Prof Caroline Brennan
Professor of Molecular Genetics
Interim Head of The School of Biological and Behavioural Sciences
School of Biological and Behavioural Sciences
Queen Mary University of London
Queen Mary University of London
Research
zebrafish, development, comparative cognition, addiction, neurobiology
Interests
All aspects of the use of zebrafish as a developmental and behavioural model organism including cell biological and behavioural analysis in this species. Current research focuses on cell and developmental processes underlying vulnerability to behavioural and metabolic disease as well as comparative psychology approaches to cognition and psychiatric disorders. We collaborate with human geneticists to explore the cell biology underlying genetic variants associated with human disease phenotypes, and to test hypotheses regarding mechanisms of gene action, and with evolutionary geneticists to explore genetic control of behaviour.Research web page : https://brennanlab.sbcs.qmul.ac.uk/
Publications
Publications of specific relevance to the Centre for Brain and Behaviour2024
Housing and Husbandry Factors Affecting Zebrafish (Danio rerio) Novel Tank Test Responses: A Global Multi-Laboratory Study.Hillman C, Fontana BD, Amstislavskaya TG, Gorbunova MA, Altenhofen S, Barthelson K, Bastos LM, Borba JV, Bonan CD, Brennan CH, Farias-Cea A, Cooper A, Corcoran J, Dondossola ER, Martinez-Duran LM, Gallas-Lopes M, Galstyan DS, Garcia EO, Gerken E, Hindges R, et al.
Res Sq
16-10-2024
Pleiotropic contribution of rbfox1 to psychiatric and neurodevelopmental phenotypes in two zebrafish modelsAntón-Galindo E, Adel MR, García-González J, Leggieri A, López-Blanch L, Irimia M, Norton WHJ, Brennan CH, Fernàndez-Castillo N and Cormand B
Translational Psychiatry, Springer Nature vol. 14 (1)
19-02-2024
2023
Aryl hydrocarbon receptor-interacting protein (aip) loss causes failure-to-thrive and cardiac defects in zebrafishWang X, Haworth O, Abdi-Aziz N, Leggieri A, Jhosadara E-FA, Korbonits M and Brennan CH
Endocrine Abstracts, Bioscientifica
31-10-2023
THU079 Danio Rerio (Zebrafish): A New Model Of AIP Loss Of FunctionWang X, Leggieri A, Anagianni S, Brennan CH and Korbonits M
Journal of The Endocrine Society, The Endocrine Society vol. 7 (Supplement_1)
05-10-2023
EXPLORING THE GENETICS OF NUMEROSITY, FROM FISH TO MANBrennan C, Sheardown E, Pérez JVT, Petrazzini MEM, Messina A, Potrich D, Anagianni S, Perrino M, Luu P, Truong T, Fraser S and Vallortigara G
Ibro Neuroscience Reports, Elsevier vol. 15
01-10-2023
LOSS-OF-FUNCTION ZEBRAFISH (DANIO RERIO) FOR GENES ASSOCIATED WITH WILLIAMS SYNDROME SHOW ALTERED QUANTITY DISCRIMINATIONPérez JVT, Anagianni S, Sheardown E, Petrazzini MEM, Fraser S, Butterworth B, Vallortigara G and Brennan C
Ibro Neuroscience Reports, Elsevier vol. 15
01-10-2023
The Role of Crosslinker Content of Positively Charged NIPAM Nanogels on the In Vivo Toxicity in ZebrafishBilardo R, Traldi F, Brennan CH and Resmini M
Pharmaceutics, Mdpi vol. 15 (7)
07-07-2023
2022
baz1b loss-of-function in zebrafish produces phenotypic alterations consistent with the domestication syndromeTorres-Pérez JV, Anagianni S, Mech AM, Havelange W, García-González J, Fraser SE, Vallortigara G and Brennan CH
Iscience, Elsevier vol. 26 (1)
01-12-2022
A zebrafish model of AIP loss of functionWang X, Leggieri A, Anagianni S, Brennan CH and Korbonits M
Endocrine Abstracts, Bioscientifica
27-10-2022
Quantity as a Fish Views It: Behavior and NeurobiologyMessina A, Potrich D, Perrino M, Sheardown E, Petrazzini MEM, Luu P, Nadtochiy A, Truong TV, Sovrano VA, Fraser SE, Brennan CH and Vallortigara G
Frontiers in Neuroanatomy, Frontiers vol. 16
14-07-2022
Characterizing ontogeny of quantity discrimination in zebrafishSheardown E, Torres-Perez JV, Anagianni S, Fraser SE, Vallortigara G, Butterworth B, Miletto-Petrazzini ME and Brennan CH
Proceedings of The Royal Society B: Biological Sciences, The Royal Society vol. 289 (1968)
09-02-2022
Ankk1 Loss of Function Disrupts Dopaminergic Pathways in ZebrafishLeggieri A, García-González J, Torres-Perez JV, Havelange W, Hosseinian S, Mech AM, Keatinge M, Busch-Nentwich EM and Brennan CH
Frontiers in Neuroscience, Frontiers vol. 16
08-02-2022
Translational relevance of forward genetic screens in animal models for the study of psychiatric diseaseSheardown E, Mech AM, Petrazzini MEM, Leggieri A, Gidziela A, Hosseinian S, Sealy IM, Torres-Perez JV, Busch-Nentwich EM, Malanchini M and Brennan CH
Neuroscience and Biobehavioral Reviews, Elsevier vol. 135
04-02-2022
Behavioral and Gene Regulatory Responses to Developmental Drug Exposures in ZebrafishMech AM, Merteroglu M, Sealy IM, Teh M-T, White RJ, Havelange W, Brennan CH and Busch-Nentwich EM
Frontiers in Psychiatry, Frontiers vol. 12
10-01-2022
2021
A systematic review of the mental health risks and resilience among pollution-exposed adolescentsTheron LC, Abreu-Villaça Y, Augusto-Oliveira M, Brennan C, Crespo-Lopez ME, de Paula Arrifano G, Glazer L, Gwata N, Lin L, Mareschal I, Mermelstein S, Sartori L, Stieger L, Trotta A and Hadfield K
Journal of Psychiatric Research, Elsevier vol. 146, 55-66.
23-12-2021
Developmental Exposure to Low Concentrations of Methylmercury Causes Increase in Anxiety-Related Behaviour and Locomotor Impairments in ZebrafishGlazer L and Brennan CH
International Journal of Molecular Sciences, Mdpi vol. 22 (20)
11-10-2021
Neurons in the Dorso-Central Division of Zebrafish Pallium Respond to Change in Visual NumerosityMessina A, Potrich D, Schiona I, Sovrano VA, Fraser SE, Brennan CH and Vallortigara G
Cerebral Cortex, Oxford University Press (Oup) vol. 32 (2), 418-428.
28-07-2021
Conservation of mechanisms regulating emotional-like responses on spontaneous nicotine withdrawal in zebrafish and mammalsPonzoni L, Melzi G, Marabini L, Martini A, Petrillo G, Teh M-T, Torres-Perez JV, Morara S, Gotti C, Braida D, Brennan CH and Sala M
Progress in Neuro-Psychopharmacology and Biological Psychiatry, Elsevier vol. 111
24-04-2021
Effects of pollution on adolescent mental health: a systematic review protocolTheron LC, Abreu-Villaça Y, Augusto-Oliveira M, Brennan CH, Crespo-Lopez ME, de Paula Arrifano G, Glazer L, Lin L, Mareschal I, Sartori L, Stieger L, Trotta A and Hadfield K
Systematic Reviews, Springer Nature vol. 10 (1)
27-03-2021
Behavioral Effects of Developmental Exposure to JWH-018 in Wild-Type and Disrupted in Schizophrenia 1 (disc1) Mutant ZebrafishGarcía-González J, de Quadros B, Havelange W, Brock AJ and Brennan CH
Biomolecules, Mdpi vol. 11 (2)
19-02-2021
Stress reactivity elicits a tissue-specific reduction in telomere length in aging zebrafish (Danio rerio)Evans JR, Torres-Pérez JV, Miletto Petrazzini ME, Riley R and Brennan CH
Scientific Reports, Nature Publishing Group vol. 11 (1)
01-01-2021
Restoring Wnt/β-catenin pathway as potential therapeutics for Williams syndrome-associated anxiety disordersTorres-Perez JV and Brennan CH
BRITISH JOURNAL OF PHARMACOLOGY. vol. 178 (2), 447-448.
01-01-2021
2020
Are cerebral and behavioural lateralization related to anxiety-like traits in the animal model zebrafish (Danio rerio)?Petrazzini MEM, Gambaretto L, Dadda M, Brennan C and Agrillo C
Laterality Asymmetries of Body Brain and Cognition, Taylor & Francis vol. 26 (1-2), 144-162.
17-12-2020
Increased Response to 3,4-Methylenedioxymethamphetamine (MDMA) Reward and Altered Gene Expression in Zebrafish During Short- and Long-Term Nicotine WithdrawalPonzoni L, Teh MT, Torres-Perez JV, Brennan CH, Braida D and Sala M
Molecular Neurobiology, Springer (Part of Springer Nature)
24-11-2020
Application of an abstract concept across magnitude dimensions by fishMiletto Petrazzini ME and Brennan CH
Scientific Reports, Springer Nature vol. 10 (1)
09-10-2020
The effects of polygenic risk for psychiatric disorders and smoking behaviour on psychotic experiences in UK BiobankGarcía-González J, Ramírez J, Howard DM, Brennan CH, Munroe PB and Keers R
Translational Psychiatry, Nature Publishing Group vol. 10 (1)
28-09-2020
Moderate early life stress improves adult zebrafish (Danio rerio) working memory but does not affect social and anxiety-like responsesFontana BD, Gibbon AJ, Cleal M, Sudwarts A, Pritchett D, Miletto Petrazzini ME, Brennan CH and Parker MO
Developmental Psychobiology, Wiley
04-06-2020
Response to change in the number of visual stimuli in zebrafish:A behavioural and molecular studyMessina A, Potrich D, Schiona I, Sovrano VA, Fraser SE, Brennan CH and Vallortigara G
Scientific Reports, Nature Publishing Group vol. 10 (1)
01-04-2020
Identification of Slit3 as a locus affecting nicotine preference in zebrafish and human smoking behaviourGarcia Gonzalez J, Brock A, Parker M, Riley R, Joliffe D, SUDWARTS A, Teh M-T, Busch-Nentwich E, Stemple D, Martineau A, Kaprio J, Kuan V, Walton R and Brennan C
Elife, Elife Sciences Publications Ltd
25-03-2020
Chapter 7 Classical and operant conditioning in larval zebrafishPritchett D and Brennan CH
In Behavioral and Neural Genetics of Zebrafish, Elsevier 107-122.
01-01-2020
2019
The effects of polygenic risk for psychiatric disorders and smoking behaviour on psychotic experiences in UK BiobankGarcía-González J, Ramírez J, Howard DM, Brennan CH, Munroe PB and Keers R
, Cold Spring Harbor Laboratory
21-12-2019
BEHAVIOURAL EFFECTS OF DEVELOPMENTAL EXPOSURE TO THE SYNTHETIC CANNABINOID JWH-018 IN WILD TYPE AND DISRUPTED IN SCHIZOPHRENIA 1 (DISC1) MUTANT ZEBRAFISHGarcia-Gonzalez J, De Quadros B, Akkari M and Brennan C
The XXVIth World Congress of Psychiatric Genetics (WCPG), 11 - 15 October 2018. vol. 29, 1274-1274.
26-07-2019
2018
Food or friends? What motivates zebrafish (Danio rerio) performing a visual discriminationBRENNAN CH, Brown VJ and Daggett J
Behavioural Brain Research vol. 359
06-11-2018
2017
Assessing the Value of the Zebrafish Conditioned Place Preference Model for Predicting Human Abuse Potential.Brock AJ, Goody SMG, Mead AN, Sudwarts A, Parker MO and Brennan CH
J Pharmacol Exp Ther vol. 363 (1), 66-79.
15-09-2017
Zebrafish Behavioral Models of AgeingBrock AJ, Sudwarts A, Parker MO and Brennan CH
In The Rights and Wrongs of Zebrafish: Behavioral Phenotyping of Zebrafish, Springer Nature 241-258.
01-01-2017
2016
Translational Pharmacology of a Putative Measure of Motor Impulsivity in Larval ZebrafishParker M and Brennan C
Current Psychopharmacologye, Bentham Science Publishers vol. 5 (2), 73-84.
28-07-2016
Corrigendum: Beta 1-integrin-c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes.Barrow-McGee R, Kishi N, Joffre C, Ménard L, Hervieu A, Bakhouche BA, Noval AJ, Mai A, Guzmán C, Robbez-Masson L, Iturrioz X, Hulit J, Brennan CH, Hart IR, Parker PJ, Ivaska J and Kermorgant S
Nat Commun vol. 7, 12392-12392.
22-07-2016
Beta 1-integrin–c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranesBarrow-McGee R, Kishi N, Joffre C, Ménard L, Hervieu A, Bakhouche BA, Noval AJ, Mai A, Guzmán C, Robert-Masson L, Iturrioz X, Hulit J, Brennan CH, Hart IR, Parker PJ, Ivaska J and Kermorgant S
Nature Communications, Nature Publishing Group: Nature Communications vol. 7, 11942-11942.
23-06-2016
A Small Molecule Inhibitor of PDK1/PLCγ1 Interaction Blocks Breast and Melanoma Cancer Cell InvasionRaimondi C, Calleja V, Ferro R, Fantin A, Riley AM, Potter BVL, Brennan CH, Maffucci T, Larijani B and Falasca M
Scientific Reports, Nature Publishing Group: Open Access Journals - Option C vol. 6, 26142-26142.
20-05-2016
Sustained Effects of Developmental Exposure to Ethanol on Zebrafish Anxiety-Like BehaviourBaiamonte M, Parker MO, Vinson GP and Brennan CH
Plos One, Public Library of Science (Plos) vol. 11 (2)
10-02-2016
2015
Suppression of TGFβ and Angiogenesis by Type VII Collagen in Cutaneous SCC.Martins VL, Caley MP, Moore K, Szentpetery Z, Marsh ST, Murrell DF, Kim MH, Avari M, McGrath JA, Cerio R, Kivisaari A, Kähäri VM, Hodivala-Dilke K, Brennan CH, Chen M, Marshall JF and O'Toole EA
J Natl Cancer Inst vol. 108 (1)
16-10-2015
Developmental role of acetylcholinesterase in impulse control in zebrafishParker MO, Brock AJ, Sudwarts A, Teh M-T, Combe FJ and Brennan CH
Frontiers in Behavioral Neuroscience, Frontiers vol. 9
16-10-2015
Correction: Sustained Action of Developmental Ethanol Exposure on the Cortisol Response to Stress in Zebrafish Larvae and AdultsBaiamonte M, Brennan CH and Vinson GP
Plos One, Public Library of Science (Plos) vol. 10 (5)
08-05-2015
Speed–accuracy trade-offs and individually consistent decision making by individuals and dyads of zebrafish in a colour discrimination taskWang M-Y, Brennan CH, Lachlan RF and Chittka L
Animal Behaviour, Elsevier vol. 103, 277-283.
01-05-2015
Sustained Action of Developmental Ethanol Exposure on the Cortisol Response to Stress in Zebrafish Larvae and AdultsBaiamonte M, Brennan CH and Vinson GP
Plos One, Public Library of Science (Plos) vol. 10 (4)
13-04-2015
Molecular psychiatry of zebrafish.Stewart AM, Ullmann JFP, Norton WHJ, Parker MO, Brennan CH, Gerlai R and Kalueff AV
Mol Psychiatry vol. 20 (1), 2-17.
01-02-2015
2014
The utility of zebrafish to study the mechanisms by which ethanol affects social behavior and anxiety during early brain developmentParker MO, Annan LV, Kanellopoulos AH, Brock AJ, Combe FJ, Baiamonte M, Teh MT and Brennan CH
Progress in Neuro-Psychopharmacology and Biological Psychiatry vol. 55, 94-100.
03-12-2014
Moderate alcohol exposure during early brain development increases stimulus-response habits in adulthoodParker MO, Evans AMD, Brock AJ, Combe FJ, Teh MT and Brennan CH
Addiction Biology
21-08-2014
The receptor tyrosine kinase Axl regulates cell-cell adhesion and stemness in cutaneous squamous cell carcinoma.Cichoń MA, Szentpetery Z, Caley MP, Papadakis ES, Mackenzie IC, Brennan CH and O'Toole EA
Oncogene vol. 33 (32), 4185-4192.
07-08-2014
Atomoxetine reduces anticipatory responding in a 5-choice serial reaction time task for adult zebrafish.Parker MO, Brock AJ, Sudwarts A and Brennan CH
Psychopharmacology (Berl) vol. 231 (13), 2671-2679.
01-07-2014
The utility of zebrafish to study the mechanisms by which ethanol affects social behavior and anxiety during early brain developmentParker MO, Annan LV, Kanellopoulos AH, Brock AJ, Combe FJ, Baiamonte M, Teh M-T and Brennan CH
Progress in Neuro-Psychopharmacology and Biological Psychiatry
01-01-2014
Parallel mechanisms for visual search in zebrafish.Proulx MJ, Parker MO, Tahir Y and Brennan CH
Plos One vol. 9 (10)
01-01-2014
2013
Behavioural phenotyping of casper mutant and 1-pheny-2-thiourea treated adult zebrafish.Parker MO, Brock AJ, Millington ME and Brennan CH
Zebrafish vol. 10 (4), 466-471.
01-12-2013
Addiction and the adrenal cortex.Vinson GP and Brennan CH
Endocr Connect vol. 2 (3), R1-R14.
01-09-2013
The role of zebrafish (Danio rerio) in dissecting the genetics and neural circuits of executive functionParker MO, Brock AJ, Walton RT and Brennan CH
Frontiers in Neural Circuits (MAR)
19-03-2013
S100P is a metastasis-associated gene that facilitates transendothelial migration of pancreatic cancer cells.Barry S, Chelala C, Lines K, Sunamura M, Wang A, Marelli-Berg FM, Brennan C, Lemoine NR and Crnogorac-Jurcevic T
Clin Exp Metastasis vol. 30 (3), 251-264.
01-03-2013
Development and automation of a test of impulse control in zebrafish.Parker MO, Ife D, Ma J, Pancholi M, Smeraldi F, Straw C and Brennan CH
Front Syst Neurosci vol. 7
01-01-2013
2012
Zebrafish (Danio rerio) models of substance abuse: Harnessing the capabilitiesParker MO and Brennan CH
Behaviour vol. 149 (10-12), 1037-1062.
05-12-2012
Low and moderate alcohol consumption during pregnancy: effects on social behaviour and propensity to develop substance abuse in later life.Parker MO and Brennan CH
Bjog vol. 119 (13), 1671-1672.
01-12-2012
Low and Moderate alcohol consumption during pregnancy: effects on social behaviour and propensity to develop substance abuse in later lifePARKER M and BRENNAN CH
Bjog: An International Journal of Obstetrics and Gynaecology (13), 1671-1672.
01-12-2012
The role of primary cilia in mouse adrenal and zebrafish interrenal developmentCogger K, Guasti L, Ashworth R, Brennan C, Beales P, Marion V and King P
Cilia, Springer Nature vol. 1 (Suppl 1)
01-11-2012
Discrimination reversal and attentional sets in zebrafish (Danio rerio).Parker MO, Gaviria J, Haigh A, Millington ME, Brown VJ, Combe FJ and Brennan CH
Behav Brain Res vol. 232 (1), 264-268.
15-06-2012
Development and implementation of a three-choice serial reaction time task for zebrafish (Danio rerio).Parker MO, Millington ME, Combe FJ and Brennan CH
Behav Brain Res vol. 227 (1), 73-80.
01-02-2012
Housing conditions differentially affect physiological and behavioural stress responses of zebrafish, as well as the response to anxiolytics.Parker MO, Millington ME, Combe FJ and Brennan CH
Plos One vol. 7 (4)
01-01-2012
2011
Ryanodine receptors, a family of intracellular calcium ion channels, are expressed throughout early vertebrate development.Wu HH, Brennan C and Ashworth R
Bmc Res Notes vol. 4
14-12-2011
AGR2 is a novel surface antigen that promotes the dissemination of pancreatic cancer cells through regulation of cathepsins B and D.Dumartin L, Whiteman HJ, Weeks ME, Hariharan D, Dmitrovic B, Iacobuzio-Donahue CA, Brentnall TA, Bronner MP, Feakins RM, Timms JF, Brennan C, Lemoine NR and Crnogorac-Jurcevic T
Cancer Res vol. 71 (22), 7091-7102.
15-11-2011
ErratumPersonalized Medicine, Taylor & Francis vol. 8 (6), 692-692.
01-11-2011
ChemInform Abstract: Modular “Click” Sensors for Zinc and Their Application in vivo.Jobe K, Brennan CH, Motevalli M, Goldup SM and Watkinson M
Cheminform, Wiley vol. 42 (40), no-no.
08-09-2011
Treatment for tobacco dependence: a potential application for stratified medicine?Brock AJ, Takeda A, Brennan C and Walton RT
Pers Med vol. 8 (5), 571-579.
01-09-2011
USING ZEBRAFISH TO EXAMINE THE GENETICS OF DRUG SEEKING AND IMPULSIVITYBrennan CH, Parker MO and Millington ME
JOURNAL OF PSYCHOPHARMACOLOGY. vol. 25 (8), A6-A6.
01-08-2011
Modular 'click' sensors for zinc and their application in vivo.Jobe K, Brennan CH, Motevalli M, Goldup SM and Watkinson M
Chem Commun (Camb) vol. 47 (21), 6036-6038.
07-06-2011
Zebrafish behavioural assays of translational relevance for the study of psychiatric diseaseBrennan CH
Rev Neuroscience vol. 22 (1), 37-48.
01-01-2011
2010
AGR2 Regulates the Invasion of Pancreatic Cancer Cells Through Cathepsins B and DDumartin L, Whiteman HJ, Weeks ME, Timms JF, Brentnall TA, Bronner MP, Brennan C, Lemoine NR and Crnogorac-Jurcevic T
Pancreas vol. 39 (8), 1318-1319.
01-11-2010
Zebrafish Conditioned Place Preference Models of Drug Reinforcement and Relapse to Drug SeekingParmar A, Parmar M and Brennan CH
Neuromethods, Springer Nature vol. 51, 75-84.
11-10-2010
Conditioned Place Preference Models of Drug Dependence and Relapse to Drug Seeking: Studies with Nicotine and EthanolBrennan CH, Parmar A, Kily LKM, Ananthathevan A, Doshi A and Patel S
Neuromethods, Springer Nature vol. 52, 163-179.
15-09-2010
Report of the European Zebrafish Principal Investigator Meeting in Padua, Italy, March 18–22, 2010.Brennan C, Dosch R, Haramis A-P, Luckenbach T, Martinez-Morales J-R, Moro E, Polok B, Ramesh TM, Russell C, Argenton F and Strähle U
Zebrafish vol. 7 (3), 305-310.
01-09-2010
2009
A Novel Role for Ryanodine Receptors during Embryonic Development: Studies in Zebrafish.Wu HHT, Brennan C and Ashworth R
JOURNAL OF GENERAL PHYSIOLOGY. vol. 134 (1), 17A-17A.
01-07-2009
2008
Eph receptors and zonation in the rat adrenal cortex.Brennan CH, Chittka A, Barker S and Vinson GP
J Endocrinol vol. 198 (1), 185-191.
01-07-2008
Gene expression changes in a zebrafish model of drug dependency suggest conservation of neuro-adaptation pathways.Kily LJM, Cowe YCM, Hussain O, Patel S, McElwaine S, Cotter FE and Brennan CH
J Exp Biol vol. 211 (Pt 10), 1623-1634.
01-05-2008
2007
Regeneration-enhancing effects of EphA4 blocking peptide following corticospinal tract injury in adult rat spinal cord.Fabes J, Anderson P, Brennan C and Bolsover S
Eur J Neurosci vol. 26 (9), 2496-2505.
01-11-2007
2006
Accumulation of the inhibitory receptor EphA4 may prevent regeneration of corticospinal tract axons following lesionFabes J, Anderson P, Yanez-Munoz RJ, Thrasher A, Brennan C and Bolsover S
Eur J Neurosci vol. 23 (7), 1721-1730.
01-04-2006
2005
Acetylcholine and calcium signalling regulates muscle fibre formation in the zebrafish embryo.Brennan C, Mangoli M, Dyer CEF and Ashworth R
J Cell Sci vol. 118 (Pt 22), 5181-5190.
15-11-2005
Use of transgenic zebrafish reporter lines to study calcium signalling in development.Ashworth R and Brennan C
Brief Funct Genomic Proteomic vol. 4 (2), 186-193.
01-07-2005
Zebrafish in vivo modelling of the 11Q23 region of deletion in chronic lymphatic leukaemiaAuer R, Costagli A, Newland A, Fegan C, Brennan C and Cotter F
ANNALS OF ONCOLOGY. vol. 16, 87-87.
01-06-2005
Definition and zebrafish modelling of the 11 q23 critical region of deletion in CLLAuer RL, Costagli A, Newland AC, Fegan CD, Brennan C and Cotter FE
BRITISH JOURNAL OF HAEMATOLOGY. vol. 129, 25-26.
01-04-2005
2004
EphA/ephrin-A interactions during optic nerve regeneration: restoration of topography and regulation of ephrin-A2 expressionRodger J, Vitale PN, Tee LBG, King CE, Bartlett CA, Fall A, Brennan C, O'Shea JE, Dunlop SA and Beazley LD
Mol Cell Neurosci vol. 25 (1), 56-68.
01-01-2004
2003
Eph/Ephrin signaling regulates the mesenchymal-to-epithelial transition of the paraxial mesoderm during somite morphogenesisBarrios A, Poole RJ, Durbin L, Brennan C, Holder N and Wilson SW
Curr Biol vol. 13 (18), 1571-1582.
16-09-2003
Alkaline phosphatase fusion proteins as affinity probes for protein localization studies.Brennan C and Fabes J
Sci Stke vol. 2003 (168)
04-02-2003
2002
Somitogenesis.Brennan C, Amacher SL and Currie PD
Results Probl Cell Differ vol. 40, 271-297.
01-01-2002
2001
Morphogenesis of prechordal plate and notochord requires intact Eph/ephrin B signalingChan J, Mably JD, Serluca FC, Chen JN, Goldstein NB, Thomas MC, Cleary JA, Brennan C, Fishman MC and Roberts TM
Dev Biol vol. 234 (2), 470-482.
15-06-2001
Eph signalling functions downstream of Val to regulate cell sorting and boundary formation in the caudal hindbrain.Cooke J, Moens C, Roth L, Durbin L, Shiomi K, Brennan C, Kimmel C, Wilson S and Holder N
Development vol. 128 (4), 571-580.
01-02-2001
Eph Receptor Signalling and Formation of the Somites in ZebrafishBRENNAN CH
In The Origin and Fate of Somites, Ios Press. 220-235. Editors: Sanders EJ, Lash JW and Ordahl CP.
01-01-2001
2000
Anteroposterior patterning is required within segments for somite boundary formation in developing zebrafishDurbin L, Sordino P, Barrios A, Gering M, Thisse C, Thisse B, Brennan C, Green A, Wilson S and Holder N
Development, The Company of Biologists vol. 127 (8), 1703-1713.
15-04-2000
Ephrin-B Regulates the Ipsilateral Routing of Retinal Axons at the Optic ChiasmNakagawa S, Brennan C, Johnson KG, Shewan D, Harris WA and Holt CE
Neuron, Elsevier vol. 25 (3), 599-610.
01-03-2000
1999
Requirement for the zebrafish mid-hindbrain boundary in midbrain polarisation, mapping and confinement of the retinotectal projection*Picker A, Brennan C, Reifers F, Clarke JDW, Holder N and Brand M
Development, The Company of Biologists vol. 126 (13), 2967-2978.
01-07-1999
Zebrafish aussicht mutant embryos exhibit widespread overexpression of ace (fgf8) and coincident defects in CNS developmentHeisenberg C-P, Brennan C and Wilson SW
Development, The Company of Biologists vol. 126 (10), 2129-2140.
15-05-1999
An early developmental role for Eph-ephrin interaction during vertebrate gastrulationOates AC, Lackmann M, Power M-A, Brennan C, Down LM, Do C, Evans B, Holder N and Boyd AW
Cells and Development, Elsevier vol. 83 (1-2), 77-94.
01-05-1999
1998
Eph signaling is required for segmentation and differentiation of the somitesDurbin L, Brennan C, Shiomi K, Cooke J, Barrios A, Shanmugalingam S, Guthrie B, Lindberg R and Holder N
Genes & Development, Cold Spring Harbor Laboratory vol. 12 (19), 3096-3109.
01-10-1998
MINI‐REVIEW The Eph receptor tyrosine kinases and the ephrins – roles in nervous system developmentHolder N, Cooke J and Brennan C
European Journal of Neuroscience, Wiley vol. 10 (2), 405-408.
01-02-1998
1997
Analysis of axon tract formation in the zebrafish brain: the role of territories of gene expression and their boundariesWilson SW, Brennan C, Macdonald R, Brand M and Holder N
Cell and Tissue Research, Springer Nature vol. 290 (2), 189-196.
01-10-1997
The Pax protein Noi is required for commissural axon pathway formation in the rostral forebrainMacdonald R, Scholes J, Strähle U, Brennan C, Holder N, Brand M and Wilson SW
Development, The Company of Biologists vol. 124 (12), 2397-2408.
15-06-1997
Two Eph receptor tyrosine kinase ligands control axon growth and may be involved in the creation of the retinotectal map in the zebrafishBrennan C, Monschau B, Lindberg R, Guthrie B, Drescher U, Bonhoeffer F and Holder N
Development, The Company of Biologists vol. 124 (3), 655-664.
01-02-1997
1996
34 The role of signalling through eph receptors in patterning the zebrafish neural plateHolder N, Brennan C, Cooke J, Durbin L and Xu Q
International Journal of Developmental Neuroscience, Wiley vol. 14 (S1), 59-59.
01-07-1996
Effects of n-3 fatty acids on the NMR profile of plasma lipoproteins.Bell JD, Barnard ML, Parkes HG, Thomas EL, Brennan CH, Cunnane SC and Dagnelie PC
Journal of Lipid Research, Elsevier vol. 37 (8), 1664-1674.
01-01-1996
1995
The AMP‐activated Protein Kinase Gene is Highly Expressed in Rat Skeletal MuscleVerhoeven AJM, Woods A, Brennan CH, Hawley SA, Hardie DG, Scott J, Beri RK and Carling D
The Febs Journal, Wiley vol. 228 (2), 236-243.
01-03-1995
1994
Mammalian AMP-activated protein kinase is homologous to yeast and plant protein kinases involved in the regulation of carbon metabolismCarling D, Aguan K, Woods A, Verhoeven AJ, Beri RK, Brennan CH, Sidebottom C, Davison MD and Scott J
Journal of Biological Chemistry, Elsevier vol. 269 (15), 11442-11448.
01-04-1994
1993
Adaptive changes in numbers of calcium channels in drug dependence.Littleton J and Brennan C
Biochemical Society Symposia vol. 59, 193-203.
01-01-1993
1991
The Role of Calcium Flux in the Central Nervous System Actions of EthanolLITTLETON JM, BRENNAN C and BOUCHENAFA O
Annals of The New York Academy of Sciences, Wiley vol. 625 (1), 388-394.
01-06-1991
Chronic exposure to anxiolytic drugs, working by different mechanisms causes up-regulation of dihydropyridine binding sites on cultured bovine adrenal chromaffin cellsBrennan CH and Littleton JM
Neuropharmacology, Elsevier vol. 30 (2), 199-205.
01-02-1991
1990
Second messengers involved in genetic regulation of the number of calcium channels in bovine adrenal chromaffin cells in cultureBrennan CH and Littleton JM
Neuropharmacology, Elsevier vol. 29 (7), 689-693.
01-07-1990
Genetic regulation of dihydropyridine-sensitive calcium channels in brain may determine susceptibility to physical dependence on alcoholBrennan CH, Crabbe J and Littleton JM
Neuropharmacology, Elsevier vol. 29 (5), 429-432.
01-05-1990
1989
Genetic up-regulation of calcium channels in a cellular model of ethanol dependenceHarper JC, Brennan CH and Littleton JM
Neuropharmacology, Elsevier vol. 28 (12), 1299-1302.
01-12-1989
Membrane receptors, involved in up-regulation of calcium channels in bovine adrenal chromaffin cells, chronically exposed to ethanolBrennan CH, Lewis A and Littleton JM
Neuropharmacology, Elsevier vol. 28 (12), 1303-1307.
01-12-1989
Chronic Exposure to Ethanol Increases Dihydropyridine‐Sensitive Calcium Channels in Excitable CellsBRENNAN CH, GUPPY LJ and LITTLETON JM
Annals of The New York Academy of Sciences, Wiley vol. 560 (1), 467-469.
01-06-1989
1988
Adaptation in Membrane Ca2+ Channels as a Basis for Alcohol‐Related PathologyLittleton JM, Harper JC, Brennan CH and Guppy LJ
Drug and Alcohol Review, Wiley vol. 7 (1), 35-38.
01-01-1988
1987
Dihydropyridine‐Sensitive Ca2+ Channels and Inositol Phospholipid Metabolism in Ethanol Physical DependenceaHUDSPITH MJ, BRENNAN CH, CHARLES S and LITTLETON JM
Annals of The New York Academy of Sciences, Wiley vol. 492 (1), 156-170.
01-04-1987
Grants
Grants of specific relevance to the Centre for Brain and BehaviourNIH: Zebrafish addiction screenCaroline Brennan
£466,209 NIH National Institutes of Health - USA
01-08-2018 - 31-05-2025
Terpene enhancement of anxiolytic properties of cannabinoidsCaroline Brennan and Mohamed Elbadawi
£35,000 Innovate UK
25-03-2024 - 24-07-2024
Highthroughput Light Sheet Microscopy: Imaging Across ScalesViji Draviam Sastry, Caroline Brennan, Vidya Chandran Darbari, Chema Martin Duran, Ivan Kadurin, Isabel M Palacios, Richard Pickersgill, Sarah McClelland, Tyson Sharp and Martin Knight
£386,205 MRC Medical Research Council
01-10-2022 - 31-03-2023
A confocal microscope for multidisciplinary dynamic studies of complex biological systemsConrad Mullineaux, Caroline Brennan, Alexandre De Mendoza Soler, Viji Draviam Sastry, Maurice Elphick, Christoph Engl, Isabel M Palacios, Matteo Palma, Marina Resmini, Alexander Ruban, Peter Thorpe, Angelika Stollewerk, Chema Martin Duran, Paulo Baptista Ribeiro, Susana Alves Godinho, Richard Grose, Stephanie Kermorgant, Peter McCormick and Tyson Sharp
£390,834 BBSRC Biotechnology and Biological Sciences Research Council
01-08-2022 - 31-07-2023
NUMELAT - Numbers in the brain: the impact of brain lateralization on numerical abilitiesCaroline Brennan
£156,364 EU Commission - Horizon 2020
01-06-2018 - 31-05-2020
Programme grant: Imaging the neurobiology transformationsCaroline Brennan
£282,872 Human Frontier Science Program (HFSP)
01-12-2017 - 30-06-2022
GSTHgNDD - Role of GST gene variation in susceptibility to mercury (Hg)-induced neurodevelopmental disorders (NDD) in zebrafishCaroline Brennan
£146,763 EU Commission - Horizon 2020
20-06-2017 - 04-06-2020
The Genetics of Numeracy & the Evolutionary Basis of NumberCaroline Brennan
£312,614 Leverhulme Trust
12-06-2017 - 01-12-2021