Prof Rob Krams

Professor of Molecular Bioengineering
Scientific Director of the CVDHub

School of Engineering and Materials Science
Queen Mary University of London

r.krams@qmul.ac.uk

www.sems.qmul.ac.uk/staff/r.krams/

Centre for Bioengineering

Research
Publications
Grants

Research

Cardiovascular Disease, Atherosclerosis, Biomaterials, Epigenetic, Mechanobiology, Fluid Structure Interaction

Interests

Professor Krams' research is focussed on the molecular mechanism underlying biomechanical stimuli applied to blood vessels and endothelial cells. To that end he uses a combination of engineering techniques (imaging, systems biology and synthetic biology) and molecular techniques (high throughput, qPCR, CRISPR/ life cell imaging) to study the interaction of gene expression and shear stress and wall stress on cells in culture and in whole animals.

His research has led to the development of new devices for patient and experimental studies and to the development of new analysis techniques for images obtained by microscopes. The work that hase started in London consists of imaging of animals, FSI modelling and application of system biology and mult-scale modelling to vascular biology. We have developed a pipeline consisting of accurate identification of the mechanical environment of endothelial cells in vivo, their isolation by laser capture, RNA isolation and coding anf non-coding gene network synthesis. As bioinformatics tools are still in their infancy, we have a high throughput CRISPr validation platform for evaluation of the interactome. Finally, methods to replace diseased modules by synthetic biology are being explored as well. We specially focus on small and long noncoding RNA in our group.

Publications

Publications of specific relevance to the Centre for Bioengineering

2024

Editorial: Computational modelling of cardiovascular hemodynamics and machine learning
Bourantas C, Torii R, Karabasov S and Krams R
Frontiers in Cardiovascular Medicine, Frontiers vol. 11

DOI 10.3389/fcvm.2024.1355843

QMRO

22-02-2024

Assessment of the nano-mechanical properties of healthy and atherosclerotic coronary arteries by atomic force microscopy
Savvopoulos F, Keeling MC, Carassiti D, Fogell NA, Patel MB, Naser J, Gavara N, de Silva R and Krams R
Journal of The Royal Society Interface, The Royal Society vol. 21 (211)

DOI 10.1098/rsif.2023.0674

QMRO

01-02-2024

2023

TCT-613 Comparison of Histology-Trained Deep Learning Approach With Human Expert Analysts for Automated Plaque Component Classification in Hybrid Intravascular Ultrasound-Optical Coherence Tomography Images
Bajaj R, Huang X, Alves-Kotzev N, Weyers J, Levine M, Garg M, Maung S, Bransby K, Torii R, Krams R, Garcia-Garcia HM, Raber L, Mathur A, Baumbach A, Zhang Q, Courtney B and Bourantas C
Journal of The American College of Cardiology, Elsevier vol. 82 (17), b246-b247.

DOI 10.1016/j.jacc.2023.09.624

QMRO

01-10-2023

A physics-based machine learning technique rapidly reconstructs the wall-shear stress and pressure fields in coronary arteries
Morgan B, Murali AR, Preston G, Sima YA, Chamorro LM, Bourantas C, Torii R, Mathur A, Baumbach A, Jacob M, Karabasov S and Krams R
Frontiers in Cardiovascular Medicine, Frontiers Media

DOI 10.3389/fcvm.2023.1221541

QMRO

29-09-2023

Considering the Influence of Coronary Motion on Artery-Specific Biomechanics Using Fluid–Structure Interaction Simulation
Fogell NAT, Patel M, Yang P, Ruis RM, Garcia DB, Naser J, Savvopoulos F, Davies Taylor C, Post AL, Pedrigi RM, de Silva R and Krams R
Annals of Biomedical Engineering, Springer vol. 51 (9), 1950-1964.

DOI 10.1007/s10439-023-03214-0

QMRO

12-07-2023

BS15 Ultra-highly flexible, accurate, high throughput platform for knock-in studies.
Krams R, Herault S, Jaitly A, Bala R, Calistus A and Towhidi L
Basic Science., a256.1-a2a256.

DOI 10.1136/heartjnl-2023-bcs.229

01-06-2023

BS13 Ultra-highly flexible, accurate, high throughput platform for personalised drug screening studies.
Krams R and Towhidi L
Basic Science., a255.2-a2a255.

DOI 10.1136/heartjnl-2023-bcs.227

01-06-2023

BS12 A novel physics-based artificial intelligence technique rapidly reconstructs the 3D velocity, shear stress and pressure fields in coronary arteries.
Krams R, Preston G, Chamorro L, Morgan B, Sima Y, Murali A, Bourantas C, Torii R, Mathur A, Baumbach A and Karabasov S
Basic Science., a255.1-a2a255.

DOI 10.1136/heartjnl-2023-bcs.226

QMRO

01-06-2023

BS14 A fully automated vulnerable plaque classifier for oct using co-registered histological images and transfer learning learning.
Krams R, Chamorro L, Komo Z, Bashir A, Torii R, Bourantas C, Zhang Q, Mathur A, Baumbach A, Pedrigi R and de Silva R
Basic Science., a255.3-a2a256.

DOI 10.1136/heartjnl-2023-bcs.228

QMRO

01-06-2023

Editorial: Computational modeling for assessing coronary artery pathophysiology
Çap M, Torii R, Onuma Y, Krams R, Bennett MR, Stone PH, Serruys PW and Bourantas CV
Frontiers in Cardiovascular Medicine, Frontiers Media vol. 10

DOI 10.3389/fcvm.2023.1113835

QMRO

17-01-2023

2022

JAG1-NOTCH4 mechanosensing drives atherosclerosis
Souilhol C, Ayllon BT, Li X, Diagbouga MR, Zhou Z, Canham L, Roddie H, Pirri D, Chambers EV, Dunning MJ, Ariaans M, Li J, Fang Y, Jørgensen HF, Simons M, Krams R, Waltenberger J, Fragiadaki M, Ridger V, De Val S, et al.
Science Advances, American Association For The Advancement of Science vol. 8 (35)

DOI 10.1126/sciadv.abo7958

QMRO

02-09-2022

TCT-254 Histology-Trained Deep Learning Methodology for Automated Coronary Plaque Component Classification in Combined Intravascular Ultrasound-Optical Coherence Tomography Images
Bajaj R, Huang X, Alves N, Weyers J, Levine M, Garg M, Maung S, Bransby K, Torii R, Krams R, Garcia-Garcia H, Mathur A, Baumbach A, Zhang Q, Courtney B and Bourantas C
Journal of The American College of Cardiology, Elsevier vol. 80 (12)

DOI 10.1016/j.jacc.2022.08.299

QMRO

01-09-2022

Histology- Trained Deep Learning Methodology for Automated Coronary Plaque Component Classification in Combined Intravascular Ultrasound-Optical Coherence Tomography Images
Bajaj R, Huang X, Alves N, Weyers J, Levine M, Garg M, Maung S, Bransby K, Torii R, Krams R, Garcia-Garcia H, Mathur A, Baumbach A, Zhang Q, Courtney B and Bourantas C
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. vol. 80 (12), B100-B100.

QMRO

01-01-2022

2021

Mechanosensitive pathways are regulated by mechanosensitive miRNA clusters in endothelial cells
Herault S, Naser J, Carassiti D, Chooi KY, Nikolopoulou R, Font ML, Patel M, Pedrigi R and Krams R
Biophysical Reviews, Springer (Part of Springer Nature) vol. 13 (5), 787-796.

DOI 10.1007/s12551-021-00839-0

QMRO

23-10-2021

Moving shear stress towards the clinic: preclinical comparison of optical coherence tomography-based versus angiography-based time-averaged wall shear stress estimations
Naser J, Fogell N, Patel M, Yang P, Krams R, Wentzel JJ, Aben JP and De Silva R
European Heart Journal vol. 42 (Supplement_1)

DOI 10.1093/eurheartj/ehab724.1195

QMRO

12-10-2021

Correction: BS18 Profiling endothelial gene expression in coronary atherosclerotic plaques in a human-like D374Y-PCSK9 hyperlipidaemic porcine model

Heart, Bmj vol. 107 (19), e10-e10.

DOI 10.1136/heartjnl-2021-bcs.216corr1

QMRO

14-09-2021

Considerations for analysis of endothelial shear stress and strain in FSI models of atherosclerosis
Patel M, Savvopoulos F, Berggren CC, Aslanidou L, Timmins LH, de Silva R, Pedrigi RM and Krams R
Journal of Biomechanics, Elsevier vol. 128

DOI 10.1016/j.jbiomech.2021.110720

QMRO

28-08-2021

BS18 Profiling endothelial gene expression in coronary atherosclerotic plaques in a human-like D374Y-PCSK9 hyperlipidaemic porcine model
Naser J, Mein CA, Wozniak E, Carassiti D, Mahomed AS, Krams R and de Silva R
Heart. vol. 107 (Suppl 1), a166-a167.

DOI 10.1136/heartjnl-2021-bcs.216

QMRO

04-06-2021

2020

3D co-registration algorithm for catheter-based optical coherence tomography
Post AL, Cernohorsky P, Pedrigi RM, Streekstra GJ, d’Hooghe JNS, Annema JT, Strackee SD, Krams R, van Leeuwen TG, de Bruin DM and Faber DJ
Optics Continuum, Optica Publishing Group vol. 3 (10)

DOI 10.1364/osac.401599

17-09-2020

Shear Stress Estimated by Quantitative Coronary Angiography Predicts Plaques Prone to Progress and Cause Events
Bourantas CV, Zanchin T, Torii R, Serruys PW, Karagiannis A, Ramasamy A, Safi H, Coskun AU, Koning G, Onuma Y, Zanchin C, Krams R, Mathur A, Baumbach A, Mintz G, Windecker S, Lansky A, Maehara A, Stone PH, Raber L, et al.
Jacc Cardiovascular Imaging, Elsevier vol. 13 (10), 2206-2219.

DOI 10.1016/j.jcmg.2020.02.028

13-05-2020

Targeted Molecular Iron Oxide Contrast Agents for Imaging Atherosclerotic Plaque
Evans RJ, Lavin B, Phinikaridou A, Chooi KY, Mohri Z, Wong E, Boyle JJ, Krams R, Botnar R and Long NJ
Nanotheranostics, Ivyspring International Publisher vol. 4 (4), 184-194.

DOI 10.7150/ntno.44712

QMRO

01-01-2020

2019

Expert recommendations on the assessment of wall shear stress in human coronary arteries: existing methodologies, technical considerations, and clinical applications.
Gijsen F, Katagiri Y, Barlis P, Bourantas C, Collet C, Coskun U, Daemen J, Dijkstra J, Edelman E, Evans P, van der Heiden K, Hose R, Koo B-K, Krams R, Marsden A, Migliavacca F, Onuma Y, Ooi A, Poon E, Samady H, et al.
European Heart Journal, Oxford University Press (Oup)

DOI 10.1093/eurheartj/ehz551

QMRO

30-09-2019

Reliable in Vivo Intravascular Imaging Plaque Characterisation: A Challenge Unmet
Baumbach A
American Heart Journal, Elsevier

DOI 10.1016/j.ahj.2019.07.008

QMRO

23-07-2019

The emerging role of YAP/TAZ in mechanotransduction.
Mohri Z, Del Rio Hernandez A and Krams R
J Thorac Dis vol. 9 (5), E507-E509.

DOI 10.21037/jtd.2017.03.179

01-05-2019

Disturbed flow induces a sustained, stochastic NF-κB activation which may support intracranial aneurysm growth in vivo.
Baeriswyl DC, Prionisti I, Peach T, Tsolkas G, Chooi KY, Vardakis J, Morel S, Diagbouga MR, Bijlenga P, Cuhlmann S, Evans P, Kwak BR, Ventikos Y and Krams R
Sci Rep vol. 9 (1), 4738-4738.

DOI 10.1038/s41598-019-40959-y

QMRO

18-03-2019

Plaque burden influences accurate classification of fibrous cap atheroma by in vivo optical coherence tomography in a porcine model of advanced coronary atherosclerosis.
Poulsen CB, Pedrigi RM, Pareek N, Kilic ID, Holm NR, Bentzon JF, Bøtker HE, Falk E, Krams R and de Silva R
Eurointervention vol. 14 (10), 1129-1135.

DOI 10.4244/EIJ-D-17-01028

QMRO

20-02-2019

2018

P11 DEVELOPING NEW TARGETED MOLECULAR CONTRAST AGENTS FOR IMAGING INFLAMMATION OF VULNERABLE PLAQUES
Evans RJ, Hernández-Gil J, Mohri Z, Chooi KY, Lavin-Plaza B, Phinikaridou A, Pease JE, Krams R, Botnar R and Long NJ
Cardiovascular Research. vol. 114 (suppl_2), s3-s4.

DOI 10.1093/cvr/cvy216.014

01-09-2018

P34 FLUID-STRUCTURE INTERACTION MODELLING FOR ANALYSING ADVANCED CORONARY ATHEROSCLEROTIC PLAQUE FORMATION IN TRANSGENIC HYPERLIPIDAEMIC MINIPIGS
Yang P, Silva R, Pedrigi R, Patel M, Chooi Y, Ahmed R, Naser J and Krams R
Cardiovascular Research. vol. 114 (suppl_2), s10-s10.

DOI 10.1093/cvr/cvy216.037

01-09-2018

New developments in mechanotransduction: Cross talk of the Wnt, TGF-β and Notch signalling pathways in reaction to shear stress
Abuammah A, Maimari N, Towhidi L, Frueh J, Chooi KY, Warboys C and Krams R
Current Opinion in Biomedical Engineering vol. 5, 96-104.

DOI 10.1016/j.cobme.2018.03.003

01-03-2018

2017

Interferon Regulatory Factor 5 Controls Necrotic Core Formation in Atherosclerotic Lesions by Impairing Efferocytosis.
Seneviratne AN, Edsfeldt A, Cole JE, Kassiteridi C, Swart M, Park I, Green P, Khoyratty T, Saliba D, Goddard ME, Sansom SN, Goncalves I, Krams R, Udalova IA and Monaco C
Circulation, American Heart Association, Inc vol. 136 (12), 1140-1154.

DOI 10.1161/CIRCULATIONAHA.117.027844

QMRO

11-07-2017

Connexin40 controls endothelial activation by dampening NFκB activation.
Denis J-F, Scheckenbach KEL, Pfenniger A, Meens MJ, Krams R, Miquerol L, Taffet S, Chanson M, Delmar M and Kwak BR
Oncotarget, Impact Journals vol. 8 (31), 50972-50986.

DOI 10.18632/oncotarget.16438

QMRO

22-03-2017

COMPARISON OF IN VIVO OPTICAL COHERENCE TOMOGRAPHY DERIVED PLAQUE PHENOTYPE AND BURDEN WITH HISTOLOGY IN A PORCINE MODEL OF ADVANCED CORONARY ATHEROSCLEROSIS
Poulsen CB, Pedrigi R, Holm N, Pareek N, Kilic I, Post AL, Di Mario C, Bentzon J, Botker H, Falk E, Krams R and de Silva R
Journal of the American College of Cardiology. vol. 69 (11)

DOI 10.1016/s0735-1097(17)34461-3

01-03-2017

2016

Zebrafish Model for Functional Screening of Flow-Responsive Genes.
Serbanovic-Canic J, de Luca A, Warboys C, Ferreira PF, Luong LA, Hsiao S, Gauci I, Mahmoud M, Feng S, Souilhol C, Bowden N, Ashton J-P, Walczak H, Firmin D, Krams R, Mason JC, Haskard DO, Sherwin S, Ridger V, Chico TJA, et al.
Arterioscler Thromb Vasc Biol, Wolters Kluwer Health, Inc vol. 37 (1), 130-143.

DOI 10.1161/ATVBAHA.116.308502

QMRO

10-11-2016

Disturbed Cyclical Stretch of Endothelial Cells Promotes Nuclear Expression of the Pro-Atherogenic Transcription Factor NF-κB.
Pedrigi RM, Papadimitriou KI, Kondiboyina A, Sidhu S, Chau J, Patel MB, Baeriswyl DC, Drakakis EM and Krams R
Ann Biomed Eng, Springer Nature vol. 45 (4), 898-909.

DOI 10.1007/s10439-016-1750-z

QMRO

27-10-2016

Influence of shear stress magnitude and direction on atherosclerotic plaque composition
Pedrigi RM, Mehta VV, Bovens SM, Mohri Z, Poulsen CB, Gsell W, Tremoleda JL, Towhidi L, de Silva R, Petretto E and Krams R
Royal Society Open Science, The Royal Society vol. 3 (10)

DOI 10.1098/rsos.160588

QMRO

01-10-2016

Development of a synthetic gene network to modulate gene expression by mechanical forces.
Kis Z, Rodin T, Zafar A, Lai Z, Freke G, Fleck O, Del Rio Hernandez A, Towhidi L, Pedrigi RM, Homma T and Krams R
Sci Rep, Springer Nature vol. 6, 29643-29643.

DOI 10.1038/srep29643

QMRO

12-07-2016

0109 : Connexin40 controls endothelial activation by dampening NF B activation
Denis J-F, Scheckenbach L, Pfenniger A, Meens M, Krams R, Miquerol L, Taffet S, Chanson M, Delmar M and Kwak B
Archives of Cardiovascular Diseases Supplements vol. 8 (3), 203-203.

DOI 10.1016/s1878-6480(16)30366-4

01-04-2016

Quantification of plaque stiffness by Brillouin microscopy (Conference Presentation)
Antonacci G, Pedrigi R, Krams R and Török P
Optical Elastography and Tissue Biomechanics III.

DOI 10.1117/12.2228312

09-03-2016

Comparison between direct and reverse electroporation of cells in situ: a simulation study
Towhidi L, Khodadadi D, Maimari N, Pedrigi RM, Ip H, Kis Z, Kwak BR, Petrova TW, Delorenzi M and Krams R
Physiological Reports, Wiley vol. 4 (6)

DOI 10.14814/phy2.12673

QMRO

01-03-2016

Corrigendum to “Low shear stress induces M1 macrophage polarization in murine thin-cap atherosclerotic plaques” [J Mol Cell Cardiol] 89B (2015) 168–172
Seneviratne AN, Cole JE, Goddard ME, Park I, Mohri Z, Sansom S, Udalova I, Krams R and Monaco C
Journal of Molecular and Cellular Cardiology, Elsevier vol. 91

DOI 10.1016/j.yjmcc.2015.12.029

01-02-2016

Integration of flow studies for robust selection of mechanoresponsive genes
Maimari N, Pedrigi RM, Russo A, Broda K and Krams R
Thrombosis and Haemostasis, Thieme vol. 115 (03), 474-483.

DOI 10.1160/th15-09-0704

01-01-2016

A novel assay for regulating transcription factors by flow
Krams RM, Pedrigi RM and Kis Z
CARDIOVASCULAR RESEARCH. vol. 111, S117-S117.
01-01-2016

2015

Quantification of plaque stiffness by Brillouin microscopy in experimental thin cap fibroatheroma
Antonacci G, Pedrigi RM, Kondiboyina A, Mehta VV, de Silva R, Paterson C, Krams R and Török P
Journal of The Royal Society Interface, The Royal Society vol. 12 (112)

DOI 10.1098/rsif.2015.0843

01-11-2015

Low shear stress induces M1 macrophage polarization in murine thin-cap atherosclerotic plaques
Seneviratne AN, Cole JE, Goddard ME, Park I, Mohri Z, Sansom S, Udalova I, Krams R and Monaco C
Journal of Molecular and Cellular Cardiology, Elsevier vol. 89 (Pt B), 168-172.

DOI 10.1016/j.yjmcc.2015.10.034

30-10-2015

Shear stress-induced atherosclerotic plaque composition in ApoE−/− mice is modulated by connexin37
Pfenniger A, Meens MJ, Pedrigi RM, Foglia B, Sutter E, Pelli G, Rochemont V, Petrova TV, Krams R and Kwak BR
Atherosclerosis, Elsevier vol. 243 (1), 1-10.

DOI 10.1016/j.atherosclerosis.2015.08.029

25-08-2015

Inducing Persistent Flow Disturbances Accelerates Atherogenesis and Promotes Thin Cap Fibroatheroma Development in D374Y-PCSK9 Hypercholesterolemic Minipigs
Pedrigi RM, Poulsen CB, Mehta VV, Ramsing Holm N, Pareek N, Post AL, Kilic ID, Banya WAS, Dall'Ara G, Mattesini A, Bjørklund MM, Andersen NP, Grøndal AK, Petretto E, Foin N, Davies JE, Di Mario C, Fog Bentzon J, Erik Bøtker H, Falk E, et al.
Circulation, Wolters Kluwer vol. 132 (11), 1003-1012.

DOI 10.1161/circulationaha.115.016270

15-07-2015

Enhancement of Non-Invasive Trans-Membrane Drug Delivery Using Ultrasound and Microbubbles During Physiologically Relevant Flow
Shamout FE, Pouliopoulos AN, Lee P, Bonaccorsi S, Towhidi L, Krams R and Choi JJ
Ultrasound in Medicine & Biology, Elsevier vol. 41 (9), 2435-2448.

DOI 10.1016/j.ultrasmedbio.2015.05.003

09-06-2015

182 Flow Characteristics Enhanced by the Compliant Arteries and their effects in Vulnerable Plaque Formation
da Conceicao Pereira G and Krams R
Heart. vol. 101 (Suppl 4)

DOI 10.1136/heartjnl-2015-308066.182

01-06-2015

Mammalian synthetic biology: emerging medical applications
Kis Z, Pereira HS, Homma T, Pedrigi RM and Krams R
Journal of The Royal Society Interface, The Royal Society vol. 12 (106)

DOI 10.1098/rsif.2014.1000

01-05-2015

INDUCTION OF PERTURBED SHEAR STRESS LEADS TO FOCAL ADVANCED ATHEROSCLEROTIC PLAQUE FORMATION IN TRANSGENIC MINIPIGS WITH HYPERCHOLESTEROLEMIA
Poulsen CB, Pedrigi RM, Mehta VV, Post A, Pareek N, Holm NR, Kilic D, El-Bahnasawi M, Bjørklund MM, Andersen NP, Grøndal AK, Nachiappan A, Foin N, Davies JER, Di Mario C, Bøtker HE, Bentzon JF, Falk E, Krams R and de Silva R
Journal of the American College of Cardiology. vol. 65 (10)

DOI 10.1016/s0735-1097(15)61927-1

01-03-2015

Imaging phase separation in model lipid membranes through the use of BODIPY based molecular rotors
Dent MR, López-Duarte I, Dickson CJ, Geoghegan ND, Cooper JM, Gould IR, Krams R, Bull JA, Brooks NJ and Kuimova MK
Physical Chemistry Chemical Physics, Royal Society of Chemistry (Rsc) vol. 17 (28), 18393-18402.

DOI 10.1039/c5cp01937k

01-01-2015

Bifurcation and stability analysis of nonlinear dynamic systems using complete search
Villanueva ME, Pereira HSA, Rajyaguru J, Krams R and Chachuat B
Computing and Systems Technology Division 2015 - Core Programming Area at the 2015 AIChE Annual Meeting. vol. 2, 627-628.
01-01-2015

2014

Elevated Uptake of Plasma Macromolecules by Regions of Arterial Wall Predisposed to Plaque Instability in a Mouse Model
Mohri Z, Rowland EM, Clarke LA, De Luca A, Peiffer V, Krams R, Sherwin SJ and Weinberg PD
Plos One, Public Library of Science (Plos) vol. 9 (12)

DOI 10.1371/journal.pone.0115728

QMRO

22-12-2014

Transcriptome analysis of local shear dependent gene expression in endothelial cells during thin-cap fibroatheroma(TCFA) development
Homma T, Caurette P, Silva HJ, Yamada I, Makrydaki E, Bovens S, Pedrigi R, Petretto EG and Krams R
Atherosclerosis. vol. 237 (2)

DOI 10.1016/j.atherosclerosis.2014.10.057

01-12-2014

A novel high-throughput platform for siRNA transfection of primary mammalian cells
Towhidi L, Maimari N, Kis Z, Khodadadi D and Krams R
Atherosclerosis, Elsevier vol. 237 (2)

DOI 10.1016/j.atherosclerosis.2014.10.075

01-12-2014

Forecasting vulnerable plaque response to aemorheological flow
Pereira G and Krams R
Atherosclerosis, Elsevier vol. 237 (2)

DOI 10.1016/j.atherosclerosis.2014.10.068

01-12-2014

Longitudinal predictive analysis of vulnerable plaques in a mouse model of atherosclerosis
Mehta VV, Pedrigi RM, Bovens SM, Tremoleda JL, Gsell W and Krams R
Atherosclerosis, Elsevier vol. 237 (2)

DOI 10.1016/j.atherosclerosis.2014.10.066

01-12-2014

A novel integrated platform for gene network inference and validation: beyond the dream consortium
Maimari N, Towhidi L, Oh D, Broda K, Russo A and Krams R
Atherosclerosis, Elsevier vol. 237 (2)

DOI 10.1016/j.atherosclerosis.2014.10.065

01-12-2014

Symbolic representation and inference of regulatory networks: uncovering mechanosensitive gene networks
Maimari N, Broda K, Kakas A, Russo A and Krams R
Atherosclerosis, Elsevier vol. 237 (2)

DOI 10.1016/j.atherosclerosis.2014.10.064

01-12-2014

Biomechanical factors in atherosclerosis: mechanisms and clinical implications†
Kwak BR, Bäck M, Bochaton-Piallat M-L, Caligiuri G, Daemen MJAP, Davies PF, Hoefer IE, Holvoet P, Jo H, Krams R, Lehoux S, Monaco C, Steffens S, Virmani R, Weber C, Wentzel JJ and Evans PC
European Heart Journal, Oxford University Press (Oup) vol. 35 (43), 3013-3020.

DOI 10.1093/eurheartj/ehu353

17-09-2014

In Vivo Mapping of Vascular Inflammation Using the Translocator Protein Tracer 18F-FEDAA1106
Cuhlmann S, Gsell W, Van der Heiden K, Habib J, Tremoleda JL, Khalil M, Turkheimer F, Meens MJ, Kwak BR, Bird J, Davenport AP, Clark J, Haskard D, Krams R, Jones H and Evans PC
Molecular Imaging, Sage Publications vol. 13 (6)

DOI 10.2310/7290.2014.00014

01-08-2014

In Vivo Mapping of Vascular Inflammation Using the Translocator Protein Tracer 18F-FEDAA1106.
Cuhlmann S, Gsell W, Van der Heiden K, Habib J, Tremoleda JL, Khalil M, Turkheimer F, Meens MJ, Kwak BR, Bird J, Davenport AP, Clark J, Haskard D, Krams R, Jones H and Evans PC
Mol Imaging vol. 13 (6)

DOI 10.2310/7290.2014.00014

01-08-2014

Thin-Cap Fibroatheroma Rupture Is Associated With a Fine Interplay of Shear and Wall Stress
Pedrigi RM, de Silva R, Bovens SM, Mehta VV, Petretto E and Krams R
Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 34 (10), 2224-2231.

DOI 10.1161/atvbaha.114.303426

24-07-2014

Symbolic Representation and Inference of Regulatory Network Structures
Maimari N, Broda K, Kakas A, Krams R and Russo A
In Logical Modeling of Biological Systems, Wiley 1-48.

DOI 10.1002/9781119005223.ch1

10-07-2014

Intimal hyperplasia following implantation of helical-centreline and straight-centreline stents in common carotid arteries in healthy pigs: influence of intraluminal flow
Gerald C, Seneviratne A, Heraty KB, Monaco C, Burke MG, Krams R, Chang CC, Gilson P and Coppola G
Journal of The Royal Society Interface, The Royal Society vol. 11 (92)

DOI 10.1098/rsif.2013.1156

06-03-2014

Elevated arterial wall permeability may cause vulnerable plaque formation in mice
Mohri Z, Rowland E, Clarke LA, De Luca A, Krams R and Weinberg PD
Atherosclerosis. vol. 232 (2)

DOI 10.1016/j.atherosclerosis.2013.11.015

01-02-2014

Modelling the Mechanics of the Circulation: Blood Rheology and Atherosclerosis
Pereira G, Krams R and van Wachem B
Biophysical Journal. vol. 106 (2)

DOI 10.1016/j.bpj.2013.11.2127

01-01-2014

An In situ electroporation and flow device for mechanotransduction studies
Kis Z, Towhidi L, Ip H, Drakakis E, Bharath A and Krams R
In Microarrays: Principles, Applications and Technologies 49-67.
01-01-2014

2013

Intimal hyperplasia following implantation of helical-centreline and straight-centreline stents in common carotid arteries in healthy pigs: influence of intraluminal flow†
Gerald C, Seneviratne A, Heraty KB, Monaco C, Burke MG, Krams R, Chang CC, Coppola G and Gilson P
Journal of The Royal Society Interface, The Royal Society vol. 10 (89)

DOI 10.1098/rsif.2013.0578

06-12-2013

ARNI: Abductive inference of complex regulatory network structures
Maimari N, Turliuc CR, Broda K, Kakas A, Krams R and Russo A
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). vol. 8130 LNBI, 235-237.
28-10-2013

Stabilization of atherosclerotic plaques: an update
Ylä-Herttuala S, Bentzon JF, Daemen M, Falk E, Garcia-Garcia HM, Herrmann J, Hoefer I, Jauhiainen S, Jukema JW, Krams R, Kwak BR, Marx N, Naruszewicz M, Newby A, Pasterkamp G, Serruys PWJC, Waltenberger J, Weber C, Tokgözoglu L and Biology EWGOAAV
European Heart Journal, Oxford University Press (Oup) vol. 34 (42), 3251-3258.

DOI 10.1093/eurheartj/eht301

21-08-2013

M1 macrophages are an early feature of shear stress modulated vulnerable atherosclerotic plaques
Seneviratne AN, Cole JE, Goddard ME, Udalova I, Krams R and Monaco C
European Heart Journal, Oxford University Press (Oup) vol. 34 (suppl_1)

DOI 10.1093/eurheartj/eht308.p2398

02-08-2013

Shear stress and nitric oxide transport affect NFkB dynamics in endothelial cells
Bovens SM, Foin N, O'Clery N, Van Der Heiden K, Cuhlmann S, Carlsen H, Barahona M, Evans PC and Krams R
European Heart Journal, Oxford University Press (Oup) vol. 34 (suppl_1)

DOI 10.1093/eurheartj/eht307.p582

02-08-2013

Method for Percutaneously Introducing, and Removing, Anatomical Stenosis of Predetermined Severity In Vivo: The “Stenotic Stent”
Foin N, Sen S, Petraco R, Nijjer S, Torii R, Kousera C, Broyd C, Mehta V, Xu Y, Mayet J, Hughes A, Di Mario C, Krams R, Francis D and Davies J
Journal of Cardiovascular Translational Research, Springer Nature vol. 6 (4), 640-648.

DOI 10.1007/s12265-013-9476-x

04-06-2013

Systems biology of the functional and dysfunctional endothelium
Frueh J, Maimari N, Homma T, Bovens SM, Pedrigi RM, Towhidi L and Krams R
Cardiovascular Research, Oxford University Press (Oup) vol. 99 (2), 334-341.

DOI 10.1093/cvr/cvt108

06-05-2013

181 M1 MACROPHAGES AND IRF5 EXACERBATE ATHEROSCLEROTIC DISEASE
Seneviratne A, Cole J, Goddard M, Udalova I, Krams R and Monaco C
Heart. vol. 99 (suppl 2)

DOI 10.1136/heartjnl-2013-304019.181

01-05-2013

The Role of Platelet-Endothelial Cell Adhesion Molecule-1 in Atheroma Formation Varies Depending on the Site-Specific Hemodynamic Environment
Harrison M, Smith E, Ross E, Krams R, Segers D, Buckley CD, Nash GB and Rainger GE
Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 33 (4), 694-701.

DOI 10.1161/atvbaha.112.300379

31-01-2013

Arginase inhibition prevents the low shear stress-induced development of vulnerable atherosclerotic plaques in ApoE−/− mice
Olivon VC, Fraga-Silva RA, Segers D, Demougeot C, de Oliveira AM, Savergnini SS, Berthelot A, de Crom R, Krams R, Stergiopulos N and da Silva RF
Atherosclerosis, Elsevier vol. 227 (2), 236-243.

DOI 10.1016/j.atherosclerosis.2012.12.014

17-01-2013

Shear stress and nitric oxide transport affect NFkB dynamics in endothelial cells
Bovens SM, Foin N, O'Clery N, Van der Heiden K, Cuhlmann S, Carlsen H, Barahona M, Evans PC and Krams R
EUROPEAN HEART JOURNAL. vol. 34, 110-110.
01-01-2013

M1 macrophages are an early feature of shear stress modulated vulnerable atherosclerotic plaques
Seneviratne AN, Cole JE, Goddard ME, Udalova I, Krams R and Monaco C
EUROPEAN HEART JOURNAL. vol. 34, 443-443.
01-01-2013

2012

Macrophage activation during chronic inflammation in atherosclerosis
Falck-Hansen MA, Goddard ME, Cole JE, Astola N, Cross AJ, Krams R and Monaco C
Atherosclerosis. vol. 225 (2)

DOI 10.1016/j.atherosclerosis.2012.10.010

01-12-2012

Macrophage polarisation in shear stress modulated atherosclerotic plaque vulnerability
Seneviratne AN, Cole JE, Goddard ME, Mohri Z, Krams R and Monaco C
Atherosclerosis. vol. 225 (2)

DOI 10.1016/j.atherosclerosis.2012.10.005

01-12-2012

Fibromodulin Deficiency Reduces Low-Density Lipoprotein Accumulation in Atherosclerotic Plaques in Apolipoprotein E–Null Mice
Shami A, Gustafsson R, Kalamajski S, Krams R, Segers D, Rauch U, Roos G, Nilsson J, Oldberg Å and Hultgårdh-Nilsson A
Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 33 (2), 354-361.

DOI 10.1161/atvbaha.112.300723

29-11-2012

TCT-231 Investigation of Fractional Flow Reserve Correlation with Direct Anatomical Parameters Using a Percutaneous Model of Coronary Artery Stenosis
Foin N, Sen S, Petraco R, Torii R, Nijjer S, Xu YX, Mehta V, Mayet J, Hughes A, Francis D, Di Mario C, Krams R and Davies J
Journal of the American College of Cardiology. vol. 60 (17)

DOI 10.1016/j.jacc.2012.08.254

01-10-2012

Shear stress modulates the expression of the atheroprotective protein Cx37 in endothelial cells
Pfenniger A, Wong C, Sutter E, Cuhlmann S, Dunoyer-Geindre S, Mach F, Horrevoets AJ, Evans PC, Krams R and Kwak BR
Journal of Molecular and Cellular Cardiology, Elsevier vol. 53 (2), 299-309.

DOI 10.1016/j.yjmcc.2012.05.011

29-05-2012

Systems and synthetic biology of the vessel wall
Frueh J, Maimari N, Lui Y, Kis Z, Mehta V, Pormehr N, Grant C, Chalkias E, Falck-Hansen M, Bovens S, Pedrigi R, Homma T, Coppola G and Krams R
Febs Letters, Wiley vol. 586 (15), 2164-2170.

DOI 10.1016/j.febslet.2012.04.031

03-05-2012

Molecular MR Imaging of Collagen in Mouse Atherosclerosis by Using Paramagnetic CNA35 Micelles
van Bochove GS, Sanders HMHF, de Smet M, Keizer HM, Mulder WJM, Krams R, Strijkers GJ and Nicolay K
European Journal of Inorganic Chemistry, Wiley vol. 2012 (12), 2115-2125.

DOI 10.1002/ejic.201200010

28-03-2012

Poster session 1
Schlueter J, Brand T, Henderson DJ, Boczonadi V, Humbert P, Chaudhry B, Sedmera D, Svatunkova J, Kockova R, Sankova B, , Lopez Sanchez C, Franco D, Aranega A, Garcia-Martinez V, Demina E, Miroshikova V, Denisenko A, Schwarzman A, Sanchez-Cabo F, et al.
Cardiovascular Research, Oxford University Press (Oup) vol. 93 (suppl_1), s9-s45.

DOI 10.1093/cvr/cvr332

15-03-2012

Poster session 3
Nanka O, Krejci E, Pesevski Z, Sedmera D, Smart N, Rossdeutsch A, Dube KN, Riegler J, Price AN, Taylor A, Muthurangu V, Turner M, Lythgoe MF, Riley PR, Kryvorot S, Vladimirskaya T, Shved I, Schwarzl M, Seiler S, Huber S, et al.
Cardiovascular Research, Oxford University Press (Oup) vol. 93 (suppl_1), s92-s127.

DOI 10.1093/cvr/cvr336

15-03-2012

Implantation of a carotid cuff for triggering shear-stress induced atherosclerosis in mice.
Kuhlmann MT, Cuhlmann S, Hoppe I, Krams R, Evans PC, Strijkers GJ, Nicolay K, Hermann S and Schäfers M
Journal of Visualized Experiments, Myjove (59)

DOI 10.3791/3308

13-01-2012

Implantation of a Carotid Cuff for Triggering Shear-stress Induced Atherosclerosis in Mice
Kuhlmann MT, Cuhlmann S, Hoppe I, Krams R, Evans PC, Strijkers GJ, Nicolay K, Hermann S and Schäfers M
Journal of Visualized Experiments, Myjove (59)

DOI 10.3791/3308-v

13-01-2012

Kissing Balloon or Sequential Dilation of the Side Branch and Main Vessel for Provisional Stenting of Bifurcations Lessons From Micro-Computed Tomography and Computational Simulations
Foin N, Torii R, Mortier P, De Beule M, Viceconte N, Chan PH, Davies JE, Xu XY, Krams R and Di Mario C
Jacc Cardiovascular Interventions, Elsevier vol. 5 (1), 47-56.

DOI 10.1016/j.jcin.2011.08.019

01-01-2012

Macrophage heterogeneity in shear stress modulated atherosclerotic plaque development
Seneviratne AN, Cole JE, Goddard ME, Mohri Z, Cross AJ, Krams R and Monaco C
CARDIOVASCULAR RESEARCH. vol. 93, S51-S51.
01-01-2012

Arterial stent-associated intimal hyperplasia and wall hypoxia
Caro CG, Seneviratne A, Monaco C, Hou D, Singh J, Gilson P, Burke MG, Heraty KB, Krams R and Coppola G
CARDIOVASCULAR RESEARCH. vol. 93, S116-S116.
01-01-2012

Expression of the regulatory receptor CD200R on macrophages is regulated by polarization signals in atherosclerosis
Falck-Hansen M, Goddard ME, Cole JE, Astola N, Cross AJ, Krams R and Monaco C
CARDIOVASCULAR RESEARCH. vol. 93, S19-S19.
01-01-2012

2011

Final proximal post-dilatation is necessary after kissing balloon in bifurcation stenting.
Foin N, Secco GG, Ghilencea L, Krams R and Di Mario C
Eurointervention, Europa Digital & Publishing vol. 7 (5), 597-604.

DOI 10.4244/eijv7i5a96

01-09-2011

Jailed side branches
Foin N, Viceconte N, Chan PH, Lindsay AC, Krams R and Di Mario C
Journal of Cardiovascular Medicine, Wolters Kluwer vol. 12 (8), 581-582.

DOI 10.2459/jcm.0b013e32834916e3

01-08-2011

Shear stress is a major determinant for getting a heart attack
De Crom R, Leenen P, Nicolay K and Krams R
Hart Bulletin vol. 42 (3), 67-70.
01-06-2011

FINAL PROXIMAL POST-DILATATION IS NECESSARY AFTER KISSING BALLOON IN BIFURCATIONS STENTING
Foin N, Secco G, Ghilencea L, Krams R and Di Mario C
Journal of the American College of Cardiology. vol. 57 (14)

DOI 10.1016/s0735-1097(11)61721-x

01-04-2011

Disturbed Blood Flow Induces RelA Expression via c-Jun N-Terminal Kinase 1
Cuhlmann S, Van der Heiden K, Saliba D, Tremoleda JL, Khalil M, Zakkar M, Chaudhury H, Luong LA, Mason JC, Udalova I, Gsell W, Jones H, Haskard DO, Krams R and Evans PC
Circulation Research, Wolters Kluwer vol. 108 (8), 950-959.

DOI 10.1161/circresaha.110.233841

24-02-2011

Dexamethasone Arterializes Venous Endothelial Cells by Inducing Mitogen-Activated Protein Kinase Phosphatase-1
Zakkar M, Luong LA, Chaudhury H, Ruud O, Punjabi PP, Anderson JR, Mullholand JW, Clements AT, Krams R, Foin N, Athanasiou T, Leen ELS, Mason JC, Haskard DO and Evans PC
Circulation, Wolters Kluwer vol. 123 (5), 524-532.

DOI 10.1161/circulationaha.110.979542

24-01-2011

¹⁸FEDAA is a more specific probe than ¹⁸FDG for imaging vascular inflammation
Gsell W, Cuhlmann S, Van der Heiden K, Tremoleda JL, Khalil M, Clark J, Bird J, Jones H, Krams R and Evans PC
European Journal of Nuclear Medicine and Molecular Imaging vol. 38, S210-S210.
01-01-2011

Endothelial Cx37 expression is regulated by the shear stress responsive transcription factor KLF2
Pfenniger A, Sutter E, Cuhlmann S, Evans PC, Krams R and Kwak BR
EUROPEAN HEART JOURNAL. vol. 32, 937-937.
01-01-2011

Stabilisation of atherosclerotic plaques
Ylä-Herttuala S, Bentzon JF, Daemen M, Falk E, Garcia-Garcia HM, Herrmann J, Hoefer I, Jukema JW, Krams R, Kwak BR, Marx N, Naruszewicz M, Newby A, Pasterkamp G, Serruys PWJC, Waltenberger J, Weber C and Tokgözoglu L
Thrombosis and Haemostasis, Thieme vol. 106 (01), 1-19.

DOI 10.1160/th10-12-0784

01-01-2011

Atherosclerotic Plaque Stability Is Affected by the Chemokine CXCL10 in Both Mice and Humans
Segers D, Lipton JA, Leenen PJM, Cheng C, Tempel D, Pasterkamp G, Moll FL, de Crom R and Krams R
International Journal of Inflammation, Hindawi vol. 2011 (1)

DOI 10.4061/2011/936109

QMRO

01-01-2011

Bench Micro-CT study and OCT Experience of a Final Proximal Post-dilatation to Optimize Results in Bifurcation Stenting
Foin N, Secco G, Sen S, Davies JE, Krams R and Di Mario C
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. vol. 58 (20), B87-B87.
01-01-2011

Sequential Side Branch and Main Vessel Dilatation instead of Kissing Balloon after Provisional Bifurcation Stenting: Lessons from Micro-CT and Computational Simulations
Foin N, Torii R, Mortier P, De Beule M, Viceconte N, Davies JE, Xu XY, Krams R and Di Mario C
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. vol. 58 (20), B82-B82.
01-01-2011

Effects of arginase inhibition on shear stress-induced plaque size and composition
Olivon VC, Segers D, de Oliveira AM, Demougeot C, Bertholet A, de Crom R, Krams R, Stergiopulos N and da Silva RF
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. vol. 41, 6-6.
01-01-2011

2010

Multi-scale interaction of particulate flow and the artery wall
Halliday I, Atherton M, Care CM, Collins MW, Evans D, Evans PC, Hose DR, Khir AW, König CS, Krams R, Lawford PV, Lishchuk SV, Pontrelli G, Ridger V, Spencer TJ, Ventikos Y, Walker DC and Watton PN
Medical Engineering & Physics, Elsevier vol. 33 (7), 840-848.

DOI 10.1016/j.medengphy.2010.09.007

29-10-2010

Contrast enhancement by differently sized paramagnetic MRI contrast agents in mice with two phenotypes of atherosclerotic plaque
van Bochove GS, Paulis LEM, Segers D, Mulder WJM, Krams R, Nicolay K and Strijkers GJ
Contrast Media & Molecular Imaging, Wiley vol. 6 (1), 35-45.

DOI 10.1002/cmmi.402

29-09-2010

Microcalcifications in atherosclerotic lesion of apolipoprotein E‐deficient mouse
Debernardi N, Roijers RB, Krams R, De Crom R, Mutsaers PHA and Van Der Vusse GJ
International Journal of Experimental Pathology, Wiley vol. 91 (6), 485-494.

DOI 10.1111/j.1365-2613.2010.00729.x

27-08-2010

YIA4 C Jun N-terminal kinase promotes endothelial activation at atherosclerosis-susceptible sites by enhancing expression of NF-κB transcription factors
Cuhlmann S, van der Heiden K, Zakkar M, Chaudhury H, Luong LA, Mason J, Haskard DO, Carlsen H, Krams R and Evans PC
Heart, Bmj vol. 96 (17)

DOI 10.1136/hrt.2010.205781.4

26-08-2010

Endothelial Nitric Oxide Production and Transport in Flow Chambers: The Importance of Convection
Plata AM, Sherwin SJ and Krams R
Annals of Biomedical Engineering, Springer Nature vol. 38 (9), 2805-2816.

DOI 10.1007/s10439-010-0039-x

14-04-2010

Predicting Patient-Specific Expansion of Abdominal Aortic Aneurysms
Helderman F, Manoch IJ, Breeuwer M, Kose U, Boersma H, van Sambeek MRHM, Pattynama PMT, Schouten O, Poldermans D, Wisselink W, van der Steen AFW and Krams R
European Journal of Vascular and Endovascular Surgery, Elsevier vol. 40 (1), 47-53.

DOI 10.1016/j.ejvs.2010.02.017

25-03-2010

MRI-determined carotid artery flow velocities and wall shear stress in a mouse model of vulnerable and stable atherosclerotic plaque
van Bochove GS, Straathof R, Krams R, Nicolay K and Strijkers GJ
Magnetic Resonance Materials in Physics, Biology and Medicine, Springer Nature vol. 23 (2), 77-84.

DOI 10.1007/s10334-010-0200-4

13-03-2010

Flow Interactions with Cells and Tissues: Cardiovascular Flows and Fluid–Structure Interactions
Friedman MH, Krams R and Chandran KB
Annals of Biomedical Engineering, Springer Nature vol. 38 (3), 1178-1187.

DOI 10.1007/s10439-010-9900-1

14-01-2010

c-Jun N-Terminal Kinase Primes Endothelial Cells at Atheroprone Sites for Apoptosis
Chaudhury H, Zakkar M, Boyle J, Cuhlmann S, van der Heiden K, Luong LA, Davis J, Platt A, Mason JC, Krams R, Haskard DO, Clark AR and Evans PC
Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 30 (3), 546-553.

DOI 10.1161/atvbaha.109.201368

07-01-2010

Shear Stress Modulates the Expression of the Vasoprotective Protein Cx37 in Endothelial Cells
Pfenniger A, Galan K, Wong C, Cuhlmann S, Evans PC, Krams R and Kwak BR
CIRCULATION. vol. 122 (21)
01-01-2010

Dexamethasone arterializes venous endothelial cells by inducing MAP Kinase phosphatase-1 (MKP-1). A novel anti-inflammatory treatment for vein grafts.
Zakkar M, Punjabi P, Anderson J, Smith P, Krams R, Haskard D and Evans P
BRITISH JOURNAL OF SURGERY. vol. 97, S12-S13.
01-01-2010

Flow Interactions with Cells and Tissues: Cardiovascular Flows and Fluid-Structure Interactions
Friedman MH, Krams R and Chandran KB
ANNALS OF BIOMEDICAL ENGINEERING. vol. 38 (3), 1178-1187.

DOI 10.1007/s10439-010-9900-1

01-01-2010

Shear stress, inflammation and Atherosclerosis
Krams R, Cuhlmann S, Foin N and Evans P
Artery Research, Springer Nature vol. 4 (2), 41-46.

DOI 10.1016/j.artres.2010.03.002

01-01-2010

Ex Vivo and In Vivo Regulation of Arginase in Response to Wall Shear Stress
da Silva RF, Olivon VC, Segers D, de Crom R, Krams R and Stergiopuloss N
IFMBE Proceedings. vol. 29, 753-756.

DOI 10.1007/978-3-642-13039-7_190

01-01-2010

2009

3D Flow reconstruction using ultrasound PIV
Poelma C, Mari JM, Foin N, Tang M-X, Krams R, Caro CG, Weinberg PD and Westerweel J
Experiments in Fluids. vol. 50 (4), 777-785.

DOI 10.1007/s00348-009-0781-8

10-11-2009

Activation of Nrf2 in Endothelial Cells Protects Arteries From Exhibiting a Proinflammatory State
Zakkar M, Van der Heiden K, Luong LA, Chaudhury H, Cuhlmann S, Hamdulay SS, Krams R, Edirisinghe I, Rahman I, Carlsen H, Haskard DO, Mason JC and Evans PC
Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 29 (11), 1851-1857.

DOI 10.1161/atvbaha.109.193375

03-09-2009

Activation of MMP8 and MMP13 by angiotensin II correlates to severe intra-plaque hemorrhages and collagen breakdown in atherosclerotic lesions with a vulnerable phenotype
Cheng C, Tempel D, van Haperen R, van Damme L, Algür M, Krams R and de Crom R
Atherosclerosis, Elsevier vol. 204 (1), 26-33.

DOI 10.1016/j.atherosclerosis.2009.01.025

24-01-2009

HIGH SHEAR STRESS SUPPRESSES THE EXPRESSION AND ACTIVITY OF NF-KAPPAB TRANSCRIPTION FACTORS IN ARTERIAL ENDOTHELIUM
Cuhlmann S, van der Heiden K, Zakkar M, Chaudhury H, Luong LA, Mason JM, Haskard DO, Krams R and Evans PC
HEART. vol. 95 (22)

DOI 10.1136/hrt.2009.178137h

01-01-2009

ENDOTHELIAL CELLS AT ATHEROSUSCEPTIBLE SITES EXPRESS ACTIVATED C-JUN N-TERMINAL KINASE WHICH INDUCES PRO-APOPTOTIC MOLECULES
Chaudhury HA, Zakkar M, Boyle J, Dennis J, van der Heiden K, Luong L, Cuhlmann S, Mason JM, Krams R, Haskard DO and Evans PC
HEART. vol. 95 (22)

DOI 10.1136/hrt.2009.178137f

01-01-2009

SHEAR STRESS AND NITRIC OXIDE TRANSPORT AFFECT NF-KB DYNAMICS IN ENDOTHELIAL CELLS
Foin N, Plata-Garcia A, Cuhlmann S, Evans PC, Caro CG and Krams R
HEART. vol. 95 (22)

DOI 10.1136/hrt.2009.178137m

01-01-2009

ACTIVATION OF NF-E2 RELATED FACTOR-2 (NRF2) PROTECTS ARTERIES FROM EXHIBITING A PRO-INFLAMMATORY STATE
Zakkar M, van der Heiden K, Chaudhury H, Krams R, Haskard DO, Mason JC and Evans PC
HEART. vol. 95 (22)

DOI 10.1136/hrt.2009.181669m

01-01-2009

Shear Stress and Nitric Oxide Transport Affect NF-κB Dynamics In Endothelial Cells
Foin N, Plata-Garcia A, Qin Q, Cuhlmann S, Evans PC, Caro CG and Krams R
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. vol. 29 (7), E78-E78.
01-01-2009

SHEAR STRESS AND MASS TRANSPORT AFFECTS NFκB DYNAMICS IN ENDOTHELIAL CELLS
Foin N, Plata-Garcia A, Cuhlmann S, Evans P, Caro C and Krams R
Journal of Physiological Sciences vol. 59, 324-324.
01-01-2009

2008

Donor pre-treatment with tacrolimus reduces transplant vasculopathy
Susa D, van de Engel S, van Damme LCA, Roest HP, Krams R, IJzermans JNM and de Bruin RWF
Pharmacological Research, Elsevier vol. 59 (4), 273-278.

DOI 10.1016/j.phrs.2008.12.006

30-12-2008

Atherosclerosis: cell biology and lipoproteins - shear stress and inflammation in plaque formation: new evidence
Segers D, Weinberg P and Krams R
Current Opinion in Lipidology, Wolters Kluwer vol. 19 (6), 627-628.

DOI 10.1097/mol.0b013e328318db32

01-12-2008

Monocyte Adhesion in Atherosclerosis: A Biomechanical Approach
Segers D, Cheng C, Crom RD, Kirschbaum SWM, Oostlander AE, Helderman F, Wamel AV, Slager CJ, Serruys PW, Steen AFWVD and Krams R
Vascular Disease Prevention, Bentham Science Publishers vol. 2 (1), 227-235.

DOI 10.2174/1567270000502010027

01-12-2008

Personalised imaging and biomechanical modelling of large vessels
Krams R, Breeuwer M and van de Vosse F
Medical & Biological Engineering & Computing, Springer Nature vol. 46 (11), 1057-1058.

DOI 10.1007/s11517-008-0417-9

01-11-2008

A primer on the immune system in the pathogenesis and treatment of atherosclerosis.
Segers D, Garcia-Garcia HM, Cheng C, de Crom R, Krams R, Wentzel JJ, van der Steen AFW, Serruys PW, Leenen PJM and Laman JD
Eurointervention, Europa Digital & Publishing vol. 4 (3), 378-390.

DOI 10.4244/eijv4i3a67

01-11-2008

Pulmonary artery size and function after Fontan operation at a young age
Robbers‐Visser D, Helderman F, Strengers JL, van Osch‐Gevers L, Kapusta L, Pattynama PM, Bogers AJ, Krams R and Helbing WA
Journal of Magnetic Resonance Imaging, Wiley vol. 28 (5), 1101-1107.

DOI 10.1002/jmri.21544

28-10-2008

1057 Pulmonary artery size and function after Fontan operation at young age: assessment with phase contrast magnetic resonance imaging
Robbers-Visser D, Helderman F, Strengers JL, van Osch-Gevers L, Kapusta L, Pattynama PM, Bogers AJ, Krams R and Helbing WA
Journal of Cardiovascular Magnetic Resonance, Elsevier vol. 10

DOI 10.1186/1532-429x-10-s1-a182

01-10-2008

Towards patient-specific risk assessment of abdominal aortic aneurysm
Breeuwer M, de Putter S, Kose U, Speelman L, Visser K, Gerritsen F, Hoogeveen R, Krams R, van den Bosch H, Buth J, Gunther T, Wolters B, van Dam E and van de Vosse F
Medical & Biological Engineering & Computing, Springer Nature vol. 46 (11), 1085-1095.

DOI 10.1007/s11517-008-0393-0

23-09-2008

Large variations in absolute wall shear stress levels within one species and between species
de Crom R, Cheng C, Helderman F and Krams R
Atherosclerosis, Elsevier vol. 204 (1), 16-17.

DOI 10.1016/j.atherosclerosis.2008.08.010

22-08-2008

Increased Endothelial Mitogen-Activated Protein Kinase Phosphatase-1 Expression Suppresses Proinflammatory Activation at Sites That Are Resistant to Atherosclerosis
Zakkar M, Chaudhury H, Sandvik G, Enesa K, Luong LA, Cuhlmann S, Mason JC, Krams R, Clark AR, Haskard DO and Evans PC
Circulation Research, Wolters Kluwer vol. 103 (7), 726-732.

DOI 10.1161/circresaha.108.183913

21-08-2008

Hemodynamic parameters regulating vascular inflammation and atherosclerosis: A brief update
Ridger V, Krams R, Carpi A and Evans PC
Biomedicine & Pharmacotherapy, Elsevier vol. 62 (8), 536-540.

DOI 10.1016/j.biopha.2008.07.053

08-08-2008

MAP KINASE PHOSPHATASE-1 SUPPRESSES ENDOTHELIAL ACTIVATION IN REGIONS OF THE ARTERIAL TREE THAT ARE RESISTANT TO ATHEROSCLEROSIS
Zakkar M, Chaudhury H, Krams R, Mason JC, Clark AR, Haskard DO and Evans PC
Atherosclerosis. vol. 199 (2)

DOI 10.1016/j.atherosclerosis.2008.05.006

01-08-2008

DONOR PRE-TREATMENT WITH TACROLIMUS EDUCES TRANSPLANT VASCULOPATHY
de Bruin RWF, Susa D, van den Engel S, van Damme LA, Roest HP, Krams R and Jzermans JNMI
Transplantation, Wolters Kluwer vol. 86 (2S)

DOI 10.1097/01.tp.0000330936.86118.f6

27-07-2008

REGULATION OF ARGINASE IN RESPONSE SHEAR STRESS: NEW POTENTIAL THERAPEUTIC TARGET ATHEROSCLEROSIS?
da Silva RF, Olivon VC, Segers D, de Crom R, Krams R and Stergiopulos N
Journal of Biomechanics, Elsevier vol. 41

DOI 10.1016/s0021-9290(08)70184-2

01-07-2008

A numerical model to predict abdominal aortic aneurysm expansion based on local wall stress and stiffness
Helderman F, Manoch IJ, Breeuwer M, Kose U, Schouten O, van Sambeek MRM, Poldermans D, Pattynama PTM, Wisselink W, van der Steen AFW and Krams R
Medical & Biological Engineering & Computing, Springer Nature vol. 46 (11)

DOI 10.1007/s11517-008-0358-3

03-06-2008

Atherosclerosis: cell biology and lipoproteins – new developments in imaging of inflammation of the vulnerable plaque
Foin N, Evans P and Krams R
Current Opinion in Lipidology, Wolters Kluwer vol. 19 (1), 98-100.

DOI 10.1097/mol.0b013e3282f41b60

01-02-2008

Role of arginase pathway in response to shear stress: new potential therapeutic targets for atherosclerosis?
da Silva RF, Olivon VC, Segers D, de Crom R, Krams R and Stergiopulos N
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. vol. 38, 36-36.
01-01-2008

P1.57 Modulation of Arginase in Response to Wall Shear Stress
da Silva RF, Olivon VC, Segers D, de Crom R, Krams R and Stergiopulos N
Artery Research, Springer Nature vol. 2 (3), 105-106.

DOI 10.1016/j.artres.2008.08.364

01-01-2008

2007

Rapamycin modulates the eNOS vs. shear stress relationship
Cheng C, Tempel D, Oostlander A, Helderman F, Gijsen F, Wentzel J, van Haperen R, Haitsma DB, Serruys PW, van der Steen AFW, de Crom R and Krams R
Cardiovascular Research, Oxford University Press (Oup) vol. 78 (1), 123-129.

DOI 10.1093/cvr/cvm103

13-12-2007

Abstract 879: The Chemokine CXCL10 Is Involved In The Development Of Atherosclerotic Plaque Vulnerability
Segers D, de Crom R, Leenen P, Pasterkamp G and Krams R
Circulation, Wolters Kluwer vol. 116 (suppl_16)

DOI 10.1161/circ.116.suppl_16.ii_172

16-10-2007

Effect of shear stress on vascular inflammation and plaque development
Helderman F, Segers D, de Crom R, Hierck BP, Poelmann RE, Evans PC and Krams R
Current Opinion in Lipidology, Wolters Kluwer vol. 18 (5), 527-533.

DOI 10.1097/mol.0b013e3282ef7716

01-10-2007

Subharmonic Contrast Intravascular Ultrasound
Goertz DE, Frijlink ME, Tempel D, Krams R, De Jong N and van der Steen AF
2007 IEEE Ultrasonics Symposium Proceedings., 1065-1068.

DOI 10.1109/ultsym.2007.269

01-10-2007

Subharmonic Contrast Intravascular Ultrasound for Vasa Vasorum Imaging
Goertz DE, Frijlink ME, Tempel D, Bhagwandas V, Gisolf A, Krams R, de Jong N and van der Steen AFW
Ultrasound in Medicine & Biology, Elsevier vol. 33 (12), 1859-1872.

DOI 10.1016/j.ultrasmedbio.2007.05.023

02-08-2007

Endothelial primary cilia in areas of disturbed flow are at the base of atherosclerosis
Van der Heiden K, Hierck BP, Krams R, de Crom R, Cheng C, Baiker M, Pourquie MJBM, Alkemade FE, DeRuiter MC, Groot ACG-D and Poelmann RE
Atherosclerosis, Elsevier vol. 196 (2), 542-550.

DOI 10.1016/j.atherosclerosis.2007.05.030

13-07-2007

Shear stress and the vulnerable plaque
Wentzel J, Gijsen F, Krams R, de Crom R, Cheng C, Groen H, van der Giessen A and van der Steen A
In The Vulnerable Plaque, Second Edition, Taylor & Francis 233-244.

DOI 10.3109/9781439804537-23

13-06-2007

Coronary flow reserve in hypertrophic cardiomyopathy: relation with microvascular dysfunction and pathophysiological characteristics
Kofflard MJ, Michels M, Krams R, Kliffen M, Geleijnse ML, Cate FJT and Serruys PW
Netherlands Heart Journal, Springer Nature vol. 15 (6), 209-215.

DOI 10.1007/bf03085982

01-06-2007

Assessment of Unstable Atherosclerosis in Mice
Jackson CL, Bennett MR, Biessen EAL, Johnson JL and Krams R
Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 27 (4), 714-720.

DOI 10.1161/01.atv.0000261873.86623.e1

01-03-2007

Shear stress–induced changes in atherosclerotic plaque composition are modulated by chemokines
Cheng C, Tempel D, van Haperen R, de Boer HC, Segers D, Huisman M, van Zonneveld AJ, Leenen PJM, van der Steen A, Serruys PW, de Crom R and Krams R
Journal of Clinical Investigation, American Society For Clinical Investigation vol. 117 (3), 616-626.

DOI 10.1172/jci28180

15-02-2007

Vasa vasorum and molecular imaging of atherosclerotic plaques using nonlinear contrast intravascular ultrasound
Goertz DE, Frijlink ME, Krams R, de Jong N and van der Steen AFW
Netherlands Heart Journal, Springer Nature vol. 15 (2), 77-80.

DOI 10.1007/bf03085959

01-02-2007

Gelatinolytic Activity in Atherosclerotic Plaques Is Highly Localized and Is Associated With Both Macrophages and Smooth Muscle Cells In Vivo
Segers D, Helderman F, Cheng C, van Damme LCA, Tempel D, Boersma E, Serruys PW, de Crom R, van der Steen AFW, Holvoet P and Krams R
Circulation, Wolters Kluwer vol. 115 (5), 609-616.

DOI 10.1161/circulationaha.106.636415

22-01-2007

Donor pre-treatment with tacrolimus reduces transplant vasculopathy
Susa D, van den Engel S, van Damme LA, Roest HP, Krams R, IJiermans JNM and De Bruin RWF
TRANSPLANT INTERNATIONAL. vol. 20, 141-141.
01-01-2007

The chemokine CXCL10 is involved in the development of atherosclerotic plaque vulnerability
Segers D, de Crom R, Leenen P, Pasterkamp G and Krams R
CIRCULATION. vol. 116 (16), 172-172.
01-01-2007

Modulation of arginases by different patterns of shear stress: new signaling pathway in atherogenesis?
Da Silva RF, Gambillara V, Krams R and Stergiopulos N
Computer Methods in Biomechanics & Biomedical Engineering, Taylor & Francis vol. 10 (sup1), 77-78.

DOI 10.1080/10255840701478497

01-01-2007

P.096 Role of Arginase Pathway in Response to Shear Stress: New Potential Therapeutic Targets for Atherosclerosis?
da Silva RF, Gambillara V, Cheng C, Segers D, de Crom R, Krams R and Stergiopulos N
Artery Research, Springer Nature vol. 1 (2), 74-75.

DOI 10.1016/j.artres.2007.07.030

01-01-2007

The Influence of Shear Stress on Restenosis
Thury A, Wentzel JJ, Gijsen FJH, Schuurbiers JCH, Krams R, de Feyter PJ, Serruys PW and Slager CJ
In Essentials of Restenosis, Springer Nature 59-83.

DOI 10.1007/978-1-59745-001-0_5

01-01-2007

2006

Large variations in absolute wall shear stress levels within one species and between species
Cheng C, Helderman F, Tempel D, Segers D, Hierck B, Poelmann R, van Tol A, Duncker DJ, Robbers-Visser D, Ursem NTC, van Haperen R, Wentzel JJ, Gijsen F, van der Steen AFW, de Crom R and Krams R
Atherosclerosis, Elsevier vol. 195 (2), 225-235.

DOI 10.1016/j.atherosclerosis.2006.11.019

12-12-2006

Response to Letter Regarding Article, “Atherosclerotic Lesion Size and Vulnerability Are Determined by Patterns of Fluid Shear Stress”
Cheng C, Tempel D, van der Baan A, Krams R, Daemen MJAP, van Haperen R, Grosveld F and de Crom R
Circulation, Wolters Kluwer vol. 114 (22)

DOI 10.1161/circulationaha.106.658302

28-11-2006

Harmonic intravascular ultrasound imaging with a dual-frequency catheter
Frijlink ME, Goertz DE, Vos HJ, Tesselaar E, Blacquière G, Gisolf A, Krams R and van der Steen AFW
Ultrasound in Medicine & Biology, Elsevier vol. 32 (11), 1649-1654.

DOI 10.1016/j.ultrasmedbio.2006.05.024

01-11-2006

Intravascular ultrasound tissue harmonic imaging in vivo
Frijlink ME, Goertz DE, van Damme LCA, Krams R and van der Steen AFW
Ieee Transactions On Ultrasonics Ferroelectrics and Frequency Control, Institute of Electrical and Electronics Engineers (Ieee) vol. 53 (10), 1844-1852.

DOI 10.1109/tuffc.2006.116

01-10-2006

Angiotensin II induces severe intra-plaque hemorrhages in lesions with a vulnerable plaque phenotype
Cheng C, Tempel D, van Damme L, van Haperen R, Krams R and de Crom R
Vascular Pharmacology, Elsevier vol. 45 (3), e91-e92.

DOI 10.1016/j.vph.2006.08.258

01-09-2006

Patterns of fluid shear stress determine atherosclerotic lesion size and vulnerability
Cheng C, Tempel D, van Damme L, van Haperen R, Krams R and de Crom R
Vascular Pharmacology, Elsevier vol. 45 (3)

DOI 10.1016/j.vph.2006.08.136

01-09-2006

Contrast Harmonic Intravascular Ultrasound
Goertz DE, Frijlink ME, Tempel D, van Damme LCA, Krams R, Schaar JA, Cate FJT, Serruys PW, de Jong N and van der Steen AFW
Investigative Radiology, Wolters Kluwer vol. 41 (8), 631-638.

DOI 10.1097/01.rli.0000229773.11715.da

01-08-2006

Shear stress is associated with markers of plaque vulnerability and MMP-9 activity.
Krams R, Cheng C, Helderman F, Verheye S, van Damme LCA, Mousavi Gourabi B, Tempel D, Segers D, de Feyter P, Pasterkamp G, De Klein D, de Crom R, van der Steen AFW and Serruys PW
Eurointervention vol. 2 (2), 250-256.
01-08-2006

Atherosclerotic Lesion Size and Vulnerability Are Determined by Patterns of Fluid Shear Stress
Cheng C, Tempel D, van Haperen R, van der Baan A, Grosveld F, Daemen MJAP, Krams R and de Crom R
Circulation, Wolters Kluwer vol. 113 (23), 2744-2753.

DOI 10.1161/circulationaha.105.590018

05-06-2006

Norepinephrine-induced vasoconstriction results in decreased blood volume in dialysis patients
Nette RW, Ie EHY, Vletter WB, Krams R, Weimar W and Zietse R
Nephrology Dialysis Transplantation, Oxford University Press (Oup) vol. 21 (5), 1305-1311.

DOI 10.1093/ndt/gfk070

31-01-2006

High IP-10 levels identify plaques with a vulnerable phenotype
Lipton J, Segers D, Cheng C, Duckers H, Krams R, Tempel D, Busser E, De Kleijn D, Moll FL and Pasterkamp G
CIRCULATION. vol. 114 (18), 287-288.
01-01-2006

Atherosclerotic lesion size and vulnerability are determined by patterns of fluid shear stress
Cheng C, Tempel D, van Haperen R, van der Baan A, Grosveld F, Daemen MJAP, Krams R and de Crom R
Circulation vol. 113 (23), 2744-2753.

DOI 10.1161/CIRCULATIONAHA.105.590018

01-01-2006

Visualization of the Vulnerable Plaque
Krams R, Schaar J, Helderman F, Cheng C, Gourabi BM, van Damme LCA, Segers D, Regar E, Slager CJ, de Feyter PJ, van der Steen AFW and Serruys PW
In Cardiovascular Research, Springer Nature 221-234.

DOI 10.1007/0-387-23329-6_12

01-01-2006

Numerical model for predicting dilatation of an Abdominal Aortic Aneurysm (AAA)
Helderman F, Schouten O, Manoch I, Buffart H, van der Steen AFW and Krams R
Journal of Biomechanics, Elsevier vol. 39

DOI 10.1016/s0021-9290(06)85508-9

01-01-2006

Shear stress and atherosclerosis
Krams R
Journal of Biomechanics, Elsevier vol. 39

DOI 10.1016/s0021-9290(06)84109-6

01-01-2006

2005

Shear Stress Biology of the Endothelium
Davies PF, Spaan JA and Krams R
Annals of Biomedical Engineering, Springer Nature vol. 33 (12), 1714-1718.

DOI 10.1007/s10439-005-8774-0

01-12-2005

In vivo temperature heterogeneity is associated with plaque regions of increased MMP-9 activity
Krams R, Verheye S, van Damme LCA, Tempel D, Mousavi Gourabi B, Boersma E, Kockx MM, Knaapen MWM, Strijder C, van Langenhove G, Pasterkamp G, van der Steen AFW and Serruys PW
European Heart Journal, Oxford University Press (Oup) vol. 26 (20), 2200-2205.

DOI 10.1093/eurheartj/ehi461

05-09-2005

Myocardial contractility does not determine the haemodynamic response during dialysis
Ie EHY, Krams R, Vletter WB, Nette RW, Weimar W and Zietse R
Nephrology Dialysis Transplantation, Oxford University Press (Oup) vol. 20 (11), 2465-2471.

DOI 10.1093/ndt/gfi088

23-08-2005

Shear stress affects the intracellular distribution of eNOS: direct demonstration by a novel in vivo technique
Cheng C, van Haperen R, de Waard M, van Damme LCA, Tempel D, Hanemaaijer L, van Cappellen GWA, Bos J, Slager CJ, Duncker DJ, van der Steen AFW, de Crom R and Krams R
Blood, American Society of Hematology vol. 106 (12), 3691-3698.

DOI 10.1182/blood-2005-06-2326

16-08-2005

DOI 10.2174/1567270054368998

01-07-2005

Effect of vessel curvature on Doppler derived velocity profiles and fluid flow
Krams R, Bambi G, Guidi F, Helderman F, van der Steen AFW and Tortoli P
Ultrasound in Medicine & Biology, Elsevier vol. 31 (5), 663-671.

DOI 10.1016/j.ultrasmedbio.2005.01.011

01-05-2005

Letter Regarding Article by Korshunov and Berk, “Strain-Dependent Vascular Remodeling: The ‘Glagov Phenomenon’ Is Genetically Determined”
Wentzel JJ, Krams R and Slager CJ
Circulation, Wolters Kluwer vol. 111 (9), e119-e119.

DOI 10.1161/01.cir.0000157072.64410.01

21-02-2005

Three-Dimensional Palpography of Human Coronary Arteries
Schaar* JA, de Korte* CL, Mastik F, van Damme LCA, Krams R, Serruys PW and van der Steen AFW
Herz, Springer Nature vol. 30 (2), 125-133.

DOI 10.1007/s00059-005-2642-4

01-02-2005

Vulnerable lesions induced by low shear stress are characterized by expression of specific inflammatory chemokines
Cheng C, Tempel D, van Haperen R, de Crom R and Krams R
CIRCULATION. vol. 112 (17), U136-U136.
01-01-2005

Patterns of fluid shear stress determine Atherosclerotic lesion size and vulnerability
Cheng C, Tempel D, van Damme L, van Haperen R, Krams R and de Crom R
CIRCULATION. vol. 112 (17), U347-U347.
01-01-2005

Donor pre-treatment with tacrolimus reduces matrix metallo proteinase activity and transplant arteriosclerosis.
Susa D, de Engel SV, van Damme LCA, Roest HP, Krams R, Ijzermans JNM and de Bruin RWF
AMERICAN JOURNAL OF TRANSPLANTATION. vol. 5, 442-443.
01-01-2005

Angiotensin II induces severe intra-plaque hemorrhages in lesions with a vulnerable plaque phenotype in apoE KO mice
Cheng C, Tempel D, van Damme L, van Gaalen K, van Haperen R, Krams R and de Crom R
CIRCULATION. vol. 112 (17), U221-U221.
01-01-2005

2004

Geometry guided data averaging enables the interpretation of shear stress related plaque development in human coronary arteries
Wentzel JJ, Gijsen FJH, Schuurbiers JCH, Krams R, Serruys PW, De Feyter PJ and Slager CJ
Journal of Biomechanics, Elsevier vol. 38 (7), 1551-1555.

DOI 10.1016/j.jbiomech.2004.06.022

23-12-2004

Diastolic coronary vascular reserve: a new index to detect changes in the coronary microcirculation in hypertrophic cardiomyopathy
Krams R, Cate FJT, Carlier SG, van der Steen AFW and Serruys PW
Journal of The American College of Cardiology, Elsevier vol. 43 (4), 670-677.

DOI 10.1016/j.jacc.2003.09.046

01-02-2004

Intravascular thermography: Immediate functional and morphological vascular findings
Verheye S, De Meyer GRY, Krams R, Kockx MM, Van Damme LCA, Mousavi Gourabi B, Knaapen MWM, Van Langenhove G and Serruys PW
European Heart Journal, Oxford University Press (Oup) vol. 25 (2), 158-165.

DOI 10.1016/j.ehj.2003.10.023

01-01-2004

Intravascular Ultrasound Tissue Harmonic Imaging In Vivo
Frijlink ME, Goertz DE, Van Damme LCA, Krams R and Van Der Steen AFW
IEEE Ultrasonics Symposium, 2004. vol. 2, 1118-1121.

DOI 10.1109/ultsym.2004.1417976

01-01-2004

The role of shear stress in atherosclerosis
Cheng C, de Crom R, van Haperen R, Helderman F, Gourabi BM, van Damme LCA, Kirschbaum SW, Slager CJ, van der Steen AFW and Krams R
Cell Biochemistry and Biophysics, Springer Nature vol. 41 (2), 279-294.

DOI 10.1385/cbb:41:2:279

01-01-2004

In vivo induced changes in shear stress patterns affect the expression and the intracellular localization of endothelial nitric oxide synthase
Cheng C, van Haperen R, de Waard M, de Crom R and Krams R
EUROPEAN HEART JOURNAL. vol. 25, 58-58.
01-01-2004

In vivo induction of low shear stress and oscillatory shear stress causes atherosclerosis
Cheng C, de Waard M, van Haperen R, Tempel D, van der Baan A, Krams R and de Crom R
CIRCULATION. vol. 110 (17), 39-39.
01-01-2004

Multi-Dimensional Computed Coronary Visualization
van Ooijen PMA, Irwan R, Slager CJ, Wentzel JJ, Schuurbiers JCH, Oomen JAF, Gijsen FJH, Krams R, van der Giessen WJ, Serruys PW and de Feyter PJ
In Coronary Radiology, Springer Nature 227-282.

DOI 10.1007/978-3-662-06419-1_16

01-01-2004

2003

Functional Expression of Endothelial Nitric Oxide Synthase Fused to Green Fluorescent Protein in Transgenic Mice
van Haperen R, Cheng C, Mees BME, van Deel E, de Waard M, van Damme LCA, van Gent T, van Aken T, Krams R, Duncker DJ and de Crom R
American Journal of Pathology, Elsevier vol. 163 (4), 1677-1686.

DOI 10.1016/s0002-9440(10)63524-9

01-10-2003

The effect of reduced blood-flow on the coronary wall temperature
Diamantopoulos L, Liu X, De Scheerder I, Krams R, Li S, Van Cleemput J, Desmet W and Serruys PW
European Heart Journal, Oxford University Press (Oup) vol. 24 (19), 1788-1795.

DOI 10.1016/s0195-668x(03)00440-8

01-10-2003

Imaging of coronary atherosclerosis and identification of the vulnerable plaque.
de Feyter PJ, Serruys PW, Nieman K, Mollet N, Cademartiri F, van Geuns RJ, Slager C, van der Steen AFW, Krams R, Schaar JA, Wielopolski P, Pattynama PMT, Arampatzis A, van der Lugt A, Regar E, Ligthart J and Smits P
Netherlands Heart Journal vol. 11 (9), 347-358.
01-09-2003

Extension of Increased Atherosclerotic Wall Thickness Into High Shear Stress Regions Is Associated With Loss of Compensatory Remodeling
Wentzel JJ, Janssen E, Vos J, Schuurbiers JCH, Krams R, Serruys PW, de Feyter PJ and Slager CJ
Circulation, Wolters Kluwer vol. 108 (1), 17-23.

DOI 10.1161/01.cir.0000078637.21322.d3

23-06-2003

Augmentation of Wall Shear Stress Inhibits Neointimal Hyperplasia After Stent Implantation
Carlier SG, van Damme LCA, Blommerde CP, Wentzel JJ, van Langehove G, Verheye S, Kockx MM, Knaapen MWM, Cheng C, Gijsen F, Duncker DJ, Stergiopulos N, Slager CJ, Serruys PW and Krams R
Circulation, Wolters Kluwer vol. 107 (21), 2741-2746.

DOI 10.1161/01.cir.0000066914.95878.6d

12-05-2003

Shear stress, vascular remodeling and neointimal formation
Wentzel JJ, Gijsen FJH, Stergiopulos N, Serruys PW, Slager CJ and Krams R
Journal of Biomechanics, Elsevier vol. 36 (5), 681-688.

DOI 10.1016/s0021-9290(02)00446-3

01-05-2003

Inflammation and Atherosclerosis:
KRAMS R, SEGERS D, GOURABI BM, MAAT W, CHENG C, VAN PELT C, VAN DAMME LCA, DE FEYTER P, VAN DER STEEN T, DE KORTE CL and SERRUYS PW
Journal of Interventional Cardiology, Wiley vol. 16 (2), 107-113.

DOI 10.1046/j.1540-8183.2003.08021.x

01-04-2003

929 Plaque temperature heterogeneity is associated with macrophage accumulation and metalloproteinase activity
KRAMS R
European Heart Journal. vol. 24 (5)

DOI 10.1016/s0195-668x(03)94221-7

01-03-2003

P1760 Local macrophage accumulation in atherosclerotic rabbit aortas as determined by a novel three-dimensional histology technique
GOURABI B
European Heart Journal. vol. 24 (5)

DOI 10.1016/s0195-668x(03)94898-6

01-03-2003

P2242 Augmentation of wall shear stress inhibits neo intimal hyperplasia and inflammation after stent implantation
KRAMS R
European Heart Journal. vol. 24 (5)

DOI 10.1016/s0195-668x(03)95236-5

01-03-2003

P2207 High shear stress is predictive for markers of plaque inflammation
KRAMS R
European Heart Journal. vol. 24 (5)

DOI 10.1016/s0195-668x(03)95201-8

01-03-2003

eNOS expression responds to changes in shear stress: Direct demonstration in a novel in vivo mouse model
Cheng C, van Haperen R, de Waard M, de Crom R and Krams R
CIRCULATION. vol. 108 (17), 151-151.
01-01-2003

Shear stress is associated with markers of plaque vulnerability
Krams R, van Damme L, Tempel D, Gourabi BM and van der Steen AF
CIRCULATION. vol. 108 (17), 225-225.
01-01-2003

Shear stress and the IVUS derived vessel wall thickness
Wentzel JJ, Cheng C, de Crom R, Stergiopulos N, Serruys PW, Slager CJ and Krams R
In Vascular Ultrasound, Springer Nature 148-164.

DOI 10.1007/978-4-431-67871-7_10

01-01-2003

Diagnosis of vulnerable plaques in the cardiac catheterization laboratory
Schaar JA, van der Steen AFW, Arampatzis CA, Krams R, Slager CJ, ten Have AG, van de Poll SW, Gijsen FJ, Wentzel JJ, de Feyter PJ and Serruys PW
In Vascular Ultrasound, Springer Nature 220-234.

DOI 10.1007/978-4-431-67871-7_14

01-01-2003

Coronary 3-D angiography, 3-D ultrasound and their fusion
Slager CJ, Wentzel JJ, Schuurbiers JCH, Oomen JAF, Gijsen FJH, Krams R, van der Giessen WJ, Serruys PW and de Feyter PJ
In Vascular Ultrasound, Springer Nature 121-147.

DOI 10.1007/978-4-431-67871-7_9

01-01-2003

2002

High shear stress after successful balloon angioplasty is associated with restenosis and target lesion revascularization
Thury A, van Langenhove G, Carlier SG, Albertal M, Kozuma K, Regar E, Sianos G, Wentzel JJ, Krams R, Slager CJ, Piek JJ, Serruys PW and Investigators D
American Heart Journal, Elsevier vol. 144 (1), 136-143.

DOI 10.1067/mhj.2002.123110

01-07-2002

Focal In-Stent Restenosis Near Step-Up
Thury A, Wentzel JJ, Vinke RVH, Gijsen FJH, Schuurbiers JCH, Krams R, de Feyter PJ, Serruys PW and Slager CJ
Circulation, Wolters Kluwer vol. 105 (23), 185e-1187.

DOI 10.1161/01.cir.0000018282.32332.13

11-06-2002

Determination of shear stress in patients confirms that lumen preservation in atherosclerosis is associated with shear stress regulation
Wentzel JJ, Janssen EH, Krams R, Schuurbiers JCH, van der Giessen WJ, Serruys PW, de Feyter PJ and Slager CJ
Journal of the American College of Cardiology. vol. 39

DOI 10.1016/s0735-1097(02)80966-4

01-03-2002

Calcium Sensitizer EMD 57033, But Not the β 1 -Adrenoreceptor Agonist Dobutamine, Increases Mechanical Efficiency in Stunned Myocardium
Trines SAIP, Smits CAG, van der Moer J, Slager CJ, Verdouw PD and Krams R
Journal of Cardiovascular Pharmacology, Wolters Kluwer vol. 39 (1), 61-72.

DOI 10.1097/00005344-200201000-00008

01-01-2002

Vulnerable plaque detection with 3-dimensional palpography
de Korte CL, Schaar JA, Mastik F, van Damme LCA, Krams R, Serruys PW and van der Steen AFW
CIRCULATION. vol. 106 (19), 1-2.
01-01-2002

The relationship between wall thickness and shear stress in coronary arteries of patients
Wentzel JJ, Janssen E, Vos J, Schuurbiers JCH, Krams R, Serruys PW, de Feyter PJ and Slager CJ
EUROPEAN HEART JOURNAL. vol. 23, 415-415.
01-01-2002

Focal in-stent restenosis near step-up - Roles of low and oscillating shear stress?
Thury A, Wentzel JJ, Vinke RVH, Gijsen FJH, Schuurbiers JCH, Krams R, de Feyter PJ, Serruys PW and Slager CJ
Circulation vol. 105 (23), E185-E187.

DOI 10.1161/01.CIR.0000018282.32332.13

01-01-2002

Reduced end-systolic elastance indicating poor left ventricular contractility in hemodialysis patients.
Ie EHY, Krams R, Vletter WB, ten Cate FJ, Nette RW, Weimar W and Zietse R
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. vol. 13, 213A-213A.
01-01-2002

2001

Prominent Role of Tensile Stress in Propagation of a Dissection After Coronary Stenting
Thury A, Wentzel JJ, Schuurbiers JCH, Ligthart JMR, Krams R, de Feyter PJ, Serruys PW and Slager CJ
Circulation, Wolters Kluwer vol. 104 (11), e53-e54.

DOI 10.1161/hc3601.095216

11-09-2001

Decrease in coronary vascular volume in systole augments cardiac contraction
Willemsen MJJMF, Duncker DJ, Krams R, Dijkman MA, Lamberts RR, Sipkema P and Westerhof N
Ajp Heart and Circulatory Physiology, American Physiological Society vol. 281 (2), h731-h737.

DOI 10.1152/ajpheart.2001.281.2.h731

01-08-2001

Shear-Stress and Wall-Stress Regulation of Vascular Remodeling After Balloon Angioplasty
Wentzel JJ, Kloet J, Andhyiswara I, Oomen JAF, Schuurbiers JCH, de Smet BJGL, Post MJ, de Kleijn D, Pasterkamp G, Borst C, Slager CJ and Krams R
Circulation, Wolters Kluwer vol. 104 (1), 91-96.

DOI 10.1161/01.cir.104.1.91

03-07-2001

Oxygen wastage of stunned myocardium in vivo is due to an increased oxygen cost of contractility and a decreased myofibrillar efficiency
Trines SAIP, Slager CJ, Onderwater TAM, Lamers JMJ, Verdouw PD and Krams R
Cardiovascular Research, Oxford University Press (Oup) vol. 51 (1), 122-130.

DOI 10.1016/s0008-6363(01)00277-2

01-07-2001

Relationship Between Neointimal Thickness and Shear Stress After Wallstent Implantation in Human Coronary Arteries
Wentzel JJ, Krams R, Schuurbiers JCH, Oomen JA, Kloet J, van der Giessen WJ, Serruys PW and Slager CJ
Circulation, Wolters Kluwer vol. 103 (13), 1740-1745.

DOI 10.1161/01.cir.103.13.1740

03-04-2001

On the Numerical Analysis of Coronary Artery Wall Shear Stress
Wolters B, Slager C, Gijsen F, Wentzel J, Krams R and van FDV
Computers in Cardiology 2001. Vol.28 (Cat. No.01CH37287)., 169-172.

DOI 10.1109/cic.2001.977618

01-01-2001

Oxygen wastage of stunned myocardium in vivo is due to an increased oxygen cost of contractility and a decreased myofibrillar efficiency
Trines SAIP, Slager CJ, Onderwater TAM, Lamers JMJ, Verdouw PD and Krams R
EUROPEAN HEART JOURNAL. vol. 22, 516-516.
01-01-2001

An increased wall shear stress inhibits neointimal hyperplasia after stent implantation: preliminary in vivo experience of the ARED flow divider in a rabbit model of restenosis
Carlier SG, van Damme LC, Blommerde CP, Van Langenhove G, Wentzel JJ, van der Giessen WJ, Verdouw PD, Krams R, Serruys PW and Slager C
EUROPEAN HEART JOURNAL. vol. 22, 278-278.
01-01-2001

Functional assessment of eNOS transgenesis in mice aortas
Krams R, van Damme LCA, Wentzel JJ, De Crom R, Haperen R and Van Aken T
EUROPEAN HEART JOURNAL. vol. 22, 60-60.
01-01-2001

Novel method for in vivo calculation of absolute sheer stress at any location of a stented human coronary artery
Thury A, Wentzel JJ, Janssen EH, Krams R, Oomen JA, Schuurbiers JCH, Ligthart JMR, Serruys PW and Slager CJ
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. vol. 37 (2), 298A-299A.
01-01-2001

High shear stress after successful balloon angioplasty is associated with restenosis and target lesion revascularization
Thury A, van Langenhove G, Carlier SG, Albertal M, Kozuma K, Regar E, Wentzel JJ, Krams R, Slager CJ, Piek JJ and Serruys PW
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. vol. 37 (2), 16A-17A.
01-01-2001

Decrease in coronary vascular volume in systole augments cardiac contraction
Willemsen MJJMF, Duncker DJ, Krams R, Dijkman MA, Lamberts RR, Sipkema P and Westerhof N
American Journal of Physiology - Heart and Circulatory Physiology vol. 281 (2 50-2)

DOI 10.1152/ajpheart.2001.281.2.h731

01-01-2001

2000

Coronary stent implantation changes 3-D vessel geometry and 3-D shear stress distribution
Wentzel JJ, Whelan DM, van der Giessen WJ, van Beusekom HMM, Andhyiswara I, Serruys PW, Slager CJ and Krams R
Journal of Biomechanics, Elsevier vol. 33 (10), 1287-1295.

DOI 10.1016/s0021-9290(00)00066-x

01-10-2000

In vivo evidence that EMD 57033 restores myocardial responsiveness to intracoronary Ca2+ in stunned myocardium
de Zeeuw S, Trines SAIP, Krams R, Duncker DJ and Verdouw PD
European Journal of Pharmacology, Elsevier vol. 403 (1-2), 99-109.

DOI 10.1016/s0014-2999(00)00513-6

01-09-2000

Efficiency of energy transfer, but not external work, is maximized in stunned myocardium
Trines SAIP, Slager CJ, Van der Moer J, Verdouw PD and Krams R
Ajp Heart and Circulatory Physiology, American Physiological Society vol. 279 (3), h1264-h1273.

DOI 10.1152/ajpheart.2000.279.3.h1264

01-09-2000

True 3-Dimensional Reconstruction of Coronary Arteries in Patients by Fusion of Angiography and IVUS (ANGUS) and Its Quantitative Validation
Slager CJ, Wentzel JJ, Schuurbiers JCH, Oomen JAF, Kloet J, Krams R, von Birgelen C, van der Giessen WJ, Serruys PW and de Feyter PJ
Circulation, Wolters Kluwer vol. 102 (5), 511-516.

DOI 10.1161/01.cir.102.5.511

01-08-2000

Helical Velocity Patterns in a Human Coronary Artery
Van Langenhove G, Wentzel JJ, Krams R, Slager CJ, Hamburger JN and Serruys PW
Circulation, Wolters Kluwer vol. 102 (3), e22-e24.

DOI 10.1161/01.cir.102.3.e22

18-07-2000

Cardiovascular profile of the calcium sensitizer EMD 57033 in open‐chest anaesthetized pigs with regionally stunned myocardium
De Zeeuw S, Trines SAIP, Krams R, Verdouw PD and Duncker DJ
British Journal of Pharmacology, Wiley vol. 129 (7), 1413-1422.

DOI 10.1038/sj.bjp.0703231

01-04-2000

Quantification of plaque volume, shear stress on the endothelium, and mechanical properties of the arterial wall with intravascular ultrasound imaging
Bom N, de Korte CL, Wentzel JJ, Krams R, Carlier SG, van der Steen AWF, Slager CJ and Roelandt JRTC
Clinical Research in Cardiology, Springer Nature vol. 89 (Suppl 2), s105-s111.

DOI 10.1007/s003920070108

01-02-2000

Coronary systolic flow impediment is functional in cardiac contraction
Willemsen MJJMF, Duncker DJ, Krams R, Dijkman MA, Sipkema P and Westerhof N
EUROPEAN HEART JOURNAL. vol. 21, 667-667.
01-01-2000

Efficiency of energy transfer, but not external work, is maximized in stunned myocardium
Trines SAIP, Slager CJ, Van Der Moer J, Verdouw PD and Krams R
American Journal of Physiology - Heart and Circulatory Physiology vol. 279 (3 48-3)

DOI 10.1152/ajpheart.2000.279.3.h1264

01-01-2000

1999

Ca2+ sensitization and diastolic function of normal and stunned porcine myocardium
Soei LK, de Zeeuw S, Krams R, Duncker DJ and Verdouw PD
European Journal of Pharmacology, Elsevier vol. 386 (1), 55-67.

DOI 10.1016/s0014-2999(99)00684-6

01-12-1999

Effect of catheter placement on 3-D velocity profiles in curved tubes resembling the human coronary system
Krams R, Wentzel JJ, Cespedes I, Vinke R, Carlier S, van der Steen AFW, Lancee CT and Slager CJ
Ultrasound in Medicine & Biology, Elsevier vol. 25 (5), 803-810.

DOI 10.1016/s0301-5629(99)00018-6

01-06-1999

Towards assessment of regional wall stress of the left ventricle using 3D ultrasound imaging
Oomen JA, Trines SAIP, Vermeulen WB, Krams R, Schuurbiers JCH, Vletter WB, Roelandt JRTC and Slager CJ
Computers in Cardiology 1999. Vol.26 (Cat. No.99CH37004)., 129-132.

DOI 10.1109/cic.1999.825923

01-01-1999

The relationship between neo intimal thickness and shear stress after wallstent implantation in human coronary arteries at 6 months follow up
Wentzel JJ, Kloet J, Krams R, Serruys PW and Slager CJ
CIRCULATION. vol. 100 (18), 727-727.
01-01-1999

External work recruitment can be restored in stunned myocardium without increasing oxygen consumption using EMD 57033, a calcium sensitizer
Trines SA, Van der Moer J, Krams R, Slager CJ, Van Meegen JR and Verdouw PD
CIRCULATION. vol. 100 (18), 8-8.
01-01-1999

1998

AT1 Receptor A/C1166 Polymorphism Contributes to Cardiac Hypertrophy in Subjects With Hypertrophic Cardiomyopathy
Osterop APRM, Kofflard MJM, Sandkuijl LA, Cate FJT, Krams R, Schalekamp MADH and Danser AHJ
Hypertension, Wolters Kluwer vol. 32 (5), 825-830.

DOI 10.1161/01.hyp.32.5.825

01-11-1998

Shear stress in atherosclerosis, and vascular remodelling.
Krams R, Wentzel JJ, Oomen JA, Schuurbiers JC, Andhyiswara I, Kloet J, Post M, de Smet B, Borst C, Slager CJ and Serruys PW
Seminars in Interventional Cardiology vol. 3 (1), 39-44.
01-03-1998

Cyclic variation of integrated backscatter and wall thickness in stunned porcine myocardium
van der Steen AFW, Rijsterborgh H, Lancée CT, Mastik F, Krams R, Roelandt JRT and Bom N
European Journal of Ultrasound, Elsevier vol. 7

DOI 10.1016/s0929-8266(97)80279-0

01-02-1998

Decreased Coronary Flow Reserve in Hypertrophic Cardiomyopathy Is Related to Remodeling of the Coronary Microcirculation
Krams R, Kofflard MJM, Duncker DJ, Von Birgelen C, Carlier S, Kliffen M, Cate FJT and Serruys PW
Circulation, Wolters Kluwer vol. 97 (3), 230-233.

DOI 10.1161/01.cir.97.3.230

27-01-1998

AT1 receptor A/C¹¹⁶⁶ polymorphism contributes to cardiac hypertrophy in subjects with hypertrophic cardiomyopathy
Osterop APRM, Kofflard MJM, Sandkuijl LA, Ten Cate FJ, Krams R, Schalekamp MADH and Danser AHJ
Hypertension vol. 32 (5), 825-830.

DOI 10.1161/01.HYP.32.5.825

01-01-1998

Novel developments in intravascular imaging
van der Steen AFW, Cespedes EI, de Korte CL, Carlier SG, Li W, Mastik F, Lancee CT, Borsbroom J, Lupotti F, Krams R, Serruys PW and Bom N
1998 IEEE Ultrasonics Symposium. Proceedings (Cat. No. 98CH36102). vol. 2

DOI 10.1109/ultsym.1998.765284

01-01-1998

True 3-D reconstruction of coronary arteries in patients shows accurate correspondence between x-ray and IVUS derived dimensions.
Stager CJ, Wentzel JJ, Schuurbiers JC, Oomen JA, Krams R, Achterberg H, Kloet J and deFeyter PJ
CIRCULATION. vol. 98 (17), 508-509.
01-01-1998

1997

Evidence for a pivotal role of shear stress on the endothelium in human atherosclerosis
Krams R, Wentzel JJ, Oomen J, Schuurbier J, Vinke R and Slager CJ
Endothelium: Journal of Endothelial Cell Research. vol. 5 (4)
01-12-1997

Contribution of asynchrony and nonuniformity to mechanical interaction in normal and stunned myocardium
Dongsheng FA, Kie Soei LO, Stubenitsky R, Boersma E, Duncker DJ, Verdouw PD and Krams ROB
American Journal of Physiology - Heart and Circulatory Physiology vol. 42 (5)
01-12-1997

Contribution of asynchrony and nonuniformity to mechanical interaction in normal and stunned myocardium
Fan D, Soei LK, Stubenitsky R, Boersma E, Duncker DJ, Verdouw PD and Krams R
American Journal of Physiology, American Physiological Society vol. 273 (5), h2146-h2154.

DOI 10.1152/ajpheart.1997.273.5.h2146

01-11-1997

Evaluation of Endothelial Shear Stress and 3D Geometry as Factors Determining the Development of Atherosclerosis and Remodeling in Human Coronary Arteries in Vivo
Krams R, Wentzel JJ, Oomen JAF, Vinke R, Schuurbiers JCH, de Feyter PJ, Serruys PW and Slager CJ
Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 17 (10), 2061-2065.

DOI 10.1161/01.atv.17.10.2061

01-10-1997

Cardiac depression after experimental air embolism in pigs: role of addition of a surface-active agent1
van Blankenstein JH, Slager CJ, Soei LK, Boersma H, Stijnen T, Schuurbiers JCH, Krams R, Lachmann B and Verdouw PD
Cardiovascular Research, Oxford University Press (Oup) vol. 34 (3), 473-482.

DOI 10.1016/s0008-6363(97)00063-1

01-06-1997

True reconstruction of vessel geometry from combined X-ray angiographic and intracoronary ultrasound data.
Slager CJ, Wentzel JJ, Oomen JA, Schuurbiers JC, Krams R, von Birgelen C, Tjon A, Serruys PW and de Feyter PJ
Seminars in Interventional Cardiology vol. 2 (1), 43-47.
01-03-1997

Influence of data processing on cyclic variation of integrated backscatter and wall thickness in stunned porcine myocardium
van der Steen AFW, Rijsterborgh H, Lancée CT, Mastik F, Krams R, Verdouw PD, Roelandt JRTC and Bom N
Ultrasound in Medicine & Biology, Elsevier vol. 23 (3), 405-414.

DOI 10.1016/s0301-5629(96)00227-x

01-01-1997

Disturbance of 3D velocity profiles induced by an IVUS catheter: evaluation with computational fluid dynamics
Wentzel JJ, Krams R, van der Steen AFW, Li W, Cespedes E, Bom N and Slager CJ
Computers in Cardiology 1997., 597-600.

DOI 10.1109/cic.1997.648024

01-01-1997

Applying computational fluid dynamics to a spatially correct 3D reconstruction of a coronary arterial segment in the individual patient
Wentzel JJ, Krams R, Oomen JAF, Schuurbiers JCH, Vinke R, Bom N and Slager CJ
Proceedings of 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. vol. 3

DOI 10.1109/iembs.1996.652826

01-01-1997

Recovery of systolic function of stunned myocardium by the Ca2+-sensitizer EMD 57033 is not accompanied by impairment of diastolic function
deZeeuw S, Soei L, vanMeegen JR, Trines SA, Krams R, Duncker DJ and Verdouw PD
CIRCULATION. vol. 96 (8), 1109-1109.
01-01-1997

Stent implantation causes alterations in 3D-geometry and 3D-shear stress distribution at the endothelium of coronary arteries
Wentzel JJ, Krams R, vanBeusekom HMN, Whelan DM, vanderGeissen WJ, Krabbendam SC, Andhyiswara I, Tjien ATJ, Schuurbiers JC, Oomen JA, Bom N and Slager CJ
CIRCULATION. vol. 96 (8), 2349-2349.
01-01-1997

Contribution of asynchrony and nonuniformity to mechanical interaction in normal and stunned myocardium
Fan D, Soei LK, Stubenitsky R, Boersma E, Duncker DJ, Verdouw PD and Krams R
American Journal of Physiology - Heart and Circulatory Physiology vol. 273 (5 42-5)

DOI 10.1152/ajpheart.1997.273.5.h2146

01-01-1997

1996

The ca²⁺ sensmser emd 60263 only impairs diastolic function of stunned myocardium at high doses in anesthetized swine
Soei LK, Krams R, Duncker DJ and Verdouw PD
FASEB Journal. vol. 10 (3)
01-12-1996

The effect of a thiadiazinone derived Ca2+ sensitizer on the responsiveness of Mg2+-ATPase to Ca2+ in myofibrils isolated from stunned and nonstunned porcine and human myocardium
Bezstarosti K, Soei LK, Krams R, Cate FJT, Verdouw PD and Lamers JMJ
Biochemical Pharmacology, Elsevier vol. 51 (9), 1211-1220.

DOI 10.1016/0006-2952(96)00083-4

01-05-1996

The relationship between myocardial integrated backscatter, perfusion pressure and wall thickness during isovolumic contraction: An isolated pig heart study
Rijsterborgh H, van der Steen AFW, Krams R, Mastik F, Lancee CT, Verdouw PD, Roelandt JRTC and Bom N
Ultrasound in Medicine & Biology, Elsevier vol. 22 (1), 43-52.

DOI 10.1016/0301-5629(95)02030-6

01-01-1996

1995

New invasive techniques of assessment of the physiological significance of coronary stenoses in humans
Di Mario C, Gil R, Krams R, De Feyter PJ and Serruys W
European Heart Journal, Oxford University Press (Oup) vol. 16 (suppl_I), 104-114.

DOI 10.1093/eurheartj/16.suppl_i.104

01-08-1995

In Vivo Measurement of Regional Large Artery Compliance by Intravascular Ultrasound Under Pentobarbital Anesthesia
Wilson RA, Di Mario C, Krams R, Loe Kie Soei , Wenguang L, Laird AC, The SHK, Gussenhoven E, Verdouw P and Roelandt JRTC
Angiology, Sage Publications vol. 46 (6), 481-488.

DOI 10.1177/000331979504600604

01-06-1995

Mechanical efficiency of stunned myocardium is modulated by increased afterload dependency
Fan D
Cardiovascular Research, Oxford University Press (Oup) vol. 29 (3), 428-437.

DOI 10.1016/0008-6363(96)88602-0

01-03-1995

734-6 ANGUS: A New Approach to Three-dimensional Reconstruction of Geometry and Orientation of Coronary Lumen and Plaque by Combined Use of Coronary Angiography and IVUS
Slager CJ, Laban M, von Birgelen C, Krams R, Oomen JAF, Boer AD, Wenguang L, de Feyter PJ, Serruys PW and Roelandt JRTC
Journal of The American College of Cardiology, Elsevier vol. 25 (2)

DOI 10.1016/0735-1097(95)92051-6

01-02-1995

ANGUS: a new approach to three-dimensional reconstruction of coronary vessels by combined use of angiography and intravascular ultrasound
Laban M, Oomen JA, Slager CJ, Wentzel JJ, Krams R, Schuurbiers JCH, Beer AD, von Birgelen C, Serruys PW and de Feijter PJ
Computers in Cardiology 1995., 325-328.

DOI 10.1109/cic.1995.482638

01-01-1995

SYSTEMATIC STUDY OF FLOW VELOCITY PROFILES IN EPICARDIAL CORONARY-ARTERIES OF PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY AND SUBAORTIC OUTFLOW GRADIENT
VONBIRGELEN C, KRAMS R, DIMARIO C, GIL R, KOFFLARD M, TENCATE FJ, REIMERS B, SLAGER CJ, ROELANDT J and SERRUYS PW
CIRCULATION. vol. 92 (8), 1549-1549.
01-01-1995

HOW SHOULD WE EVALUATE THE VASODILATORY CAPACITY OF CORONARY RESISTANCE VESSELS IN PATIENTS WITH ASYMMETRIC HYPERTROPHIC CARDIOMYOPATHY
VONBIRGELEN C, KRAMS R, GIL R, TENGATE FJ and DIMARIO C
CIRCULATION. vol. 92 (8), 960-960.
01-01-1995

1994

Loss of elastic recoil in postischemic myocardium induces rightward shift of the systolic pressure-volume relationship
Krams R, Janssen M, Van der Lee C, Van Meegen J, De Jong JW, Slager CJ and Verdouw PD
American Journal of Physiology, American Physiological Society vol. 267 (4), h1557-h1564.

DOI 10.1152/ajpheart.1994.267.4.h1557

01-10-1994

Slope of the instantaneous hyperemic diastolic coronary flow velocity-pressure relation. A new index for assessment of the physiological significance of coronary stenosis in humans.
Di Mario C, Krams R, Gil R and Serruys PW
Circulation, Wolters Kluwer vol. 90 (3), 1215-1224.

DOI 10.1161/01.cir.90.3.1215

01-09-1994

Mechanical efficiency of stunned myocardium is modulated by increased afterload dependency
Fan D, Soei LK, Sassen LM, Krams R and Verdouw PD
Cardiovascular Research vol. 28 (9), 428-437.

DOI 10.1016/S0008-6363(96)88602-0

01-09-1994

Myofibrillar Ca2+ sensitization predominantly enhances function and mechanical efficiency of stunned myocardium.
Soei LK, Sassen LM, Fan DS, van Veen T, Krams R and Verdouw PD
Circulation, Wolters Kluwer vol. 90 (2), 959-969.

DOI 10.1161/01.cir.90.2.959

01-08-1994

On the Reversal of Myocardial Stunning: A Role for Ca2+‐Sensitizers
FAN D, SOEI LK, SASSEN LMA, KRAMS R, HENDRIK E and VERDOUW PD
Annals of The New York Academy of Sciences, Wiley vol. 723 (1), 364-367.

DOI 10.1111/j.1749-6632.1994.tb36748.x

01-06-1994

On the Reversal of Myocardial Stunning: A Role for Ca2+-Sensitizers.
Fan D, Kie Soei L, Sassen LMA, Krams R, Hendrik E and Verdouw PD
Ann N Y Acad Sci vol. 723 (1), 364-367.

DOI 10.1111/j.1749-6632.1994.tb36748.x

01-06-1994

Loss of elastic recoil in postischemic myocardium induces rightward shift of the systolic pressure-volume relationship
Krams R, Janssen M, Van der Lee C, Van Meegen J, De Jong JW, Slager CJ and Verdouw PD
American Journal of Physiology - Heart and Circulatory Physiology vol. 267 (4 36-4)

DOI 10.1152/ajpheart.1994.267.4.h1557

01-01-1994

Increasing the Ca⁺⁺ sensitivity reverses the increased afterload dependency of external work and the efficiency of energy conversion of stunned myocardium
Fan D, Sassen LMA, Trines SAIP, Soei LK, Krams R and Verdouw PD
Applied Cardiopulmonary Pathophysiology vol. 5 (2), 63-72.
01-01-1994

LOSS OF ELASTIC RECOIL IN POSTISCHEMIC MYOCARDIUM INDUCES RIGHTWARD SHIFT OF THE SYSTOLIC PRESSURE-VOLUME RELATIONSHIP
KRAMS R, JANSSEN M, VANDERLEE C, VANMEEGEN J, DEJONG JW, SLAGER CJ and VERDOUW PD
American Journal of Physiology-Heart and Circulatory Physiology vol. 267 (4), H1557-H1564.

DOI 10.1152/ajpheart.1994.267.4.H1557

01-01-1994

REVERSAL OF INCREASED LOAD-DEPENDENCY OF EFFICIENCY OF ENERGY-CONVERSION IN STUNNED MYOCARDIUM BY INCREASING THE CA2+ SENSITIVITY
FAN DS, KRAMS R, SOEI LK, SASSEN LMA and VERDOUW PD
CIRCULATION. vol. 90 (4), 645-645.
01-01-1994

VARIABILITY IN OXYGEN-CONSUMPTION MEASUREMENTS DURING MYOCARDIAL STUNNING CAN BE EXPLAINED BY A PRONOUNCED AFTERLOAD DEPENDENCY OF SEGMENT LENGTH SHORTENING, EXTERNAL WORK AND MECHANICAL EFFICIENCY
FAN DS, KRAMS R, SOEI LK, SASSEN LMA and VERDOUW PD
CIRCULATION. vol. 90 (4), 645-645.
01-01-1994

The instantaneous hyperemic pressure-flow relationship in conscious humans
Di Mario C, Krams R, Gil R, Meneveau N and Serruys PW
In Progress in Quantitative Coronary Arteriography, Springer Nature 247-268.

DOI 10.1007/978-94-011-1172-0_16

01-01-1994

1993

End-systolic pressure length relations of stunned right and left ventricles after inotropic stimulation
Krams R, Soei LK, McFalls EO, Prins EAW, Sassen LM and Verdouw PD
American Journal of Physiology, American Physiological Society vol. 265 (6), h2099-h2109.

DOI 10.1152/ajpheart.1993.265.6.h2099

01-12-1993

Intracoronary trimetazidine does not improve recovery of regional function in a porcine model of repeated ischemia
Koning MMG, Krams R, Xiao CS, van Meegen JR, Bezstarosti K, Lamers JMJ and Verdouw PD
Cardiovascular Drugs and Therapy, Springer Nature vol. 7 (5), 801-807.

DOI 10.1007/bf00878934

01-11-1993

L-Propionylcarnitine Does Not Affect Myocardial Metabolic or Functional Response to Chronotropic and Inotropic Stimulation After Repetitive Ischemia in Anesthetized Pigs
Duncker DJ, Sassen LMA, Bartels GL, van Meegen JR, McFalls EO, Krams R, Bezstarosti K, Lamers JMJ and Verdouw PD
Journal of Cardiovascular Pharmacology, Wolters Kluwer vol. 22 (3), 488-498.

DOI 10.1097/00005344-199309000-00022

01-09-1993

Dobutamine restores the reduced efficiency of energy transfer from total mechanical work to external mechanical work in stunned porcine myocardium
Krams R, Duncker DJ, McFalls EO, Hogendoorn A and Verdouw PD
Cardiovascular Research, Oxford University Press (Oup) vol. 27 (5), 740-747.

DOI 10.1093/cvr/27.5.740

01-05-1993

Altered coronary flow reserve in the hypertrophied heart: implications for therapy.
McFalls EO, Duncker DJ, Sassen LM, Krams R, Man in't Veld AJ, Ruffolo RR and Verdouw PD
Journal of Human Hypertension vol. 7 Suppl 1, s29-s36.
01-02-1993

END-SYSTOLIC PRESSURE LENGTH RELATIONS OF STUNNED RIGHT-AND-LEFT-VENTRICLES AFTER INOTROPIC STIMULATION
KRAMS R, SOEI LK, MCFALLS EO, PRINS EAW, SASSEN LMA and VERDOUW PD
American Journal of Physiology vol. 265 (6), H2099-H2109.

DOI 10.1152/ajpheart.1993.265.6.H2099

01-01-1993

A modular hard and software system for the analysis of cardiac signals: application to real time pressure-volume loops
Bruining N, Krams R, Passchier H, Meij S, de Feijter P and Keane D
Proceedings of Computers in Cardiology Conference., 161-164.

DOI 10.1109/cic.1993.378479

01-01-1993

CAN THE ZERO-FLOW PRESSURE BE EXTRAPOLATED FROM THE FLOW VELOCITY-PRESSURE RELATION DURING LONG DIASTOLIC PAUSES IN HUMANS
DIMARIO C, KRAMS R, BALK A, VERDOUW PD and ROELANDT J
CIRCULATION. vol. 88 (4), 204-204.
01-01-1993

End-systolic pressure length relations of stunned right and left ventricles after inotropic stimulation
Krams R, Loe Kie Soei , McFalls EO, Prins EAW, Sassen LMA and Verdouw PD
American Journal of Physiology - Heart and Circulatory Physiology vol. 265 (6 34-6)

DOI 10.1152/ajpheart.1993.265.6.h2099

01-01-1993

High-energy phosphates and their catabolites
De Jong JW, Huizer T, Janssen M, Krams R, Tavenier M and Verdouw PD
In Ischemia-Reperfusion in Cardiac Surgery, Springer Nature 295-315.

DOI 10.1007/978-94-011-1713-5_13

01-01-1993

1992

Recruitment of myocardial work and metabolism in regionally stunned porcine myocardium
McFalls EO, Duncker DJ, Krams R, Sassen LM, Hoogendoorn A and Verdouw PD
American Journal of Physiology, American Physiological Society vol. 263 (6), h1724-h1731.

DOI 10.1152/ajpheart.1992.263.6.h1724

01-12-1992

L-propionylcarnitine and myocardial performance in stunned porcine myocardium
Sassen LMA, Duncker DJ, Hogendoorn A, McFalls EO, Krams R, Bezstarosti K, Lamers JMJ and Verdouw PD
Molecular and Cellular Biochemistry, Springer Nature vol. 116 (1-2), 147-153.

DOI 10.1007/bf01270582

01-10-1992

Pressure-maximal coronary flow relationship in regionally stunned porcine myocardium
Duncker DJ, McFalls EO, Krams R and Verdouw PD
American Journal of Physiology, American Physiological Society vol. 262 (6), h1744-h1751.

DOI 10.1152/ajpheart.1992.262.6.h1744

01-06-1992

Amiodarone increases ATP and decreases NaK ATPase activity and protein content of cultured rat heart myocytes
Verdouw PD, Krams R, McFalls EO, Duncker DJ, Hogendoorn A and Kie Soei L
Journal of Molecular and Cellular Cardiology, Elsevier vol. 24

DOI 10.1016/0022-2828(92)90484-h

01-05-1992

Inotropic stimulation restores efficiency of energy transfer from pressure-segment length area to external mechanical work in stunned porcine myocardium
Verdouw PD, Krams R, McFalls EO, Duncker DJ, Hogendoorn A and Soei LK
Journal of Molecular and Cellular Cardiology, Elsevier vol. 24

DOI 10.1016/0022-2828(92)90821-g

01-05-1992

Recruitment of myocardial work and metabolism in regionally stunned porcine myocardium
McFalls EO, Duncker DJ, Krams R, Sassen LMA, Hoogendoorn A and Verdouw PD
American Journal of Physiology - Heart and Circulatory Physiology vol. 263 (6 32-6)

DOI 10.1152/ajpheart.1992.263.6.h1724

01-01-1992

PRESSURE-MAXIMAL CORONARY FLOW RELATIONSHIP IN REGIONALLY STUNNED PORCINE MYOCARDIUM
DUNCKER DJ, MCFALLS EO, KRAMS R and VERDOUW PD
American Journal of Physiology vol. 262 (6), H1744-H1751.

DOI 10.1152/ajpheart.1992.262.6.H1744

01-01-1992

Pressure-maximal coronary flow relationship in regionally stunned porcine myocardium
Duncker DJ, McFalls EO, Krams R and Verdouw PD
American Journal of Physiology - Heart and Circulatory Physiology vol. 262 (6 31-6)

DOI 10.1152/ajpheart.1992.262.6.h1744

01-01-1992

RECRUITMENT OF MYOCARDIAL WORK AND METABOLISM IN REGIONALLY STUNNED PORCINE MYOCARDIUM
MCFALLS EO, DUNCKER DJ, KRAMS R, SASSEN LMA, HOOGENDOORN A and VERDOUW PD
American Journal of Physiology vol. 263 (6), H1724-H1731.

DOI 10.1152/ajpheart.1992.263.6.H1724

01-01-1992

RECRUITMENT OF REGIONAL EXTERNAL WORK AND OXYGEN-CONSUMPTION IN STUNNED PORCINE MYOCARDIUM
MCFALLS EO, KRAMS R, DUNCKER DJ, SASSEN LMA, HOOGENDOORN A and VERDOUW PD
CIRCULATION. vol. 86 (4), 613-613.
01-01-1992

L-propionylcarnitine and myocardial performance in stunned porcine myocardium
Sassen LMA, Duncker DJ, Hogendoorn A, McFalls EO, Krams R, Bezstarosti K, Lamers JMJ and Verdouw PD
In Lipid Metabolism in The Healthy and Disease Heart, Springer Nature 147-153.

DOI 10.1007/978-1-4615-3514-0_21

01-01-1992

1991

Endothelium dependent vasodilatation following brief ischaemia and reperfusion in anaesthetised swine
McFalls EO, Duncker DJ, Krams R, Ward H, Gornick C and Verdouw PD
Cardiovascular Research, Oxford University Press (Oup) vol. 25 (8), 659-665.

DOI 10.1093/cvr/25.8.659

01-08-1991

Changes in oxygen-pressure volume area's (O2-PVA) studied after brief periods of ischemia
Krams R, Duncker DJ, McFalls EO and Verdouw PD
Journal of Molecular and Cellular Cardiology, Elsevier vol. 23

DOI 10.1016/0022-2828(91)90585-a

01-07-1991

Elastic recoil: A sensitive measure of loss of function during brief periods of ischemia and reperfusion
Krams R, Duncker DJ, McFalls EO and Verdouw PD
Journal of Molecular and Cellular Cardiology, Elsevier vol. 23

DOI 10.1016/0022-2828(91)90588-d

01-07-1991

Does intravenous milrinone have a direct effect on diastolic function?
Krams R, McFalls E, van der Giessen WJ, Serruys PW, Verdoun PD and Roelandt J
Am Heart J vol. 121 (6 Pt 2), 1951-1955.

DOI 10.1016/0002-8703(91)90831-2

01-06-1991

Endothelium dependent vasodilatation following brief ischaemia and reperfusion in anaesthetised swine
Mcfalls EO, Duncker DJ, Krams R, Ward H, Gornick C and Verdouw PD
Cardiovascular Research vol. 25 (8), 659-665.

DOI 10.1093/cvr/25.8.659

01-01-1991

THE EFFECT OF MILRINONE ON DIASTOLIC FUNCTION - DIRECT OR INDIRECT EFFECT
KRAMS R, MCFALLS E, VANDERGIESSEN WJ, SERRUYS PW and ROELANDT J
ACUTE THERAPY OF HEART FAILURE. vol. 2, 35-42.
01-01-1991

1990

Effect of wall stretch on coronary hemodynamics in isolated canine interventricular septum
Resar J, Livingston JZ, Halperin HR, Sipkema P, Krams R and Yin FC
American Journal of Physiology, American Physiological Society vol. 259 (6), h1869-h1880.

DOI 10.1152/ajpheart.1990.259.6.h1869

01-12-1990

Myocardial modulation of coronary circulation Reply)
Westerhof N, Sipkema P and Krams R
American Journal of Physiology - Heart and Circulatory Physiology vol. 259 (6 28-6)
01-12-1990

Coronary oscillatory flow amplitude is more affected by perfusion pressure than ventricular pressure
Krams R, Sipkema P and Westerhof N
American Journal of Physiology, American Physiological Society vol. 258 (6), h1889-h1898.

DOI 10.1152/ajpheart.1990.258.6.h1889

01-06-1990

MYOCARDIAL MODULATION OF CORONARY CIRCULATION - REPLY
WESTERHOF N, SIPKEMA P and KRAMS R
American Journal of Physiology vol. 259 (6), H1936-H1937.
01-01-1990

EFFECT OF WALL STRETCH ON CORONARY HEMODYNAMICS IN ISOLATED CANINE INTERVENTRICULAR SEPTUM
RESAR J, LIVINGSTON JZ, HALPERIN HR, SIPKEMA P, KRAMS R and YIN FCP
American Journal of Physiology vol. 259 (6), H1869-H1880.

DOI 10.1152/ajpheart.1990.259.6.H1869

01-01-1990

Effect of wall stretch on coronary hemodynamics in isolated canine interventricular septum
Resar J, Livingston JZ, Halperin HR, Sipkema P, Krams R and Yin FCP
American Journal of Physiology - Heart and Circulatory Physiology vol. 259 (6 28-6)

DOI 10.1152/ajpheart.1990.259.6.h1869

01-01-1990

Coronary oscillatory flow amplitude is more affected by perfusion pressure than ventricular pressure
Krams R, Sipkema P and Westerhof N
American Journal of Physiology - Heart and Circulatory Physiology vol. 258 (6 27-6)

DOI 10.1152/ajpheart.1990.258.6.h1889

01-01-1990

CORONARY OSCILLATORY FLOW AMPLITUDE IS MORE AFFECTED BY PERFUSION-PRESSURE THAN VENTRICULAR PRESSURE
KRAMS R, SIPKEMA P and WESTERHOF N
American Journal of Physiology vol. 258 (6), H1889-H1898.

DOI 10.1152/ajpheart.1990.258.6.H1889

01-01-1990

1989

Contractility is the main determinant of coronary systolic flow impediment
Krams R, Sipkema P, Zegers J and Westerhof N
American Journal of Physiology - Heart and Circulatory Physiology vol. 257 (6)

DOI 10.1152/ajpheart.1989.257.6.H1936

01-12-1989

Varying elastance concept may explain coronary systolic flow impediment
Krams R, Sipkema P and Westerhof N
American Journal of Physiology, American Physiological Society vol. 257 (5), h1471-h1479.

DOI 10.1152/ajpheart.1989.257.5.h1471

01-11-1989

Varying elastance concept may explain coronary systolic flow impediment.
Krams R, Sipkema P and Westerhof N
Am J Physiol vol. 257 (5 Pt 2), H1471-H1479.

DOI 10.1152/ajpheart.1989.257.5.H1471

01-11-1989

Can coronary systolic-diastolic flow differences be predicted by left ventricular pressure or time-varying intramyocardial elastance?
Krams R, van Haelst ACTA, Sipkema P and Westerhof N
Basic Research in Cardiology, Springer Nature vol. 84 (2), 149-159.

DOI 10.1007/bf01907924

01-03-1989

1988

Changes in coronary pressure-flow relation after transition from blood to Tyrode perfusion
Van Dijk LC, Krams R, Sipkema P and Westerhof N
American Journal of Physiology, American Physiological Society vol. 255 (3), h476-h482.

DOI 10.1152/ajpheart.1988.255.3.h476

01-09-1988

EFFECTS OF STRETCH ON THE PRESSURE-FLOW RELATION OF THE ISOLATED ARRESTED DOG SEPTUM
YIN F, SIPKEMA P, KRAMS R, STRUMPF R and RESAR J
FASEB JOURNAL. vol. 2 (4), A302-A302.
01-01-1988

Changes in coronary pressure-flow relation after transition from blood to Tyrode perfusion
Van Dijk LC, Krams R, Sipkema P and Westerhof N
American Journal of Physiology - Heart and Circulatory Physiology vol. 255 (3)

DOI 10.1152/ajpheart.1988.255.3.H476

01-01-1988

SYSTOLIC CORONARY FLOW IMPEDIMENT EXPLAINED ON BASIS OF THE TIME-VARYING ELASTANCE CONCEPT
SIPKEMA P, KRAMS R and WESTERHOF N
FASEB JOURNAL. vol. 2 (4), A929-A929.
01-01-1988

1986

Comments on Pressure and tone dependence of coronary diastolic input impedance and capacitance
Westerhof N and Krams R
American Journal of Physiology, American Physiological Society vol. 250 (2), h330-h331.

DOI 10.1152/ajpheart.1986.250.2.h330

01-02-1986

Comments on Pressure and tone dependence of coronary diastolic input impedance and capacitance.
Westerhof N and Krams R
Am J Physiol vol. 250 (2 Pt 2), H330-H331.

DOI 10.1152/ajpheart.1986.250.2.H330

01-02-1986

Comments on 'pressure and tone dependence of coronary diastolic input impedance and capacitance'
Westerhof N, Krams R and Canty JM
American Journal of Physiology - Heart and Circulatory Physiology vol. 250 (2 (19/2))

DOI 10.1152/ajpheart.1986.250.2.h330

01-01-1986

1985

DOES LEFT-VENTRICULAR PRESSURE INFLUENCE THE CORONARY PRESSURE-FLOW RELATION IN THE CAT
KRAMS R, SIPKEMA P and WESTERHOF N
JOURNAL OF PHYSIOLOGY-LONDON. vol. 366 (SEP), P42-P42.
01-01-1985

1984

EFFECTS OF CARDIAC CONTRACTION ON CORONARY FLOW.
Sipkema P, Burattini R, van Haelst ACTA, Krams R and Westerhof N
Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings.
01-12-1984

Consistent parallel relationships among myocardial oxygen consumption, coronary blood flow, and pericardial infusate adenosine concentration with various interventions and beta-blockade in the dog.
Borgdorff P, Braakman R, van Haelst AC, van Huis GA, de Jong JP, Krams R, Langewouters GJ, Sipkema P and Westerhof N
Circulation Research, Wolters Kluwer vol. 54 (3), 348-348.

DOI 10.1161/01.res.54.3.348

01-03-1984

Can left ventricular pressure explain coronary flow impediment?
Westerhof N, Krams R, Van Haelst ACTA and Sipkema P
Federation Proceedings. vol. 43 (3)
01-01-1984

1982

THE EFFECTS OF THE CORONARY CAPACITANCE ON THE INTERPRETATION OF DIASTOLIC PRESSURE-FLOW RELATIONSHIPS - COMMENTS
BRAAKMAN R, VANDERHORN GJ, VONHUIS GA, KRAMS R, LANGEWOUTERS GJ, SIPKEMA P and WESTERHOF N
Circulation Research vol. 51 (6), 822-822.
01-01-1982

Grants

Grants of specific relevance to the Centre for Bioengineering

G1F1Application of a new high throughput platform for validation of mechanosensitive miRNA
Rob Krams and Gleb Sukhorukov
£117,986 BHF British Heart Foundation
01-09-2023 - 31-08-2026

Inorganic nitrate treatment reduces inflammation in humans: assessment of mechanisms
Amrita Ahluwalia, Rob Krams, Federica Marelli-Berg and Jacqueline Cooper
£206,297 BHF British Heart Foundation
19-08-2019 - 18-02-2022

Biomechanical determinants of advanced coronary atherosclerotic plaque formation in transgenic hyperlipidaemic minipigs
Rob Krams
£167,563 BHF British Heart Foundation
01-11-2018 - 31-01-2021

Disturbed shear stress and strain act synergistically to promote the pro-atherogenic endothelial cell phenotype responsible for TCFA - GRANT TRANSFER
Rob Krams
£46,226 BHF British Heart Foundation
01-02-2018 - 16-08-2018

Aliah Mohammed Ahmad Abuammah - Studentship
Rob Krams
£28,000 UKSACB Saudi Arabian Cultural Bureau in London
22-01-2018 - 12-01-2019