 (208)
01-11-2023
Hepatocytes undergo punctuated expansion dynamics from a periportal stem cell niche in normal human liverPassman AM, Haughey MJ, Carlotti E, Williams MJ, Cereser B, Lin M-L, Devkumar S, Gabriel JP, Gringeri E, Cillo U, Russo FP, Hoare M, ChinAleong J, Jansen M, Wright NA, Kocher HM, Huang W, Alison MR and McDonald SAC
Journal of Hepatology, Elsevier vol. 79 (2), 417-432.
21-04-2023
2022
A Novel, Simple, and Low-Cost Approach for Machine Learning Screening of Kidney Cancer: An Eight-Indicator Blood Test Panel with Predictive Value for Early DiagnosisLi H, Wang F and Huang W
Current Oncology, Mdpi vol. 29 (12), 9135-9149.
24-11-2022
The evolutionary dynamics of extrachromosomal DNA in human cancersLange JT, Rose JC, Chen CY, Pichugin Y, Xie L, Tang J, Hung KL, Yost KE, Shi Q, Erb ML, Rajkumar U, Wu S, Taschner-Mandl S, Bernkopf M, Swanton C, Liu Z, Huang W, Chang HY, Bafna V, Henssen AG, et al.
Nature Genetics, Springer Nature vol. 54 (10), 1527-1533.
19-09-2022
A novel cell line panel reveals non-genetic mediators of platinum resistance and phenotypic diversity in high grade serous ovarian cancerHoare JI, Hockings H, Saxena J, Silva VL, Haughey MJ, Wood GE, Nicolini F, Mirza H, McNeish IA, Huang W, Maniati E, Graham TA and Lockley M
Gynecologic Oncology, Elsevier vol. 167 (1), 96-106.
30-07-2022
Abstract PR015: Developing adaptive therapy to suppress the evolution of treatment resistance in high-grade serous ovarian cancerHockings H, Lockley M, Graham T, Lakatos E and Huang W
Cancer Research, American Association For Cancer Research (Aacr) vol. 82 (10_Supplement), pr015-pr015.
15-05-2022
First passage time analysis of spatial mutation patterns reveals evolutionary dynamics of pre-existing resistance in colorectal cancerHaughey MJ, Bassolas A, Sousa S, Baker A-M, Graham TA, Nicosia V and Huang W
, Cold Spring Harbor Laboratory
24-02-2022
An improved approximation for Maximum k -dependent Set on bipartite graphsHosseinian S and Butenko S
Discrete Applied Mathematics, Elsevier vol. 307, 95-101.
01-01-2022
2021
Clonal Transitions and Phenotypic Evolution in Barrett’s EsophagusEvans JA, Carlotti E, Lin M-L, Hackett RJ, Haughey MJ, Passman AM, Dunn L, Elia G, Porter RJ, McLean MH, Hughes F, ChinAleong J, Woodland P, Preston SL, Griffin SM, Lovat L, Rodriguez-Justo M, Huang W, Wright NA, Jansen M, et al.
Gastroenterology, Elsevier vol. 162 (4), 1197-1209.e13.
29-12-2021
LiquidCNA: Tracking subclonal evolution from longitudinal liquid biopsies using somatic copy number alterationsLakatos E, Hockings H, Mossner M, Huang W, Lockley M and Graham TA
Iscience, Elsevier vol. 24 (8)
21-07-2021
LiquidCNA: tracking subclonal evolution from longitudinal liquid biopsies using somatic copy number alterationsLakatos E, Hockings H, Mossner M, Huang W, Lockley M and Graham TA
, Cold Spring Harbor Laboratory
06-01-2021
2020
Platinum resistance induces diverse evolutionary trajectories in high grade serous ovarian cancerHoare JI, Hockings H, Saxena J, Silva VL, Maniati E, Mirza HB, Huang W, Wood GE, Nicolini F, Graham TA, McNeish IA and Lockley M
, Cold Spring Harbor Laboratory
24-07-2020
CLONAL DYNAMICS AND CELL-OF-ORIGIN OF NORMAL HEPATOCYTE EXPANSIONS IN HOMEOSTATIC HUMAN LIVERS AND THEIR ASSOCIATION WITH THE BILIARY EPITHELIUMPassman AM, Haughey MJ, Carlotti E, Williams M, Cereser B, Russo FP, Hoare M, Kocher H, Chin-Aleong J, Graham TA, Wright NA, Huang W, Alison M and McDonald SA
AACR. vol. 158 (6), S1276-S1276.
01-05-2020
450 CLONAL DYNAMICS AND CELL-OF-ORIGIN OF NORMAL HEPATOCYTE EXPANSIONS IN HOMEOSTATIC HUMAN LIVERS AND THEIR ASSOCIATION WITH THE BILIARY EPITHELIUMPassman AM, Haughey MJ, Carlotti E, Williams M, Cereser B, Russo FP, Hoare M, Kocher H, Chin-Aleong J, Graham TA, Wright NA, Huang W, Alison M and McDonald SA
Gastroenterology, Elsevier vol. 158 (6), s-1276.
01-05-2020
Measuring single cell divisions in human tissues from multi-region sequencing dataWerner B, Case J, Williams MJ, Chkhaidze K, Temko D, Fernández-Mateos J, Cresswell GD, Nichol D, Cross W, Spiteri I, Huang W, Tomlinson IPM, Barnes CP, Graham TA and Sottoriva A
Nature Communications, Springer Nature vol. 11 (1)
25-02-2020
2019
Stochastic dynamics of extra-chromosomal DNAPichugin Y, Huang W and Werner B
, Cold Spring Harbor Laboratory
15-12-2019
The feedback between selection and demography shapes genomic diversity during coevolutionRetel C, Kowallik V, Huang W, Werner B, Becks L, Feulner P and Huang W
Science Advances
02-10-2019
Abstract 4232: Spatially constrained tumor growth affects the patterns of clonal selection and neutral drift in cancer genomic dataChkhaidze K, Heide T, Werner B, Williams MJ, Huang W, Caravagna G, Baker A-M, Graham TA and Sottoriva A
Bioinformatics, Convergence Science, and Systems Biology., 4232-4232.
01-07-2019
Measuring single cell divisions in human cancers from multi-region sequencing dataWerner B, Case J, Williams MJ, Chkhaidze K, Temko D, Fernandez-Mateos J, Cresswell GD, Nichol D, Cross W, Spiteri I, Huang W, Tomlinson I, Barnes CP, Graham TA and Sottoriva A
, Cold Spring Harbor Laboratory
25-02-2019
Spatially constrained tumour growth affects the patterns of clonal selection and neutral drift in cancer genomic dataChkhaidze K, Heide T, Werner B, Williams MJ, Huang W, Caravagna G, Graham TA and Sottoriva A
, Cold Spring Harbor Laboratory
08-02-2019
Population size changes and extinction risk of populations driven by mutant interactors.Park HJ, Pichugin Y, Huang W and Traulsen A
Phys Rev E vol. 99 (2-1), 022305-022305.
06-02-2019
2018
Life History Trade-Offs in Tumors.Boddy AM, Huang W and Aktipis A
Curr Pathobiol Rep vol. 6 (4), 201-207.
10-11-2018
In Situ Mutation Detection Maps the Clonal Architecture of Colorectal Cancer and AdenomasBaker A-M, Huang W, Wang X-MM, Jansen M, Ma X-J, Domingo E, Wright NA, Rodriguez-Justo M, Park E, Tomlinson I and Graham TA
JOURNAL OF PATHOLOGY. vol. 245, S10-S10.
01-01-2018
2017
Dynamical trade-offs arise from antagonistic coevolution and decrease intraspecific diversity.Huang W, Traulsen A, Werner B, Hiltunen T and Becks L
Nat Commun, Macmillan Publishers Limited, Part of Springer Nature vol. 8 (1), 2059-2059.
12-12-2017
Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution.Baker A-M, Huang W, Wang X-MM, Jansen M, Ma X-J, Kim J, Anderson CM, Wu X, Pan L, Su N, Luo Y, Domingo E, Heide T, Sottoriva A, Lewis A, Beggs AD, Wright NA, Rodriguez-Justo M, Park E, Tomlinson I, et al.
Nat Commun, Macmillan Publishers Limited, Part of Springer Nature vol. 8 (1), 1998-1998.
08-12-2017
Abstract 3953: Visualization of treatment resistant subclones in colorectal cancer by mutation specific RNA in situ hybridizationBaker A-M, Wang M, Ma X-J, Anderson C, Huang W, Domingo E, Lewis A, Bridgewater J, Jansen M, Wright NA, Rodriguez-Justo M, Park E, Tomlinson I and Graham TA
Cancer Research. vol. 77 (13_Supplement), 3953-3953.
01-07-2017
2016
Competing metabolic strategies in a multilevel selection modelAmado A, Fernández L, Huang W, Ferreira FF and Campos PRA
Royal Society Open Science vol. 3 (11), 160544-160544.
16-11-2016
A resource-based game theoretical approach for the paradox of the plankton.Huang W, de Araujo Campos PR, Moraes de Oliveira V and Fagundes Ferrreira F
Peerj vol. 4, e2329-e2329.
18-08-2016
2015
Stochastic game dynamics under demographic fluctuationsHuang W, Hauert C and Traulsen A
Proceedings of The National Academy of Sciences of The United States of America, Proceedings of The National Academy of Sciences vol. 112 (29), 9064-9069.
06-07-2015
Learning process in public goods gamesAmado A, Huang W, Campos PRA and Ferreira FF
Physica a Statistical Mechanics and Its Applications, Elsevier vol. 430, 21-31.
01-07-2015
2012
The impact of random frequency-dependent mutations on the average population fitnessHuang W, Werner B and Traulsen A
Bmc Ecology and Evolution, Springer Nature vol. 12 (1)
30-08-2012
Grants
Grants of specific relevance to the Centre for Complex SystemsCancer Grand Challenges Weini Huang & Benjamin WernerWeini Huang and Benjamin Werner
£1,434,952 CR-UK Cancer Research UK
01-06-2022 - 31-05-2027
EvoGamesPlus - ITN 2020 Weini Huang/Benjamin WernerWeini Huang and Benjamin Werner
£432,596 EU Commission - Horizon 2020
01-03-2021 - 28-02-2025
ATI Data Science for Science Programme: Molecular Biology - WHuangWeini Huang and Benjamin Werner
£49,056 Alan Turing Institute, The
01-12-2020 - 31-07-2021